DK1229030T3 - Hydrolysefremmende, hydrofobe taxanderivater - Google Patents

Hydrolysefremmende, hydrofobe taxanderivater

Info

Publication number: DK1229030T3
Authority: DK; Denmark
Prior art keywords: hydrolysis; taxane; hydrocarbon; promoting; taxane derivatives
Prior art date: 1995-09-12

Application number

DK02008590T

Other languages

English (en)

Inventor

Eric Mayhew

Shaukat Ali

Andrew S Janoff

Original Assignee

Zeneus Pharma Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-12

Filing date

1996-09-12

Publication date

2006-02-13

1996-09-12 Application filed by Zeneus Pharma Ltd filed Critical Zeneus Pharma Ltd

2006-02-13 Application granted granted Critical

2006-02-13 Publication of DK1229030T3 publication Critical patent/DK1229030T3/da

Links

DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 4
230000002209 hydrophobic effect Effects 0.000 title 1
229940123237 Taxane Drugs 0.000 abstract 5
239000004215 Carbon black (E152) Substances 0.000 abstract 2
229930195733 hydrocarbon Natural products 0.000 abstract 2
150000002430 hydrocarbons Chemical class 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Medicinal Preparation (AREA)

DK02008590T 1995-09-12 1996-09-12 Hydrolysefremmende, hydrofobe taxanderivater DK1229030T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US357595P	1995-09-12	1995-09-12

Publications (1)

Publication Number	Publication Date
DK1229030T3 true DK1229030T3 (da)	2006-02-13

Family

ID=21706522

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK02008590T DK1229030T3 (da)	1995-09-12	1996-09-12	Hydrolysefremmende, hydrofobe taxanderivater
DK96930847T DK0902783T3 (da)	1995-09-12	1996-09-12	Hydrolysefremmende, hydrofobe taxanderivater

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK96930847T DK0902783T3 (da)	1995-09-12	1996-09-12	Hydrolysefremmende, hydrofobe taxanderivater

Country Status (21)

Country	Link
US (1)	US5703117A (da)
EP (1)	EP0902783B1 (da)
JP (1)	JP4192208B2 (da)
KR (1)	KR100401220B1 (da)
CN (1)	CN1100770C (da)
AT (2)	ATE309235T1 (da)
CA (1)	CA2231750C (da)
CZ (1)	CZ288562B6 (da)
DE (2)	DE69635428T2 (da)
DK (2)	DK1229030T3 (da)
ES (2)	ES2179208T3 (da)
HU (1)	HU226325B1 (da)
IL (1)	IL123595A (da)
MX (1)	MX9801871A (da)
NO (1)	NO319521B1 (da)
NZ (1)	NZ318300A (da)
PL (1)	PL187738B1 (da)
PT (1)	PT902783E (da)
SK (1)	SK283199B6 (da)
TR (1)	TR199800443T1 (da)
WO (1)	WO1997010234A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6107332A (en) *	1995-09-12	2000-08-22	The Liposome Company, Inc.	Hydrolysis-promoting hydrophobic taxane derivatives
US6667053B1 (en) *	1996-02-16	2003-12-23	Elan Pharmaceuticals, Inc.	D and L etherlipid stereoisomers and liposomes
US5912264A (en) *	1997-03-03	1999-06-15	Bristol-Myers Squibb Company	6-halo-or nitrate-substituted paclitaxels
US8853260B2 (en)	1997-06-27	2014-10-07	Abraxis Bioscience, Llc	Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
IL136051A0 (en) *	1997-11-10	2001-05-20	Sloan Kettering Inst Cancer	Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol
JP2002535242A (ja) *	1998-05-20	2002-10-22	ザリポソームカンパニー、インコーポレーテッド	新規な粒子状剤型
US7314637B1 (en)	1999-06-29	2008-01-01	Neopharm, Inc.	Method of administering liposomal encapsulated taxane
US6146659A (en) *	1998-07-01	2000-11-14	Neopharm, Inc.	Method of administering liposomal encapsulated taxane
DE60004630T2 (de) *	1999-01-12	2004-06-17	Quanam Medical Corp., Santa Clara	Arzneimittel und verfahren zur verabreichung von wasserunlöslichen paclitaxelderivaten
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
CA2410632A1 (en)	2000-06-22	2001-12-27	David S. Garvey	Nitrosated and nitrosylated taxanes, compositions and methods of use
US6607689B1 (en) *	2000-08-29	2003-08-19	Micron Technology, Inc.	Layer thickness control for stereolithography utilizing variable liquid elevation and laser focal length
EP1304103B1 (en) *	2001-10-22	2008-12-31	Viroblock SA	New non-phospholipid lipid vesicles (npLV) and their use in cosmetic, therapeutic and prophylactic applications
CA2466851C (en) *	2001-11-26	2012-09-11	Supergen, Inc.	Method for preparing and using polyoxyethylated castor oil in pharmaceutical compositions
JP2005534718A (ja) *	2002-06-26	2005-11-17	メディゲーネオンコロギーゲゼルシャフトミットベシュレンクテルハフツング	カチオンキャリヤー系において診断化合物および治療化合物を安定化させる新規方法
EA200501252A1 (ru)	2003-02-03	2006-02-24	Неофарм, Инк.	Липосомальная композиция, способ ее получения и лекарственное средство на ее основе (варианты)
EP3345631A1 (en) *	2005-02-18	2018-07-11	Abraxis BioScience, LLC	Drugs with improved hydrophobicity for incorporation in medical devices
WO2006110862A2 (en) *	2005-04-12	2006-10-19	Wisconsin Alumni Research Foundation	Micelle composition of polymer and passenger drug
WO2009126175A1 (en) *	2008-04-10	2009-10-15	Abraxis Bioscience, Llc	Compositions of hydrophobic taxane derivatives and uses thereof
CA2721153C (en) *	2008-04-10	2018-10-02	Abraxis Bioscience, Llc	Compositions of hydrophobic taxane derivatives and uses thereof
WO2011038278A2 (en)	2009-09-25	2011-03-31	Wisconsin Alumni Research Foundation	Micelle encapsulation of therapeutic agents
CN105503844A (zh) *	2015-12-11	2016-04-20	上海大学	C-13和c-7位结构改造的紫杉醇类化合物及其制备方法
CN111004195B (zh) *	2019-12-03	2022-01-28	沈阳药科大学	卡巴他赛弱碱性衍生物及其制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5278324A (en) *	1990-08-28	1994-01-11	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
US5059699A (en) *	1990-08-28	1991-10-22	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
HU0203995D0 (en) *	1992-12-23	2003-04-28	Bristol Myers Squibb Co	Oxazole derivatives for synthesis of sidechain-bearing taxanes and preparation thereof
IL108316A (en) *	1993-01-15	2006-10-31	Univ Florida State	C10 taxane derivatives and pharmaceutical compositions containing them
US5580899A (en) *	1995-01-09	1996-12-03	The Liposome Company, Inc.	Hydrophobic taxane derivatives

