DK0934329T3 - Glycokonjugater af modificerede camptothecinderivater (20-O-binding) - Google Patents
Glycokonjugater af modificerede camptothecinderivater (20-O-binding)Info
- Publication number
- DK0934329T3 DK0934329T3 DK97942940T DK97942940T DK0934329T3 DK 0934329 T3 DK0934329 T3 DK 0934329T3 DK 97942940 T DK97942940 T DK 97942940T DK 97942940 T DK97942940 T DK 97942940T DK 0934329 T3 DK0934329 T3 DK 0934329T3
- Authority
- DK
- Denmark
- Prior art keywords
- glycoconjugates
- bond
- camptothecin derivatives
- modified camptothecin
- modified
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19640206 | 1996-09-30 | ||
| DE19643764A DE19643764A1 (de) | 1996-09-30 | 1996-10-23 | Glycokonjugate von modifizierten Camptothecin-Derivaten (20-0-Verknüpfung) |
| PCT/EP1997/005088 WO1998014459A1 (de) | 1996-09-30 | 1997-09-17 | Glycokonjugate von modifizierten camptothecin-derivaten (20-o-verknüpfung) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0934329T3 true DK0934329T3 (da) | 2002-04-08 |
Family
ID=26029947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97942940T DK0934329T3 (da) | 1996-09-30 | 1997-09-17 | Glycokonjugater af modificerede camptothecinderivater (20-O-binding) |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6492335B1 (es) |
| EP (1) | EP0934329B1 (es) |
| JP (1) | JP2001504453A (es) |
| AT (1) | ATE210673T1 (es) |
| AU (1) | AU4459297A (es) |
| CA (1) | CA2267328A1 (es) |
| DK (1) | DK0934329T3 (es) |
| ES (1) | ES2169429T3 (es) |
| PT (1) | PT934329E (es) |
| WO (1) | WO1998014459A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID23424A (id) * | 1997-05-14 | 2000-04-20 | Bayer Ag | Glikokonjugat dari 20(s)-kamptotesin |
| US7049410B2 (en) | 1999-05-14 | 2006-05-23 | Majumdar Adhip P N | Antibodies to a novel EGF-receptor related protein (ERRP) |
| DE10005275A1 (de) * | 2000-02-07 | 2001-08-09 | Bayer Ag | Neuartige Glycokonjugate |
| US6350756B1 (en) | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
| US6403604B1 (en) | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| US6855720B2 (en) | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| WO2003101998A1 (en) | 2002-06-03 | 2003-12-11 | California Pacific Medical Center | Nitrogen-based homo-camptothecin derivatives |
| GB0513881D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
| US20080182801A1 (en) | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
| GB0329667D0 (en) | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
| US7700612B2 (en) * | 2003-12-23 | 2010-04-20 | Abraxis Bioscience, Llc | Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications |
| US20060135546A1 (en) * | 2004-12-16 | 2006-06-22 | Jagadevappa Basavaraja | Methods for the purification of 20(S)- camptothecin |
| GB0513888D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
| US7875602B2 (en) * | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
| CN102153607B (zh) * | 2010-02-11 | 2015-07-15 | 湖南方盛华美医药科技有限公司 | 水溶性喜树碱衍生物及包含其的药物组合物 |
| JP2021095424A (ja) * | 2018-03-28 | 2021-06-24 | 持田製薬株式会社 | 抗癌剤結合アルギン酸誘導体 |
| CN108822120A (zh) * | 2018-07-11 | 2018-11-16 | 浙江工业大学 | Fl118氨基酸盐酸盐及其制备方法与应用 |
| CN111171041B (zh) * | 2018-11-12 | 2021-07-27 | 中国海洋大学 | 20位取代的喜树碱衍生物及其制备方法和应用 |
| CN115850291B (zh) * | 2021-09-24 | 2024-11-15 | 石药集团巨石生物制药有限公司 | 喜树碱衍生物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943579A (en) | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| DK0418099T3 (da) * | 1989-09-15 | 2002-04-02 | Res Triangle Inst | Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger |
| DE4236237A1 (de) * | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
| ES2149867T3 (es) * | 1993-02-26 | 2000-11-16 | Drug Delivery System Inst Ltd | Derivados de polisacaridos y soportes para farmacos. |
| US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| GB9320781D0 (en) * | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
| US5646159A (en) | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| US5646262A (en) * | 1994-07-28 | 1997-07-08 | Georgetown University | Antisense oligonucleotides against hepatitis B viral replication |
