DK1310517T3 - Mælkesyrepolymer og fremgangsmåde til fremstilling af denne - Google Patents

Mælkesyrepolymer og fremgangsmåde til fremstilling af denne

Info

Publication number
DK1310517T3
DK1310517T3 DK01954447T DK01954447T DK1310517T3 DK 1310517 T3 DK1310517 T3 DK 1310517T3 DK 01954447 T DK01954447 T DK 01954447T DK 01954447 T DK01954447 T DK 01954447T DK 1310517 T3 DK1310517 T3 DK 1310517T3
Authority
DK
Denmark
Prior art keywords
weight
preparation
lactic acid
acid polymer
sustained
Prior art date
Application number
DK01954447T
Other languages
English (en)
Other versions
DK1310517T4 (da
Inventor
Yoshio Hata
Kohei Yamamoto
Tsutomu Tani
Takashi Aoki
Original Assignee
Wako Pure Chem Ind Ltd
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18729814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1310517(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wako Pure Chem Ind Ltd, Takeda Pharmaceutical filed Critical Wako Pure Chem Ind Ltd
Application granted granted Critical
Publication of DK1310517T3 publication Critical patent/DK1310517T3/da
Publication of DK1310517T4 publication Critical patent/DK1310517T4/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88Post-polymerisation treatment
    • C08G63/89Recovery of the polymer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/09Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08Lactones or lactides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88Post-polymerisation treatment
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91Polymers modified by chemical after-treatment
    • C08G63/912Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK01954447.7T 2000-08-07 2001-08-06 Mælkesyrepolymer og fremgangsmåde til fremstilling af denne DK1310517T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000238051 2000-08-07
PCT/JP2001/006721 WO2002012369A1 (en) 2000-08-07 2001-08-06 Lactic acid polymer and process for producing the same

Publications (2)

Publication Number Publication Date
DK1310517T3 true DK1310517T3 (da) 2006-07-24
DK1310517T4 DK1310517T4 (da) 2011-01-17

Family

ID=18729814

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01954447.7T DK1310517T4 (da) 2000-08-07 2001-08-06 Mælkesyrepolymer og fremgangsmåde til fremstilling af denne

Country Status (14)

