DK0975359T3 - Anvendelse af forbindelser, der binder en cytoplasmisk dipeptidase til synergistisk virkning af immunreaktionen - Google Patents
Anvendelse af forbindelser, der binder en cytoplasmisk dipeptidase til synergistisk virkning af immunreaktionenInfo
- Publication number
- DK0975359T3 DK0975359T3 DK98920101T DK98920101T DK0975359T3 DK 0975359 T3 DK0975359 T3 DK 0975359T3 DK 98920101 T DK98920101 T DK 98920101T DK 98920101 T DK98920101 T DK 98920101T DK 0975359 T3 DK0975359 T3 DK 0975359T3
- Authority
- DK
- Denmark
- Prior art keywords
- immune response
- synergistic effect
- sup
- cells
- compounds binding
- Prior art date
Links
- 102000004860 Dipeptidases Human genes 0.000 title abstract 3
- 108090001081 Dipeptidases Proteins 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000001086 cytosolic effect Effects 0.000 title abstract 2
- 230000028993 immune response Effects 0.000 title 1
- 230000002195 synergetic effect Effects 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 2
- 230000035755 proliferation Effects 0.000 abstract 2
- 210000000805 cytoplasm Anatomy 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 150000002894 organic compounds Chemical class 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
- G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
- G01N2333/16—HIV-1, HIV-2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Exchange Systems With Centralized Control (AREA)
- Slide Fasteners, Snap Fasteners, And Hook Fasteners (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/852,395 US6040145A (en) | 1997-05-07 | 1997-05-07 | Potentiation of the immune response |
| PCT/US1998/008838 WO1998050066A1 (en) | 1997-05-07 | 1998-04-30 | Potentiation of the immune response through delivery of compounds binding a cytoplasmic dipeptidase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0975359T3 true DK0975359T3 (da) | 2003-11-24 |
Family
ID=25313198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98920101T DK0975359T3 (da) | 1997-05-07 | 1998-04-30 | Anvendelse af forbindelser, der binder en cytoplasmisk dipeptidase til synergistisk virkning af immunreaktionen |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6040145A (da) |
| EP (1) | EP0975359B1 (da) |
| JP (1) | JP2002511063A (da) |
| AT (1) | ATE250426T1 (da) |
| AU (1) | AU724257B2 (da) |
| CA (1) | CA2289125A1 (da) |
| DE (1) | DE69818445T2 (da) |
| DK (1) | DK0975359T3 (da) |
| ES (1) | ES2207831T3 (da) |
| PT (1) | PT975359E (da) |
| WO (1) | WO1998050066A1 (da) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6825169B1 (en) | 1991-10-22 | 2004-11-30 | Trustees Of Tufts College | Inhibitors of dipeptidyl-aminopeptidase type IV |
| US5965532A (en) | 1996-06-28 | 1999-10-12 | Trustees Of Tufts College | Multivalent compounds for crosslinking receptors and uses thereof |
| US6040145A (en) * | 1997-05-07 | 2000-03-21 | Tufts University | Potentiation of the immune response |
| JP2001518290A (ja) | 1997-09-29 | 2001-10-16 | ポイント セラピューティクス, インコーポレイテッド | インビトロでの造血細胞の刺激 |
| US6485955B1 (en) | 1997-10-06 | 2002-11-26 | The Trustees Of Tufts University | Quiescent cell dipeptidyl peptidase: a novel cytoplasmic serine protease |
| US6300314B1 (en) * | 1998-05-04 | 2001-10-09 | Point Therapeutics, Inc. | Hematopoietic stimulation |
| US6979697B1 (en) | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| AU2003205186A1 (en) * | 2002-01-16 | 2003-09-02 | Regents Of The University Of California | Functional ligand display |
| WO2004004661A2 (en) * | 2002-07-09 | 2004-01-15 | Point Therapeutics, Inc. | Boroproline compound combination therapy |
| US7317109B2 (en) * | 2003-11-12 | 2008-01-08 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US7767828B2 (en) * | 2003-11-12 | 2010-08-03 | Phenomix Corporation | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| AU2004288831B2 (en) * | 2003-11-12 | 2010-08-26 | Phenomix Corporation | Heterocyclic boronic acid compounds |
