DK0902783T3 - Hydrolysefremmende, hydrofobe taxanderivater - Google Patents

Hydrolysefremmende, hydrofobe taxanderivater

Info

Publication number
DK0902783T3
DK0902783T3 DK96930847T DK96930847T DK0902783T3 DK 0902783 T3 DK0902783 T3 DK 0902783T3 DK 96930847 T DK96930847 T DK 96930847T DK 96930847 T DK96930847 T DK 96930847T DK 0902783 T3 DK0902783 T3 DK 0902783T3
Authority
DK
Denmark
Prior art keywords
hydrolysis
taxane
hydrocarbon
promoting
taxane derivatives
Prior art date
Application number
DK96930847T
Other languages
Danish (da)
English (en)
Inventor
Eric Mayhew
Shaukat Ali
Andrew S Janoff
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of DK0902783T3 publication Critical patent/DK0902783T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
DK96930847T 1995-09-12 1996-09-12 Hydrolysefremmende, hydrofobe taxanderivater DK0902783T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US357595P 1995-09-12 1995-09-12
PCT/US1996/014631 WO1997010234A1 (fr) 1995-09-12 1996-09-12 Derives hydrophobes de taxane favorisant l'hydrolyse

Publications (1)

Publication Number Publication Date
DK0902783T3 true DK0902783T3 (da) 2002-07-22

Family

ID=21706522

Family Applications (2)

Application Number Title Priority Date Filing Date
DK02008590T DK1229030T3 (da) 1995-09-12 1996-09-12 Hydrolysefremmende, hydrofobe taxanderivater
DK96930847T DK0902783T3 (da) 1995-09-12 1996-09-12 Hydrolysefremmende, hydrofobe taxanderivater

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK02008590T DK1229030T3 (da) 1995-09-12 1996-09-12 Hydrolysefremmende, hydrofobe taxanderivater

Country Status (21)

Country Link
US (1) US5703117A (fr)
EP (1) EP0902783B1 (fr)
JP (1) JP4192208B2 (fr)
KR (1) KR100401220B1 (fr)
CN (1) CN1100770C (fr)
AT (2) ATE216377T1 (fr)
CA (1) CA2231750C (fr)
CZ (1) CZ288562B6 (fr)
DE (2) DE69620802T2 (fr)
DK (2) DK1229030T3 (fr)
ES (2) ES2179208T3 (fr)
HU (1) HU226325B1 (fr)
IL (1) IL123595A (fr)
MX (1) MX9801871A (fr)
NO (1) NO319521B1 (fr)
NZ (1) NZ318300A (fr)
PL (1) PL187738B1 (fr)
PT (1) PT902783E (fr)
SK (1) SK283199B6 (fr)
TR (1) TR199800443T1 (fr)
WO (1) WO1997010234A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107332A (en) * 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
US6667053B1 (en) * 1996-02-16 2003-12-23 Elan Pharmaceuticals, Inc. D and L etherlipid stereoisomers and liposomes
US5912264A (en) * 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
DK2255800T3 (da) 1997-11-10 2013-02-04 Sloan Kettering Inst Cancer Arsentrioxid til anvendelse ved behandling af leukæmi
EE200000693A (et) * 1998-05-20 2002-04-15 The Liposome Company, Inc. Uudsed makroosakeste formulatsioonid
US7314637B1 (en) 1999-06-29 2008-01-01 Neopharm, Inc. Method of administering liposomal encapsulated taxane
US6146659A (en) * 1998-07-01 2000-11-14 Neopharm, Inc. Method of administering liposomal encapsulated taxane
ATE247465T1 (de) * 1999-01-12 2003-09-15 Quanam Medical Corp Arzneimittel und verfahren zur verabreichung von wasserunlöslichen paclitaxelderivaten
CA2385528C (fr) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques
DE60131537T2 (de) 2000-06-22 2008-10-23 Nitromed, Inc., Lexington Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung
US6607689B1 (en) * 2000-08-29 2003-08-19 Micron Technology, Inc. Layer thickness control for stereolithography utilizing variable liquid elevation and laser focal length
EP1304103B1 (fr) * 2001-10-22 2008-12-31 Viroblock SA Vesicles non-phospholipidiques (npLV) et leur utilisation en cosmetique, therapeutique et preventive
US6710195B2 (en) * 2001-11-26 2004-03-23 Supergen, Inc. Method for preparing and using polyoxyethylated castor oil in pharmaceutical compositions
WO2004002455A1 (fr) * 2002-06-26 2004-01-08 Medigene Oncology Gmbh Procede pour stabiliser des composes destines au diagnostic ou a la therapie dans un systeme support cationique
CN1700906A (zh) 2003-02-03 2005-11-23 新药物公司 稳定的无菌过滤性脂质体包封的紫杉烷和其他抗肿瘤药物
US20090130163A1 (en) * 2005-02-18 2009-05-21 Abraxis Bio Scoence, Inc. Drugs With Improved Hydrophobicity For Incorporation in Medical Devices
EP1871343A2 (fr) 2005-04-12 2008-01-02 Wisconsin Alumni Research Foundation Composition micellaire polymere et medicament contenu dans celle-ci
KR20150136137A (ko) * 2008-04-10 2015-12-04 아브락시스 바이오사이언스, 엘엘씨 소수성 탁산 유도체의 조성물 및 그의 용도
CA2721153C (fr) * 2008-04-10 2018-10-02 Abraxis Bioscience, Llc Compositions de derives hydrophobes de taxane et leurs utilisations
WO2011038278A2 (fr) 2009-09-25 2011-03-31 Wisconsin Alumni Research Foundation Encapsulation d'agents thérapeutiques dans des micelles
CN105503844A (zh) * 2015-12-11 2016-04-20 上海大学 C-13和c-7位结构改造的紫杉醇类化合物及其制备方法
CN111004195B (zh) * 2019-12-03 2022-01-28 沈阳药科大学 卡巴他赛弱碱性衍生物及其制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
ATE309229T1 (de) * 1992-12-23 2005-11-15 Bristol Myers Squibb Co Seitenkette tragende taxanen und deren zwischenprodukten
IL108316A (en) * 1993-01-15 2006-10-31 Univ Florida State C10 taxane derivatives and pharmaceutical compositions containing them
US5580899A (en) * 1995-01-09 1996-12-03 The Liposome Company, Inc. Hydrophobic taxane derivatives

