DK0909562T3 - Injektionspræparat indeholdende en lipid A analog og fremgangsmåde til fremstilling deraf - Google Patents

Injektionspræparat indeholdende en lipid A analog og fremgangsmåde til fremstilling deraf

Info

Publication number: DK0909562T3
Authority: DK; Denmark
Prior art keywords: preparation; lipid; analog; injection; preparing
Prior art date: 1996-07-03

Application number

DK97929518T

Other languages

Danish (da)

English (en)

Inventor

Yasuyuki Asai

Katsumi Onai

Kazuhide Ashizawa

Kiyoshi Iwamoto

Yasuo Ishibashi

Sumio Watanabe

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-03

Filing date

1997-07-03

Publication date

2005-08-22

1997-07-03 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

2005-08-22 Application granted granted Critical

2005-08-22 Publication of DK0909562T3 publication Critical patent/DK0909562T3/da

Links

238000002347 injection Methods 0.000 title abstract 3
239000007924 injection Substances 0.000 title abstract 3
GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title 1
238000004519 manufacturing process Methods 0.000 abstract 2
239000007864 aqueous solution Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK97929518T 1996-07-03 1997-07-03 Injektionspræparat indeholdende en lipid A analog og fremgangsmåde til fremstilling deraf DK0909562T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP17361596		1996-07-03
EP97929518A EP0909562B1 (fr)	1996-07-03	1997-07-03	Produits pour injection contenant des analogues de lipides a et procede de preparation correspondant

Publications (1)

Publication Number	Publication Date
DK0909562T3 true DK0909562T3 (da)	2005-08-22

Family

ID=15963903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97929518T DK0909562T3 (da)	1996-07-03	1997-07-03	Injektionspræparat indeholdende en lipid A analog og fremgangsmåde til fremstilling deraf

Country Status (9)

