DK0929547T3 - Benzamidinderivater substitueret af cykliske aminosyrederivater eller cykliske hydroxysyrederivater og deres anvendelse som antikoagulantia - Google Patents
Benzamidinderivater substitueret af cykliske aminosyrederivater eller cykliske hydroxysyrederivater og deres anvendelse som antikoagulantiaInfo
- Publication number
- DK0929547T3 DK0929547T3 DK97942015T DK97942015T DK0929547T3 DK 0929547 T3 DK0929547 T3 DK 0929547T3 DK 97942015 T DK97942015 T DK 97942015T DK 97942015 T DK97942015 T DK 97942015T DK 0929547 T3 DK0929547 T3 DK 0929547T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid derivatives
- cyclic
- derivatives
- amino acid
- anticoagulants
- Prior art date
Links
- -1 cyclic amino acid derivatives Chemical class 0.000 title abstract 4
- 239000003146 anticoagulant agent Substances 0.000 title abstract 2
- 229940127219 anticoagulant drug Drugs 0.000 title abstract 2
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical group NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71306696A | 1996-09-12 | 1996-09-12 | |
| US08/920,319 US6008234A (en) | 1996-09-12 | 1997-08-27 | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants |
| PCT/EP1997/004961 WO1998011094A1 (en) | 1996-09-12 | 1997-09-11 | Benzamidine derivatives substituted by cyclic amino acid or cycl ic hydroxy acid derivatives and their use as anti-coagulants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0929547T3 true DK0929547T3 (da) | 2003-03-10 |
Family
ID=27108932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97942015T DK0929547T3 (da) | 1996-09-12 | 1997-09-11 | Benzamidinderivater substitueret af cykliske aminosyrederivater eller cykliske hydroxysyrederivater og deres anvendelse som antikoagulantia |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6232325B1 (da) |
| EP (1) | EP0929547B1 (da) |
| JP (1) | JP3565864B2 (da) |
| KR (1) | KR20000036017A (da) |
| CN (2) | CN1234798A (da) |
| AT (1) | ATE228513T1 (da) |
| AU (1) | AU723999B2 (da) |
| CA (1) | CA2264521A1 (da) |
| CZ (1) | CZ86199A3 (da) |
| DE (1) | DE69717474T2 (da) |
| DK (1) | DK0929547T3 (da) |
| ES (1) | ES2188979T3 (da) |
| IL (1) | IL128691A (da) |
| NO (1) | NO991206L (da) |
| NZ (1) | NZ334264A (da) |
| PT (1) | PT929547E (da) |
| SK (1) | SK29599A3 (da) |
| WO (1) | WO1998011094A1 (da) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69630214T2 (de) | 1995-03-10 | 2004-07-15 | Berlex Laboratories, Inc., Richmond | Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien |
| US5994375A (en) | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
| US6004985A (en) * | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
| EP0993448A1 (en) * | 1997-06-19 | 2000-04-19 | The Du Pont Merck Pharmaceutical Company | (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS |
| US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| NZ503809A (en) | 1997-12-19 | 2002-04-26 | Schering Ag | Ortho-anthranilamide derivatives as anti-coagulants |
| US6262088B1 (en) * | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
| US6127376A (en) * | 1998-12-04 | 2000-10-03 | Berlex Laboratories, Inc. | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants |
| DE60027204T2 (de) * | 1999-10-28 | 2006-11-23 | Sankyo Co., Ltd. | Benzamidinderivate |
| AU2004203154B2 (en) * | 1999-10-28 | 2006-06-01 | Sankyo Company, Limited | Benzamidine derivatives |
| EP1569912B1 (en) | 2002-12-03 | 2015-04-29 | Pharmacyclics, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| AR040456A1 (es) | 2002-06-27 | 2005-04-06 | Bristol Myers Squibb Co | Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana |
| NZ541234A (en) | 2002-12-20 | 2008-06-30 | Amgen Inc | Asthma and allergic inflammation modulators |
| CN102558155A (zh) | 2003-01-14 | 2012-07-11 | 阿伦纳药品公司 | 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗 |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| WO2009085177A1 (en) | 2007-12-19 | 2009-07-09 | Amgen Inc. | Phenyl acetic acid derivatives as inflammation modulators |
| MX2010011463A (es) | 2008-04-16 | 2011-06-03 | Portola Pharm Inc | 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas. |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| EP2300013B2 (en) | 2008-05-21 | 2024-11-13 | Takeda Pharmaceutical Company Limited | Phosphorous derivatives as kinase inhibitors |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| MX2013003184A (es) | 2010-09-22 | 2013-06-07 | Arena Pharm Inc | Moduladores del receptor gpr119 y el tratamiento de transtornos relacionados con el mismo. |
| EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| SG11201402570QA (en) | 2011-11-23 | 2014-06-27 | Portola Pharm Inc | Pyrazine kinase inhibitors |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| AU2016205361C1 (en) | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| PL3310760T3 (pl) | 2015-06-22 | 2023-03-06 | Arena Pharmaceuticals, Inc. | Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1 |
