DK0946169T3 - Fremgangsmåde til fremstilling af et præparat med vedvarende frigivelse - Google Patents

Fremgangsmåde til fremstilling af et præparat med vedvarende frigivelse

Info

Publication number
DK0946169T3
DK0946169T3 DK97949131T DK97949131T DK0946169T3 DK 0946169 T3 DK0946169 T3 DK 0946169T3 DK 97949131 T DK97949131 T DK 97949131T DK 97949131 T DK97949131 T DK 97949131T DK 0946169 T3 DK0946169 T3 DK 0946169T3
Authority
DK
Denmark
Prior art keywords
preparation
sustained release
organic solvent
physiologically active
active polypeptide
Prior art date
Application number
DK97949131T
Other languages
Danish (da)
English (en)
Inventor
Yutaka Yamagata
Masafumi Misaki
Susumu Iwasa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DK0946169T3 publication Critical patent/DK0946169T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK97949131T 1996-12-20 1997-12-18 Fremgangsmåde til fremstilling af et præparat med vedvarende frigivelse DK0946169T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34204696 1996-12-20
PCT/JP1997/004671 WO1998027980A2 (fr) 1996-12-20 1997-12-18 Procede de production d'une preparation a liberation prolongee

Publications (1)

Publication Number Publication Date
DK0946169T3 true DK0946169T3 (da) 2003-04-22

Family

ID=18350747

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97949131T DK0946169T3 (da) 1996-12-20 1997-12-18 Fremgangsmåde til fremstilling af et præparat med vedvarende frigivelse

Country Status (10)

Country Link
US (2) US6197350B1 (fr)
EP (1) EP0946169B1 (fr)
KR (1) KR20000057693A (fr)
AT (1) ATE233088T1 (fr)
AU (1) AU7871298A (fr)
CA (1) CA2275422A1 (fr)
DE (1) DE69719367T2 (fr)
DK (1) DK0946169T3 (fr)
WO (1) WO1998027980A2 (fr)
ZA (1) ZA9711385B (fr)