1996
- 1996-09-12 DK DK02008590T patent/DK1229030T3/da active
- 1996-09-12 NZ NZ318300A patent/NZ318300A/xx unknown
- 1996-09-12 DK DK96930847T patent/DK0902783T3/da active
- 1996-09-12 EP EP96930847A patent/EP0902783B1/en not_active Expired - Lifetime
- 1996-09-12 ES ES96930847T patent/ES2179208T3/es not_active Expired - Lifetime
- 1996-09-12 PL PL96325477A patent/PL187738B1/pl not_active IP Right Cessation
- 1996-09-12 HU HU9901433A patent/HU226325B1/hu unknown
- 1996-09-12 JP JP51210297A patent/JP4192208B2/ja not_active Expired - Fee Related
- 1996-09-12 DE DE69635428T patent/DE69635428T2/de not_active Expired - Fee Related
- 1996-09-12 CZ CZ1998711A patent/CZ288562B6/cs not_active IP Right Cessation
- 1996-09-12 ES ES02008590T patent/ES2252347T3/es not_active Expired - Lifetime
- 1996-09-12 US US08/712,684 patent/US5703117A/en not_active Expired - Fee Related
- 1996-09-12 IL IL12359596A patent/IL123595A/xx not_active IP Right Cessation
- 1996-09-12 KR KR10-1998-0701653A patent/KR100401220B1/ko not_active Expired - Fee Related
- 1996-09-12 SK SK334-98A patent/SK283199B6/sk unknown
- 1996-09-12 AT AT02008590T patent/ATE309235T1/de not_active IP Right Cessation
- 1996-09-12 WO PCT/US1996/014631 patent/WO1997010234A1/en not_active Ceased
- 1996-09-12 TR TR1998/00443T patent/TR199800443T1/xx unknown
- 1996-09-12 CN CN96198237A patent/CN1100770C/zh not_active Expired - Fee Related
- 1996-09-12 CA CA002231750A patent/CA2231750C/en not_active Expired - Fee Related
- 1996-09-12 MX MX9801871A patent/MX9801871A/es not_active IP Right Cessation
- 1996-09-12 AT AT96930847T patent/ATE216377T1/de not_active IP Right Cessation
- 1996-09-12 DE DE69620802T patent/DE69620802T2/de not_active Expired - Fee Related
- 1996-09-12 PT PT96930847T patent/PT902783E/pt unknown
1998
- 1998-03-11 NO NO19981071A patent/NO319521B1/no unknown