Country Link
US (3) US7019106B2 (da)
EP (2) EP1310517B2 (da)
JP (2) JP5046447B2 (da)
KR (1) KR100772950B1 (da)
CN (1) CN1269870C (da)
AT (1) ATE322513T1 (da)
AU (1) AU2001276733A1 (da)
CA (1) CA2419065C (da)
CY (1) CY1117889T1 (da)
DE (1) DE60118575T3 (da)
DK (1) DK1310517T4 (da)
ES (2) ES2256276T5 (da)
PT (2) PT1310517E (da)
WO (1) WO2002012369A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1310517B2 (en) * 2000-08-07 2010-11-17 Wako Pure Chemical Industries, Ltd. Lactic acid polymer and process for producing the same
AR034641A1 (es) 2001-06-29 2004-03-03 Takeda Pharmaceutical Composicion de liberacion controlada y metodo para producirla
WO2004067756A1 (en) * 2003-01-29 2004-08-12 Biomatera Inc. Method for controlling molecular weight and distribution of biopolymers
JP4205497B2 (ja) * 2003-06-23 2009-01-07 帝人株式会社 リン脂質を含有するポリ乳酸樹脂組成物および成形体
WO2005023906A1 (ja) 2003-09-08 2005-03-17 Chugai Seiyaku Kabushiki Kaisha ヒアルロン酸修飾物、及びそれを用いた薬物担体
US20050238618A1 (en) * 2004-04-23 2005-10-27 Yujin Huang Low molecular weight polymers
JP2007537007A (ja) * 2004-05-12 2007-12-20 マサチューセッツ インスティテュート オブ テクノロジー 溶剤蒸気膜形成を含んだ立体印刷法等の製法
TW200613012A (en) * 2004-07-02 2006-05-01 Takeda Pharmaceuticals Co Sustained-release composition, process for producing the same and use of the same
ATE382337T1 (de) 2005-04-28 2008-01-15 Nipro Corp Bioabsorbierbare pharmazeutische zusammensetzung enthaltend einen plga-copolymer
MX2008009125A (es) 2006-01-18 2008-10-23 Qps Llc Composiciones farmaceuticas con estabilidad mejorada.
US8076448B2 (en) * 2006-10-11 2011-12-13 Tolmar Therapeutics, Inc. Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction
JP2010510975A (ja) * 2006-11-28 2010-04-08 ピュラック バイオケム ビー.ブイ. 安定なラクチド粒子
US20080146822A1 (en) 2006-11-28 2008-06-19 Purac Biochem B.V. Stable lactide particles
NL2000454C1 (nl) * 2006-11-28 2008-01-02 Purac Biochem Bv Stabiele lactidedeeltjes.
NO347209B1 (no) 2006-12-18 2023-07-03 Takeda Pharmaceutical Sammensetning med forlenget frigjøring og fremgangsmåte for å produsere det samme
HUE025842T2 (en) 2007-02-15 2016-04-28 Tolmar Therapeutics Inc Poly (lactide / glycolide) with reduced fracture properties and methods for producing polymers
JP5229917B2 (ja) * 2007-05-16 2013-07-03 独立行政法人産業技術総合研究所 乳酸オリゴマーおよびその製造方法
CN102112107A (zh) 2008-06-03 2011-06-29 托马医疗科技公司 具有改进的释放动力学特征的控制释放共聚物制剂
US9486531B2 (en) * 2008-06-03 2016-11-08 Indivior Uk Limited Dehydrated hydrogel inclusion complex of a bioactive agent with flowable drug delivery system
BR112012032544A2 (pt) * 2010-06-25 2016-10-11 Takeda Pharmaceutical formulação de liberação prolongada, uso de um composto, e, método para produzir a formulação de liberação prolongada.
US8834694B2 (en) * 2010-12-27 2014-09-16 Mo Bio Laboratories, Inc. Dry compositions and methods for gel electrophoresis
JP5959728B2 (ja) * 2013-04-11 2016-08-02 三井化学株式会社 乳酸―グリコール酸共重合体の製造法またはその塩の製造法
US9956164B2 (en) 2014-04-16 2018-05-01 Veyx-Pharma Gmbh Veterinary pharmaceutical composition and use thereof
EP4374861A3 (en) 2015-11-16 2024-08-07 MedinCell S.A. A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
KR102688314B1 (ko) * 2017-08-31 2024-07-26 에보닉 코포레이션 개선된 재흡수성 중합체 정제 방법
AU2021351927A1 (en) 2020-09-30 2023-05-11 Tolmar International Limited Biodegradable polymer delivery system for extended delivery of testosterone
EP4661840A2 (en) 2023-02-10 2025-12-17 Tolmar International Limited Degarelix polymeric formulations
AU2024291054A1 (en) 2023-07-05 2025-11-27 Tolmar International Limited Polymeric leuprolide acetate formulations