Families Citing this family (302)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191107B1 (en) 1997-09-26 2001-02-20 Takeda Chemical Industries, Ltd. Complex of human growth hormone and zinc
WO1999048519A1 (fr) 1998-03-20 1999-09-30 Takeda Chemical Industries, Ltd. Preparation de polypeptide physiologiquement actif, a liberation prolongee, et production correspondante
CA2383144A1 (fr) 1999-09-17 2001-03-29 Takeda Chemical Industries, Ltd. Procede de production d'une poudre proteique
US6992065B2 (en) 2000-04-19 2006-01-31 Genentech, Inc. Sustained release formulations
US20030185878A1 (en) * 2000-06-23 2003-10-02 Tetsuo Hoshino Process for producing phospholipid-containing drug
CA2433037C (fr) 2000-12-28 2010-12-21 Takeda Chemical Industries, Ltd. Preparation a liberation prolongee
ATE427760T1 (de) * 2001-02-23 2009-04-15 Genentech Inc Erodierbare polymere zur injektion
US20040126900A1 (en) * 2001-04-13 2004-07-01 Barry Stephen E High affinity peptide- containing nanoparticles
JP4460892B2 (ja) * 2001-06-21 2010-05-12 ジェネンテック インコーポレイテッド 徐放性組成物
WO2003000156A1 (fr) 2001-06-22 2003-01-03 Southern Biosystems, Inc. Implants coaxiaux a liberation prolongee d'ordre 0
AU2003269904A1 (en) * 2002-07-10 2004-01-23 The Ohio State University Research Foundation Antigen-polymer compositions
ATE386054T1 (de) * 2002-08-31 2008-03-15 Cj Corp Glycosylierte humane interferon alpha isoform
WO2004035537A2 (fr) 2002-10-16 2004-04-29 Euro-Celtique S.A. Anticorps se fixant sur des polypeptides ca 125/0722p associes a des cellules et leurs procedes d'utilisation
CN100364499C (zh) * 2003-05-01 2008-01-30 日本株式会社Ltt生物医药 包含锌的缓释组合物、其制剂及其制备方法
US20040244806A1 (en) * 2003-06-09 2004-12-09 Ferree Bret A. Treating disc herniation and other conditions with leukocytes
US20050196455A1 (en) * 2003-10-27 2005-09-08 Jianbing Chen Suspension delivery system for the sustained and controlled local release of pharmaceuticals
US20090156545A1 (en) * 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
ATE534652T1 (de) 2005-04-01 2011-12-15 Univ California Phosphono-pent-2-en-1-yl-nukleoside und analoga
US20070106271A1 (en) * 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Remote control of substance delivery system
ES2755032T3 (es) * 2005-12-22 2020-04-21 Novartis Ag Formulación de liberación sostenida que comprende octreótido y dos o más polímeros de poliláctido-co-glicólido
ES2530526T3 (es) 2005-12-30 2015-03-03 Zensun Shanghai Science And Technology Ltd Liberación extendida de neurregulina para mejorar la función cardíaca
CA2644784A1 (fr) * 2006-03-13 2007-09-20 Jinling Chen Formulations de sitaxsentan sodium
JP2009530284A (ja) * 2006-03-13 2009-08-27 エンサイシブ・ファーマシューティカルズ・インコーポレイテッド 拡張期心不全を治療するための方法と組成物
CA2645376C (fr) 2006-03-13 2017-06-20 Activx Biosciences, Inc. Aminoquinolones utilisees comme inhibiteurs de la gsk-3
US20080026061A1 (en) * 2006-06-22 2008-01-31 Reichwein John F Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
PL2066662T3 (pl) 2006-09-21 2013-05-31 Kyorin Seiyaku Kk Inhibitory hydrolaz serynowych
CA2666149A1 (fr) 2006-10-19 2008-04-24 Auspex Pharmaceuticals, Inc. Indoles substitues
US20100137421A1 (en) * 2006-11-08 2010-06-03 Emmanuel Theodorakis Small molecule therapeutics, synthesis of analogues and derivatives and methods of use
US20080188528A1 (en) * 2006-12-22 2008-08-07 Biediger Ronald J Modulators of C3a receptor and methods of use thereof
JP2010520200A (ja) 2007-02-28 2010-06-10 クオナトウス ファーマシューティカルズ，インコーポレイテッド 特定のマトリックスメタロプロテイナーゼ（ｍｍｐ）阻害剤を使用する肝疾患を治療する方法
WO2008106167A1 (fr) * 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Polythérapie incluant des inhibiteurs de métalloprotéinases matricielles et des inhibiteurs de caspases pour le traitement de maladies hépatiques
SI2125698T1 (sl) 2007-03-15 2016-12-30 Auspex Pharmaceuticals, Inc. Devterirani d9-venlafaksin
US7892776B2 (en) 2007-05-04 2011-02-22 The Regents Of The University Of California Screening assay to identify modulators of protein kinase A
MX2010000465A (es) * 2007-07-12 2010-08-30 Tragara Pharmaceuticals Inc Metodos y composiciones para el tratamiento de cancer, tumores y alteraciones relacionadas con tumores.
CN102351880B (zh) * 2007-09-11 2014-11-12 杏林制药株式会社 作为gsk-3 抑制剂的氰基氨基喹诺酮和四唑并氨基喹诺酮
US8476261B2 (en) 2007-09-12 2013-07-02 Kyorin Pharmaceutical Co., Ltd. Spirocyclic aminoquinolones as GSK-3 inhibitors
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8007904B2 (en) * 2008-01-11 2011-08-30 Fiber Innovation Technology, Inc. Metal-coated fiber
EP3147281A1 (fr) 2008-03-17 2017-03-29 Ambit Biosciences Corporation Dérivés de quinazoline utilisés comme modulateurs de la kinase raf et leurs procédés d'utilisation
US20090298882A1 (en) * 2008-05-13 2009-12-03 Muller George W Thioxoisoindoline compounds and compositions comprising and methods of using the same
CN102083466A (zh) * 2008-05-20 2011-06-01 科莱尼斯医疗公司 用于组合疗法的烟酸和nsaid
TW201004632A (en) 2008-07-02 2010-02-01 Idenix Pharmaceuticals Inc Compounds and pharmaceutical compositions for the treatment of viral infections
EP2376524B1 (fr) 2008-12-31 2017-03-15 Cypralis Limited Dérivés de cyclosporine a
WO2010088450A2 (fr) 2009-01-30 2010-08-05 Celladon Corporation Procédés de traitement de maladies associées à la modulation de serca
US8568793B2 (en) 2009-02-11 2013-10-29 Hope Medical Enterprises, Inc. Sodium nitrite-containing pharmaceutical compositions
MY159327A (en) 2009-02-27 2016-12-25 Ambit Biosciences Corp Jak kinase modulating quinazoline derivatives and methods of use thereof
JP5690286B2 (ja) 2009-03-04 2015-03-25 イデニク プハルマセウティカルス，インコーポレイテッド ホスホチオフェン及びホスホチアゾールｈｃｖポリメラーゼ阻害剤
MX2011009414A (es) * 2009-03-11 2011-10-19 Kyorin Seiyaku Kk 7-cicloalquiloaminoquinolonas como inhibidores de gsk-3.
MX2011009413A (es) 2009-03-11 2011-10-21 Ambit Biosciences Corp Combinacion de una indazolilaminopirrolotriazina y taxano para tratamiento contra cancer.
TW201038567A (en) 2009-03-27 2010-11-01 Pathway Therapeutics Ltd Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
WO2010110686A1 (fr) 2009-03-27 2010-09-30 Pathway Therapeutics Limited Pyrimidinyl et 1,3,5-triazinyl benzimidazoles et leur utilisation en thérapie anticancéreuse
ES2556235T3 (es) 2009-04-22 2016-01-14 Axikin Pharmaceuticals, Inc. Arilsulfonamidas 2,5-disustituidas antagonistas de CCR3
MX2011011080A (es) 2009-04-22 2012-02-23 Axikin Pharmaceuticals Inc Antagonistas de ccr3 de arilsulfonamida 2, 5-disustituida.
RU2539591C2 (ru) 2009-04-22 2015-01-20 Аксикин Фармасьютикалз, Инк. Антагонисты арилсульфонамида ccr3
WO2011003870A2 (fr) 2009-07-06 2011-01-13 Creabilis S.A. Corticostéroïdes mini-pegylés, compositions les comprenant et procédés pour les préparer et les utiliser
CA2767008C (fr) 2009-07-07 2018-01-30 Pathway Therapeutics, Inc. Pyrimidinyl et 1,3,5-triazinyl benzimidazoles et leur utilisation dans le traitement du cancer
AU2010270605B2 (en) 2009-07-08 2014-07-31 Hope Medical Enterprises, Inc. Dba Hope Pharmaceuticals Sodium thiosulfate-containing pharmaceutical compositions
EP2467144A1 (fr) 2009-07-24 2012-06-27 ViroLogik GmbH Association d'inhibiteurs du protéasome et de médicaments anti-hépatite dans le traitement de l'hépatite
TW201117812A (en) 2009-08-05 2011-06-01 Idenix Pharmaceuticals Inc Macrocyclic serine protease inhibitors
MX2012001974A (es) 2009-08-19 2012-04-11 Ambit Biosciences Corp Compuestos de biarilo y metodos de uso de los mismos.
TW201120037A (en) * 2009-10-26 2011-06-16 Sunesis Pharmaceuticals Inc Compounds and methods for treatment of cancer
