ATE216377T1 - Hydrolysierbare hydrophobe taxanderivate - Google Patents

Hydrolysierbare hydrophobe taxanderivate

Info

Publication number: ATE216377T1
Authority: AT; Austria
Prior art keywords: taxane; hydrocarbon; hpg; enhanced; alpha position
Prior art date: 1995-09-12

Application number

AT96930847T

Other languages

English (en)

Inventor

Eric Mayhew

Shaukat Ali

Andrew S Janoff

Original Assignee

Liposome Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-12

Filing date

1996-09-12

Publication date

2002-05-15

1996-09-12 Application filed by Liposome Co Inc filed Critical Liposome Co Inc

2002-05-15 Application granted granted Critical

2002-05-15 Publication of ATE216377T1 publication Critical patent/ATE216377T1/de

Links

230000002209 hydrophobic effect Effects 0.000 title 1
229940123237 Taxane Drugs 0.000 abstract 5
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 3
239000004215 Carbon black (E152) Substances 0.000 abstract 2
229930195733 hydrocarbon Natural products 0.000 abstract 2
150000002430 hydrocarbons Chemical class 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Medicinal Preparation (AREA)

AT96930847T 1995-09-12 1996-09-12 Hydrolysierbare hydrophobe taxanderivate ATE216377T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US357595P	1995-09-12	1995-09-12
PCT/US1996/014631 WO1997010234A1 (en)	1995-09-12	1996-09-12	Hydrolysis-promoting taxane hydrophobic derivatives

Publications (1)

Publication Number	Publication Date
ATE216377T1 true ATE216377T1 (de)	2002-05-15

Family

ID=21706522

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT02008590T ATE309235T1 (de)	1995-09-12	1996-09-12	Hydrolyse-einleitende hydrophobe taxane derivate
AT96930847T ATE216377T1 (de)	1995-09-12	1996-09-12	Hydrolysierbare hydrophobe taxanderivate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT02008590T ATE309235T1 (de)	1995-09-12	1996-09-12	Hydrolyse-einleitende hydrophobe taxane derivate

Country Status (21)

Country	Link
US (1)	US5703117A (de)
EP (1)	EP0902783B1 (de)
JP (1)	JP4192208B2 (de)
KR (1)	KR100401220B1 (de)
CN (1)	CN1100770C (de)
AT (2)	ATE309235T1 (de)
CA (1)	CA2231750C (de)
CZ (1)	CZ288562B6 (de)
DE (2)	DE69635428T2 (de)
DK (2)	DK0902783T3 (de)
ES (2)	ES2252347T3 (de)
HU (1)	HU226325B1 (de)
IL (1)	IL123595A (de)
MX (1)	MX9801871A (de)
NO (1)	NO319521B1 (de)
NZ (1)	NZ318300A (de)
PL (1)	PL187738B1 (de)
PT (1)	PT902783E (de)
SK (1)	SK283199B6 (de)
TR (1)	TR199800443T1 (de)
WO (1)	WO1997010234A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6107332A (en) *	1995-09-12	2000-08-22	The Liposome Company, Inc.	Hydrolysis-promoting hydrophobic taxane derivatives
US6667053B1 (en) *	1996-02-16	2003-12-23	Elan Pharmaceuticals, Inc.	D and L etherlipid stereoisomers and liposomes
US5912264A (en) *	1997-03-03	1999-06-15	Bristol-Myers Squibb Company	6-halo-or nitrate-substituted paclitaxels
US8853260B2 (en)	1997-06-27	2014-10-07	Abraxis Bioscience, Llc	Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
TR200002243T2 (tr) *	1997-11-10	2000-12-21	Memorial Sloan-Kettering Cancer Center	Arsenik trioksitin hazırlanması için işlem ve bunların kanser tedavisi için kullanımı.
SK17422000A3 (sk) *	1998-05-20	2001-09-11	The Liposome Company, Inc.	Kompozöcie ¬astöc
US6146659A (en) *	1998-07-01	2000-11-14	Neopharm, Inc.	Method of administering liposomal encapsulated taxane
US7314637B1 (en)	1999-06-29	2008-01-01	Neopharm, Inc.	Method of administering liposomal encapsulated taxane
JP2002534461A (ja) *	1999-01-12	2002-10-15	クアナムメディカルコーポレイション	水不溶性のパクリタキセル誘導体の投与のための組成物および方法
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CA2410632A1 (en)	2000-06-22	2001-12-27	David S. Garvey	Nitrosated and nitrosylated taxanes, compositions and methods of use
US6607689B1 (en) *	2000-08-29	2003-08-19	Micron Technology, Inc.	Layer thickness control for stereolithography utilizing variable liquid elevation and laser focal length
EP1304103B1 (de) *	2001-10-22	2008-12-31	Viroblock SA	Non-phospholipid Vesikel (npLV) und ihre Verwendung in kosmetischen, therapeutischen und prophylaktischen Anwendungen
US6710195B2 (en) *	2001-11-26	2004-03-23	Supergen, Inc.	Method for preparing and using polyoxyethylated castor oil in pharmaceutical compositions
EP1553924B1 (de) *	2002-06-26	2010-12-08	MediGene AG	Neues verfahren zur stabilisierung von diagnostischen und therapeutischen verbindungen in einem kationischen trägersystem
BRPI0407096A (pt)	2003-02-03	2006-01-24	Neopharm Inc	Taxano encapsulado em lipossomo estável, estéril e filtrável e outros fármacos antineoplásicos
US20090130163A1 (en) *	2005-02-18	2009-05-21	Abraxis Bio Scoence, Inc.	Drugs With Improved Hydrophobicity For Incorporation in Medical Devices
AU2006235538A1 (en) *	2005-04-12	2006-10-19	Wisconsin Alumni Research Foundation	Micelle composition of polymer and passenger drug
TW200942233A (en) *	2008-04-10	2009-10-16	Abraxis Bioscience Llc	Compositions of hydrophobic taxane derivatives and uses thereof
MX2010011165A (es) *	2008-04-10	2011-02-22	Abraxis Bioscience Llc	Composiciones de derivados de taxano hidrofobos y sus usos.
EP2480207B1 (de)	2009-09-25	2016-11-09	Wisconsin Alumni Research Foundation	Verkapselung von arzneistoffen in mizellen
CN105503844A (zh) *	2015-12-11	2016-04-20	上海大学	C-13和c-7位结构改造的紫杉醇类化合物及其制备方法
CN111004195B (zh) *	2019-12-03	2022-01-28	沈阳药科大学	卡巴他赛弱碱性衍生物及其制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5059699A (en) *	1990-08-28	1991-10-22	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
US5278324A (en) *	1990-08-28	1994-01-11	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
CZ292993B6 (cs) *	1992-12-23	2004-01-14	Bristol-Myers Squibb Company	Způsob přípravy taxanu nesoucího oxazolinový postranní řetězec a taxan tímto způsobem připravený
IL108316A (en) *	1993-01-15	2006-10-31	Univ Florida State	C10 taxane derivatives and pharmaceutical compositions containing them
US5580899A (en) *	1995-01-09	1996-12-03	The Liposome Company, Inc.	Hydrophobic taxane derivatives