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3297033A (en) * 1963-10-31 1967-01-10 American Cyanamid Co Surgical sutures
US3565869A (en) * 1968-12-23 1971-02-23 American Cyanamid Co Extrudable and stretchable polyglycolic acid and process for preparing same
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3755558A (en) * 1971-02-23 1973-08-28 Du Pont Polylactide drug mixtures for topical application atelet aggregation
US3839297A (en) * 1971-11-22 1974-10-01 Ethicon Inc Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures
US3912692A (en) * 1973-05-03 1975-10-14 American Cyanamid Co Process for polymerizing a substantially pure glycolide composition
US3890283A (en) * 1973-06-04 1975-06-17 American Cyanamid Co Process for post-polymerizing polyglycolic acid
US4249531A (en) * 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
PH19942A (en) 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
FR2507115A1 (fr) * 1981-06-04 1982-12-10 Atelier Rectification Affutage Outil de percage comprenant au moins trois goujures
NL8200101A (nl) * 1982-01-13 1983-08-01 Philips Nv Scheerapparaat.
US4479911A (en) * 1982-01-28 1984-10-30 Sandoz, Inc. Process for preparation of microspheres and modification of release rate of core material
US4605730A (en) * 1982-10-01 1986-08-12 Ethicon, Inc. Surgical articles of copolymers of glycolide and ε-caprolactone and methods of producing the same
US4539981A (en) * 1982-11-08 1985-09-10 Johnson & Johnson Products, Inc. Absorbable bone fixation device
FR2537980B1 (fr) * 1982-12-17 1986-12-19 Sandoz Sa Derives d'acides hydroxycarboxyliques oligomeres, leur preparation et leur utilisation
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
CA1256638A (en) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production
JP2551756B2 (ja) 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
GB8609537D0 (en) * 1986-04-18 1986-05-21 Ici Plc Polyesters
JP3200706B2 (ja) * 1990-04-13 2001-08-20 武田薬品工業株式会社 生体内分解型高分子重合物
CA2040141C (en) * 1990-04-13 2002-05-14 Minoru Yamada Biodegradable high-molecular polymers, production and use therof
JP3065384B2 (ja) * 1991-06-05 2000-07-17 旭硝子株式会社 ラクチド系重合体の製造方法
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
JP3490171B2 (ja) 1994-02-21 2004-01-26 武田薬品工業株式会社 生体内分解性ポリマーの末端カルボキシル基におけるエステル
US5594091A (en) * 1994-02-21 1997-01-14 Takeda Chemical Industries, Ltd. Matrix for sustained-release preparation
US5763513A (en) * 1994-05-19 1998-06-09 Mitsui Toatsu Chemicals, Inc. L-lactic acid polymer composition, molded product and film
JP3520609B2 (ja) * 1995-06-26 2004-04-19 東洋紡績株式会社 脂肪族ポリエステルの製造方法
JP3086851B2 (ja) * 1997-02-12 2000-09-11 西川ゴム工業株式会社 ポリヒドロキシカルボン酸樹脂の製造方法
US6264970B1 (en) * 1996-06-26 2001-07-24 Takeda Chemical Industries, Ltd. Sustained-release preparation
DE69730093T2 (de) * 1996-10-31 2006-07-20 Takeda Pharmaceutical Co. Ltd. Zubereitung mit verzögerter Freisetzung
JPH1135670A (ja) * 1997-07-23 1999-02-09 Mitsui Chem Inc ポリヒドロキシカルボン酸の単離方法
JPH11269094A (ja) 1998-01-16 1999-10-05 Takeda Chem Ind Ltd 徐放性組成物、その製造法および用途
CA2316273A1 (en) 1998-01-16 1999-07-22 Takeda Chemical Industries, Ltd. Sustained-release composition, method of its production and use thereof
US6114495A (en) * 1998-04-01 2000-09-05 Cargill Incorporated Lactic acid residue containing polymer composition and product having improved stability, and method for preparation and use thereof
US6565874B1 (en) * 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
JP3716146B2 (ja) * 1998-12-15 2005-11-16 武田薬品工業株式会社 ポリマーの製造方法
US6756472B1 (en) * 1998-12-15 2004-06-29 Takeda Chemical Industries, Ltd. Process for producing polymer
JP2000238051A (ja) 1999-02-23 2000-09-05 Kansei Corp 表皮シートの発泡成形型へのセッティング方法
DE60034568T2 (de) 1999-07-15 2008-01-03 Takeda Pharmaceutical Co. Ltd. Zusammensetzungen mit verzögerter freigabe, verfahren zu deren herstellung und verwendung
EP1310517B2 (en) 2000-08-07 2010-11-17 Wako Pure Chemical Industries, Ltd. Lactic acid polymer and process for producing the same
US6362308B1 (en) * 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content