WO2011056764A1 (fr) 2009-11-05 2011-05-12 Ambit Biosciences Corp. Imidazo[2,1-b][1,3]benzothiazoles enrichis en isotopes ou fluores
WO2011064769A1 (fr) 2009-11-24 2011-06-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédés et compositions pharmaceutiques pour le traitement des bouffées de chaleur
US20110301235A1 (en) 2009-12-02 2011-12-08 Alquest Therapeutics, Inc. Organoselenium compounds and uses thereof
MX2012006877A (es) 2009-12-18 2012-08-31 Idenix Pharmaceuticals Inc Inhibidores de virus de hepatitis c de arileno o heteroarileno 5, 5 - fusionado.
IN2012DN04858A (fr) * 2009-12-23 2015-09-25 Map Pharmaceuticals Inc
KR101224004B1 (ko) * 2009-12-29 2013-01-22 주식회사 삼양바이오팜 단백질, 폴리펩타이드 또는 펩타이드 약물 전달용 고분자 및 그 제조방법, 및 단백질, 폴리펩타이드 또는 펩타이드 약물의 서방형 조성물 및 그 제조 방법
WO2011082289A1 (fr) 2009-12-30 2011-07-07 Scynexis Inc. Analogues de cyclosporine
WO2011089167A1 (fr) 2010-01-19 2011-07-28 Virologik Gmbh Inhibiteur du protéasome destiné à traiter le vih
WO2011094890A1 (fr) 2010-02-02 2011-08-11 Argusina Inc. Dérivés phénylalanines et leur utilisation comme modulateurs non peptidiques du récepteur de glp-1
EA027622B1 (ru) 2010-02-05 2017-08-31 ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НоваМедика" Твердофазные формы макроциклических ингибиторов киназы
PL3202460T3 (pl) 2010-02-11 2019-12-31 Celgene Corporation Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania
EP2542542B1 (fr) 2010-03-02 2015-04-22 Axikin Pharmaceuticals, Inc. Antagonistes de ccr3 à base d'arylsulfonamide enrichi en isotope
WO2011112689A2 (fr) 2010-03-11 2011-09-15 Ambit Biosciences Corp. Sels d'indazolylpyrrolotriazine
TW201134820A (en) 2010-03-17 2011-10-16 Axikin Pharmaceuticals Inc Arylsulfonamide CCR3 antagonists
WO2011150201A2 (fr) 2010-05-27 2011-12-01 Ambit Biosciences Corporation Composés azolylamide et leurs procédés d'utilisation
US9296722B2 (en) 2010-05-27 2016-03-29 Ambit Biosciences Corporation Azolyl urea compounds and methods of use thereof
AU2011261501B2 (en) 2010-06-01 2016-01-21 Biotheryx, Inc. Methods of treating hematologic malignancies using 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone
EP2576513A1 (fr) 2010-06-01 2013-04-10 Biotheryx Inc. Dérivés d'hydroxypyridone, compositions pharmaceutiques réalisées à partir de ces dérivés, et utilisations thérapeutiques correspondants pour traiter des maladies prolifératives
JP5855095B2 (ja) 2010-06-07 2016-02-09 ノボメディックス, エルエルシーNovomedix, Llc フラニル化合物およびその使用
WO2012012370A1 (fr) 2010-07-19 2012-01-26 Summa Health System Vitamine c et vitamine k sans chrome, et leurs compositions dans le traitement d'une pathologie ou d'une maladie dans laquelle intervient le facteur nf‑kb
EP2611448A1 (fr) 2010-09-01 2013-07-10 Ambit Biosciences Corporation Dérivés de 7-cyclylquinazoline et leurs méthodes d'utilisation
AU2011296078B2 (en) 2010-09-01 2015-06-18 Ambit Biosciences Corporation An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof
US20130225614A1 (en) 2010-09-01 2013-08-29 Ambit Biosciences Corporation 4-azolylaminoquinazoline derivatives and methods of use thereof
AU2011296046B2 (en) 2010-09-01 2015-05-14 Ambit Biosciences Corporation Hydrobromide salts of a pyrazolylaminoquinazoline
EP2611793A1 (fr) 2010-09-01 2013-07-10 Ambit Biosciences Corporation Dérivés de 2-cycloquinazoline et leurs méthodes d'utilisation
WO2012030948A1 (fr) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Composés de quinazoline et leurs méthodes d'utilisation
EP2611812A1 (fr) 2010-09-01 2013-07-10 Ambit Biosciences Corporation Composés thiénopyridines et thiénopyrimidines et leurs procédés d'utilisation
EP2663553B1 (fr) 2010-09-01 2015-08-26 Ambit Biosciences Corporation Composés quinoléine et isoquinoléine en tant que modulateurs de jak
WO2012030918A1 (fr) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Composés de modulation du récepteur a3 de l'adénosine et leurs méthodes d'utilisation
WO2012030924A1 (fr) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Composés d'azolopyridine et d'azolopyrimidine et méthodes d'utilisation associées
WO2012044641A1 (fr) 2010-09-29 2012-04-05 Pathway Therapeutics Inc. 1,3,5-triazinylbenzimidazolsulfonamides et leur utilisation en thérapie anticancéreuse
US20120088769A1 (en) 2010-10-11 2012-04-12 Axikin Pharmaceuticals, Inc. Salts of arylsulfonamide ccr3 antagonists
JP2013545749A (ja) 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
AU2011338530B2 (en) 2010-12-06 2017-06-15 Follica, Inc. Methods for treating baldness and promoting hair growth
WO2012080050A1 (fr) 2010-12-14 2012-06-21 F. Hoffmann-La Roche Ag Formes solides d'un composé de phénoxybenzènesulfonyle
ES2637113T3 (es) 2011-01-10 2017-10-10 Infinity Pharmaceuticals, Inc. Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas
JP2014503597A (ja) 2011-01-31 2014-02-13 セルジーン コーポレイション シチジンアナログの医薬組成物及びその使用方法
US9353100B2 (en) 2011-02-10 2016-05-31 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections
PH12013501837A1 (en) 2011-03-11 2013-11-18 Celgene Corp Use of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2,6-dione in treatment of immune-related and inflammatory diseases
WO2012135166A1 (fr) 2011-03-28 2012-10-04 Pathway Therapeutics Inc. (arylamino et hétérocyclylamino à cycle condensé)pyrimidinyl- et 1,3,5-triazinylbenzimidazoles, compositions pharmaceutiques de ceux-ci et leur utilisation dans le traitement de maladies prolifératives
TWI572599B (zh) 2011-03-28 2017-03-01 Ｍｅｉ製藥公司 （α－經取代之芳烷胺基及雜芳烷胺基）嘧啶基及１，３，５－三基苯并咪唑，其醫藥組合物及其在治療增生性疾病之用途
AU2012236722A1 (en) 2011-03-28 2013-10-17 Mei Pharma, Inc. (alpha-substituted cycloalkylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
US20120252721A1 (en) 2011-03-31 2012-10-04 Idenix Pharmaceuticals, Inc. Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
KR20140042868A (ko) 2011-06-23 2014-04-07 맵 파마슈티컬스, 인코포레이티드 신규한 플루오로에르골린 유사체
AR088218A1 (es) 2011-07-19 2014-05-21 Infinity Pharmaceuticals Inc Compuestos heterociclicos utiles como inhibidores de pi3k
HK1198443A1 (en) 2011-07-19 2015-04-24 无限药品股份有限公司 Heterocyclic compounds and uses thereof
MX2014002542A (es) 2011-08-29 2014-07-09 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
AR088441A1 (es) 2011-09-12 2014-06-11 Idenix Pharmaceuticals Inc Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales
CA2847892A1 (fr) 2011-09-12 2013-03-21 Idenix Pharmaceuticals, Inc. Composes et compositions pharmaceutiques pour le traitement d'infections virales
WO2013049332A1 (fr) 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibiteurs de monoacylglycérol lipase et procédés de leur utilisation
US8507460B2 (en) 2011-10-14 2013-08-13 Idenix Pharmaceuticals, Inc. Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
AU2012322095B2 (en) 2011-10-14 2017-06-29 Ambit Biosciences Corporation Heterocyclic compounds and use thereof as modulators of type III receptor tyrosine kinases
SG10201509139QA (en) 2011-12-19 2015-12-30 Map Pharmaceuticals Inc Novel iso-ergoline derivatives
CA2859175A1 (fr) 2011-12-21 2013-06-27 Map Pharmaceuticals, Inc. Nouveaux composes neuromodulateurs
WO2013130600A1 (fr) 2012-02-29 2013-09-06 Ambit Biosciences Corporation Formes solides comprenant de la pyrazolylaminoquinazoline optiquement active, compositions à base de celles-ci et leurs utilisations
WO2013138617A1 (fr) 2012-03-16 2013-09-19 Axikin Pharmaceuticals, Inc. Inhibiteurs de 3,5-diaminopyrazole kinase
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
JP6165848B2 (ja) 2012-05-22 2017-07-19 イデニク ファーマシューティカルズ エルエルシー 肝疾患のためのｄ−アミノ酸化合物
WO2013177188A1 (fr) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. Promédicaments de 3',5'-phosphoramidate cyclique pour traiter une infection par le virus de l'hépatite c
