DK0937458T3 - Pyrrolidin- og piperidinderivater - Google Patents

Pyrrolidin- og piperidinderivater

Info

Publication number: DK0937458T3
Authority: DK; Denmark
Prior art keywords: pyrrolidine; piperidine derivatives; piperidine; derivatives
Prior art date: 1998-02-10

Application number

DK99102078T

Other languages

Danish (da)

English (en)

Inventor

Alexander Alanine

Bernd Buettelmann

Neidhart Marie-Paule Heitz

Emmanuel Pinard

Rene Wyler

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-10

Filing date

1999-02-02

Publication date

2005-05-17

1999-02-02 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-05-17 Application granted granted Critical

2005-05-17 Publication of DK0937458T3 publication Critical patent/DK0937458T3/da

Links

RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 3
150000003053 piperidines Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK99102078T 1998-02-10 1999-02-02 Pyrrolidin- og piperidinderivater DK0937458T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98102246		1998-02-10
EP99102078A EP0937458B1 (de)	1998-02-10	1999-02-02	Pyrrolidin und Piperidin Derivate

Publications (1)

Publication Number	Publication Date
DK0937458T3 true DK0937458T3 (da)	2005-05-17

Family

ID=8231382

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99102078T DK0937458T3 (da)	1998-02-10	1999-02-02	Pyrrolidin- og piperidinderivater

Country Status (28)

Country	Link
US (2)	US6015824A (de)
EP (1)	EP0937458B1 (de)
JP (1)	JP3142527B2 (de)
KR (1)	KR100319249B1 (de)
CN (1)	CN1144789C (de)
AR (1)	AR018077A1 (de)
AT (1)	ATE285766T1 (de)
AU (1)	AU748335B2 (de)
BR (1)	BR9900742A (de)
CA (1)	CA2260698A1 (de)
CZ (1)	CZ41099A3 (de)
DE (1)	DE69922858T2 (de)
DK (1)	DK0937458T3 (de)
ES (1)	ES2245808T3 (de)
HR (1)	HRP990042A2 (de)
HU (1)	HUP9900275A3 (de)
ID (1)	ID23456A (de)
IL (2)	IL128389A0 (de)
MA (1)	MA26607A1 (de)
NO (1)	NO990609L (de)
NZ (1)	NZ334081A (de)
PE (1)	PE20000276A1 (de)
PL (1)	PL331336A1 (de)
PT (1)	PT937458E (de)
SG (1)	SG74120A1 (de)
TR (1)	TR199900286A2 (de)
YU (1)	YU5899A (de)
ZA (1)	ZA991038B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2793245B1 (fr) *	1999-05-05	2002-10-11	Adir	Nouveaux composes pyridiniques ou piperidiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6369078B1 (en) *	1999-08-31	2002-04-09	J. Phillip Bowen	Solenopsin derivatives and analogues as fire ant suppressants
CA2404464C (en)	2000-04-20	2008-03-11	F. Hoffmann-La Roche Ag	Pyrrolidine and piperidine derivatives and their use for the treatment of neurodegenerative disorders
AU2002223968A1 (en)	2000-12-21	2002-07-01	Warner Lambert Company Llc	Piperidine derivatives as subtype selective n-methyl-d-aspartate antagonists
MXPA02002749A (es)	2001-03-27	2002-10-28	Warner Lambert Co	Derivados de ciclohexilamina como antagonistas del subtipo selectivo del n-metil-d-aspartato.
US7005432B2 (en) *	2002-05-16	2006-02-28	Hoffman-La Roche Inc.	Substituted imidazol-pyridazine derivatives
MX2010009649A (es) *	2008-03-27	2010-12-17	Evotecv Neurosciences Gmbh	Metodos para tratar trastornos utilizando un antagonista selectivo del subtipo nr2b de nmda.
CA2770475C (en) *	2009-08-27	2017-06-27	Merck Sharp & Dohme Corp.	Novel pyrrolidine derived beta 3 adrenergic receptor agonists
US8354403B2 (en) *	2009-08-27	2013-01-15	Merck Sharp & Dohme Corp.	Pyrrolidine derived beta 3 adrenergic receptor agonists
GB201714734D0 (en)	2017-09-13	2017-10-25	Atrogi Ab	New compounds and uses
GB201903832D0 (en)	2019-03-20	2019-05-01	Atrogi Ab	New compounds and methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3941796A (en) *	1970-05-21	1976-03-02	Minnesota Mining And Manufacturing Company	α-(Hydroxy and alkoxy substituted)phenyl-α-(2-piperidinyl)-methanols
US4407670A (en) *	1980-02-28	1983-10-04	National Research Development Corporation	Biocidal compounds and compositions
US4342692A (en) *	1980-10-20	1982-08-03	Usv Pharmaceutical Corporation	Pyrrolidines
ZA825227B (en) *	1981-07-22	1984-03-28	Syntex Inc	Substituted pyrrolidine cardiovascular system regulators antihypertensives
EP0115413A1 (de) *	1983-01-24	1984-08-08	Syntex (U.S.A.) Inc.	+/- 2-(phenethyl)-5-((3,4-Methylenedioxy)-alpha-hydroxybenzyl)-Pyrrolidine, pharmazeutische Zusammenstellungen die sie enthalten, Verfahren zur Herstellung und deren Zwischenprodukte
IL70752A0 (en) *	1983-01-24	1984-06-29	Syntex Inc	(+-)2-(3,4-methylenedioxyphenethyl)-5-(3-carbamoyl-alpha,4-dihydroxybenzyl)pyrrolidines and salts thereof,their preparation and pharmaceutical compositions containing them
US4569941A (en) *	1983-03-21	1986-02-11	Usv Pharmaceutical Corp.	Method of using phenyl-alkylene-2-pyridyl derivatives to increase cardiac contractility in a mammal
US4548951A (en) *	1983-04-21	1985-10-22	Syntex (U.S.A.) Inc.	Hypotensive benzoxathiole pyrrolidines
US4558066A (en) *	1984-05-17	1985-12-10	Syntex (U.S.A.) Inc.	Treatment and prevention of ocular hypertension
US4632929A (en) *	1985-01-17	1986-12-30	Usv Pharmaceutical Corp.	Method of hypertensive treatment using phenyl-alkylene-2-pyridyl derivatives