Also Published As

Publication number Publication date
WO2002012369A9 (en) 2003-04-24
ES2256276T3 (es) 2006-07-16
EP1693054B1 (en) 2016-05-25
PT1310517E (pt) 2006-05-31
KR20030046405A (ko) 2003-06-12
CN1269870C (zh) 2006-08-16
US20070259036A1 (en) 2007-11-08
US20060128938A1 (en) 2006-06-15
JP5622760B2 (ja) 2014-11-12
CN1461321A (zh) 2003-12-10
EP1310517A4 (en) 2005-01-05
HK1095526A1 (en) 2007-05-11
DE60118575T3 (de) 2011-05-19
WO2002012369A1 (en) 2002-02-14
PT1693054T (pt) 2016-07-07
KR100772950B1 (ko) 2007-11-02
EP1693054A2 (en) 2006-08-23
JP5046447B2 (ja) 2012-10-10
ES2256276T5 (es) 2011-02-22
US7019106B2 (en) 2006-03-28
AU2001276733A1 (en) 2002-02-18
ES2577389T3 (es) 2016-07-14
DE60118575D1 (de) 2006-05-18
US20030153724A1 (en) 2003-08-14
EP1310517B1 (en) 2006-04-05
JP2002121272A (ja) 2002-04-23
DK1310517T4 (da) 2011-01-17
CY1117889T1 (el) 2017-05-17
US8092830B2 (en) 2012-01-10
EP1310517B2 (en) 2010-11-17
EP1310517A1 (en) 2003-05-14
DE60118575T2 (de) 2006-08-24
CA2419065A1 (en) 2002-02-14
EP1693054A3 (en) 2007-07-11
CA2419065C (en) 2009-12-22
ATE322513T1 (de) 2006-04-15
JP2012107256A (ja) 2012-06-07

Similar Documents

Publication Publication Date Title
DK1310517T4 (da) Mælkesyrepolymer og fremgangsmåde til fremstilling af denne
ATE272394T1 (de) Zubereitung mit verzögerter freisetzung
DE69622510D1 (de) Nifedipinzubereitung mit langanhaltender Freisetzung
EA200000584A3 (ru) Твердые фармацевтические композиции с контролируемым высвобождением, получаемые тепловым формованием
MY139606A (en) Sustained-release composition and process for producing the same
DE69930240D1 (de) Matrizes gebildet aus polymer und hydrophoben verbindungen zur verwendung bei der freisetzung von arzneimitteln
BR9808933A (pt) Composição sob forma de microcápsulas ou de implantes, processo de preparação de uma substância hidrossolúvel, substância ativa, acetato de triptorelina, acetato de lanreotìdeo, ou acetato de octreotìdeo, e rna de filamento duplo
ATE324872T1 (de) Orale pharmazeutische zusammensetzung mit verzögerter wirkstofffreigabe von protonenpumpen- hemmern
DE69721489D1 (de) Herstellungsverfahren von löslichen verabreichungssystemen unter verwendung von flüchtigen salzen
NO20020084L (no) Vedvarende frigivelsessammensetninger, fremgangsmåter for fremstilling av disse, og anvendelse av disse
MY142066A (en) Controlled release composition comprising lactic acid polymer, and method of producing the same
TN2009000197A1 (en) Sustained - release composition and method for producing the same
NO970990D0 (no) Implanterbare formlegemer for administrering av virkestoffer til planter
SE9704401D0 (sv) Matrix pellets for greasy, oily or sticky drug substances
ATE442852T1 (de) Trimetazidine enthaltendes arzneimittel mit verzögerter wirkstoffabgabe und verfahren zur herstellung
DE50108114D1 (de) Mikropartikel mit verbessertem freisetzungsprofil und verfahren zu deren herstellung
CA2532714A1 (en) Oral sustained-release tablet comprising 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide
RU2002124643A (ru) Биологически активная добавка "витаминка цветочная"