DK1131308T3 - Piperazin- og piperidinderivater - Google Patents

Piperazin- og piperidinderivater

Info

Publication number
DK1131308T3
DK1131308T3 DK99955980T DK99955980T DK1131308T3 DK 1131308 T3 DK1131308 T3 DK 1131308T3 DK 99955980 T DK99955980 T DK 99955980T DK 99955980 T DK99955980 T DK 99955980T DK 1131308 T3 DK1131308 T3 DK 1131308T3
Authority
DK
Denmark
Prior art keywords
piperazine
piperidine derivatives
piperidine
derivatives
Prior art date
Application number
DK99955980T
Other languages
English (en)
Inventor
Roelof W Feenstra
Der Heijden Johannes A M Van
Johannes Mos
Stephen K Long
Gerben M Visser
Cornelis G Kruse
Scharrenburg Gustaaf J M Van
Anne G Hf Toorop
Gerrit P Toorop
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8234340&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1131308(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Duphar Int Res filed Critical Duphar Int Res
Application granted granted Critical
Publication of DK1131308T3 publication Critical patent/DK1131308T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK99955980T 1998-11-13 1999-11-10 Piperazin- og piperidinderivater DK1131308T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98203871 1998-11-13

Publications (1)

Publication Number Publication Date
DK1131308T3 true DK1131308T3 (da) 2004-06-28

Family

ID=8234340

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99955980T DK1131308T3 (da) 1998-11-13 1999-11-10 Piperazin- og piperidinderivater

Country Status (27)

Country Link
US (1) US6780864B1 (da)
EP (1) EP1131308B1 (da)
JP (1) JP3638874B2 (da)
KR (1) KR100619465B1 (da)
CN (1) CN1225462C (da)
AR (1) AR021256A1 (da)
AT (1) ATE267183T1 (da)
AU (1) AU756470B2 (da)
BR (1) BR9915293B1 (da)
CA (1) CA2350137C (da)
CZ (1) CZ299774B6 (da)
DE (1) DE69917478T2 (da)
DK (1) DK1131308T3 (da)
DZ (1) DZ2934A1 (da)
ES (1) ES2217833T3 (da)
HU (1) HUP0104922A3 (da)
IL (2) IL143028A0 (da)
MX (1) MXPA01004854A (da)
NO (1) NO318888B1 (da)
NZ (1) NZ511584A (da)
PL (1) PL193685B1 (da)
RU (1) RU2225406C2 (da)
SI (1) SI1131308T1 (da)
SK (1) SK285648B6 (da)
TW (1) TWI252230B (da)
UA (1) UA71590C2 (da)
WO (1) WO2000029397A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
WO2001085168A1 (en) * 2000-05-12 2001-11-15 Solvay Pharmaceuticals B.V. Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders
US6911448B2 (en) * 2000-05-12 2005-06-28 Solvay Pharmaceuticals B.V. Piperazine and piperidine compounds
CA2428519A1 (en) * 2000-11-14 2002-05-23 Merck Patent Gesellschaft Mit Beschraenkter Haftung Novel uses of combined selective dopamine d2 receptor antagonists and 5-ht1a receptor agonists
AR034206A1 (es) * 2001-02-16 2004-02-04 Solvay Pharm Bv Un procedimiento para la preparacion de mesilatos de derivados de piperazina y dichos mesilatos
US6800648B2 (en) * 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
US6743796B2 (en) * 2001-05-07 2004-06-01 Wyeth Piperazinyl-isatins
US7504395B2 (en) 2001-07-20 2009-03-17 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
BR0211358A (pt) 2001-07-26 2004-09-21 Merck Patent Gmbh Uso do composto de 2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-croman o e seus sais fisiologicamente aceitáveis
EP1336406A1 (en) * 2002-02-14 2003-08-20 Solvay Pharmaceuticals B.V. Partial dopamine-D2 receptor agonist plus serotonin and/or noradrenaline inhibitory activity
AU2003244160A1 (en) * 2002-06-25 2004-01-06 Sumitomo Pharmaceuticals Co., Ltd. Novel benzoxazolinone derivative
US7435738B2 (en) 2003-08-18 2008-10-14 Solvay Pharmaceuticals, Inc. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
EP1595542A1 (en) * 2004-03-26 2005-11-16 Solvay Pharmaceuticals B.V. Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds
US7596407B2 (en) 2004-03-26 2009-09-29 Solvay Pharmaceuticals, B.V. Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds
ES2332597T3 (es) 2004-05-27 2010-02-09 Ucb Pharma S.A. Derivados de benzoxazolona, procedimientos para su preparacion y su uso.
US7405216B2 (en) 2004-08-18 2008-07-29 Solvay Pharmaceuticals, B.V. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7964604B2 (en) 2005-02-18 2011-06-21 Solvay Pharmaceuticals B.V. Bifeprunox mesylate maintenance dose compositions and methods for using the same
US7423040B2 (en) 2005-02-18 2008-09-09 Irene Eijgendaal Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same
ATE417834T1 (de) * 2005-08-22 2009-01-15 Solvay Pharm Bv N-oxide als prodrugs von piperazin- und piperidinderivaten
AR058022A1 (es) * 2005-08-22 2008-01-23 Solvay Pharm Bv Derivados de benzooxazoles, composiciones farmaceuticas y su uso para el tratamiento de desordenes del sistema nervioso.
US7750013B2 (en) 2005-08-22 2010-07-06 Solvay Pharmaceuticals, B.V. N-oxides as prodrugs of piperazine and piperidine derivatives
US8106056B2 (en) 2006-06-16 2012-01-31 Solvay Pharmaceuticals B.V. Combination preparations comprising bifeprunox and a dopamine agonist
US7786126B2 (en) 2006-06-16 2010-08-31 Solvay Pharmaceuticals B.V. Combination preparations comprising SLV308 and a dopamine agonist
UY32934A (es) 2009-10-12 2011-05-31 Abbott Healthcare Products Bv Monohidrato de pardoprunox
JP7096813B2 (ja) 2016-08-26 2022-07-06 エクシーバ ゲーエムベーハー 組成物及びその方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567884B1 (fr) * 1984-07-19 1987-03-06 Roussel Uclaf Nouveaux derives de l'indole, leur preparation, leur application comme medicaments et les compositions les renfermant
EP0190472B1 (en) * 1984-12-21 1989-07-12 Duphar International Research B.V New pharmaceutical compositions having anti-psychotic properties
DE3586794T2 (de) * 1984-12-21 1993-05-27 Duphar Int Res Arzneimittel mit psychotroper wirkung.
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
IL114026A (en) 1994-06-08 1999-06-20 Lundbeck & Co As H 4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzo thiophenemethyl) piperidines tetrahydropyridines or piperazines and pharmaceutical compositions containing them
CA2194984C (en) 1994-07-26 2002-07-02 John Eugene Macor 4-indole derivatives as serotonin agonists and antagonists
AU708053B2 (en) * 1996-03-29 1999-07-29 Duphar International Research B.V. Piperazine and piperidine compounds
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists

Also Published As

Publication number Publication date
US6780864B1 (en) 2004-08-24
NO20012339D0 (no) 2001-05-11
HUP0104922A3 (en) 2003-05-28
JP2002530276A (ja) 2002-09-17
BR9915293A (pt) 2001-08-07
CA2350137A1 (en) 2000-05-25
CN1225462C (zh) 2005-11-02
PL193685B1 (pl) 2007-03-30
WO2000029397A1 (en) 2000-05-25
IL143028A (en) 2006-12-10
RU2225406C2 (ru) 2004-03-10
SK285648B6 (sk) 2007-05-03
SK6492001A3 (en) 2001-10-08
CA2350137C (en) 2008-04-22
HK1039489A1 (en) 2002-04-26
UA71590C2 (en) 2004-12-15
KR100619465B1 (ko) 2006-09-05
ATE267183T1 (de) 2004-06-15
BR9915293B1 (pt) 2011-11-01
AU1270900A (en) 2000-06-05
CZ20011657A3 (cs) 2001-10-17
PL347635A1 (en) 2002-04-22
NO20012339L (no) 2001-05-11
EP1131308B1 (en) 2004-05-19
AU756470B2 (en) 2003-01-16
HUP0104922A2 (en) 2002-08-28
DE69917478T2 (de) 2004-09-16
AR021256A1 (es) 2002-07-03
TWI252230B (en) 2006-04-01
DZ2934A1 (fr) 2004-03-15
DE69917478D1 (de) 2004-06-24
SI1131308T1 (en) 2004-10-31
EP1131308A1 (en) 2001-09-12
ES2217833T3 (es) 2004-11-01
CZ299774B6 (cs) 2008-11-19
KR20010080995A (ko) 2001-08-25
IL143028A0 (en) 2002-04-21
NO318888B1 (no) 2005-05-18
JP3638874B2 (ja) 2005-04-13
NZ511584A (en) 2003-01-31
CN1378540A (zh) 2002-11-06
MXPA01004854A (es) 2005-07-25

Similar Documents

Publication Publication Date Title
NO20023787D0 (no) Piperazin- og piperidinderivater
ATE353326T1 (de) Piperazin-derivate
DE69917478D1 (de) Piperazine und piperidine derivate
AR028343A1 (es) Derivados de pirrolidina y piperidina
BR9712037A (pt) Derivados de piperazina
ATE278695T1 (de) Piperidinderivate
DK1454907T3 (da) Quninazolin og pyridopyrmidin-derivativer
ATE236136T1 (de) Benzosulfonderivate
FI955184L (fi) Bentsyylipiperidiinijohdannaiset
NO20010514D0 (no) Aminometylkarboksylsyre-derivater
ATE259810T1 (de) Phenyl-xanthinderivate
ATE321042T1 (de) Piperazin-derivate
HU9802129D0 (en) New piperazine and piperidine derivatives
DK1070059T3 (da) Chromanon- og thiochromanonderivater
DE60101386D1 (de) Piperazin- und piperidinverbindungen
ATE266637T1 (de) 3,3-biarylpiperidin- und 3,3- biarylmorpholinderivate
DK0937458T3 (da) Pyrrolidin- og piperidinderivater
ATE233253T1 (de) Chromanderivate
NO992302L (no) Piperidin-derivater
FI982246L (fi) Kasvisterolijohdannaisia
DE59907635D1 (de) Pyrazolyldioxothiochromanoyl-derivate
PT1131308E (pt) Novos compostos de piperazina e piperidina
NO20001778D0 (no) Substituerte piperidinderivater
DK1037892T3 (da) Piperidinderivater