DK1229030T3 - Hydrolysefremmende, hydrofobe taxanderivater - Google Patents

Hydrolysefremmende, hydrofobe taxanderivater

Info

Publication number: DK1229030T3
Authority: DK; Denmark
Prior art keywords: hydrolysis; taxane; hydrocarbon; promoting; taxane derivatives
Prior art date: 1995-09-12

Application number

DK02008590T

Other languages

English (en)

Inventor

Eric Mayhew

Shaukat Ali

Andrew S Janoff

Original Assignee

Zeneus Pharma Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-12

Filing date

1996-09-12

Publication date

2006-02-13

1996-09-12 Application filed by Zeneus Pharma Ltd filed Critical Zeneus Pharma Ltd

2006-02-13 Application granted granted Critical

2006-02-13 Publication of DK1229030T3 publication Critical patent/DK1229030T3/da

Links

DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 4
230000002209 hydrophobic effect Effects 0.000 title 1
229940123237 Taxane Drugs 0.000 abstract 5
239000004215 Carbon black (E152) Substances 0.000 abstract 2
229930195733 hydrocarbon Natural products 0.000 abstract 2
150000002430 hydrocarbons Chemical class 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Medicinal Preparation (AREA)

DK02008590T 1995-09-12 1996-09-12 Hydrolysefremmende, hydrofobe taxanderivater DK1229030T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US357595P	1995-09-12	1995-09-12

Publications (1)

Publication Number	Publication Date
DK1229030T3 true DK1229030T3 (da)	2006-02-13

Family

ID=21706522

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK02008590T DK1229030T3 (da)	1995-09-12	1996-09-12	Hydrolysefremmende, hydrofobe taxanderivater
DK96930847T DK0902783T3 (da)	1995-09-12	1996-09-12	Hydrolysefremmende, hydrofobe taxanderivater

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK96930847T DK0902783T3 (da)	1995-09-12	1996-09-12	Hydrolysefremmende, hydrofobe taxanderivater

Country Status (21)

Country	Link
US (1)	US5703117A (da)
EP (1)	EP0902783B1 (da)
JP (1)	JP4192208B2 (da)
KR (1)	KR100401220B1 (da)
CN (1)	CN1100770C (da)
AT (2)	ATE216377T1 (da)
CA (1)	CA2231750C (da)
CZ (1)	CZ288562B6 (da)
DE (2)	DE69620802T2 (da)
DK (2)	DK1229030T3 (da)
ES (2)	ES2179208T3 (da)
HU (1)	HU226325B1 (da)
IL (1)	IL123595A (da)
MX (1)	MX9801871A (da)
NO (1)	NO319521B1 (da)
NZ (1)	NZ318300A (da)
PL (1)	PL187738B1 (da)
PT (1)	PT902783E (da)
SK (1)	SK283199B6 (da)
TR (1)	TR199800443T1 (da)
WO (1)	WO1997010234A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6107332A (en) *	1995-09-12	2000-08-22	The Liposome Company, Inc.	Hydrolysis-promoting hydrophobic taxane derivatives
US6667053B1 (en) *	1996-02-16	2003-12-23	Elan Pharmaceuticals, Inc.	D and L etherlipid stereoisomers and liposomes
US5912264A (en) *	1997-03-03	1999-06-15	Bristol-Myers Squibb Company	6-halo-or nitrate-substituted paclitaxels
US8853260B2 (en)	1997-06-27	2014-10-07	Abraxis Bioscience, Llc	Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
DK2255800T3 (da)	1997-11-10	2013-02-04	Sloan Kettering Inst Cancer	Arsentrioxid til anvendelse ved behandling af leukæmi
EE200000693A (et) *	1998-05-20	2002-04-15	The Liposome Company, Inc.	Uudsed makroosakeste formulatsioonid
US7314637B1 (en)	1999-06-29	2008-01-01	Neopharm, Inc.	Method of administering liposomal encapsulated taxane
US6146659A (en) *	1998-07-01	2000-11-14	Neopharm, Inc.	Method of administering liposomal encapsulated taxane
ATE247465T1 (de) *	1999-01-12	2003-09-15	Quanam Medical Corp	Arzneimittel und verfahren zur verabreichung von wasserunlöslichen paclitaxelderivaten
CA2385528C (en)	1999-10-01	2013-12-10	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
DE60131537T2 (de)	2000-06-22	2008-10-23	Nitromed, Inc., Lexington	Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung
US6607689B1 (en) *	2000-08-29	2003-08-19	Micron Technology, Inc.	Layer thickness control for stereolithography utilizing variable liquid elevation and laser focal length
EP1304103B1 (en) *	2001-10-22	2008-12-31	Viroblock SA	New non-phospholipid lipid vesicles (npLV) and their use in cosmetic, therapeutic and prophylactic applications
US6710195B2 (en) *	2001-11-26	2004-03-23	Supergen, Inc.	Method for preparing and using polyoxyethylated castor oil in pharmaceutical compositions
WO2004002455A1 (en) *	2002-06-26	2004-01-08	Medigene Oncology Gmbh	Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system
CN1700906A (zh)	2003-02-03	2005-11-23	新药物公司	稳定的无菌过滤性脂质体包封的紫杉烷和其他抗肿瘤药物
US20090130163A1 (en) *	2005-02-18	2009-05-21	Abraxis Bio Scoence, Inc.	Drugs With Improved Hydrophobicity For Incorporation in Medical Devices
EP1871343A2 (en)	2005-04-12	2008-01-02	Wisconsin Alumni Research Foundation	Micelle composition of polymer and passenger drug
KR20150136137A (ko) *	2008-04-10	2015-12-04	아브락시스 바이오사이언스, 엘엘씨	소수성 탁산 유도체의 조성물 및 그의 용도
CA2721153C (en) *	2008-04-10	2018-10-02	Abraxis Bioscience, Llc	Compositions of hydrophobic taxane derivatives and uses thereof
WO2011038278A2 (en)	2009-09-25	2011-03-31	Wisconsin Alumni Research Foundation	Micelle encapsulation of therapeutic agents
CN105503844A (zh) *	2015-12-11	2016-04-20	上海大学	C-13和c-7位结构改造的紫杉醇类化合物及其制备方法
CN111004195B (zh) *	2019-12-03	2022-01-28	沈阳药科大学	卡巴他赛弱碱性衍生物及其制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5278324A (en) *	1990-08-28	1994-01-11	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
US5059699A (en) *	1990-08-28	1991-10-22	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
ATE309229T1 (de) *	1992-12-23	2005-11-15	Bristol Myers Squibb Co	Seitenkette tragende taxanen und deren zwischenprodukten
IL108316A (en) *	1993-01-15	2006-10-31	Univ Florida State	C10 taxane derivatives and pharmaceutical compositions containing them
US5580899A (en) *	1995-01-09	1996-12-03	The Liposome Company, Inc.	Hydrophobic taxane derivatives