1999
- 1999-01-20 US US09/234,266 patent/US6015824A/en not_active Expired - Fee Related
- 1999-02-02 DK DK99102078T patent/DK0937458T3/da active
- 1999-02-02 DE DE69922858T patent/DE69922858T2/de not_active Expired - Fee Related
- 1999-02-02 EP EP99102078A patent/EP0937458B1/de not_active Expired - Lifetime
- 1999-02-02 PT PT99102078T patent/PT937458E/pt unknown
- 1999-02-02 ES ES99102078T patent/ES2245808T3/es not_active Expired - Lifetime
- 1999-02-02 AT AT99102078T patent/ATE285766T1/de not_active IP Right Cessation
- 1999-02-05 IL IL12838999A patent/IL128389A0/xx unknown
- 1999-02-05 BR BR9900742-8A patent/BR9900742A/pt not_active IP Right Cessation
- 1999-02-05 CA CA002260698A patent/CA2260698A1/en not_active Abandoned
- 1999-02-05 NZ NZ334081A patent/NZ334081A/xx unknown
- 1999-02-05 CZ CZ99410A patent/CZ41099A3/cs unknown
- 1999-02-05 MA MA25457A patent/MA26607A1/fr unknown
- 1999-02-06 KR KR1019990004058A patent/KR100319249B1/ko not_active Expired - Fee Related
- 1999-02-08 AU AU16354/99A patent/AU748335B2/en not_active Ceased
- 1999-02-08 JP JP11029850A patent/JP3142527B2/ja not_active Expired - Fee Related
- 1999-02-08 SG SG1999000363A patent/SG74120A1/en unknown
- 1999-02-08 AR ARP990100528A patent/AR018077A1/es unknown
- 1999-02-08 PE PE1999000101A patent/PE20000276A1/es not_active Application Discontinuation
- 1999-02-08 HU HU9900275A patent/HUP9900275A3/hu unknown
- 1999-02-09 HR HR98102246.0A patent/HRP990042A2/hr not_active Application Discontinuation
- 1999-02-09 ZA ZA9901038A patent/ZA991038B/xx unknown
- 1999-02-09 NO NO990609A patent/NO990609L/no not_active Application Discontinuation
- 1999-02-09 PL PL99331336A patent/PL331336A1/xx unknown
- 1999-02-09 ID IDP990095A patent/ID23456A/id unknown
- 1999-02-09 YU YU5899A patent/YU5899A/sh unknown
- 1999-02-10 CN CNB991018001A patent/CN1144789C/zh not_active Expired - Fee Related
- 1999-02-10 TR TR1999/00286A patent/TR199900286A2/xx unknown
- 1999-07-28 US US09/362,932 patent/US6153624A/en not_active Expired - Fee Related
2001
- 2001-07-19 IL IL14445601A patent/IL144456A0/xx unknown