| US7576121B2 (en) * | 2003-11-12 | 2009-08-18 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US20060063719A1 (en) * | 2004-09-21 | 2006-03-23 | Point Therapeutics, Inc. | Methods for treating diabetes |
| DOP2006000008A (es) * | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| US7825139B2 (en) * | 2005-05-25 | 2010-11-02 | Forest Laboratories Holdings Limited (BM) | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| PE20071221A1 (es) * | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
| NZ571110A (en) * | 2006-04-11 | 2011-03-31 | Arena Pharm Inc | Methods of using GPR119 receptor to identify Glucose-dependent Insulinotropic Peptide (GIP) secretagogue compounds useful for increasing bone mass in an individual |
| EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
| AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
| JP2013523819A (ja) | 2010-04-06 | 2013-06-17 | アリーナ ファーマシューティカルズ, インコーポレイテッド | Gpr119レセプターのモジュレーターおよびそれに関連する障害の処置 |
| CN103221410B (zh) | 2010-09-22 | 2017-09-15 | 艾尼纳制药公司 | Gpr119受体调节剂和对与其相关的障碍的治疗 |
| US20140018371A1 (en) | 2011-04-01 | 2014-01-16 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012145361A1 (en) | 2011-04-19 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012145603A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012145604A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US9284337B2 (en) * | 2011-11-22 | 2016-03-15 | Trustees Of Tufts College | Small molecule enhancer for dendritic cell cancer vaccines |
| WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
| CN107683135A (zh) | 2015-03-09 | 2018-02-09 | 因特克林医疗有限公司 | 用于治疗非酒精性脂肪肝疾病和/或脂肪营养不良的方法 |
| AU2018249822A1 (en) | 2017-04-03 | 2019-10-31 | Coherus Biosciences Inc. | PPArgamma agonist for treatment of progressive supranuclear palsy |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4318904A (en) | 1980-04-25 | 1982-03-09 | Research Corporation | Peptide affinity labels for thrombin and other trypsin-like proteases |
| US4443609A (en) | 1980-05-19 | 1984-04-17 | Petrolite Corporation | Tetrahydrothiazole phosphonic acids or esters thereof |
| DD158109A1 (de) | 1981-04-10 | 1982-12-29 | Gunter Fischer | Verfahren zur hemmung der katalytischen aktivitaet von peptidhydrolasen |
| US4582821A (en) | 1983-11-16 | 1986-04-15 | E. I. Du Pont De Nemours And Company | Inhibition of cyclic nucleotide independent protein kinases |
| US4499082A (en) | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
| US4636492A (en) | 1984-08-29 | 1987-01-13 | E. I. Du Pont De Nemours And Company | Inhibition of viral protease activity by peptide halomethyl ketones |
| US4652552A (en) | 1984-09-10 | 1987-03-24 | E. I. Du Pont De Nemours And Company | Tetrapeptide methyl ketone inhibitors of viral proteases |
| US4644055A (en) | 1984-12-17 | 1987-02-17 | E. I. Du Pont De Nemours And Company | Method for preparing specific inhibitors of virus-specified proteases |
| DD270382A1 (de) | 1986-10-31 | 1989-07-26 | Univ Halle Wittenberg | Verfahren zur kolorimetrischen bestimmung von dipeptidylpeptidase iv mittels dipeptidhydraziden |
| US5242904A (en) | 1987-06-05 | 1993-09-07 | The Dupont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| US5250720A (en) | 1987-06-05 | 1993-10-05 | The Dupont Merck Pharmaceutical Company | Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| US4935493A (en) | 1987-10-06 | 1990-06-19 | E. I. Du Pont De Nemours And Company | Protease inhibitors |
| WO1989006280A1 (en) | 1988-01-04 | 1989-07-13 | E.I. Du Pont De Nemours And Company | Multiple stage affinity process for isolation of specific cells from a cell mixture |
| US4963655A (en) | 1988-05-27 | 1990-10-16 | Mayo Foundation For Medical Education And Research | Boron analogs of amino acid/peptide protease inhibitors |