Also Published As

Publication number Publication date
HUP9901433A2 (hu) 2001-04-28
KR19990044409A (ko) 1999-06-25
US5703117A (en) 1997-12-30
CN1202166A (zh) 1998-12-16
ES2252347T3 (es) 2006-05-16
PL325477A1 (en) 1998-07-20
AU6975696A (en) 1997-04-01
TR199800443T1 (xx) 1998-06-22
WO1997010234A1 (fr) 1997-03-20
DK1229030T3 (da) 2006-02-13
SK283199B6 (sk) 2003-03-04
IL123595A (en) 2000-10-31
EP0902783A4 (fr) 1999-03-24
CZ288562B6 (cs) 2001-07-11
CZ71198A3 (cs) 1998-07-15
ATE216377T1 (de) 2002-05-15
PT902783E (pt) 2002-09-30
AU706290B2 (en) 1999-06-10
EP0902783A1 (fr) 1999-03-24
CN1100770C (zh) 2003-02-05
ATE309235T1 (de) 2005-11-15
JP2001519755A (ja) 2001-10-23
NZ318300A (en) 1999-08-30
DE69635428D1 (de) 2005-12-15
KR100401220B1 (ko) 2004-03-20
MX9801871A (es) 1998-05-31
CA2231750C (fr) 2006-07-11
NO981071L (no) 1998-05-12
PL187738B1 (pl) 2004-09-30
CA2231750A1 (fr) 1997-03-20
DE69620802D1 (de) 2002-05-23
NO319521B1 (no) 2005-08-22
ES2179208T3 (es) 2003-01-16
DE69620802T2 (de) 2002-10-10
SK33498A3 (en) 1998-08-05
HU226325B1 (en) 2008-08-28
IL123595A0 (en) 1998-10-30
HK1016169A1 (en) 1999-10-29
JP4192208B2 (ja) 2008-12-10
NO981071D0 (no) 1998-03-11
EP0902783B1 (fr) 2002-04-17
HUP9901433A3 (en) 2001-05-28
DE69635428T2 (de) 2006-06-14

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