DK0940386T3 - Benzocyklobutanforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende sådanne forbindelser - Google Patents
Benzocyklobutanforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende sådanne forbindelserInfo
- Publication number
- DK0940386T3 DK0940386T3 DK99400506T DK99400506T DK0940386T3 DK 0940386 T3 DK0940386 T3 DK 0940386T3 DK 99400506 T DK99400506 T DK 99400506T DK 99400506 T DK99400506 T DK 99400506T DK 0940386 T3 DK0940386 T3 DK 0940386T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- alkyl
- benzocyclobutane
- preparation
- methods
- Prior art date
Links
- UMIVXZPTRXBADB-UHFFFAOYSA-N benzocyclobutene Chemical class C1=CC=C2CCC2=C1 UMIVXZPTRXBADB-UHFFFAOYSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- -1 4,5-dihydro-2-oxazolylamino Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002827 triflate group Chemical group FC(S(=O)(=O)O*)(F)F 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9802585A FR2775687B1 (fr) | 1998-03-04 | 1998-03-04 | Nouveaux composes du benzocyclobutane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0940386T3 true DK0940386T3 (da) | 2002-09-16 |
Family
ID=9523607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99400506T DK0940386T3 (da) | 1998-03-04 | 1999-03-03 | Benzocyklobutanforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende sådanne forbindelser |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6107345A (de) |
| EP (1) | EP0940386B1 (de) |
| JP (1) | JP3676110B2 (de) |
| CN (1) | CN1137083C (de) |
| AT (1) | ATE217861T1 (de) |
| AU (1) | AU745808B2 (de) |
| BR (1) | BR9900850A (de) |
| CA (1) | CA2264372C (de) |
| DE (1) | DE69901522T2 (de) |
| DK (1) | DK0940386T3 (de) |
| ES (1) | ES2178357T3 (de) |
| FR (1) | FR2775687B1 (de) |
| HU (1) | HU224310B1 (de) |
| NO (1) | NO312096B1 (de) |
| NZ (1) | NZ334447A (de) |
| PL (1) | PL331729A1 (de) |
| PT (1) | PT940386E (de) |
| ZA (1) | ZA991748B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2807753B1 (fr) * | 2000-04-13 | 2002-06-07 | Adir | Nouveaux derives d'heterocycloalkylbenzocyclobutane et d'heteroarylbenzocyclobutane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN102264689B (zh) * | 2008-12-22 | 2014-12-31 | 新梅斯托克尔卡公司 | 制备伊伐布雷定的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5214055A (en) * | 1990-05-18 | 1993-05-25 | Adir Et Compagnie | Aminopiperidine 4-oxo-4H-chromen-2-yl compounds |
| FR2662162B1 (fr) * | 1990-05-18 | 1995-01-20 | Adir | Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1998
- 1998-03-04 FR FR9802585A patent/FR2775687B1/fr not_active Expired - Fee Related
-
1999
- 1999-03-03 DE DE69901522T patent/DE69901522T2/de not_active Expired - Fee Related
- 1999-03-03 HU HU9900519A patent/HU224310B1/hu not_active IP Right Cessation
- 1999-03-03 PL PL99331729A patent/PL331729A1/xx unknown
- 1999-03-03 PT PT99400506T patent/PT940386E/pt unknown
- 1999-03-03 NZ NZ334447A patent/NZ334447A/xx unknown
- 1999-03-03 AT AT99400506T patent/ATE217861T1/de not_active IP Right Cessation
- 1999-03-03 NO NO19991043A patent/NO312096B1/no unknown
- 1999-03-03 EP EP99400506A patent/EP0940386B1/de not_active Expired - Lifetime
- 1999-03-03 US US09/261,803 patent/US6107345A/en not_active Expired - Fee Related
- 1999-03-03 JP JP05510299A patent/JP3676110B2/ja not_active Expired - Fee Related
- 1999-03-03 DK DK99400506T patent/DK0940386T3/da active
- 1999-03-03 BR BR9900850-5A patent/BR9900850A/pt not_active Application Discontinuation
- 1999-03-03 ES ES99400506T patent/ES2178357T3/es not_active Expired - Lifetime
- 1999-03-04 ZA ZA9901748A patent/ZA991748B/xx unknown
- 1999-03-04 CN CNB991024915A patent/CN1137083C/zh not_active Expired - Fee Related
- 1999-03-04 CA CA002264372A patent/CA2264372C/fr not_active Expired - Fee Related
- 1999-03-04 AU AU18618/99A patent/AU745808B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN1137083C (zh) | 2004-02-04 |
| JPH11310557A (ja) | 1999-11-09 |
| ATE217861T1 (de) | 2002-06-15 |
| ES2178357T3 (es) | 2002-12-16 |
| DE69901522D1 (de) | 2002-06-27 |
| CA2264372C (fr) | 2003-07-08 |
| BR9900850A (pt) | 2000-05-02 |
| NZ334447A (en) | 2000-01-28 |
| ZA991748B (en) | 1999-09-16 |
| EP0940386A1 (de) | 1999-09-08 |
| CA2264372A1 (fr) | 1999-09-04 |
| PL331729A1 (en) | 1999-09-13 |
| AU745808B2 (en) | 2002-04-11 |
| NO312096B1 (no) | 2002-03-18 |
| PT940386E (pt) | 2002-09-30 |
| DE69901522T2 (de) | 2003-01-09 |
| AU1861899A (en) | 2000-06-08 |
| CN1228414A (zh) | 1999-09-15 |
| NO991043D0 (no) | 1999-03-03 |
| HU9900519D0 (en) | 1999-04-28 |
| JP3676110B2 (ja) | 2005-07-27 |
| NO991043L (no) | 1999-09-06 |
| US6107345A (en) | 2000-08-22 |
| HK1021895A1 (en) | 2000-07-14 |
| FR2775687B1 (fr) | 2000-04-14 |
| HU224310B1 (hu) | 2005-07-28 |
| HUP9900519A1 (hu) | 2000-08-28 |
| FR2775687A1 (fr) | 1999-09-10 |
| EP0940386B1 (de) | 2002-05-22 |
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