ATE385496T1 - Dihydrobenzofurane und verwandte verbindungen als entzündungshemmende mittel - Google Patents

Dihydrobenzofurane und verwandte verbindungen als entzündungshemmende mittel

Info

Publication number: ATE385496T1
Authority: AT; Austria
Prior art keywords: unsubstituted; hydrogen; branched; alkanyl; atoms
Prior art date: 1994-07-27

Application number

AT95926314T

Other languages

English (en)

Inventor

Michael Scherz

Randall Matthews

Original Assignee

Univ Vanderbilt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-27

Filing date

1995-07-19

Publication date

2008-02-15

1995-06-07 Priority claimed from US08/481,727 external-priority patent/US5656661A/en

1995-07-19 Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt

2008-02-15 Application granted granted Critical

2008-02-15 Publication of ATE385496T1 publication Critical patent/ATE385496T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 4
229940121363 anti-inflammatory agent Drugs 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000004429 atom Chemical group 0.000 abstract 2
206010061218 Inflammation Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT95926314T 1994-07-27 1995-07-19 Dihydrobenzofurane und verwandte verbindungen als entzündungshemmende mittel ATE385496T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28089294A	1994-07-27	1994-07-27
US08/481,727 US5656661A (en)	1994-07-27	1995-06-07	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (1)

Publication Number	Publication Date
ATE385496T1 true ATE385496T1 (de)	2008-02-15

Family

ID=26960588

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95926314T ATE385496T1 (de)	1994-07-27	1995-07-19	Dihydrobenzofurane und verwandte verbindungen als entzündungshemmende mittel

Country Status (11)

Country	Link
EP (1)	EP0773939B1 (de)
JP (1)	JPH10506615A (de)
CN (1)	CN1191243C (de)
AT (1)	ATE385496T1 (de)
AU (1)	AU704085B2 (de)
BR (1)	BR9508436A (de)
CA (1)	CA2196054C (de)
ES (1)	ES2301161T3 (de)
IL (1)	IL114698A (de)
NZ (1)	NZ290080A (de)
WO (1)	WO1996003396A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5618835A (en) *	1996-02-01	1997-04-08	The Procter & Gamble Company	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5672620A (en) *	1996-02-01	1997-09-30	The Procter & Gamble Company	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) *	1996-02-01	1997-11-04	The Procter & Gamble Company	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5686471A (en) *	1996-02-01	1997-11-11	The Procter & Gamble Company	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5750543A (en) *	1996-02-01	1998-05-12	The Procter & Gamble Company	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5821250A (en) *	1996-02-01	1998-10-13	The Procter & Gamble Company	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
FR2744452B1 (fr) *	1996-02-06	1998-03-06	Cird Galderma	Composes biaryles heterocycliques, compositions pharmaceutiques et cosmetiques les contenant et utilisations
FR2754260B1 (fr) *	1996-10-04	1998-10-30	Adir	Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5985930A (en) *	1996-11-21	1999-11-16	Pasinetti; Giulio M.	Treatment of neurodegenerative conditions with nimesulide
EP2641903B1 (de)	2012-03-19	2014-10-22	Symrise AG	Dihydrobenzofuran-Derivate als Riech- und/oder Aromastoffe
KR101592560B1 (ko) *	2013-06-21	2016-02-05	제주대학교 산학협력단	신규 플라보노이드 및 그 용도

