DK0908449T3 - Fremstilling af carotenoider - Google Patents

Fremstilling af carotenoider

Info

Publication number
DK0908449T3
DK0908449T3 DK98118349T DK98118349T DK0908449T3 DK 0908449 T3 DK0908449 T3 DK 0908449T3 DK 98118349 T DK98118349 T DK 98118349T DK 98118349 T DK98118349 T DK 98118349T DK 0908449 T3 DK0908449 T3 DK 0908449T3
Authority
DK
Denmark
Prior art keywords
carotenoids
preparation
Prior art date
Application number
DK98118349T
Other languages
English (en)
Inventor
Paul Kreienbuehl
Peter Rudin
Werner Rudolph
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0908449T3 publication Critical patent/DK0908449T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/32—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero-atoms other than or in addition to oxygen or halogen
    • C07C1/34—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero-atoms other than or in addition to oxygen or halogen reacting phosphines with aldehydes or ketones, e.g. Wittig reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK98118349T 1997-10-03 1998-09-28 Fremstilling af carotenoider DK0908449T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97117192 1997-10-03

Publications (1)

Publication Number Publication Date
DK0908449T3 true DK0908449T3 (da) 2002-05-21

Family

ID=8227436

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98118349T DK0908449T3 (da) 1997-10-03 1998-09-28 Fremstilling af carotenoider

Country Status (10)