Country	Link
US (1)	US6235724B1 (fr)
EP (1)	EP0909562B1 (fr)
CN (1)	CN1150001C (fr)
AT (1)	ATE298578T1 (fr)
CA (1)	CA2259520C (fr)
DE (1)	DE69733651T2 (fr)
DK (1)	DK0909562T3 (fr)
ES (1)	ES2242226T3 (fr)
WO (1)	WO1998001139A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7799198A (en) *	1997-05-23	1998-12-21	Eisai Co. Ltd.	Method for preparing pharmaceutical formulation
CA2333578C (fr) *	1998-07-14	2010-11-16	American Cyanamid Company	Compositions d'adjuvants et de vaccins contenant un lipide monophosphoryle a
US6306404B1 (en)	1998-07-14	2001-10-23	American Cyanamid Company	Adjuvant and vaccine compositions containing monophosphoryl lipid A
US6635261B2 (en)	1999-07-13	2003-10-21	Wyeth Holdings Corporation	Adjuvant and vaccine compositions containing monophosphoryl lipid A
KR100841813B1 (ko) *	2000-02-18	2008-06-26	에자이 알앤드디 매니지먼트 가부시키가이샤	미셀
PT1326638E (pt)	2000-10-18	2008-02-06	Glaxosmithkline Biolog Sa	Vacinas contra cancros
WO2002094019A1 (fr) *	2001-05-22	2002-11-28	Eisai Co., Ltd	Compose d'anti-endotoxine hautement purifie
EP3403667B1 (fr)	2006-09-26	2020-07-22	Infectious Disease Research Institute	Composition de vaccin contenant un adjuvant synthétique
US20090181078A1 (en)	2006-09-26	2009-07-16	Infectious Disease Research Institute	Vaccine composition containing synthetic adjuvant
KR101701198B1 (ko)	2008-06-19	2017-02-01	배리에이션 바이오테크놀로지스 아이엔씨.	인플루엔자를 치료하기 위한 조성물 및 방법
SI2437753T1 (sl)	2009-06-05	2016-12-30	Infectious Disease Research Institute	Sintetični glukopiranozil-lipidni adjuvansi in cepivni sestavki, ki jih vsebujejo
EP2451950B9 (fr)	2009-07-06	2016-11-23	Variation Biotechnologies Inc.	Procédés de préparation de vésicules et formulations obtenues à partir de celles-ci
WO2011005772A1 (fr)	2009-07-06	2011-01-13	Variation Biotechnologies, Inc.	Procédés pour préparer des vésicules et formulations produites à partir de ces procédés
BR112013000394B8 (pt)	2010-07-06	2022-01-18	Variation Biotechnologies Inc	Composição imunogênica, uso da mesma e método para preparar a referida composição
CN107296792B (zh)	2011-01-13	2021-07-27	变异生物技术公司	囊泡及由其产生之制剂的制备方法
EP2663327A4 (fr)	2011-01-13	2015-12-02	Variation Biotechnologies Inc	Compositions et méthodes de traitement d'infections virales
BR112013025799A2 (pt)	2011-04-08	2016-12-20	Immune Design Corp	método para induzir uma resposta imune em um sujeito, e, preparação
US20140356399A1 (en)	2012-01-12	2014-12-04	Variation Biotechnologies, Inc.	Compositions and methods for treating viral infections
EP4008354A1 (fr)	2012-01-27	2022-06-08	Variation Biotechnologies Inc.	Procédés et compositions pour agents thérapeutiques
EP2850431B1 (fr)	2012-05-16	2018-04-18	Immune Design Corp.	Vaccins contre le hsv-2
JP6426706B2 (ja)	2013-04-18	2018-11-21	イミューンデザインコーポレイション	がん処置で使用するためのｇｌａ単剤療法
US9463198B2 (en)	2013-06-04	2016-10-11	Infectious Disease Research Institute	Compositions and methods for reducing or preventing metastasis
JP2018509384A (ja)	2015-01-06	2018-04-05	イミューノヴァクシーンテクノロジーズインコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅＴｅｃｈｎｏｌｏｇｉｅｓＩｎｃ．	リピドａ模倣体、調製方法、及びその使用
KR102755593B1 (ko)	2017-09-08	2025-01-20	액세스 투 어드밴스드 헬스 인스티튜트	사포닌을 포함하는 리포솜 제형 및 사용 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1216686B (it) *	1988-04-01	1990-03-08	Chiesi Farma Spa	Formulazioni farmaceutiche acquose di piroxicam e procedimento per laloro preparazione.
JPH04198192A (ja) *	1990-11-28	1992-07-17	Japan Tobacco Inc	リピッドａ類縁体の水溶液
AU660325B2 (en) *	1991-10-11	1995-06-22	Eisai Co. Ltd.	Anti-endotoxin compounds and related molecules and methods
US5530113A (en) *	1991-10-11	1996-06-25	Eisai Co., Ltd.	Anti-endotoxin compounds
US5750664A (en) *	1995-06-05	1998-05-12	Eisai Co., Ltd.	Substituted liposaccharides useful in the treatment and prevention of endotoxemia

1997
- 1997-07-03 WO PCT/JP1997/002316 patent/WO1998001139A1/fr not_active Ceased
- 1997-07-03 DK DK97929518T patent/DK0909562T3/da active
- 1997-07-03 CN CNB971960518A patent/CN1150001C/zh not_active Expired - Fee Related
- 1997-07-03 EP EP97929518A patent/EP0909562B1/fr not_active Expired - Lifetime
- 1997-07-03 AT AT97929518T patent/ATE298578T1/de active
- 1997-07-03 US US09/194,704 patent/US6235724B1/en not_active Expired - Fee Related
- 1997-07-03 DE DE69733651T patent/DE69733651T2/de not_active Expired - Lifetime
- 1997-07-03 ES ES97929518T patent/ES2242226T3/es not_active Expired - Lifetime
- 1997-07-03 CA CA002259520A patent/CA2259520C/fr not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE298578T1 (de)	2005-07-15
ES2242226T3 (es)	2005-11-01
DE69733651T2 (de)	2006-05-18
EP0909562A1 (fr)	1999-04-21
CN1150001C (zh)	2004-05-19
CA2259520C (fr)	2007-09-11
WO1998001139A1 (fr)	1998-01-15
US6235724B1 (en)	2001-05-22
CA2259520A1 (fr)	1998-01-15
EP0909562B1 (fr)	2005-06-29
CN1224355A (zh)	1999-07-28
EP0909562A4 (fr)	1999-12-29
DE69733651D1 (de)	2005-08-04