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3551456A (en) *	1968-04-18	1970-12-29	Universal Oil Prod Co	Acetyl derivatives of substituted chromans and coumarans
FR2370472A2 (fr) *	1976-11-10	1978-06-09	Continental Pharma	Amino-alcool heterocyclique, son sel et son procede de preparation
EP0026593A1 (de) *	1979-09-15	1981-04-08	Pfizer Limited	Bicyclische Keto- und Aminosäuren, Ester und Amide und deren pharmazeutische Zusammensetzungen
HUT36107A (en) *	1982-12-04	1985-08-28	Lilly Industries Ltd	Process for production of new aurone-derivatives and medical preparatives consisting of such compounds
DE3460315D1 (en) *	1983-02-19	1986-08-28	Beecham Group Plc	Benzofuran and benzothiophene-carboxylic-acid derivatives
FI842738L (fi) *	1983-07-14	1985-01-15	Syntex Inc	Aroylbenzofuran- och benzotiofenaettik- och propionsyror.
US4613611A (en) *	1983-10-14	1986-09-23	American Cyanamid Company	Method of treating diabetes mellitus using arylglyoxals
AU4261285A (en) *	1984-06-01	1985-12-05	Tokyo Tanabe Company Limited	1-propanone derivatives
FR2613364B1 (fr) *	1987-04-01	1989-06-09	Adir	Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2613365B1 (fr) *	1987-04-01	1989-07-28	Adir	Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US4849428A (en) *	1987-11-23	1989-07-18	The Procter & Gamble Company	Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
IL88674A0 (en) *	1987-12-18	1989-07-31	Norwich Eaton Pharma	Preparation of certain substituted aromatic compounds
GB8906166D0 (en) *	1989-03-17	1989-05-04	Pfizer Ltd	Therapeutic agents
JP2808460B2 (ja) *	1989-11-16	1998-10-08	大正製薬株式会社	イミダゾール誘導体
JPH03215485A (ja) *	1990-01-11	1991-09-20	Taisho Pharmaceut Co Ltd	ベンゾチエニルイミダゾール誘導体
TW197435B (de) *	1990-11-22	1993-01-01	Takeda Pharm Industry Co Ltd
JPH06263733A (ja) *	1993-01-14	1994-09-20	Sankyo Co Ltd	ベンゼン誘導体

1995
- 1995-07-19 CN CNB951948911A patent/CN1191243C/zh not_active Expired - Fee Related
- 1995-07-19 WO PCT/US1995/009109 patent/WO1996003396A1/en not_active Ceased
- 1995-07-19 BR BR9508436A patent/BR9508436A/pt not_active Application Discontinuation
- 1995-07-19 NZ NZ290080A patent/NZ290080A/en unknown
- 1995-07-19 CA CA002196054A patent/CA2196054C/en not_active Expired - Fee Related
- 1995-07-19 AT AT95926314T patent/ATE385496T1/de not_active IP Right Cessation
- 1995-07-19 JP JP8505840A patent/JPH10506615A/ja active Pending
- 1995-07-19 EP EP95926314A patent/EP0773939B1/de not_active Expired - Lifetime
- 1995-07-19 ES ES95926314T patent/ES2301161T3/es not_active Expired - Lifetime
- 1995-07-19 AU AU30711/95A patent/AU704085B2/en not_active Ceased
- 1995-07-24 IL IL11469895A patent/IL114698A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1191243C (zh)	2005-03-02
AU3071195A (en)	1996-02-22
CA2196054A1 (en)	1996-02-08
ES2301161T3 (es)	2008-06-16
BR9508436A (pt)	1998-07-14
IL114698A (en)	2001-03-19
JPH10506615A (ja)	1998-06-30
CN1156993A (zh)	1997-08-13
WO1996003396A1 (en)	1996-02-08
CA2196054C (en)	2001-04-17
EP0773939A1 (de)	1997-05-21
NZ290080A (en)	1999-04-29
EP0773939B1 (de)	2008-02-06
AU704085B2 (en)	1999-04-15
IL114698A0 (en)	1995-11-27

Legal Events

Date	Code	Title	Description
2008-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE274506T1 (de)	2004-09-15	Als entzündungshemmende mittel nützliche dihydrobenzofurane und verwandte verbindungen
ATE210125T1 (de)	2001-12-15	Dihydrobenzofuran und verwandte verbindungen als entzündungshemmende mittel
ATE385496T1 (de)	2008-02-15	Dihydrobenzofurane und verwandte verbindungen als entzündungshemmende mittel
DE69722202D1 (de)	2003-06-26	Dihydrobenzopyran und ähnliche verbindungen verwendbar als antientzündungsmittel
MX9806251A (es)	1998-11-30	Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.
MX9700726A (es)	1997-05-31	Dihidrobenzofurano y compuestos relacionados, utiles como agentes antiinflamatorios.
ATE266652T1 (de)	2004-05-15	Als entzündungshemmende mittel nützliche dihydrobenzofurane und verwandte verbindungen
ATE250594T1 (de)	2003-10-15	Als entzündungshemmende mittel nützliche dihydrobenzofurane und verwandte verbindungen
ATE236900T1 (de)	2003-04-15	Als entzündungshemmende mittel nützliche dihydrobenzofurane und verwandte verbindungen
MX9806247A (es)	1998-11-30	Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.