DK0953576T3 - Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse - Google Patents

Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse

Info

Publication number
DK0953576T3
DK0953576T3 DK99108032T DK99108032T DK0953576T3 DK 0953576 T3 DK0953576 T3 DK 0953576T3 DK 99108032 T DK99108032 T DK 99108032T DK 99108032 T DK99108032 T DK 99108032T DK 0953576 T3 DK0953576 T3 DK 0953576T3
Authority
DK
Denmark
Prior art keywords
hedgehog protein
preparation
hydrophobic
protein conjugate
amino acids
Prior art date
Application number
DK99108032T
Other languages
Danish (da)
English (en)
Inventor
Angelika Esswein
Kurt Lang
Petra Rueger
Tilmann Seytter
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP98107911A external-priority patent/EP0953575A1/fr
Application filed by Curis Inc filed Critical Curis Inc
Application granted granted Critical
Publication of DK0953576T3 publication Critical patent/DK0953576T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK99108032T 1998-04-30 1999-04-23 Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse DK0953576T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98107911A EP0953575A1 (fr) 1998-04-30 1998-04-30 Conjugué de proteine hedgehog active, procédé pour sa production et utilisation
EP98116733 1998-09-03

Publications (1)

Publication Number Publication Date
DK0953576T3 true DK0953576T3 (da) 2006-03-20

Family

ID=26149214

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99108032T DK0953576T3 (da) 1998-04-30 1999-04-23 Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse

Country Status (18)

Country Link
US (4) US6468978B1 (fr)
EP (2) EP1557427A3 (fr)
JP (1) JP3433136B2 (fr)
KR (1) KR19990083621A (fr)
CN (1) CN1233616A (fr)
AT (1) ATE308563T1 (fr)
AU (1) AU719797B2 (fr)
CA (1) CA2269221A1 (fr)
CY (1) CY1105683T1 (fr)
DE (1) DE69928040T2 (fr)
DK (1) DK0953576T3 (fr)
ES (1) ES2252886T3 (fr)
HU (1) HUP9901411A2 (fr)
IL (1) IL129620A (fr)
MA (1) MA26625A1 (fr)
NO (1) NO992090L (fr)
NZ (1) NZ335385A (fr)
SG (1) SG80028A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999028454A1 (fr) * 1997-11-28 1999-06-10 Roche Diagnostics Gmbh Mutant actif de proteine du herisson, son procede de preparation et son utilisation a des fins pharmaceutiques
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
ES2252886T3 (es) * 1998-04-30 2006-05-16 Curis, Inc. Conjugado de proteinas de erizo activo, proceso para su produccion y uso.
ES2253851T3 (es) 1998-08-07 2006-06-01 Curis, Inc. Composicion farmaceutica estable de proteinas hedgehog y uso de la misma.
TW570805B (en) * 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
EP1135411B1 (fr) * 1998-12-03 2006-05-17 Curis, Inc. Procedes et compositions servant a traiter des troubles entrainant une excitotoxicite
EP1025861A1 (fr) * 1999-02-04 2000-08-09 Roche Diagnostics GmbH Compositions pharmaceutiques des Proteines Hedgehog rendues hydrophobes, et leur utilisation
AU782493B2 (en) * 1999-06-01 2005-08-04 Curis, Inc. Polymer conjugates of hedgehog proteins and uses
WO2001082994A1 (fr) * 2000-04-28 2001-11-08 Curis, Inc. Methodes et reactifs d'elaboration de cartilages in vitro
US7573637B2 (en) * 2004-08-03 2009-08-11 Seiko Epson Corporation Intrinsic polarizer and method of manufacturing an intrinsic polarizer
US8669418B2 (en) * 2005-12-22 2014-03-11 Vib Vzw Means and methods for mediating protein interference
US20100316566A1 (en) * 2008-02-27 2010-12-16 Radiomedix Inc. Radiolabeled hedgehog derivatives for imaging and therapy
WO2010065908A2 (fr) * 2008-12-05 2010-06-10 Catchmark Jeffrey M Compositions de biomolécule dégradables
US20110086236A1 (en) * 2009-10-13 2011-04-14 The Penn State Research Foundation Composites containing polypeptides attached to polysaccharides and molecules
SG195302A1 (en) * 2011-06-06 2013-12-30 Kineta One Llc Shk-based pharmaceutical compositions and methods of manufacturing and using the same
US10202517B2 (en) 2013-07-26 2019-02-12 The Penn State Research Foundation Polymer compositions and coatings
EP3384935A4 (fr) * 2015-12-02 2019-08-21 Hanmi Pharm. Co., Ltd. Complexe protéique faisant appel à un dérivé d'acide gras, et son procédé de préparation
CA3116768A1 (fr) * 2018-10-30 2020-05-07 Somalogic, Inc. Procedes d'evaluation de qualite d'echantillon