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives
LT2882441T (lt) 2012-08-09 2020-07-27 Celgene Corporation Su imunitetu susijusių ir uždegiminių ligų gydymas
ES2885769T3 (es) 2012-08-09 2021-12-15 Celgene Corp Una forma sólida de clorhidrato de (s)-3-(4-((4-morpholinometil)bencil)oxi)-1-oxoisoindolin-2-il)piperidina-2,6-diona
EP2890370B1 (fr) 2012-08-31 2019-10-09 The Regents of the University of California Agents utiles pour le traitement de l'obésité, du diabète et de troubles associés
WO2014039748A1 (fr) 2012-09-07 2014-03-13 Axikin Pharmaceuticals, Inc. Antagonistes de ccr3 de type arylsulfonamides enrichis en isotopes
WO2014055647A1 (fr) 2012-10-03 2014-04-10 Mei Pharma, Inc. (sulfinyl et sulfonyl benzimidazolyl) pyrimidines et triazines, compositions pharmaceutiques les contenant, et leur utilisation pour traiter les maladies prolifératives
EP2906579B1 (fr) 2012-10-08 2018-04-18 Idenix Pharmaceuticals LLC. Analogues de nucléosides 2'-chloro pour traiter une infection par le virus de l'hépatite c
EP2909223B1 (fr) 2012-10-19 2017-03-22 Idenix Pharmaceuticals LLC Composés dinucléotides contre une infection par le vhc
US10723754B2 (en) 2012-10-22 2020-07-28 Idenix Pharmaceuticals Llc 2′,4′-bridged nucleosides for HCV infection
AU2013337717B2 (en) 2012-11-01 2018-10-25 Infinity Pharmaceuticals, Inc. Treatment of cancers using PI3 kinase isoform modulators
WO2014074765A2 (fr) 2012-11-08 2014-05-15 Summa Health System Vitamine c, vitamine k, un polyphénol et leurs combinaisons pour la cicatrisation des plaies
EP2938624A1 (fr) 2012-11-14 2015-11-04 IDENIX Pharmaceuticals, Inc. Ester de d-alanine d'analogue de sp-nucléoside
US20140140951A1 (en) 2012-11-14 2014-05-22 Idenix Pharmaceuticals, Inc. D-Alanine Ester of Rp-Nucleoside Analog
WO2014085633A1 (fr) 2012-11-30 2014-06-05 Novomedix, Llc Sulfonamides biaryliques substitués et leur utilisation
EP2935304A1 (fr) 2012-12-19 2015-10-28 IDENIX Pharmaceuticals, Inc. 4'-fluoro-nucléosides pour le traitement du vhc
CA2895829A1 (fr) 2012-12-21 2014-06-26 Map Pharmaceuticals, Inc. Nouveaux derives de methysergide
AU2014205324A1 (en) 2013-01-11 2015-07-30 Mayo Foundation For Medical Education And Research Vitamins C and K for treating polycystic diseases
WO2014137930A1 (fr) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. Nucléosides de thiophosphate pour le traitement du vhc
WO2014137926A1 (fr) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. 3'-désoxynucléosides utilisables en vue du traitement d'une infection par le vhc
WO2014151386A1 (fr) 2013-03-15 2014-09-25 Infinity Pharmaceuticals, Inc. Sels et formes solides d'isoquinolinones et compositions les comprenant et procédés pour les utiliser
EP2981542B1 (fr) 2013-04-01 2021-09-15 Idenix Pharmaceuticals LLC 2',4'-fluoronucléosides pour le traitement du vhc
CA2914284A1 (fr) 2013-05-30 2014-12-04 Infinity Pharmaceuticals, Inc. Traitement anticancer au moyen de modulateurs isoformes de la kinase p13
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
WO2015017713A1 (fr) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. Pronucléotides phosphoramidates avec acides aminés d de composés halogéno pyrimidines pour le traitement des hépatopathies
KR20160055170A (ko) 2013-08-30 2016-05-17 암비트 바이오사이언시즈 코포레이션 바이아릴 아세트아미드 화합물 및 이의 사용 방법
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
WO2015042375A1 (fr) 2013-09-20 2015-03-26 Idenix Pharmaceuticals, Inc. Inhibiteurs du virus de l'hépatite c
US9700549B2 (en) 2013-10-03 2017-07-11 David Wise Compositions and methods for treating pelvic pain and other conditions
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
PT3052485T (pt) 2013-10-04 2021-10-22 Infinity Pharmaceuticals Inc Compostos heterocíclicos e suas utilizações
US20160244452A1 (en) 2013-10-21 2016-08-25 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015061683A1 (fr) 2013-10-25 2015-04-30 Idenix Pharmaceuticals, Inc. Pronucléotides thiophosphoramidates à acide aminé d et pronucléotides thiophosphoramidates à d-analine de composés de nucléoside utiles pour le traitement du vhc
US20160271162A1 (en) 2013-11-01 2016-09-22 Idenix Pharmacueticals, Llc D-alanine phosphoramide pronucleotides of 2'-methyl 2'-fluro guanosine nucleoside compounds for the treatment of hcv
EP3074399A1 (fr) 2013-11-27 2016-10-05 Idenix Pharmaceuticals LLC Analogues de nucléoside 2'-dichloro et 2'-fluoro-2'-chloro analogues pour l'infection par le vhc
CN105934438A (zh) 2013-11-27 2016-09-07 艾登尼克斯药业有限公司 用于治疗肝癌的核苷酸
US10683321B2 (en) 2013-12-18 2020-06-16 Idenix Pharmaceuticals Llc 4′-or nucleosides for the treatment of HCV
US20170066779A1 (en) 2014-03-05 2017-03-09 Idenix Pharmaceuticals Llc Solid forms of a flaviviridae virus inhibitor compound and salts thereof
MX382033B (es) 2014-03-19 2025-03-13 Infinity Pharmaceuticals Inc Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma.
JP6568926B2 (ja) 2014-03-20 2019-08-28 カペラ セラピューティクス，インコーポレーテッド 癌の治療のためのｅｒｂｂチロシンキナーゼ阻害剤としてのベンゾイミダゾール誘導体
CA2943220C (fr) 2014-03-20 2024-01-16 Capella Therapeutics, Inc. Derives de benzimidazole comme inhibiteurs de tyrosine kinase de famille erbb pour le traitement du cancer
WO2015157559A2 (fr) 2014-04-09 2015-10-15 Siteone Therapeutics, Inc. Saxitoxines 10',11'-modifiées pour le traitement de la douleur
US10202411B2 (en) 2014-04-16 2019-02-12 Idenix Pharmaceuticals Llc 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV
WO2015168079A1 (fr) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Dérivés de pyrimidine ou de pyridine utiles en tant qu'inhibiteurs de pi3k
JP2017515854A (ja) 2014-05-12 2017-06-15 クオナトウス ファーマシューティカルズ，インコーポレイテッド カスパーゼ阻害剤による慢性肝疾患の合併症の治療
KR20170005492A (ko) 2014-05-28 2017-01-13 아이데닉스 파마슈티칼스 엘엘씨 암의 치료를 위한 뉴클레오시드 유도체
WO2015195474A1 (fr) 2014-06-18 2015-12-23 Biotheryx, Inc. Dérivés d'hydroxypyridone, compositions pharmaceutiques contenant lesdits dérivés, et leur utilisation thérapeutique pour traiter des maladies inflammatoires, neurodégénératives ou d'origine immunologique
EP3778584A1 (fr) 2014-06-19 2021-02-17 ARIAD Pharmaceuticals, Inc. Procédé de préparation de dérivés de 2-chloro-4-hétéroaryl-pyridimidines
US9499514B2 (en) 2014-07-11 2016-11-22 Celgene Corporation Antiproliferative compounds and methods of use thereof
EP3777863A1 (fr) 2014-09-12 2021-02-17 Tobira Therapeutics, Inc. Polythérapie faisant appel au cénicriviroc pour le traitement de la fibrose
WO2016054491A1 (fr) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
UA119794C2 (uk) 2014-10-21 2019-08-12 Аріад Фармасьютикалз, Інк. Кристалічна форма 5-хлор-n4-[2-(диметилфосфорил)феніл]-n2-{2-метокси-4-[4-(4-метилпіперазин-1-іл)піперидин-1-іл]}піримідин-2,4-діаміну
EP3209658A1 (fr) 2014-10-24 2017-08-30 Biogen MA Inc. Dérivés de diterpénoïdes et leurs procédés d'utilisation
TWI703133B (zh) 2014-12-23 2020-09-01 美商艾克斯基製藥公司 ３,５-二胺基吡唑激酶抑制劑
EP3247357A4 (fr) 2015-01-20 2018-07-11 Xoc Pharmaceuticals, Inc Composés d'isoergoline et leurs utilisations
MX2017009405A (es) 2015-01-20 2018-01-18 Xoc Pharmaceuticals Inc Compuestos de tipo ergolina y usos de estos.
US10815264B2 (en) 2015-05-27 2020-10-27 Southern Research Institute Nucleotides for the treatment of cancer
KR20240125709A (ko) 2015-06-23 2024-08-19 뉴로크린 바이오사이언시즈 인코퍼레이티드 신경계 질환 또는 장애를 치료하기 위한 vmat2 억제제
US10835604B2 (en) 2015-08-13 2020-11-17 Northeastern University Biomaterials for combined radiotherapy and immunotherapy of cancer
SMT202100712T1 (it) 2015-08-17 2022-01-10 Kura Oncology Inc Metodi di trattamento di pazienti di cancro con inibitori di farnesil trasferasi
