DK0902022T3 - Hidtil ukendte benzofuranonderivater og fremgangsmåde til deres fremstilling - Google Patents
Hidtil ukendte benzofuranonderivater og fremgangsmåde til deres fremstillingInfo
- Publication number
- DK0902022T3 DK0902022T3 DK98900226T DK98900226T DK0902022T3 DK 0902022 T3 DK0902022 T3 DK 0902022T3 DK 98900226 T DK98900226 T DK 98900226T DK 98900226 T DK98900226 T DK 98900226T DK 0902022 T3 DK0902022 T3 DK 0902022T3
- Authority
- DK
- Denmark
- Prior art keywords
- processes
- preparation
- derivatives
- new
- benzofuranone
- Prior art date
Links
- ACZGCWSMSTYWDQ-UHFFFAOYSA-N 3h-1-benzofuran-2-one Chemical class C1=CC=C2OC(=O)CC2=C1 ACZGCWSMSTYWDQ-UHFFFAOYSA-N 0.000 title abstract 3
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- -1 benzofuranone compound Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/54—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1599197 | 1997-01-14 | ||
| JP22556597A JP3783810B2 (ja) | 1997-01-14 | 1997-08-08 | 新規ベンゾフラノン誘導体及びその製造方法 |
| PCT/JP1998/000090 WO1998030556A1 (fr) | 1997-01-14 | 1998-01-13 | Nouveaux derives de benzofuranone et procede d'elaboration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0902022T3 true DK0902022T3 (da) | 2003-11-24 |
Family
ID=26352227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98900226T DK0902022T3 (da) | 1997-01-14 | 1998-01-13 | Hidtil ukendte benzofuranonderivater og fremgangsmåde til deres fremstilling |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6143779A (fr) |
| EP (1) | EP0902022B1 (fr) |
| JP (1) | JP3783810B2 (fr) |
| KR (1) | KR100293907B1 (fr) |
| CN (1) | CN1173964C (fr) |
| AT (1) | ATE246180T1 (fr) |
| AU (1) | AU717159B2 (fr) |
| CA (1) | CA2248953C (fr) |
| DE (1) | DE69816731T2 (fr) |
| DK (1) | DK0902022T3 (fr) |
| ES (1) | ES2203921T3 (fr) |
| HU (1) | HUP9901616A3 (fr) |
| IL (1) | IL126137A (fr) |
| NO (1) | NO319608B1 (fr) |
| NZ (1) | NZ331857A (fr) |
| PT (1) | PT902022E (fr) |
| RU (1) | RU2152391C1 (fr) |
| WO (1) | WO1998030556A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999012540A1 (fr) * | 1997-09-11 | 1999-03-18 | Snow Brand Milk Products Co., Ltd. | Remedes contre des maladies hormonales |
| RU2285696C2 (ru) * | 2002-08-21 | 2006-10-20 | Шицзячжуан Фарма, Груп Чжунци Фармасьютикал Текнолоджи (Шицзячжуан) Ко., Лтд. | Комплексы включения бутилфталида с циклодекстрином или его производными, способ их получения и их применение |
| US7754709B2 (en) | 2003-06-10 | 2010-07-13 | Solvay Pharmaceuticals Bv | Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds |
| US7465739B2 (en) | 2003-06-10 | 2008-12-16 | Solvay Pharmaceuticals B.V. | Compounds and their use in therapy |
| CN101014327A (zh) * | 2004-07-14 | 2007-08-08 | 詹森药业有限公司 | 用于治疗雌激素相关α受体介导的疾病的亚芳基类物质 |
| GB0513702D0 (en) | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
| ES2381205T3 (es) * | 2005-11-10 | 2012-05-24 | Msd K.K. | Derivado espiro aza-sustituido |
| KR20080114711A (ko) * | 2006-03-02 | 2008-12-31 | 아스텔라스세이야쿠 가부시키가이샤 | 17β ＨＳＤ 타입 5 저해제 |
| US8080540B2 (en) | 2006-09-19 | 2011-12-20 | Abbott Products Gmbh | Therapeutically active triazoles and their use |
| WO2009028418A1 (fr) | 2007-08-24 | 2009-03-05 | Sapporo Medical University | Protéine de liaison à la cyclosporine a |
| GB0722779D0 (en) | 2007-11-20 | 2008-01-02 | Sterix Ltd | Compound |
| US20090192147A1 (en) * | 2008-01-30 | 2009-07-30 | Wyeth | [a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES |
| WO2009155052A1 (fr) * | 2008-05-28 | 2009-12-23 | Wyeth | Composés de 1h-pyrrolo[2,3-b]pyridine substituée en position 3 et composés de 1h-pyrrolo[3,2-b]pyridine substituée en position 3, leur utilisation en tant qu’inhibiteurs de kinase mtor et pi3 kinase, et leur synthèses |