| AU2019280822A1 (en) | 2018-06-06 | 2021-01-07 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB824908A (en) | 1958-06-03 | 1959-12-09 | May & Baker Ltd | Improvements in or relating to triazine derivatives |
| JPS5922697B2 (ja) | 1976-01-13 | 1984-05-28 | エーザイ株式会社 | ビス−（メタ−アミジノフエノキシ）−化合物 |
| EP0518818A3 (en) | 1991-06-11 | 1993-04-28 | Ciba-Geigy Ag | Arylethers, their manufacture and use as medicament |
| US5451700A (en) | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
| ZA928276B (en) | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| ATE171709T1 (de) | 1992-02-14 | 1998-10-15 | Corvas Int Inc | Inhibitoren der thrombose |
| US5492895A (en) | 1992-02-14 | 1996-02-20 | Corvas International, Inc. | Inhibitors of thrombosis |
| DE4213919A1 (de) | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| TW234077B (da) | 1992-07-17 | 1994-11-11 | Shell Internat Res Schappej B V | |
| AU675981B2 (en) | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
| CA2151044A1 (en) | 1992-12-15 | 1994-06-23 | Terence K. Brunck | Novel inhibitors for factor xa |
| US5332822A (en) | 1992-12-24 | 1994-07-26 | Bristol-Myers Squibb Company | Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors |
| US5633381A (en) | 1994-07-05 | 1997-05-27 | Berlex Laboratories, Inc. | (Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| DE69630214T2 (de) | 1995-03-10 | 2004-07-15 | Berlex Laboratories, Inc., Richmond | Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien |
| US5691364A (en) | 1995-03-10 | 1997-11-25 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| US5612363A (en) | 1995-06-02 | 1997-03-18 | Berlex Laboratories, Inc. | N,N-di(aryl) cyclic urea derivatives as anti-coagulants |
| US5849759A (en) | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
| US5977117A (en) * | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
| US5994375A (en) | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
| US5753635A (en) | 1996-08-16 | 1998-05-19 | Berlex Laboratories, Inc. | Purine derivatives and their use as anti-coagulants |
| US5693641A (en) | 1996-08-16 | 1997-12-02 | Berlex Laboratories Inc. | Bicyclic pyrimidine derivatives and their use as anti-coagulants |
| US6004985A (en) | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
| NZ503809A (en) | 1997-12-19 | 2002-04-26 | Schering Ag | Ortho-anthranilamide derivatives as anti-coagulants |
-
1997
- 1997-09-11 ES ES97942015T patent/ES2188979T3/es not_active Expired - Lifetime
- 1997-09-11 NZ NZ334264A patent/NZ334264A/xx unknown
- 1997-09-11 DK DK97942015T patent/DK0929547T3/da active
- 1997-09-11 IL IL128691A patent/IL128691A/en not_active IP Right Cessation
- 1997-09-11 KR KR1019997001989A patent/KR20000036017A/ko not_active Ceased
- 1997-09-11 CN CN97198664A patent/CN1234798A/zh active Pending
- 1997-09-11 CA CA002264521A patent/CA2264521A1/en not_active Abandoned
- 1997-09-11 DE DE69717474T patent/DE69717474T2/de not_active Expired - Fee Related
- 1997-09-11 PT PT97942015T patent/PT929547E/pt unknown
- 1997-09-11 CZ CZ99861A patent/CZ86199A3/cs unknown
- 1997-09-11 JP JP51325798A patent/JP3565864B2/ja not_active Expired - Fee Related
- 1997-09-11 AT AT97942015T patent/ATE228513T1/de not_active IP Right Cessation
- 1997-09-11 WO PCT/EP1997/004961 patent/WO1998011094A1/en not_active Ceased
- 1997-09-11 AU AU43843/97A patent/AU723999B2/en not_active Ceased
- 1997-09-11 SK SK295-99A patent/SK29599A3/sk unknown
- 1997-09-11 EP EP97942015A patent/EP0929547B1/en not_active Expired - Lifetime
-
1999
- 1999-03-11 NO NO991206A patent/NO991206L/no not_active Application Discontinuation
- 1999-11-12 US US09/438,354 patent/US6232325B1/en not_active Expired - Fee Related
- 1999-11-12 US US09/439,065 patent/US6177473B1/en not_active Expired - Fee Related
- 1999-11-12 US US09/438,270 patent/US6265404B1/en not_active Expired - Fee Related
-
2001
- 2001-07-03 CN CN01121736A patent/CN1338454A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001500147A (ja) | 2001-01-09 |
| KR20000036017A (ko) | 2000-06-26 |
| AU4384397A (en) | 1998-04-02 |
| ATE228513T1 (de) | 2002-12-15 |
| JP3565864B2 (ja) | 2004-09-15 |
| IL128691A0 (en) | 2000-01-31 |
| NO991206D0 (no) | 1999-03-11 |
| EP0929547B1 (en) | 2002-11-27 |
| AU723999B2 (en) | 2000-09-07 |
| SK29599A3 (en) | 1999-08-06 |
| CN1338454A (zh) | 2002-03-06 |
| DE69717474D1 (de) | 2003-01-09 |
| EP0929547A1 (en) | 1999-07-21 |
| US6177473B1 (en) | 2001-01-23 |
| ES2188979T3 (es) | 2003-07-01 |
| CZ86199A3 (cs) | 1999-08-11 |
| PT929547E (pt) | 2003-03-31 |
| NZ334264A (en) | 2000-08-25 |
| CN1234798A (zh) | 1999-11-10 |
| US6232325B1 (en) | 2001-05-15 |
| NO991206L (no) | 1999-05-11 |
| CA2264521A1 (en) | 1998-03-19 |
| IL128691A (en) | 2007-07-24 |
| WO1998011094A1 (en) | 1998-03-19 |
| DE69717474T2 (de) | 2003-06-26 |
| US6265404B1 (en) | 2001-07-24 |
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