WO2017048702A1 (fr) 2015-09-14 2017-03-23 Infinity Pharmaceuticals, Inc. Formes solides de dérivés d'isoquinolinone, leur procédé de fabrication, compositions les comprenant et méthodes d'utilisation de celles-ci
ES2895155T3 (es) 2015-09-30 2022-02-17 Siteone Therapeutics Inc Saxitoxinas modificadas en 11,13 para el tratamiento del dolor
RS61645B1 (sr) 2015-10-30 2021-04-29 Neurocrine Biosciences Inc Valbenazin ditozilat i njihovi polimorfi
WO2017079566A1 (fr) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Inhibiteurs de caspase destinés à être utilisés dans le traitement du cancer
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
CN108883103A (zh) 2015-12-02 2018-11-23 阿斯特来亚治疗有限责任公司 哌啶基痛敏肽受体化合物
JP6869988B2 (ja) 2015-12-23 2021-05-12 ニューロクライン バイオサイエンシーズ，インコーポレイテッド （Ｓ）−（２Ｒ，３Ｒ，１１ｂＲ）−３−イソブチル−９，１０−ジメトキシ−２，３，４，６，７，１１ｂ−ヘキサヒドロ−１Ｈ−ピリド［２，１−ａ］イソキノリン−２−イル２−アミノ−３−メチルブタノエートジ（４−メチルベンゼンスルホネート）の調製のための合成方法
CA3010286A1 (fr) 2015-12-31 2017-07-06 Conatus Pharmaceuticals Inc. Methodes d'utilisation d'inhibiteurs de caspase dans le traitement d'une hepatopathie
KR20180095094A (ko) 2016-01-08 2018-08-24 셀진 코포레이션 암을 치료하기 위한 방법 및 치료요법에 대한 임상 감수성의 예측변수로서 바이오마커의 용도
SG11201805779TA (en) 2016-01-08 2018-08-30 Celgene Corp Antiproliferative compounds, and their pharmaceutical compositions and uses
WO2017120415A1 (fr) 2016-01-08 2017-07-13 Celgene Corporation Formes solides de 2-(4-chlorophényl)-n-((2-2,6-dioxopipéridine-3-yl)-1-oxoisoindoline-5-yl)méthyl) -2,2-difluoroacétamide, compositions pharmaceutiques et utilisations de celles-ci
WO2017161116A1 (fr) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues de composés isoquinolinone et quinazolinone et leurs utilisations comme inhibiteurs de la kinase pi3k
EP3442940A1 (fr) 2016-04-11 2019-02-20 Clexio Biosciences Ltd. Dérivés de kétamine deutérés
US10047077B2 (en) 2016-04-13 2018-08-14 Skyline Antiinfectives, Inc. Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams
US20190119758A1 (en) 2016-04-22 2019-04-25 Kura Oncology, Inc. Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
KR102498741B1 (ko) 2016-04-29 2023-02-10 에프지에이치 바이오테크 인코포레이티드 질환 치료용 이-치환된 피라졸 화합물
TWI753910B (zh) 2016-05-16 2022-02-01 美商拜歐斯瑞克斯公司 吡啶硫酮、其醫藥組合物及其治療增生性、炎性、神經退化性或免疫介導疾病之治療用途
WO2017214269A1 (fr) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
ES2932187T3 (es) 2016-09-07 2023-01-16 Fgh Biotech Inc Compuestos de pirazol disustituidos para el tratamiento de enfermedades
IL292938A (en) 2016-09-19 2022-07-01 Mei Pharma Inc Combined treatment
TW201818965A (zh) 2016-11-03 2018-06-01 美商庫拉腫瘤技術股份有限公司 以法呢基轉移酶（ｆａｒｎｅｓｙｌ ｔｒａｎｓｆｅｒａｓｅ）抑制劑治療癌症病患之方法
TW201828932A (zh) 2016-11-09 2018-08-16 美商諾沃麥迪斯有限責任公司 1,1-二甲基雙胍之亞硝酸鹽、醫藥組合物及使用方法
US10106521B2 (en) 2016-11-09 2018-10-23 Phloronol, Inc. Eckol derivatives, methods of synthesis and uses thereof
EP3548007A4 (fr) 2016-12-01 2020-08-12 Ignyta, Inc. Méthodes de traitement du cancer
WO2018102673A1 (fr) 2016-12-02 2018-06-07 Neurocrine Biosciences, Inc. Utilisation de valbénazine pour le traitement de la schizophrénie ou d'un trouble schizo-affectif
CA3051830A1 (fr) 2017-01-27 2018-08-02 Neurocrine Bioscienes, Inc. Methodes d'administration de certains inhibiteurs de vmat2
TWI738314B (zh) 2017-02-21 2021-09-01 美商庫拉腫瘤技術股份有限公司 以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症之方法
US10137121B2 (en) 2017-02-21 2018-11-27 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2018164996A1 (fr) 2017-03-06 2018-09-13 Neurocrine Biosciences, Inc. Posologie pour la valbénazine
US11555031B2 (en) 2017-03-20 2023-01-17 The Broad Institute, Inc. Compounds and methods for regulating insulin secretion
JP7777915B2 (ja) 2017-03-27 2025-12-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア がんを処置する組成物及び方法
US11279706B2 (en) 2017-03-29 2022-03-22 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain
CN110831945B (zh) 2017-03-29 2023-08-08 赛特温治疗公司 用于治疗疼痛的11,13-修饰的石房蛤毒素类化合物
WO2018200605A1 (fr) 2017-04-26 2018-11-01 Neurocrine Biosciences, Inc. Utilisation de valbénazine pour le traitement de la dyskinésie induite par la lévodopa
JOP20190219A1 (ar) 2017-05-09 2019-09-22 Cardix Therapeutics LLC تركيبات صيدلانية وطرق لعلاج أمراض القلب والأوعية الدموية
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
JP7237941B2 (ja) 2017-05-19 2023-03-13 エヌフレクション セラピューティクス インコーポレイテッド 皮膚障害の処置用の融合複素環式芳香族アニリン化合物
PT3624796T (pt) 2017-05-19 2025-06-02 Nflection Therapeutics Inc Compostos de pirrolopiridina-anilina para tratamento de distúrbios dérmicos
WO2018223065A1 (fr) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Dérivés d'ergoline destinés à être utilisés en médecine
MX2020001207A (es) 2017-08-07 2020-03-20 Kura Oncology Inc Metodos de tratamiento del cancer con inhibidores de farnesiltransferasa.
US10806730B2 (en) 2017-08-07 2020-10-20 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
CA3076000A1 (fr) 2017-09-21 2019-03-28 Neurocrine Biosciences, Inc. Formulation de valbenazine a dosage eleve et compositions, procedes et kits associes
CN111356461A (zh) 2017-10-04 2020-06-30 加利福尼亚大学董事会 免疫调节性低聚糖
KR20250070134A (ko) 2017-10-10 2025-05-20 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
JP2021502959A (ja) 2017-10-10 2021-02-04 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 特定のｖｍａｔ２インヒビターを投与するための方法
WO2019113269A1 (fr) 2017-12-08 2019-06-13 Kura Oncology, Inc. Méthodes de traitement de patients cancéreux avec des inhibiteurs de la farnésyltransférase
TW202406538A (zh) 2018-01-10 2024-02-16 美商克拉治療有限責任公司 包含苯基磺醯胺之醫藥組合物及其治療應用
WO2019139871A1 (fr) 2018-01-10 2019-07-18 Cura Therapeutics Llc Compositions pharmaceutiques comprenant des acides dicarboxyliques et leurs applications thérapeutiques
AU2019287524A1 (en) 2018-06-14 2020-12-24 Neurocrine Biosciences, Inc. VMAT2 inhibitor compounds, compositions, and methods relating thereto
EP3814327A1 (fr) 2018-06-29 2021-05-05 Histogen, Inc. Dérivés d'acide (s)-3-(2-(4-(benzyl)-3-oxopipérazin-1-yl)acétamido)-4-oxo-5-(2,3,5,6-tétrafluorophénoxy)pentanoïque et composés apparentés utilisés en tant qu'inhibiteurs de caspase pour le traitement de maladies cardiovasculaires
MA53239A (fr) 2018-08-15 2022-05-04 Neurocrine Biosciences Inc Procédés d'administration de certains inhibiteurs de vmat2
EP3860714B1 (fr) 2018-10-03 2023-09-06 Siteone Therapeutics, Inc. Saxitoxines 11,13-modifiées destinées au traitement de la douleur
EP3873469A2 (fr) 2018-11-01 2021-09-08 Kura Oncology, Inc. Méthodes de traitement du cancer avec des inhibiteurs de la farnésyltransférase
CA3120351A1 (fr) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Composes aryl-aniline et heteroaryl-aniline pour le traitement de cancers de la peau
WO2020106306A1 (fr) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Composés cyanoaryl-aniline pour le traitement d'affections de la peau
EP4233834A3 (fr) 2018-11-20 2023-10-25 NFlection Therapeutics, Inc. Composés d'aryl-aniline et d'hétéroaryl-aniline pour le traitement de marques de naissance
WO2020106308A1 (fr) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Composés naphthyridinone-aniline destinés au traitement d'affections de la peau
US12391705B2 (en) 2018-12-19 2025-08-19 Shy Therapeutics, Llc Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
TW202038953A (zh) 2018-12-21 2020-11-01 美商庫拉腫瘤技術股份有限公司 鱗狀細胞癌之治療
WO2020132700A1 (fr) 2018-12-21 2020-06-25 Fgh Biotech Inc. Procédés d'utilisation d'inhibiteurs de srebp en combinaison avec du niclosamide et des analogues de celui-ci
CN113874080B (zh) 2019-02-06 2024-09-27 戴斯阿尔法公司 Il-17a调节剂及其用途
