DK0918455T3 - Anvendelse af galanin til reparation af nerveskader - Google Patents

Anvendelse af galanin til reparation af nerveskader

Info

Publication number: DK0918455T3
Authority: DK; Denmark
Prior art keywords: galanin; treatment; nerve damage; damage repair; supression
Prior art date: 1996-07-24

Application number

DK97932939T

Other languages

English (en)

Inventor

David Wynick

Original Assignee

Neurotargets Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-24

Filing date

1997-07-24

Publication date

2003-08-04

1996-07-24 Priority claimed from GBGB9615551.0A external-priority patent/GB9615551D0/en

1996-11-15 Priority claimed from GBGB9623869.6A external-priority patent/GB9623869D0/en

1997-07-24 Application filed by Neurotargets Ltd filed Critical Neurotargets Ltd

2003-08-04 Application granted granted Critical

2003-08-04 Publication of DK0918455T3 publication Critical patent/DK0918455T3/da

Links

101800002068 Galanin Proteins 0.000 title abstract 6
102000019432 Galanin Human genes 0.000 title abstract 5
SLZIZIJTGAYEKK-CIJSCKBQSA-N molport-023-220-247 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CNC=N1 SLZIZIJTGAYEKK-CIJSCKBQSA-N 0.000 title abstract 5
208000028389 Nerve injury Diseases 0.000 title abstract 2
230000008764 nerve damage Effects 0.000 title abstract 2
230000036407 pain Effects 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
206010002091 Anaesthesia Diseases 0.000 abstract 1
206010036832 Prolactinoma Diseases 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
230000037005 anaesthesia Effects 0.000 abstract 1
238000001949 anaesthesia Methods 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000019771 cognition Effects 0.000 abstract 1
238000011813 knockout mouse model Methods 0.000 abstract 1
210000005036 nerve Anatomy 0.000 abstract 1
208000005877 painful neuropathy Diseases 0.000 abstract 1
208000030153 prolactin-producing pituitary gland adenoma Diseases 0.000 abstract 1
230000008929 regeneration Effects 0.000 abstract 1
238000011069 regeneration method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Environmental Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biophysics (AREA)
Hematology (AREA)
Biochemistry (AREA)
Animal Husbandry (AREA)
Biodiversity & Conservation Biology (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Obesity (AREA)
Molecular Biology (AREA)

DK97932939T 1996-07-24 1997-07-24 Anvendelse af galanin til reparation af nerveskader DK0918455T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9615551.0A GB9615551D0 (en)	1996-07-24	1996-07-24	Galanin
GBGB9623869.6A GB9623869D0 (en)	1996-11-15	1996-11-15	Galanin
PCT/GB1997/001991 WO1998003059A1 (en)	1996-07-24	1997-07-24	Galanin

Publications (1)

Publication Number	Publication Date
DK0918455T3 true DK0918455T3 (da)	2003-08-04

Family

ID=26309752

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK97932939T DK0918455T3 (da)	1996-07-24	1997-07-24	Anvendelse af galanin til reparation af nerveskader
DK02028584.7T DK1342410T3 (da)	1996-07-24	1997-07-24	Anvendelse af en galaninagonist til fremstilling af et medikament til forbedring af hukommelse og andre kognitive funktioner

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK02028584.7T DK1342410T3 (da)	1996-07-24	1997-07-24	Anvendelse af en galaninagonist til fremstilling af et medikament til forbedring af hukommelse og andre kognitive funktioner

Country Status (11)