1996
- 1996-09-12 IL IL12359596A patent/IL123595A/xx not_active IP Right Cessation
- 1996-09-12 SK SK334-98A patent/SK283199B6/sk unknown
- 1996-09-12 CN CN96198237A patent/CN1100770C/zh not_active Expired - Fee Related
- 1996-09-12 HU HU9901433A patent/HU226325B1/hu unknown
- 1996-09-12 KR KR10-1998-0701653A patent/KR100401220B1/ko not_active Expired - Fee Related
- 1996-09-12 PL PL96325477A patent/PL187738B1/pl not_active IP Right Cessation
- 1996-09-12 EP EP96930847A patent/EP0902783B1/en not_active Expired - Lifetime
- 1996-09-12 CA CA002231750A patent/CA2231750C/en not_active Expired - Fee Related
- 1996-09-12 TR TR1998/00443T patent/TR199800443T1/xx unknown
- 1996-09-12 MX MX9801871A patent/MX9801871A/es not_active IP Right Cessation
- 1996-09-12 CZ CZ1998711A patent/CZ288562B6/cs not_active IP Right Cessation
- 1996-09-12 JP JP51210297A patent/JP4192208B2/ja not_active Expired - Fee Related
- 1996-09-12 NZ NZ318300A patent/NZ318300A/xx unknown
- 1996-09-12 ES ES96930847T patent/ES2179208T3/es not_active Expired - Lifetime
- 1996-09-12 AT AT96930847T patent/ATE216377T1/de not_active IP Right Cessation
- 1996-09-12 ES ES02008590T patent/ES2252347T3/es not_active Expired - Lifetime
- 1996-09-12 DK DK02008590T patent/DK1229030T3/da active
- 1996-09-12 DK DK96930847T patent/DK0902783T3/da active
- 1996-09-12 PT PT96930847T patent/PT902783E/pt unknown
- 1996-09-12 US US08/712,684 patent/US5703117A/en not_active Expired - Fee Related
- 1996-09-12 WO PCT/US1996/014631 patent/WO1997010234A1/en not_active Ceased
- 1996-09-12 DE DE69620802T patent/DE69620802T2/de not_active Expired - Fee Related
- 1996-09-12 DE DE69635428T patent/DE69635428T2/de not_active Expired - Fee Related
- 1996-09-12 AT AT02008590T patent/ATE309235T1/de not_active IP Right Cessation
1998
- 1998-03-11 NO NO19981071A patent/NO319521B1/no unknown