1996
- 1996-09-12 AT AT02008590T patent/ATE309235T1/de not_active IP Right Cessation
- 1996-09-12 US US08/712,684 patent/US5703117A/en not_active Expired - Fee Related
- 1996-09-12 AT AT96930847T patent/ATE216377T1/de not_active IP Right Cessation
- 1996-09-12 CZ CZ1998711A patent/CZ288562B6/cs not_active IP Right Cessation
- 1996-09-12 TR TR1998/00443T patent/TR199800443T1/xx unknown
- 1996-09-12 SK SK334-98A patent/SK283199B6/sk unknown
- 1996-09-12 DE DE69635428T patent/DE69635428T2/de not_active Expired - Fee Related
- 1996-09-12 DK DK96930847T patent/DK0902783T3/da active
- 1996-09-12 EP EP96930847A patent/EP0902783B1/de not_active Expired - Lifetime
- 1996-09-12 ES ES02008590T patent/ES2252347T3/es not_active Expired - Lifetime
- 1996-09-12 HU HU9901433A patent/HU226325B1/hu unknown
- 1996-09-12 PL PL96325477A patent/PL187738B1/pl not_active IP Right Cessation
- 1996-09-12 WO PCT/US1996/014631 patent/WO1997010234A1/en not_active Ceased
- 1996-09-12 DK DK02008590T patent/DK1229030T3/da active
- 1996-09-12 MX MX9801871A patent/MX9801871A/es not_active IP Right Cessation
- 1996-09-12 JP JP51210297A patent/JP4192208B2/ja not_active Expired - Fee Related
- 1996-09-12 CA CA002231750A patent/CA2231750C/en not_active Expired - Fee Related
- 1996-09-12 IL IL12359596A patent/IL123595A/xx not_active IP Right Cessation
- 1996-09-12 KR KR10-1998-0701653A patent/KR100401220B1/ko not_active Expired - Fee Related
- 1996-09-12 DE DE69620802T patent/DE69620802T2/de not_active Expired - Fee Related
- 1996-09-12 ES ES96930847T patent/ES2179208T3/es not_active Expired - Lifetime
- 1996-09-12 PT PT96930847T patent/PT902783E/pt unknown
- 1996-09-12 CN CN96198237A patent/CN1100770C/zh not_active Expired - Fee Related
- 1996-09-12 NZ NZ318300A patent/NZ318300A/xx unknown
1998
- 1998-03-11 NO NO19981071A patent/NO319521B1/no unknown