WO2020180663A1 (fr) 2019-03-01 2020-09-10 Kura Oncology, Inc. Méthodes de traitement du cancer à l'aide d'inhibiteurs de farnésyltransférase
ES2988904T3 (es) 2019-03-07 2024-11-22 Nobo Medicine Inc Inhibidores de caspasa y métodos de utilización de los mismos
US20220143006A1 (en) 2019-03-15 2022-05-12 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
CA3134825A1 (fr) 2019-03-29 2020-10-08 Kura Oncology, Inc. Procedes de traitement de carcinomes squameux par des inhibiteurs de farnesyltransferase
US20220168296A1 (en) 2019-04-01 2022-06-02 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
US20220305001A1 (en) 2019-05-02 2022-09-29 Kura Oncology, Inc. Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors
AU2020311404A1 (en) 2019-07-11 2022-03-03 Cura Therapeutics, Llc Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases
US20220274921A1 (en) 2019-07-11 2022-09-01 Cura Therapeutics, Llc Phenyl compounds and pharmaceutical compositions thereof, and their therapeutic applications
US11098002B2 (en) 2019-07-26 2021-08-24 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and their use for the prevention or treatment of disease
US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
EP4031534A1 (fr) 2019-09-16 2022-07-27 Dice Alpha, Inc. Modulateurs d'il-17a et leurs utilisations
EP4034236A1 (fr) 2019-09-26 2022-08-03 Abionyx Pharma SA Composés utiles pour le traitement des maladies du foie
ES3053975T3 (en) 2019-10-01 2026-01-28 Molecular Skin Therapeutics Inc Benzoxazinone compounds as klk5/7 dual inhibitors
EP4157271A1 (fr) 2020-05-29 2023-04-05 Boulder Bioscience LLC Procédés pour une thrombectomie endovasculaire améliorée à l'aide de 3,3'-diindolylméthane
US20230227466A1 (en) 2020-06-18 2023-07-20 Shy Therapeutics, Llc Substituted thienopyrimidines that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
US12024521B2 (en) 2020-06-30 2024-07-02 Prosetta Biosciences, Inc. Isoquinoline derivatives, methods of synthesis and uses thereof
EP4196482B1 (fr) 2020-08-14 2025-10-01 SiteOne Therapeutics, Inc. Inhibiteurs de cétone non hydratés de nav1.7 pour le traitement de la douleur
US20240124483A1 (en) 2021-01-27 2024-04-18 Shy Therapeutics, Llc Methods for the Treatment of Fibrotic Disease
WO2022165000A1 (fr) 2021-01-27 2022-08-04 Shy Therapeutics, Llc Méthodes pour le traitement d'une maladie fibrotique
WO2022189856A1 (fr) 2021-03-08 2022-09-15 Abionyx Pharma Sa Composés utiles pour le traitement des maladies du foie
KR20230169979A (ko) 2021-03-10 2023-12-18 다이스 몰레큘스 에스브이, 인크. 알파 v 베타 6 및 알파 v 베타 1 인테그린 억제제 및 그의 용도
WO2022226166A1 (fr) 2021-04-22 2022-10-27 Protego Biopharma, Inc. Imidazolidinediones et imidazolidinones spirocycliques pour le traitement d'une amylose à chaîne légère
EP4347568A1 (fr) 2021-05-27 2024-04-10 Protego Biopharma, Inc. Hétéroaryl-diamides activateurs d'ire1/xbp1s
CA3236150A1 (fr) 2021-10-22 2023-04-27 Prosetta Biosciences, Inc. Nouveaux agents therapeutiques antiviraux pan-respiratoires a petites molecules ciblant l'hote
EP4441038A1 (fr) 2021-11-30 2024-10-09 Kura Oncology, Inc. Composés macrocycliques ayant une activité inhibitrice de la farnésyltransférase
WO2023129577A1 (fr) 2022-01-03 2023-07-06 Lilac Therapeutics, Inc. Promédicaments à base de thiol cyclique
US11981694B2 (en) 2022-01-03 2024-05-14 Lilac Therapeutics, Inc. Acyclic thiol prodrugs
CA3253352A1 (fr) 2022-03-02 2023-09-07 Mitopower, Inc. Nouveaux promédicaments dérivés de l'acide nicotinique et du ribose
KR20250006833A (ko) 2022-03-28 2025-01-13 아이소스테릭스, 인코포레이티드 라이신 아세틸 전이효소의 myst 계열의 억제제
AR128918A1 (es) 2022-03-30 2024-06-26 Biomarin Pharm Inc Oligonucleótidos que omiten el exón 51 de distrofina y sus aplicaciones
GB2619907A (en) 2022-04-01 2023-12-27 Kanna Health Ltd Novel crystalline salt forms of mesembrine
CA3255290A1 (fr) 2022-04-14 2023-10-19 Bristol-Myers Squibb Company Nouveaux composés gspt1 et procédés d'utilisation des nouveaux composés
KR20250006012A (ko) 2022-04-15 2025-01-10 셀진 코포레이션 약물에 대한 림프종의 반응성을 예측하는 방법 및 림프종을 치료하는 방법
JP2025516005A (ja) 2022-04-25 2025-05-23 サイトワン セラピューティクス インコーポレイテッド 疼痛の処置のためのｎａｖ１．８の二環式複素環アミド阻害剤
KR20250006069A (ko) 2022-05-05 2025-01-10 바이오마린 파머수티컬 인크. 뒤시엔느 근이영양증을 치료하는 방법
EP4584259A1 (fr) 2022-09-09 2025-07-16 Innovo Therapeutics, Inc. Composés de dégradation ck1? et double ck1?/gspt1
CA3268510A1 (fr) 2022-09-30 2024-04-04 Boulder Bioscience Llc Compositions comprenant du 3,3'-diindolylméthane pour traiter une blessure fermée à la tête non hémorragique
AU2023365200A1 (en) 2022-10-18 2025-05-15 Eluciderm Inc. 2-substituted 3,4 a, 5, 7, 8, 8 a-hexahydro-4h-thiop yrano [4,3- d]pyrimidin-4-ones for wound treatment
EP4608838A1 (fr) 2022-10-26 2025-09-03 Protego Biopharma, Inc. Composés de pyridone contenant un spirocycle
US20240174673A1 (en) 2022-10-26 2024-05-30 Protego Biopharma, Inc. Spirocycle Containing Pyridine Compounds
US20240174695A1 (en) 2022-10-26 2024-05-30 Protego Biopharma, Inc. Spirocycle Containing Bicyclic Heteroaryl Compounds
WO2024118801A1 (fr) 2022-11-30 2024-06-06 Protego Biopharma, Inc. Diamides hétéroaryles linéaires comme activateurs d'ire1/xbp1s
EP4626865A1 (fr) 2022-11-30 2025-10-08 Protego Biopharma, Inc. Activateurs de ire1/xbp1 diamide de pyrazole cyclique
CN120418231A (zh) 2022-12-30 2025-08-01 阿勒泰治疗公司 2-取代噻唑和苯并噻唑组合物和作为dux4抑制剂的方法
EP4702143A2 (fr) 2023-04-24 2026-03-04 BioMarin Pharmaceutical Inc. Compositions et méthodes de traitement de troubles liés à stxbp1
WO2024233303A1 (fr) 2023-05-05 2024-11-14 Biomarin Pharmaceutical Inc. Oligonucléotides de saut d'exon de dystrophine
WO2025063888A1 (fr) 2023-09-19 2025-03-27 Kancure Pte. Ltd. Composés ciblant la survivine
TW202530223A (zh) 2023-09-27 2025-08-01 美商艾索司特瑞克斯公司 Ｍｙｓｔ抑制劑
WO2025072489A2 (fr) 2023-09-27 2025-04-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Analogues de n-lactoyl-phénylalanine, procédés de synthèse et procédés d'utilisation
WO2025085416A1 (fr) 2023-10-16 2025-04-24 Bristol-Myers Squibb Company Composés gspt1 et procédés d'utilisation des composés
WO2025085878A1 (fr) 2023-10-20 2025-04-24 Altay Therapeutics, Inc. Dérivés de n-phényl-3-(2,5-dioxopyrrolidin-1-yl)propanamide et composés analogues en tant qu'inhibiteurs de dux4 pour le traitement par ex. de troubles neuromusculaires
WO2025102082A1 (fr) 2023-11-10 2025-05-15 Altay Therapeutics, Inc. Compositions et procédés à base d'inhibiteurs de stat3 carbocycliques et hétérocycliques
GB2636969A (en) 2023-11-24 2025-07-09 Ontrack Therapeutics Ltd Novel crystalline salt forms
WO2025147691A1 (fr) 2024-01-04 2025-07-10 Innovo Therapeutics, Inc. Compositions et procédés de dégradation de protéine de translocation nucléaire de récepteur d'hydrocarbure aryle
WO2025160286A1 (fr) 2024-01-24 2025-07-31 Siteone Therapeutics, Inc. 2-aryl cycloalkyle et inhibiteurs d'hétérocycloalkyle de nav1.8 pour le traitement de la douleur
WO2025179161A1 (fr) 2024-02-21 2025-08-28 Innovo Therapeutics, Inc. Composés de dégradation de protéines
WO2025221809A1 (fr) 2024-04-16 2025-10-23 Eluciderm Inc. Inhibiteurs de 2-aryl-quinazolin-4(3h)-one pour le traitement de maladies
WO2025240895A1 (fr) 2024-05-17 2025-11-20 Siteone Therapeutics, Inc. Inhibiteurs cycloalkyle et hétérocycloalkyle substitués de nav1.8 pour le traitement de la douleur
WO2025255341A1 (fr) 2024-06-05 2025-12-11 Protego Biopharma, Inc. Activateurs de tétrahydrofuranyle ire1/xbp1s
WO2026013449A2 (fr) 2024-07-11 2026-01-15 Sea4Us - Biotecnologia E Recursos Marinhos, Sa Composés dérivés d'oxazolidone et leur utilisation dans le traitement de la douleur chronique et aiguë