| JP2011521961A (ja) * | 2008-05-28 | 2011-07-28 | ワイス・エルエルシー | ３−置換−１Ｈ−インドール化合物、ｍＴＯＲキナーゼおよびＰＩ３キナーゼ阻害剤としてのそれらの使用、ならびにそれらの合成 |
| US20120040974A1 (en) * | 2008-08-18 | 2012-02-16 | Yale University | Mif modulators |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
| WO2011136319A1 (fr) | 2010-04-30 | 2011-11-03 | 国立大学法人 東京大学 | Agent anticancéreux |
| WO2019144009A1 (fr) * | 2018-01-22 | 2019-07-25 | University Of Kentucky Research Foundation | Aurones semi-synthétiques et leurs méthodes d'utilisation |
| CN115925665B (zh) * | 2022-12-09 | 2024-06-25 | 中国药科大学 | 一种pde4抑制剂及其应用 |
| CN117756761B (zh) * | 2023-12-14 | 2024-06-21 | 酒泉亚佳化学有限公司 | 一种苯并呋喃酮衍生物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3975380A (en) * | 1974-06-03 | 1976-08-17 | Smithkline Corporation | Substituted aurones |
| RU2032683C1 (ru) * | 1991-07-02 | 1995-04-10 | Андрейчиков Юрий Сергеевич | 2-метил-5-метокси-3-метоксалилацетобензофуран, проявляющий противовирусную активность в отношении вируса гриппа типа а и в |
| US5354861A (en) * | 1992-11-04 | 1994-10-11 | National University Of Singapore | 2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents |
| JP3872834B2 (ja) * | 1996-03-04 | 2007-01-24 | 第一製薬株式会社 | メイラード反応抑制剤 |
-
1997
- 1997-08-08 JP JP22556597A patent/JP3783810B2/ja not_active Expired - Fee Related
-
1998
- 1998-01-13 KR KR1019980707198A patent/KR100293907B1/ko not_active Expired - Fee Related
- 1998-01-13 WO PCT/JP1998/000090 patent/WO1998030556A1/fr not_active Ceased
- 1998-01-13 CA CA002248953A patent/CA2248953C/fr not_active Expired - Fee Related
- 1998-01-13 EP EP98900226A patent/EP0902022B1/fr not_active Expired - Lifetime
- 1998-01-13 DE DE69816731T patent/DE69816731T2/de not_active Expired - Fee Related
- 1998-01-13 PT PT98900226T patent/PT902022E/pt unknown
- 1998-01-13 HU HU9901616A patent/HUP9901616A3/hu unknown
- 1998-01-13 DK DK98900226T patent/DK0902022T3/da active
- 1998-01-13 RU RU98118569/04A patent/RU2152391C1/ru not_active IP Right Cessation
- 1998-01-13 CN CNB988001365A patent/CN1173964C/zh not_active Expired - Fee Related
- 1998-01-13 IL IL126137A patent/IL126137A/en not_active IP Right Cessation
- 1998-01-13 NZ NZ331857A patent/NZ331857A/en unknown
- 1998-01-13 AT AT98900226T patent/ATE246180T1/de not_active IP Right Cessation
- 1998-01-13 US US09/142,666 patent/US6143779A/en not_active Expired - Fee Related
- 1998-01-13 AU AU53436/98A patent/AU717159B2/en not_active Ceased
- 1998-01-13 ES ES98900226T patent/ES2203921T3/es not_active Expired - Lifetime
- 1998-09-11 NO NO19984195A patent/NO319608B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0902022A1 (fr) | 1999-03-17 |
| AU717159B2 (en) | 2000-03-16 |
| CA2248953C (fr) | 2003-09-09 |
| CN1217719A (zh) | 1999-05-26 |
| RU2152391C1 (ru) | 2000-07-10 |
| IL126137A0 (en) | 1999-05-09 |
| DE69816731T2 (de) | 2004-06-03 |
| IL126137A (en) | 2006-08-01 |
| NO984195D0 (no) | 1998-09-11 |
| US6143779A (en) | 2000-11-07 |
| KR100293907B1 (ko) | 2001-09-17 |
| AU5343698A (en) | 1998-08-03 |
| EP0902022B1 (fr) | 2003-07-30 |
| JP3783810B2 (ja) | 2006-06-07 |
| JPH10259182A (ja) | 1998-09-29 |
| NO984195L (no) | 1998-10-26 |
| HUP9901616A1 (hu) | 2001-04-28 |
| NO319608B1 (no) | 2005-08-29 |
| ATE246180T1 (de) | 2003-08-15 |
| KR20000064582A (ko) | 2000-11-06 |
| HUP9901616A3 (en) | 2001-05-28 |
| ES2203921T3 (es) | 2004-04-16 |
| WO1998030556A1 (fr) | 1998-07-16 |
| PT902022E (pt) | 2003-12-31 |
| DE69816731D1 (de) | 2003-09-04 |
| EP0902022A4 (fr) | 2002-01-23 |
| CA2248953A1 (fr) | 1998-07-16 |
| NZ331857A (en) | 2000-02-28 |
| CN1173964C (zh) | 2004-11-03 |
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