Also Published As

Publication number	Publication date
KR100401220B1 (ko)	2004-03-20
ES2179208T3 (es)	2003-01-16
DE69620802T2 (de)	2002-10-10
SK33498A3 (en)	1998-08-05
US5703117A (en)	1997-12-30
KR19990044409A (ko)	1999-06-25
JP2001519755A (ja)	2001-10-23
PL187738B1 (pl)	2004-09-30
HK1016169A1 (en)	1999-10-29
JP4192208B2 (ja)	2008-12-10
MX9801871A (es)	1998-05-31
AU6975696A (en)	1997-04-01
HUP9901433A3 (en)	2001-05-28
IL123595A0 (en)	1998-10-30
HU226325B1 (en)	2008-08-28
NO319521B1 (no)	2005-08-22
NO981071D0 (no)	1998-03-11
CA2231750C (en)	2006-07-11
HUP9901433A2 (hu)	2001-04-28
EP0902783B1 (de)	2002-04-17
EP0902783A4 (de)	1999-03-24
IL123595A (en)	2000-10-31
DK0902783T3 (da)	2002-07-22
CZ71198A3 (cs)	1998-07-15
DE69635428T2 (de)	2006-06-14
DE69620802D1 (de)	2002-05-23
CZ288562B6 (cs)	2001-07-11
CN1202166A (zh)	1998-12-16
ATE309235T1 (de)	2005-11-15
ES2252347T3 (es)	2006-05-16
CA2231750A1 (en)	1997-03-20
AU706290B2 (en)	1999-06-10
WO1997010234A1 (en)	1997-03-20
EP0902783A1 (de)	1999-03-24
CN1100770C (zh)	2003-02-05
DK1229030T3 (da)	2006-02-13
NO981071L (no)	1998-05-12
PL325477A1 (en)	1998-07-20
NZ318300A (en)	1999-08-30
TR199800443T1 (xx)	1998-06-22
DE69635428D1 (de)	2005-12-15
SK283199B6 (sk)	2003-03-04
PT902783E (pt)	2002-09-30

Legal Events

Date	Code	Title
2003-11-15	EEIH	Change in the person of patent owner
2009-06-15	EEIH	Change in the person of patent owner
2009-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE216377T1 (de)	2002-05-15	Hydrolysierbare hydrophobe taxanderivate
DE69713526D1 (de)	2002-07-25	Lösliche prodrugs von paclitaxel
EA200000282A1 (ru)	2000-10-30	Способ введения таксана пациенту, нуждающемуся в лечении таксаном, способ лечения человека таксаном (варианты)
CY1109695T1 (el)	2014-08-13	Μικροοργανισμοι αποδομησης οξαλικου ή ενζυμα αποδομησης οξαλικου για την προληψη παθησης σχετιζομενης με οξαλικο
FI952248A7 (fi)	1995-05-09	Kasvainvastaisia koostumuksia, jotka sisältävät taksaanijohdannaisia
PT802911E (pt)	2002-05-31	Derivados de taxano hidrofobos
TR200102603T2 (tr)	2002-01-21	Antitümör aktiviteye sahip olan kamptotesin türevleri
NL970006I1 (nl)	1997-04-01	Gebruik van indolon-derivaten voor het bereiden van geneesmiddelen ter behandeling van de ziekte vanParkinson.
ATE262515T1 (de)	2004-04-15	Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie
NZ508585A (en)	2002-11-26	Metabolites of ecteinascidin 743
SE8404283L (sv)	1986-03-01	Anvendning av ett specifikt tumorassocierat antigen, nemligen sialosyllaktotetraos, for diagnostiska och terapeutiska forfaranden vid cancersjukdomar
ES2038642T3 (es)	1993-08-01	Tratamiento dermico de enfermedades vermiculares del gato con pracicuantel.
EP1229030A3 (de)	2002-09-25	Hydrolyse-einleitende hydrophobe Taxane Derivate
BR0014687A (pt)	2002-11-19	Compostos de taxano pentacìclico
ES2074332T3 (es)	1995-09-01	Derivados de polihidroxiciclopentano, su preparacion y su uso terapeutico.
IL150787A0 (en)	2003-02-12	Semi-synthetic taxanes with antitumor and antiangiogenetic activities
NO20002176L (no)	2000-07-05	Diagnostikk og terapi av kronisk obstruktiv luftveissykdom
IT208536Z2 (it)	1988-05-28	Struttura di cannula vaginale monouso, per l'applicazione di pomate, medicamenti semidensi e simili.
MX9604305A (es)	1997-12-31	Novedosos carbamatos y ureas como modificadores a la resistencia a multiples drogas.