Also Published As

Publication number	Publication date
CN1144789C (zh)	2004-04-07
DE69922858D1 (de)	2005-02-03
CN1232025A (zh)	1999-10-20
PE20000276A1 (es)	2000-04-18
BR9900742A (pt)	2000-05-09
US6015824A (en)	2000-01-18
US6153624A (en)	2000-11-28
NZ334081A (en)	2000-07-28
NO990609L (no)	1999-08-11
AR018077A1 (es)	2001-10-31
YU5899A (sh)	2001-07-10
EP0937458A3 (de)	2001-05-23
ZA991038B (en)	1999-08-10
TR199900286A3 (tr)	1999-09-21
NO990609D0 (no)	1999-02-09
HUP9900275A3 (en)	2001-08-28
CA2260698A1 (en)	1999-08-10
AU748335B2 (en)	2002-05-30
KR100319249B1 (ko)	2002-01-05
KR19990072459A (ko)	1999-09-27
MA26607A1 (fr)	2004-12-20
DE69922858T2 (de)	2006-04-13
EP0937458B1 (de)	2004-12-29
ES2245808T3 (es)	2006-01-16
IL128389A0 (en)	2000-01-31
AU1635499A (en)	1999-08-26
PT937458E (pt)	2005-04-29
JP3142527B2 (ja)	2001-03-07
CZ41099A3 (cs)	1999-09-15
IL144456A0 (en)	2002-05-23
SG74120A1 (en)	2000-07-18
ATE285766T1 (de)	2005-01-15
EP0937458A2 (de)	1999-08-25
PL331336A1 (en)	1999-08-16
ID23456A (id)	2000-04-27
HRP990042A2 (en)	2000-02-29
HUP9900275A2 (hu)	1999-12-28
HU9900275D0 (en)	1999-04-28
JP2000063384A (ja)	2000-02-29
TR199900286A2 (xx)	1999-09-21

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DK1454907T3 (da)	2009-03-09	Quninazolin og pyridopyrmidin-derivativer
AR028343A1 (es)	2003-05-07	Derivados de pirrolidina y piperidina
DK1131308T3 (da)	2004-06-28	Piperazin- og piperidinderivater
IS6385A (is)	2002-05-15	Ný notkun og nýjar N-asabísýkló-amíð afleiður
ATE278695T1 (de)	2004-10-15	Piperidinderivate
DK1137635T3 (da)	2006-02-13	N-substituerede 2-cyanopyrrolidiner
NO20023787D0 (no)	2002-08-09	Piperazin- og piperidinderivater
FI955184A7 (fi)	1996-05-01	Bentsyylipiperidiinijohdannaiset
ATE271543T1 (de)	2004-08-15	N-substituierte 2-cyanopyrrolidine
DE69707782D1 (de)	2001-12-06	4-Hydroxypiperidinderivate
DE60032898D1 (de)	2007-02-22	Arylthiazolidindion- und aryloxazolidinderivate
NO20003916D0 (no)	2000-08-02	Benzotiadiazoler og derivater
BR9708677A (pt)	1999-08-03	Piperidinas e pirrolidinas
NO990609D0 (no)	1999-02-09	Pyrrolidin- og piperidin-derivater
NO992302L (no)	1999-05-14	Piperidin-derivater
DE69706813D1 (de)	2001-10-25	4-Hydroxypiperidinderivate
NO20001778D0 (no)	2000-04-06	Substituerte piperidinderivater
DK1037892T3 (da)	2005-02-07	Piperidinderivater
PT1131308E (pt)	2004-10-29	Novos compostos de piperazina e piperidina
FI980691A0 (fi)	1998-03-26	Xylitoltillsats i roektobak