Also Published As

Publication number	Publication date
HUP9901433A2 (hu)	2001-04-28
KR19990044409A (ko)	1999-06-25
US5703117A (en)	1997-12-30
CN1202166A (zh)	1998-12-16
ES2252347T3 (es)	2006-05-16
PL325477A1 (en)	1998-07-20
AU6975696A (en)	1997-04-01
TR199800443T1 (xx)	1998-06-22
WO1997010234A1 (en)	1997-03-20
DK0902783T3 (da)	2002-07-22
SK283199B6 (sk)	2003-03-04
IL123595A (en)	2000-10-31
EP0902783A4 (da)	1999-03-24
CZ288562B6 (cs)	2001-07-11
CZ71198A3 (cs)	1998-07-15
ATE216377T1 (de)	2002-05-15
PT902783E (pt)	2002-09-30
AU706290B2 (en)	1999-06-10
EP0902783A1 (en)	1999-03-24
CN1100770C (zh)	2003-02-05
ATE309235T1 (de)	2005-11-15
JP2001519755A (ja)	2001-10-23
NZ318300A (en)	1999-08-30
DE69635428D1 (de)	2005-12-15
KR100401220B1 (ko)	2004-03-20
MX9801871A (es)	1998-05-31
CA2231750C (en)	2006-07-11
NO981071L (no)	1998-05-12
PL187738B1 (pl)	2004-09-30
CA2231750A1 (en)	1997-03-20
DE69620802D1 (de)	2002-05-23
NO319521B1 (no)	2005-08-22
ES2179208T3 (es)	2003-01-16
DE69620802T2 (de)	2002-10-10
SK33498A3 (en)	1998-08-05
HU226325B1 (en)	2008-08-28
IL123595A0 (en)	1998-10-30
HK1016169A1 (en)	1999-10-29
JP4192208B2 (ja)	2008-12-10
NO981071D0 (no)	1998-03-11
EP0902783B1 (en)	2002-04-17
HUP9901433A3 (en)	2001-05-28
DE69635428T2 (de)	2006-06-14

Publication	Publication Date	Title
DK0902783T3 (da)	2002-07-22	Hydrolysefremmende, hydrofobe taxanderivater
DE69713526D1 (de)	2002-07-25	Lösliche prodrugs von paclitaxel
PT802911E (pt)	2002-05-31	Derivados de taxano hidrofobos
FI952248A7 (fi)	1995-05-09	Kasvainvastaisia koostumuksia, jotka sisältävät taksaanijohdannaisia
ES2170141T3 (es)	2002-08-01	4-aminoderivados del acido micofenolico con actividad inmunosupresora.
CA2301057A1 (en)	2000-01-13	A method of administering liposomal encapsulated taxane
DE69226197D1 (de)	1998-08-13	Hämoglobine als arzneimittelabgabesystem
TR200102603T2 (tr)	2002-01-21	Antitümör aktiviteye sahip olan kamptotesin türevleri
DK0975595T3 (da)	2009-10-19	Kokainanaloger
PT977564E (pt)	2005-08-31	Forscolina para promocao da massa corporal magra
EP0802767A4 (en)	1999-06-23	INHALABLE CONTRAST
ATE324119T1 (de)	2006-05-15	Verwendung von saccharid-konjugaten
DK275488D0 (da)	1988-05-19	Indolonderivater
CY1109695T1 (el)	2014-08-13	Μικροοργανισμοι αποδομησης οξαλικου ή ενζυμα αποδομησης οξαλικου για την προληψη παθησης σχετιζομενης με οξαλικο
ATE262515T1 (de)	2004-04-15	Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie
SE8404283L (sv)	1986-03-01	Anvendning av ett specifikt tumorassocierat antigen, nemligen sialosyllaktotetraos, for diagnostiska och terapeutiska forfaranden vid cancersjukdomar
PT1058544E (pt)	2005-04-29	Inibicao da actividade do tnf
EP1229030A3 (en)	2002-09-25	Hydrolysis-promoting taxane hydrophobic derivates
TR199901395T2 (xx)	1999-11-22	Yeni karboksi ikameli siklik karboksamid t�revleri.
FI862561A0 (fi)	1986-06-16	Foerfarande foer framstaellning av ergolinderivat.
Speaking et al.	1962	PRELIMINARY COMMUNICATIONS
RU94018405A (ru)	1996-04-27	Устройство для воздействия магнитным полем
MX9603483A (es)	1998-01-31	Acido micofenolico 6-sustituido y derivados.
MX9709683A (es)	1998-06-28	Uso de derivados de vitamina d4 para tratamiento contra el cancer.