| US5215926A (en) | 1988-06-03 | 1993-06-01 | Cellpro, Inc. | Procedure for designing efficient affinity cell separation processes |
| DE68924850T2 (de) | 1988-06-14 | 1996-10-10 | Cell Med Inc | Heterofunktionelle zellular immunologische reagenzien, impfstoffe daraus und verwendungsverfahren. |
| IL91307A0 (en) | 1988-08-24 | 1990-03-19 | Merck & Co Inc | Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them |
| DE3840452A1 (de) | 1988-12-01 | 1990-06-07 | Hoechst Ag | (beta)-amino-boronsaeure-derivate |
| DE3842197A1 (de) | 1988-12-15 | 1990-06-21 | Hoechst Ag | Rasch spaltbares substrat fuer die hiv-protease |
| US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5635386A (en) | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
| DD296075A5 (de) | 1989-08-07 | 1991-11-21 | Martin-Luther-Universitaet Halle-Wittenberg,De | Verfahren zur herstellung neuer inhibitoren der dipeptidyl peptidase iv |
| DE4033062A1 (de) | 1990-10-18 | 1992-04-23 | Merck Patent Gmbh | Aminosaeurederivate |
| EP0528858B1 (en) | 1990-04-14 | 1997-01-22 | New England Medical Center Hospitals, Inc. | Inhibitors of dipeptidyl-aminopeptidase type iv |
| US5462928A (en) | 1990-04-14 | 1995-10-31 | New England Medical Center Hospitals, Inc. | Inhibitors of dipeptidyl-aminopeptidase type IV |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| US5378624A (en) | 1990-04-23 | 1995-01-03 | Cellpro, Incorporated | Methods for removing ligands from a particle surface |
| WO1991017767A1 (en) * | 1990-05-21 | 1991-11-28 | New England Medical Center Hospitals, Inc. | Method of treating inhibition of dipeptidyl aminopeptidase type iv |
| US5288707A (en) | 1990-08-13 | 1994-02-22 | Sandoz Ltd. | Borolysine peptidomimetics |
| GB9017694D0 (en) | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
| JPH06504547A (ja) | 1990-12-28 | 1994-05-26 | ジョージア・テック・リサーチ・コーポレーション | ペプチドケトアミド、ケト酸およびケトエステル |
| EP0578745A1 (en) | 1991-04-04 | 1994-01-19 | The Upjohn Company | Phosphorus containing compounds as inhibitors of retroviruses |
| IE922316A1 (en) | 1991-07-17 | 1993-01-27 | Smithkline Beecham Corp | Retroviral protease inhibitors |
| US5554728A (en) | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
| WO1993005011A1 (en) | 1991-08-29 | 1993-03-18 | Sandoz Ltd. | Novel immunosuppressants |
| US6825169B1 (en) * | 1991-10-22 | 2004-11-30 | Trustees Of Tufts College | Inhibitors of dipeptidyl-aminopeptidase type IV |
| CA2121369C (en) * | 1991-10-22 | 2003-04-29 | William W. Bachovchin | Inhibitors of dipeptidyl-aminopeptidase type iv |
| MX9206628A (es) | 1991-11-22 | 1993-05-01 | Boehringer Ingelheim Pharma | Ester de prolinaboronato y metodo para su preparacion. |
| WO1993016102A1 (en) | 1992-02-06 | 1993-08-19 | Dana-Farber Cancer Institute, Inc. | Human cd26 and methods for use |
| US5296604A (en) | 1992-05-15 | 1994-03-22 | Miles Inc. | Proline derivatives and compositions for their use as inhibitors of HIV protease |
| AU4794393A (en) * | 1992-07-31 | 1994-03-03 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Producing increased numbers of hematopoietic cells by administering inhibitors of dipeptidyl peptidase iv |
| US5329028A (en) * | 1992-08-05 | 1994-07-12 | Genentech, Inc. | Carbohydrate-directed cross-linking reagents |
| WO1994009132A1 (en) | 1992-08-21 | 1994-04-28 | Dana-Farber Cancer Institute, Inc. | Human cd26 and methods for use |
| FR2701951B1 (fr) | 1993-02-24 | 1995-06-09 | Adir | Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| HUT72735A (en) | 1993-03-03 | 1996-05-28 | Sandoz Ag | Process for producing peptides inhibiting serine-proteaze enzymes and pharmaceutical compositions containing them |
| US5384410A (en) | 1993-03-24 | 1995-01-24 | The Du Pont Merck Pharmaceutical Company | Removal of boronic acid protecting groups by transesterification |