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092918B1 (fr) * 1982-04-22 1988-10-19 Imperial Chemical Industries Plc Formulations à libération continue
DK168790D0 (fr) * 1990-07-13 1990-07-13 Novo Nordisk As
AU1757092A (en) 1991-03-28 1992-11-02 Genentech Inc. Stable growth hormone metal ion formulations
WO1993013792A1 (fr) 1992-01-13 1993-07-22 Pitman-Moore, Inc. Dispositif de liberation retard de complexes constitues par un metal de transition et une proteine
DE69311538D1 (de) 1992-03-12 1997-07-17 Alkermes Inc Acth enthaltende mikrokugeln mit gesteuerter abgabe
US5656297A (en) 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
CA2150803C (fr) * 1992-12-02 2006-01-31 Henry Auer Hormone de croissance a liberation controlee qui contient des microspheres
AU685784B2 (en) 1993-02-23 1998-01-29 Genentech Inc. Excipient stabilization of polypeptides treated with organic solvents
NZ260909A (en) * 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
JP3414539B2 (ja) * 1994-05-11 2003-06-09 有限会社ドット 経鼻吸収用組成物
PT779806E (pt) * 1994-09-09 2001-02-28 Takeda Chemical Industries Ltd Preparacao de libertacao sustentada contendo um sal metalico de um peptido
PT831787E (pt) * 1995-06-07 2002-02-28 Alkermes Inc Composicao para libertacao sustentada da hormona de crescimento humano
AU6242096A (en) 1995-06-27 1997-01-30 Takeda Chemical Industries Ltd. Method of producing sustained-release preparation
ZA965368B (en) * 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
US5985312A (en) 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery

Also Published As

Publication number Publication date
ZA9711385B (en) 1999-06-18
ATE233088T1 (de) 2003-03-15
CA2275422A1 (fr) 1998-07-02
WO1998027980A2 (fr) 1998-07-02
DE69719367T2 (de) 2003-10-16
EP0946169A2 (fr) 1999-10-06
KR20000057693A (ko) 2000-09-25
US6399103B1 (en) 2002-06-04
WO1998027980A3 (fr) 1998-08-13
US6197350B1 (en) 2001-03-06
EP0946169B1 (fr) 2003-02-26
DE69719367D1 (de) 2003-04-03
AU7871298A (en) 1998-07-17

Similar Documents

Publication Publication Date Title
DK0946169T3 (da) Fremgangsmåde til fremstilling af et præparat med vedvarende frigivelse
DK0914095T3 (da) Fremgangsmåde til fremstilling af polymerbaseret præparat til kontrolleret frigivelse
DE60011243D1 (de) Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat
DE59803468D1 (de) Verfahren zur herstellung von lösungsmittelfreien nicht-kristallinen biologisch aktiven substanzen
MXPA03004680A (es) Materiales antimicrobianos estabilizados con respecto a la luz.
DK0436370T3 (da) Farmaceutisk præparat til kontrolleret afgivelse og fremgangsmåde til fremstilling deraf
ATE248150T1 (de) Lactam-enthaltende hydroxamsäure-derivate, deren herstellung und deren verwendung als inhibitoren von matrix-metalloproteasen
EA200100538A1 (ru) Новая гранула с контролируемым высвобождением, способ ее изготовления и включающая ее композиция из множества единиц
DE3769379D1 (de) Entzuendungshemmende wirkstoffe, pharmazeutische zusammensetzungen und verfahren zur bekaempfung von entzuendungen.
ATE152092T1 (de) Salpetersäureester mit pharmazeutischer wirkung und verfahren zu deren herstellung
DE69930642D1 (de) Mikropartikel mit adsorbenten oberflächen, verfahren zu ihrer herstellung und ihrer verwendung
DK1165791T3 (da) Humant cytokin som zalpha-receptor-ligand og anvendelse deraf
DE3762867D1 (de) Mesomorpher polymerwirkstoff, verwendungsfaehig zur nichtlinearoptik.
ATE272394T1 (de) Zubereitung mit verzögerter freisetzung
DK1310517T3 (da) Mælkesyrepolymer og fremgangsmåde til fremstilling af denne
ATE365340T1 (de) Zur bilderzeugung mit tiefer uv-strahlung geeignete photoresistzusammensetzung und diese verwendendes bilderzeugungsverfahren
DK0831787T3 (da) Sammensætning til vedvarende frigivelse af humant væksthormon
BR0207775A (pt) Lipossomos anfotéricos métodos para carregamento dos mesmos com ingredientes ativos e sua utilização
DE69019180D1 (de) Organopolysiloxan-Polyharnstoff Blockcopolymer und Methode zu seiner Herstellung.
ATE212230T1 (de) Methoden zur krankheitsbehandlung unter verwendung von sertoli-zellen und allotransplantat oder xenotransplantat
EP0983994A3 (fr) Composés diméthyl-(3-aryl-but-3-ènyl)-amine pharmaceutiquement actifs
DK1061948T3 (da) Præparat til vedvarende frigivelse af et fysiologisk aktivt polypeptid samt fremstilling deraf
HUT77631A (hu) Eljárás a levobupivakain és származékai rezolválására
AR005342A1 (es) Metodo para la manufactura de felodipina
ATE205498T1 (de) Verfahren zur herstellung von kaliumclavulanat