| GB9504065D0 (en) * | 1995-03-01 | 1995-04-19 | Pharmacia Spa | Poly-pyrrolecarboxamidonaphthalenic acid derivatives |
| DE19512484A1 (de) * | 1995-04-04 | 1996-10-17 | Bayer Ag | Kohlenhydratmodifizierte Cytostatika |
| SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| CA2192725C (en) * | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
-
1997
- 1997-09-17 CA CA002267328A patent/CA2267328A1/en not_active Abandoned
- 1997-09-17 AU AU44592/97A patent/AU4459297A/en not_active Abandoned
- 1997-09-17 ES ES97942940T patent/ES2169429T3/es not_active Expired - Lifetime
- 1997-09-17 WO PCT/EP1997/005088 patent/WO1998014459A1/de not_active Ceased
- 1997-09-17 EP EP97942940A patent/EP0934329B1/de not_active Expired - Lifetime
- 1997-09-17 US US09/269,317 patent/US6492335B1/en not_active Expired - Fee Related
- 1997-09-17 AT AT97942940T patent/ATE210673T1/de not_active IP Right Cessation
- 1997-09-17 PT PT97942940T patent/PT934329E/pt unknown
- 1997-09-17 JP JP51618198A patent/JP2001504453A/ja active Pending
- 1997-09-17 DK DK97942940T patent/DK0934329T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0934329B1 (de) | 2001-12-12 |
| WO1998014459A1 (de) | 1998-04-09 |
| ES2169429T3 (es) | 2002-07-01 |
| US6492335B1 (en) | 2002-12-10 |
| EP0934329A1 (de) | 1999-08-11 |
| ATE210673T1 (de) | 2001-12-15 |
| CA2267328A1 (en) | 1998-04-09 |
| AU4459297A (en) | 1998-04-24 |
| PT934329E (pt) | 2002-05-31 |
| JP2001504453A (ja) | 2001-04-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0934329T3 (da) | Glycokonjugater af modificerede camptothecinderivater (20-O-binding) | |
| DK0939765T3 (da) | Glycokonjugater af modificerede camptothecin-derivater (A- eller B-ringbinding) | |
| DE69834923D1 (en) | Hochgradig lipophile camptothecin-derivate | |
| FI954898A7 (fi) | Vesiliukoiset kamptotesiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö kasvaintenvastaisina aineina | |
| EE03231B1 (et) | Tetratsüklilised derivaadid, nende valmistamismeetod ja kasutamine | |
| PL285248A1 (en) | Method of obtaining novel aminophenol derivatives | |
| HUP9900987A3 (en) | Camptothecin derivatives process for their preparation, use thereof as antitumor agents and pharmaceutical compositions containing them | |
| NO995481D0 (no) | Glykokonjugater av 20 (S)-camptothecin | |
| YU63696A (sh) | Novi fenilamidin-derivati, postupci za njihovo pripremanje i njihova primena kao lekova | |
| FI924110A7 (fi) | Menetelmä dihydropyridiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia kasvainten vastaisessa terapiassa | |
| ES2132556T3 (es) | Nuevo derivado de benzo-tiadiazina, su procedimiento de preparacion y las composiciones farmaceuticas que lo contienen. | |
| FI92195C (fi) | Menetelmä terapeuttisesti käyttökelpoisten pyridiinijohdannaisten valmistamiseksi | |
| AU641279B2 (en) | Oligosaccharide derivatives | |
| BG102707A (bg) | Нови триазолопурини, метод за тяхното получаване и тяхното приложение като лекарствени средства | |
| ES2111561T3 (es) | Derivados de benzopirano antihipertensivos. | |
| KR950700684A (ko) | 시클릭 항-종양 촉진제 화합물, 그의 조성물, 제조 방법 및 용도(Cyclic Anti-Tumor Promoter Compounds, Compositions and Methods for Production and Use) | |
| IT8822654A0 (it) | Derivati indolici, processo per la loro preparazione e loro uso comefarmaci antitrombotici | |
| DE58907399D1 (de) | Cyclopropyl-Substituierte Azolylmethylcarbinole, Verfarhren zu ihrer Herstellung und ihre Verwendung als Arzneimittel. | |
| SE9803107D0 (sv) | Novel Compunds | |
| DE60039122D1 (de) | 6-o-alkyl-2-nor-2-substituierte ketolidderivate | |
| DZ1655A1 (fr) | Dérivés de la benzofuranylimidazole ainsi que leurprocédé de préparation. | |
| DZ1472A1 (fr) | Dérivés du glycérol, ainsi que leur de préparation. | |
| FR2704549B1 (fr) | Procédé de préparation de dérivés de la 2-propanone, de la 2-thiopropanone et de la 2-sélénopropanone, en particulier de dérivés des 3-phosphino-1-phosphoranylidène-2-propanone et phosphines ainsi obtenues. |