| AU6773994A (en) * | 1993-04-23 | 1994-11-21 | Cellpro, Incorporated | Methods for enriching fetal progenitor cells from maternal blood |
| SE9301911D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptide derivatives |
| FR2707170A1 (fr) | 1993-06-04 | 1995-01-13 | Pasteur Institut | Expression des récepteurs CD4 et CD26 dans des cellules recombinantes, inhibiteurs du récepteur CD26. |
| WO1995011689A1 (en) | 1993-10-29 | 1995-05-04 | Trustees Of Tufts College | Use of inhibitors of dipeptidyl-aminopeptidase to block entry of hiv into cells |
| NL9400309A (nl) | 1993-11-04 | 1995-06-01 | Eurogenetics Nv | Ligande die in staat is te binden aan de adenosine deaminase bindingsplaats van CD26. |
| IL111785A0 (en) | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
| FR2719049B1 (fr) | 1994-04-22 | 1996-06-14 | Pasteur Institut | Multireprésentation d'un analogue peptidique du substrat de la DPPIV, notamment de type KPR, afin d'inhiber l'entrée du HIV dans les cellules. |
| US5543396A (en) | 1994-04-28 | 1996-08-06 | Georgia Tech Research Corp. | Proline phosphonate derivatives |
| DE4416963C1 (de) | 1994-05-13 | 1995-07-13 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von enantiomerenreinen Diarylprolinolen |
| EP0764151A2 (en) | 1994-06-10 | 1997-03-26 | Universitaire Instelling Antwerpen | Purification of serine protease and synthetic inhibitors thereof |
| FR2721611B1 (fr) | 1994-06-22 | 1996-09-27 | Adir | Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent . |
| US5856571A (en) | 1995-06-07 | 1999-01-05 | Cellpro, Incorporated | Semicarbazide-containing linker compounds for formation of stably-linked conjugates and methods related thereto |
| ES2162081T3 (es) | 1995-06-07 | 2001-12-16 | Aastrom Biosciences Inc | Aparato y procedimiento para el mantenimiento y crecimiento de celulas biologicas. |
| US5965532A (en) * | 1996-06-28 | 1999-10-12 | Trustees Of Tufts College | Multivalent compounds for crosslinking receptors and uses thereof |
| US6100234A (en) * | 1997-05-07 | 2000-08-08 | Tufts University | Treatment of HIV |
| US6040145A (en) * | 1997-05-07 | 2000-03-21 | Tufts University | Potentiation of the immune response |
-
1997
- 1997-05-07 US US08/852,395 patent/US6040145A/en not_active Expired - Fee Related
-
1998
- 1998-04-30 ES ES98920101T patent/ES2207831T3/es not_active Expired - Lifetime
- 1998-04-30 DK DK98920101T patent/DK0975359T3/da active
- 1998-04-30 DE DE69818445T patent/DE69818445T2/de not_active Expired - Fee Related
- 1998-04-30 CA CA002289125A patent/CA2289125A1/en not_active Abandoned
- 1998-04-30 JP JP54823998A patent/JP2002511063A/ja not_active Ceased
- 1998-04-30 EP EP98920101A patent/EP0975359B1/en not_active Expired - Lifetime
- 1998-04-30 AT AT98920101T patent/ATE250426T1/de not_active IP Right Cessation
- 1998-04-30 AU AU72747/98A patent/AU724257B2/en not_active Ceased
- 1998-04-30 PT PT98920101T patent/PT975359E/pt unknown
- 1998-04-30 WO PCT/US1998/008838 patent/WO1998050066A1/en not_active Ceased
-
2000
- 2000-01-26 US US09/491,855 patent/US6692753B2/en not_active Expired - Fee Related
-
2004
- 2004-02-13 US US10/778,667 patent/US20050008644A1/en not_active Abandoned
-
2007
- 2007-02-06 US US11/703,058 patent/US20080026007A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69818445T2 (de) | 2004-07-22 |
| AU724257B2 (en) | 2000-09-14 |
| US6040145A (en) | 2000-03-21 |
| US20050008644A1 (en) | 2005-01-13 |
| US20010055777A1 (en) | 2001-12-27 |
| EP0975359A1 (en) | 2000-02-02 |
| PT975359E (pt) | 2004-02-27 |
| ATE250426T1 (de) | 2003-10-15 |
| US6692753B2 (en) | 2004-02-17 |
| DE69818445D1 (de) | 2003-10-30 |
| EP0975359B1 (en) | 2003-09-24 |
| JP2002511063A (ja) | 2002-04-09 |
| AU7274798A (en) | 1998-11-27 |
| CA2289125A1 (en) | 1998-11-12 |
| US20080026007A1 (en) | 2008-01-31 |
| ES2207831T3 (es) | 2004-06-01 |
| WO1998050066A1 (en) | 1998-11-12 |
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