Publication	Publication Date	Title
DK0909562T3 (da)	2005-08-22	Injektionspræparat indeholdende en lipid A analog og fremgangsmåde til fremstilling deraf
NO901399D0 (no)	1990-03-27	Aminosyrederivater.
NL300181I1 (nl)	2005-05-02	N-(pyrroloÄ2,3-dÜpyrimidine-3-ylacyl)-glutaminezuurderivaten.
FI920674A0 (fi)	1992-02-17	Laogkalorihaltiga, graeddaktiga naeringsprodukter med mjuka organoleptiska egenskaper.
NO871333D0 (no)	1987-03-31	Kinolin-3-karboksylsyrederivater, fremgangsmaate til fremstilling og anvendelse derav.
DE60044515D1 (de)	2010-07-15	Azithromycinmonohydrat
NO901033D0 (no)	1990-03-05	Aminosyrederivater.
TR199800077T1 (xx)	1998-05-21	Kontroll� ��z�len paroksetin terkipleri.
DK15089D0 (da)	1989-01-13	Aminofunktionelle forbindelser, fremgangsmaade til fremstilling heraf samt vaskemidler omfattende samme.
NO903757L (no)	1991-03-01	Kitin.kitosan-oligomer med 2,5-anhydromannitol endegruppeeller 2,5-anhydromannose endegruppe og fremgangsmaate til fremstilling derav.
NO900309L (no)	1990-07-25	Benzocykloalkenyldihydroksyalkansyrederivater, og fremgangsmaate til fremstilling derav.
DE69019572D1 (de)	1995-06-29	Gasauflösung.
NO894549L (no)	1990-05-30	Titandioksyd, fremgangsmaate for fremstilling derav og anvendelse derav.
DE69006896D1 (de)	1994-04-07	Makromolekulares endoplasmatisches Retikulum.
TR200001102T2 (tr)	2000-08-21	İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
NO901533L (no)	1990-10-08	Aminosyrederivater.
NO903780L (no)	1991-03-04	Fremgangsmaate til fremstilling av epipodofyllotoksinaltrosid-derivater.
NO932823L (no)	1993-10-08	Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og konjugater, for anvendelse som kontrastmidler og fremgangsmåter for deres fremstilling
EP0636611A3 (en)	1995-03-01	Optically active 1,4-dihydropyridine derivatives and process for preparing the same.
NO905244D0 (no)	1990-12-04	Fremgangsmaate for fremstilling av des(64,65)-proinsulin.
DK191290A (da)	1991-03-30	Extracellulaer exopolymer, fremgangsmaade til fremstilling af samme og farmaceutiske praeparater indeholdende exopolymeren
NO904034L (no)	1991-03-19	Fremgangsmaate for fremstilling av 1-etylfenoksatiin-10,10-dioksyd.
IT9067139A0 (it)	1990-02-23	Procedimento per convertire ,lattoni alfa-acetil-sostituiti in lattoni alfa-alchiliden-sostituiti.
FI945414L (fi)	1994-11-17	Menetelmä N,N-disubstituoidun aminofenolin valmistamiseksi
DE69002478D1 (de)	1993-09-09	N-substituierte 3-((2,3-dimethylmaleimido)-amino)-benzolsulfonamid-derivate, verfahren zu ihrer herstellung und herbicid wirkende zusammensetzungen.