Country Link
US (1) US6150561A (da)
EP (1) EP0908449B1 (da)
JP (1) JPH11180901A (da)
KR (1) KR19990036861A (da)
CN (1) CN1158255C (da)
BR (1) BR9803955A (da)
CA (1) CA2248450A1 (da)
DE (1) DE59802696D1 (da)
DK (1) DK0908449T3 (da)
ES (1) ES2167044T3 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759506B2 (en) * 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
WO2003072734A2 (en) * 2002-02-25 2003-09-04 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
DE10254809A1 (de) * 2002-11-22 2004-06-03 Basf Ag Verfahren zur Herstellung von Carotinoiden
EP1667954B1 (en) * 2003-08-25 2018-11-14 Diffusion Pharmaceuticals LLC Bipolar trans carotenoid salts and their uses
UA95903C2 (ru) * 2005-02-24 2011-09-26 Дифьюжен Фармасьютикалз Ллк Транс-каротиноиды, их синтез, лекарственная форма и применение
EP3483140A1 (en) 2007-04-13 2019-05-15 Diffusion Pharmaceuticals LLC Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
EA201070544A1 (ru) * 2007-10-31 2010-12-30 Диффьюжн Фармасьютикалз Ллс Новый класс терапевтических веществ, усиливающих диффузию низкомолекулярных соединений
CN101157645B (zh) * 2007-11-27 2010-06-02 江南大学 一种藏红花酸的合成方法
CN102438970B (zh) * 2009-04-06 2015-10-14 德州大学体系董事会 催化的维蒂希反应及光延反应
KR101875843B1 (ko) * 2009-06-22 2018-07-06 디퓨젼 파마슈티컬즈 엘엘씨 확산 촉진 화합물 및 그 화합물 단독 또는 혈전 용해제와 합쳐진 화합물의 용도
JP2010090151A (ja) * 2009-12-09 2010-04-22 Diffusion Pharmaceuticals Llc 双極性トランスカロテノイド塩及びそれらの使用
CN105287473A (zh) 2010-06-02 2016-02-03 扩散药品有限公司 包含双极性反式类胡萝卜素的组合物及其应用
CN102311320B (zh) * 2011-06-30 2013-09-25 绍兴文理学院 一种2,6,10-三甲基-1,1-二烷氧基-3,5,9-十一烷三烯的制备方法
EP3065565B1 (en) 2013-11-07 2019-12-25 DSM IP Assets B.V. Process for the purification of astaxanthin
WO2015067705A1 (en) 2013-11-07 2015-05-14 Dsm Ip Assets B.V. Process for the purification of astaxanthin
CN105705042B (zh) 2013-11-07 2018-11-09 帝斯曼知识产权资产管理有限公司 纯化虾青素的方法
WO2015067709A1 (en) 2013-11-07 2015-05-14 Dsm Ip Assets B.V. Process for the purification of astaxanthin
WO2015097717A2 (en) * 2013-12-23 2015-07-02 Laurus Labs Private Limited AN IMPROVED PROCESS FOR THE PREPARATION OF β-CAROTENE
JP2014144952A (ja) * 2014-01-10 2014-08-14 Diffusion Pharmaceuticals Llc 双極性トランスカロテノイド塩及びそれらの使用
EP2957565B1 (en) 2014-06-18 2018-03-07 Allied Biotech Corporation Methods for preparation of lycopenes from C-15 Wittig salts and methods for purification of high all-E containing and high 6Z containing C15-Wittig salts
JP6689831B2 (ja) * 2014-10-02 2020-04-28 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ アスタキサンチン及びカンタキサンチンの精製方法
US10480274B2 (en) * 2014-12-15 2019-11-19 Enpro Subsea Limited Apparatus, systems and method for oil and gas operations
WO2017165667A1 (en) 2016-03-24 2017-09-28 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
CN105906672B (zh) * 2016-04-29 2017-12-29 暨南大学 藏红花色素类化合物及其用途
JP2016183174A (ja) * 2016-05-12 2016-10-20 ディフュージョン・ファーマシューティカルズ・エルエルシー 双極性トランスカロテノイド塩及びそれらの使用
CN109715638A (zh) * 2016-09-16 2019-05-03 巴斯夫欧洲公司 制备作为类胡萝卜素的结构单元的鏻盐酯的方法
CN106753775B (zh) * 2016-12-29 2020-05-05 山东师范大学 一种高虾青素及其酯含量的南极磷虾油脂的提取方法
JP2018135329A (ja) * 2018-02-19 2018-08-30 ディフュージョン・ファーマシューティカルズ・エルエルシー 双極性トランスカロテノイド塩及びそれらの使用
CN110749688A (zh) * 2019-11-07 2020-02-04 贵州省兽药饲料监察所(贵州省兽药残留监测中心) 一种测定饲料中β-阿朴-8＇-胡萝卜素酸乙酯着色剂含量的方法
CN113511993B (zh) * 2021-07-06 2023-02-24 广州智特奇生物科技股份有限公司 一种β-阿朴-8’-胡萝卜素酸乙酯的合成方法
US20260098010A1 (en) * 2022-09-29 2026-04-09 Dsm Ip Assets B.V. ß-CAROTENE SYNTHESIS (I)
EP4594301A1 (en) * 2022-09-29 2025-08-06 DSM IP Assets B.V. ?-carotene synthesis (ii)
CN116102480B (zh) * 2022-12-09 2024-02-27 万华化学集团股份有限公司 一种β-阿朴-12’-胡萝卜醛的连续制备工艺
CN115784957B (zh) * 2022-12-15 2024-12-10 上虞新和成生物化工有限公司 一种虾青素的提纯方法
CN116120218B (zh) * 2023-01-03 2024-05-03 万华化学集团股份有限公司 一种β-阿朴-8’-胡萝卜素酸乙酯的制备方法
CN116854576B (zh) * 2023-06-28 2025-11-04 万华化学集团股份有限公司 一种阿朴酯中间体c25醛的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3517067A (en) * 1964-02-11 1970-06-23 Eastman Kodak Co Syntheses of quaternary phosphonium salts
US3496170A (en) * 1966-03-23 1970-02-17 Eastman Kodak Co Carotenoid compounds
DE19509955A1 (de) * 1995-03-18 1996-09-19 Basf Ag Verfahren zur Herstellung von Astaxanthin

Also Published As

Publication number Publication date
ES2167044T3 (es) 2002-05-01
CN1215723A (zh) 1999-05-05
KR19990036861A (ko) 1999-05-25
EP0908449A1 (de) 1999-04-14
EP0908449B1 (de) 2001-11-21
DE59802696D1 (de) 2002-02-21
US6150561A (en) 2000-11-21
CN1158255C (zh) 2004-07-21
BR9803955A (pt) 2000-04-11
JPH11180901A (ja) 1999-07-06
CA2248450A1 (en) 1999-04-03

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