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
WO1992009697A1 (fr) * 1990-11-30 1992-06-11 Celtrix Laboratories, Inc. UTILISATION EN OSTEOPATHIE D'UNE PROTEINE MORPHOGENETIQUE D'ORIGINE OSSEUSE ASSOCIEE DE MANIERE SYNERGIQUE AVEC DU BETA DE FACTEUR DE CROISSANCE DE TRANSFORMATION (β-FCT).
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
EP0741783B1 (fr) * 1993-12-30 2009-03-18 President And Fellows Of Harvard College Proteines de type "hedgehog" induisant une structure embryonnaire chez les vertebres
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
GB9614871D0 (en) 1996-07-15 1996-09-04 Smithkline Beecham Plc Compounds
CA2267106A1 (fr) * 1996-10-07 1998-07-16 The Johns Hopkins University School Of Medicine Nouveaux polypeptides derives d'une proteine herisson
WO1999028454A1 (fr) * 1997-11-28 1999-06-10 Roche Diagnostics Gmbh Mutant actif de proteine du herisson, son procede de preparation et son utilisation a des fins pharmaceutiques
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
PT1036092E (pt) * 1997-12-03 2005-09-30 Biogen Inc Compos~icoes e metodos de proteinas hidrofobicamente modificadas
ES2252886T3 (es) * 1998-04-30 2006-05-16 Curis, Inc. Conjugado de proteinas de erizo activo, proceso para su produccion y uso.
ES2253851T3 (es) * 1998-08-07 2006-06-01 Curis, Inc. Composicion farmaceutica estable de proteinas hedgehog y uso de la misma.
WO2001082994A1 (fr) * 2000-04-28 2001-11-08 Curis, Inc. Methodes et reactifs d'elaboration de cartilages in vitro

Also Published As

Publication number Publication date
US6468978B1 (en) 2002-10-22
IL129620A0 (en) 2000-02-29
US20050148510A1 (en) 2005-07-07
SG80028A1 (en) 2001-04-17
DE69928040D1 (de) 2005-12-08
HUP9901411A2 (hu) 1999-12-28
AU2500999A (en) 1999-11-11
IL129620A (en) 2009-06-15
MA26625A1 (fr) 2004-12-20
EP0953576A1 (fr) 1999-11-03
ATE308563T1 (de) 2005-11-15
EP1557427A3 (fr) 2005-10-19
CN1233616A (zh) 1999-11-03
CA2269221A1 (fr) 1999-10-30
EP0953576B1 (fr) 2005-11-02
CY1105683T1 (el) 2010-12-22
US20030139574A1 (en) 2003-07-24
HU9901411D0 (en) 1999-07-28
US6818623B2 (en) 2004-11-16
NO992090D0 (no) 1999-04-29
US20070191274A1 (en) 2007-08-16
JP2000053699A (ja) 2000-02-22
JP3433136B2 (ja) 2003-08-04
EP1557427A2 (fr) 2005-07-27
DE69928040T2 (de) 2006-07-27
NO992090L (no) 1999-11-01
NZ335385A (en) 2000-09-29
US7153836B2 (en) 2006-12-26
ES2252886T3 (es) 2006-05-16
AU719797B2 (en) 2000-05-18
KR19990083621A (ko) 1999-11-25

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