Country	Link
US (1)	US20030009777A1 (da)
EP (2)	EP0918455B1 (da)
JP (1)	JP2000516212A (da)
AT (2)	ATE237346T1 (da)
AU (1)	AU3630297A (da)
DE (2)	DE69721005T2 (da)
DK (2)	DK0918455T3 (da)
ES (2)	ES2340984T3 (da)
GB (1)	GB2331301C (da)
PT (2)	PT918455E (da)
WO (1)	WO1998003059A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6790656B1 (en)	1996-01-24	2004-09-14	Synaptic Pharmaceutical Corporation	DNA encoding galanin GALR2 receptors
US6329197B2 (en)	1996-10-09	2001-12-11	Synaptic Pharmaceutical Corporation	DNA encoding galanin GALR3 receptors and uses thereof
CA2459183A1 (en) *	2001-08-27	2003-03-06	Tularik Inc.	Amplified oncogenes and their involvement in cancer
AU2003211562A1 (en) *	2002-02-22	2003-09-09	Takeda Chemical Industries, Ltd.	Novel dna and use thereof
GB0403509D0 (en) *	2004-02-17	2004-03-24	Neuro Targets Ltd	Galanin receptors and brain injury
EP1809619A1 (en)	2004-10-21	2007-07-25	Transtech Pharma, Inc.	Bissulfonamide compounds as agonists of galr1, compositions, and methods of use
GB0523550D0 (en)	2005-11-18	2005-12-28	Hunter Fleming Ltd	Therapeutic uses of steroidal compounds
WO2008086573A1 (en) *	2007-01-19	2008-07-24	Howard Florey Institute Of Experimental Physiology And Medicine	Use of galanin in a method of treating neurodegenerative diseases or conditions
AU2008306190A1 (en) *	2007-09-11	2009-04-09	Mondobiotech Laboratories Ag	Use of bubuc and optionally EAA-MART1 (26-35) as a therapeutic agent for the treatment of HCMV infections
US20100204129A1 (en) *	2008-09-09	2010-08-12	Dorian Bevec	Use of a peptide as a therapeutic agent
ES2883838A1 (es) *	2020-06-04	2021-12-09	Univ Malaga	Prevencion y/o tratamiento del deterioro cognitivo asociado a sindromes de demencia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992012997A1 (en) *	1991-01-16	1992-08-06	The General Hospital Corporation	Human galanin
WO1992015015A1 (en) *	1991-02-25	1992-09-03	Zymogenetic, Inc.	Methods for detecting galanin antagonists
JP3135262B2 (ja) *	1991-03-06	2001-02-13	ガーヴァンインスティチュートオブメディカルリサーチ	ヒトのガラニン、ヒトのガラニンをエンコードするｃＤＮＡクローンとヒトのガラニン製造方法
SE9101472D0 (sv) *	1991-05-15	1991-05-15	Trion Forskning & Utveckling	Galanin antagonist
JPH06172387A (ja) *	1992-12-11	1994-06-21	Aibaitsu Kk	合成ペプチド誘導体
US6225282B1 (en) *	1996-01-05	2001-05-01	Genentech, Inc.	Treatment of hearing impairments
US6790656B1 (en) *	1996-01-24	2004-09-14	Synaptic Pharmaceutical Corporation	DNA encoding galanin GALR2 receptors

1997
- 1997-07-24 EP EP97932939A patent/EP0918455B1/en not_active Expired - Lifetime
- 1997-07-24 DE DE69721005T patent/DE69721005T2/de not_active Expired - Lifetime
- 1997-07-24 EP EP02028584A patent/EP1342410B1/en not_active Expired - Lifetime
- 1997-07-24 DE DE69739760T patent/DE69739760D1/de not_active Expired - Lifetime
- 1997-07-24 AT AT97932939T patent/ATE237346T1/de not_active IP Right Cessation
- 1997-07-24 AU AU36302/97A patent/AU3630297A/en not_active Abandoned
- 1997-07-24 DK DK97932939T patent/DK0918455T3/da active
- 1997-07-24 ES ES02028584T patent/ES2340984T3/es not_active Expired - Lifetime
- 1997-07-24 US US09/230,463 patent/US20030009777A1/en not_active Abandoned
- 1997-07-24 PT PT97932939T patent/PT918455E/pt unknown
- 1997-07-24 AT AT02028584T patent/ATE457125T1/de not_active IP Right Cessation
- 1997-07-24 JP JP10506711A patent/JP2000516212A/ja not_active Ceased
- 1997-07-24 ES ES97932939T patent/ES2196349T3/es not_active Expired - Lifetime
- 1997-07-24 PT PT02028584T patent/PT1342410E/pt unknown
- 1997-07-24 WO PCT/GB1997/001991 patent/WO1998003059A1/en not_active Ceased
- 1997-07-24 GB GB9901264A patent/GB2331301C/en not_active Expired - Fee Related
- 1997-07-24 DK DK02028584.7T patent/DK1342410T3/da active

Also Published As

Publication number	Publication date
DK1342410T3 (da)	2010-05-31
EP1342410B1 (en)	2010-02-10
DE69721005T2 (de)	2004-06-09
JP2000516212A (ja)	2000-12-05
DE69721005D1 (de)	2003-05-22
ES2196349T3 (es)	2003-12-16
DE69739760D1 (de)	2010-03-25
US20030009777A1 (en)	2003-01-09
ES2340984T3 (es)	2010-06-14
ATE237346T1 (de)	2003-05-15
EP1342410A2 (en)	2003-09-10
PT1342410E (pt)	2010-05-11
EP1342410A3 (en)	2003-12-10
WO1998003059A1 (en)	1998-01-29
GB2331301C (en)	2005-05-22
GB2331301A (en)	1999-05-19
AU3630297A (en)	1998-02-10
ATE457125T1 (de)	2010-02-15
EP0918455A1 (en)	1999-06-02
GB9901264D0 (en)	1999-03-10
GB2331301B (en)	2001-02-14
EP0918455B1 (en)	2003-04-16
PT918455E (pt)	2003-09-30

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