Also Published As

Publication number	Publication date
AU706290B2 (en)	1999-06-10
CN1100770C (zh)	2003-02-05
HK1016169A1 (en)	1999-10-29
NO319521B1 (no)	2005-08-22
KR19990044409A (ko)	1999-06-25
TR199800443T1 (xx)	1998-06-22
HU226325B1 (en)	2008-08-28
DE69635428T2 (de)	2006-06-14
KR100401220B1 (ko)	2004-03-20
AU6975696A (en)	1997-04-01
ATE309235T1 (de)	2005-11-15
CZ288562B6 (cs)	2001-07-11
SK33498A3 (en)	1998-08-05
NZ318300A (en)	1999-08-30
DE69620802T2 (de)	2002-10-10
ES2179208T3 (es)	2003-01-16
SK283199B6 (sk)	2003-03-04
JP2001519755A (ja)	2001-10-23
WO1997010234A1 (en)	1997-03-20
MX9801871A (es)	1998-05-31
IL123595A (en)	2000-10-31
EP0902783B1 (en)	2002-04-17
CZ71198A3 (cs)	1998-07-15
ATE216377T1 (de)	2002-05-15
IL123595A0 (en)	1998-10-30
JP4192208B2 (ja)	2008-12-10
EP0902783A4 (da)	1999-03-24
HUP9901433A3 (en)	2001-05-28
EP0902783A1 (en)	1999-03-24
US5703117A (en)	1997-12-30
CA2231750C (en)	2006-07-11
NO981071L (no)	1998-05-12
PL187738B1 (pl)	2004-09-30
HUP9901433A2 (hu)	2001-04-28
DE69635428D1 (de)	2005-12-15
CA2231750A1 (en)	1997-03-20
NO981071D0 (no)	1998-03-11
DK0902783T3 (da)	2002-07-22
CN1202166A (zh)	1998-12-16
DE69620802D1 (de)	2002-05-23
PT902783E (pt)	2002-09-30
PL325477A1 (en)	1998-07-20
ES2252347T3 (es)	2006-05-16

Publication	Publication Date	Title
DK0902783T3 (da)	2002-07-22	Hydrolysefremmende, hydrofobe taxanderivater
DE69713526D1 (de)	2002-07-25	Lösliche prodrugs von paclitaxel
PT1063234E (pt)	2003-09-30	Derivados de taxano hidrofobos
FI952248A7 (fi)	1995-05-09	Kasvainvastaisia koostumuksia, jotka sisältävät taksaanijohdannaisia
ES2170141T3 (es)	2002-08-01	4-aminoderivados del acido micofenolico con actividad inmunosupresora.
CA2301057A1 (en)	2000-01-13	A method of administering liposomal encapsulated taxane
DE69226197D1 (de)	1998-08-13	Hämoglobine als arzneimittelabgabesystem
TR200102603T2 (tr)	2002-01-21	Antitümör aktiviteye sahip olan kamptotesin türevleri
DK0975595T3 (da)	2009-10-19	Kokainanaloger
PT977564E (pt)	2005-08-31	Forscolina para promocao da massa corporal magra
EP0802767A4 (en)	1999-06-23	INHALABLE CONTRAST
ATE324119T1 (de)	2006-05-15	Verwendung von saccharid-konjugaten
DK275488D0 (da)	1988-05-19	Indolonderivater
CY1109695T1 (el)	2014-08-13	Μικροοργανισμοι αποδομησης οξαλικου ή ενζυμα αποδομησης οξαλικου για την προληψη παθησης σχετιζομενης με οξαλικο
DE69631975D1 (de)	2004-04-29	Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie
SE8404283L (sv)	1986-03-01	Anvendning av ett specifikt tumorassocierat antigen, nemligen sialosyllaktotetraos, for diagnostiska och terapeutiska forfaranden vid cancersjukdomar
PT1058544E (pt)	2005-04-29	Inibicao da actividade do tnf
EP1229030A3 (en)	2002-09-25	Hydrolysis-promoting taxane hydrophobic derivates
TR199901395T2 (xx)	1999-11-22	Yeni karboksi ikameli siklik karboksamid t�revleri.
FI862561A0 (fi)	1986-06-16	Foerfarande foer framstaellning av ergolinderivat.
RU94018405A (ru)	1996-04-27	Устройство для воздействия магнитным полем
MX9603483A (es)	1998-01-31	Acido micofenolico 6-sustituido y derivados.
MX9709683A (es)	1998-06-28	Uso de derivados de vitamina d4 para tratamiento contra el cancer.