DK0971938T3 - Fremgangsmåde til produktion af 4-amino-1-hydroxybutyldien-1,1-biphosphonsyre eller salte deraf - Google Patents

Fremgangsmåde til produktion af 4-amino-1-hydroxybutyldien-1,1-biphosphonsyre eller salte deraf

Info

Publication number
DK0971938T3
DK0971938T3 DK98902890T DK98902890T DK0971938T3 DK 0971938 T3 DK0971938 T3 DK 0971938T3 DK 98902890 T DK98902890 T DK 98902890T DK 98902890 T DK98902890 T DK 98902890T DK 0971938 T3 DK0971938 T3 DK 0971938T3
Authority
DK
Denmark
Prior art keywords
salts
amino
hydroxybutyldien
producing
acid
Prior art date
Application number
DK98902890T
Other languages
English (en)
Inventor
Rudolf Kubela
Yong Tao
Original Assignee
Apotex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Inc filed Critical Apotex Inc
Application granted granted Critical
Publication of DK0971938T3 publication Critical patent/DK0971938T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK98902890T 1997-02-11 1998-02-06 Fremgangsmåde til produktion af 4-amino-1-hydroxybutyldien-1,1-biphosphonsyre eller salte deraf DK0971938T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002197267A CA2197267C (en) 1997-02-11 1997-02-11 Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PCT/CA1998/000091 WO1998034940A1 (en) 1997-02-11 1998-02-06 Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid

Publications (1)

Publication Number Publication Date
DK0971938T3 true DK0971938T3 (da) 2002-10-14

Family

ID=4159900

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98902890T DK0971938T3 (da) 1997-02-11 1998-02-06 Fremgangsmåde til produktion af 4-amino-1-hydroxybutyldien-1,1-biphosphonsyre eller salte deraf

Country Status (12)

Country Link
US (1) US5908959A (da)
EP (1) EP0971938B1 (da)
AT (1) ATE220404T1 (da)
AU (1) AU728164B2 (da)
BR (1) BR9807568A (da)
CA (1) CA2197267C (da)
DE (1) DE69806470T2 (da)
DK (1) DK0971938T3 (da)
ES (1) ES2180141T3 (da)
PL (1) PL335053A1 (da)
PT (1) PT971938E (da)
WO (1) WO1998034940A1 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU59401A (sh) * 1999-02-17 2004-05-12 Teva Pharmaceutical Industries Ltd. Postupak za proizvodnju alendronske kiseline
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6562974B2 (en) * 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
GB0115824D0 (en) * 2001-06-28 2001-08-22 Rhodia Cons Spec Ltd Improved solvent systems
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
EA006053B1 (ru) * 2001-12-24 2005-08-25 Тева Фармасьютикал Индастриес Лтд. Твёрдая лекарственная форма, способ её изготовления и устройство
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
ATE461205T1 (de) * 2002-05-17 2010-04-15 Teva Pharma Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20040213917A1 (en) * 2003-04-23 2004-10-28 Courtney Douglas L. Spray booth and filter system
ES2337063T3 (es) 2003-08-21 2010-04-20 Sun Pharmaceuticals Industries Ltd. Proceso para la preparacion de acido bisfosfonico.
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
WO2006134603A1 (en) * 2005-06-13 2006-12-21 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
AR058168A1 (es) * 2005-11-07 2008-01-23 Merck & Co Inc Sintesis del alendronato de sodio trihidratado
DE602006005597D1 (de) 2005-12-27 2009-04-23 Ipca Lab Ltd Verbesserter Herstellungsprozess von 4-Amino-Hydroxybutyliden-1,1-bisphosphonischer Säure und ihrer Salze
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
CN101443341A (zh) * 2006-03-21 2009-05-27 雅宝公司 制造二膦酸的方法
JP5354858B2 (ja) * 2006-05-09 2013-11-27 株式会社Ａｄｅｋａ スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
EP2016084A2 (en) 2006-05-11 2009-01-21 Ind-Swift Laboratories Limited Process for the preparation of pure risedronic acid or salts
EP2041148A1 (en) * 2006-07-03 2009-04-01 Generics Ýuk¨Limited Novel process for the preparation of bisphosphonic acids
CA2570949A1 (en) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
WO2008157050A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
CN102124016A (zh) 2008-07-11 2011-07-13 斯索恩有限公司 制备1-羟基亚烷基-1，1-双膦酸的方法
EP2192126B1 (en) 2008-11-26 2013-03-27 Synthon B.V. Process for making zoledronic acid
WO2010060619A1 (en) * 2008-11-26 2010-06-03 Synthon B.V. Process for making zoledronic acid
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
WO2011023280A1 (en) 2009-08-28 2011-03-03 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
CA2775004A1 (en) 2009-10-02 2011-04-07 Straitmark Holding Ag Method for the manufacture of aminohydroxy diphosphonic acids

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163733A (en) * 1977-10-25 1979-08-07 Buckman Laboratories, Inc. Synergistic compositions for corrosion and scale control
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids

Also Published As

Publication number Publication date
DE69806470T2 (de) 2003-02-20
CA2197267A1 (en) 1998-08-11
ATE220404T1 (de) 2002-07-15
AU5977298A (en) 1998-08-26
CA2197267C (en) 2000-02-08
ES2180141T3 (es) 2003-02-01
US5908959A (en) 1999-06-01
PL335053A1 (en) 2000-03-27
WO1998034940A1 (en) 1998-08-13
MX9801171A (es) 1998-12-31
DE69806470D1 (de) 2002-08-14
EP0971938A1 (en) 2000-01-19
BR9807568A (pt) 2000-03-21
PT971938E (pt) 2002-11-29
AU728164B2 (en) 2001-01-04
EP0971938B1 (en) 2002-07-10

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