DK0977586T3 - Kombinationer af antigen og mucosa-bindende bestanddel til induktion af specifik immunologisk tolerans - Google Patents

Kombinationer af antigen og mucosa-bindende bestanddel til induktion af specifik immunologisk tolerans

Info

Publication number: DK0977586T3
Authority: DK; Denmark
Prior art keywords: combinations; antigen; tolerance; binding component; mucosa
Prior art date: 1997-04-23

Application number

DK98918742T

Other languages

Danish (da)

English (en)

Inventor

Jacob Sten Petersen

Original Assignee

Pedersen Jacob Sten

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-23

Filing date

1998-04-23

Publication date

2005-12-05

1998-04-23 Application filed by Pedersen Jacob Sten filed Critical Pedersen Jacob Sten

2005-12-05 Application granted granted Critical

2005-12-05 Publication of DK0977586T3 publication Critical patent/DK0977586T3/da

Links

239000000427 antigen Substances 0.000 title abstract 3
102000036639 antigens Human genes 0.000 title abstract 3
108091007433 antigens Proteins 0.000 title abstract 3
230000001900 immune effect Effects 0.000 title abstract 2
210000004877 mucosa Anatomy 0.000 title 1
230000001939 inductive effect Effects 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
QPJBWNIQKHGLAU-IQZHVAEDSA-N ganglioside GM1 Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 QPJBWNIQKHGLAU-IQZHVAEDSA-N 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000002459 sustained effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Mycology (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK98918742T 1997-04-23 1998-04-23 Kombinationer af antigen og mucosa-bindende bestanddel til induktion af specifik immunologisk tolerans DK0977586T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4418297P	1997-04-23	1997-04-23
US4418497P	1997-04-23	1997-04-23

Publications (1)

Publication Number	Publication Date
DK0977586T3 true DK0977586T3 (da)	2005-12-05

Family

ID=26721263

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98918742T DK0977586T3 (da)	1997-04-23	1998-04-23	Kombinationer af antigen og mucosa-bindende bestanddel til induktion af specifik immunologisk tolerans

Country Status (8)

Country	Link
US (1)	US7097845B2 (de)
EP (1)	EP0977586B1 (de)
JP (1)	JP2001523249A (de)
AT (1)	ATE299711T1 (de)
AU (1)	AU7161098A (de)
DE (1)	DE69830900T2 (de)
DK (1)	DK0977586T3 (de)
WO (1)	WO1998047529A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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GB9800487D0 (en) *	1998-01-09	1998-03-04	Oratol Limited	Therapies
WO2001022995A1 (en) *	1999-09-30	2001-04-05	Novo Nordisk A/S	A method for preparing conjugates between an antigen and mucosal binding component
AU781909B2 (en) *	2000-01-25	2005-06-23	Board Of Regents Of The University Of Nebraska, The	Pre-transplant accommodated organs resistant to anti-donor immunity
US7897575B2 (en) *	2000-05-24	2011-03-01	The United States Of America As Represented By The Department Of Health And Human Services	Treatment and prevention of vascular dementia
CA2447795A1 (en) *	2001-05-23	2002-11-28	Duotol Ab	Suppression of allergic reactions by transdermal administration of allergens in conjunction with or conjugated to toxin subunits or fragments thereof
EP2107069B1 (de)	2003-08-05	2013-01-16	Novo Nordisk A/S	Neuartige Insulinderivate
US20090074882A1 (en)	2005-12-28	2009-03-19	Novo Nordisk A/S	Insulin compositions and method of making a composition
JP5552046B2 (ja)	2007-06-13	2014-07-16	ノボ・ノルデイスク・エー／エス	インスリン誘導体を含有する薬学的製剤
KR20110085985A (ko)	2008-10-30	2011-07-27	노보 노르디스크 에이/에스	하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료
JP6249773B2 (ja) *	2010-05-10	2017-12-20	ノヴォノルディスクアー／エス	インスリン−亜鉛錯体の調製方法
BR112013010345A2 (pt)	2010-10-27	2017-07-25	Novo Nordisk As	tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
US12605432B2 (en)	2014-06-04	2026-04-21	Diamyd Medical Ab	Combinations for antigen based therapy
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation
WO2022177890A1 (en) *	2021-02-16	2022-08-25	Applied Molecular Transport Inc.	Solid oral compositions with zinc

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US4666837A (en)	1982-05-24	1987-05-19	Smithkline-Rit	DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits
DK97986A (da) *	1985-03-08	1986-09-09	Takeda Chemical Industries Ltd	Middel til inhibering af fordoejelse af sakkarid
US5399347A (en)	1987-06-24	1995-03-21	Autoimmune, Inc.	Method of treating rheumatoid arthritis with type II collagen
DE3856566T2 (de)	1987-06-24	2004-06-24	Brigham And Women's Hospital, Boston	Behandlung von Autoimmun-Erkrankungen durch orale Verabreichung von Autoantigenen
JPH02235823A (ja)	1989-03-09	1990-09-18	Watanabe Mitsuko	抗アレルギー剤
JP2891485B2 (ja)	1989-09-25	1999-05-17	科学技術振興事業団	移植拒絶反応抑制剤
WO1991008760A1 (en)	1989-12-20	1991-06-27	Brigham And Women's Hospital	Improved treatment of autoimmune diseases by aerosol administration of auto antigens
DE69127470T2 (de)	1990-03-02	1998-02-19	Autoimmune Inc	Verstärkung der unterdrückungsregulation von autoimmunkrankheiten durch orale oder enterale verabreichung von autoantigenen
CA2050425A1 (en)	1990-09-03	1992-03-04	Yoshiaki Uda	Pharmaceutical composition and its mucous use
JP3198390B2 (ja) *	1990-09-03	2001-08-13	武田薬品工業株式会社	経粘膜用製剤
IL99864A (en)	1990-10-31	2000-11-21	Autoimmune Inc	Compositions for suppressing transplant rejection in mammals which contain tissue donor derived MHC antigens
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JP3109328B2 (ja)	1993-05-19	2000-11-13	ウシオ電機株式会社	加熱定着装置
WO1994027634A1 (en)	1993-06-02	1994-12-08	Institute For Child Health Research	Cryptic peptides for use in inducing immunologic tolerance
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JP2847696B2 (ja) *	1994-05-11	1999-01-20	田辺製薬株式会社	プロピオフェノン誘導体及びその製法
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AU6113896A (en)	1995-06-05	1996-12-24	Brigham And Women's Hospital	Use of oral tolerance to suppress both th1 and th2 immune re sponses and to suppress antibody production
GB9513733D0 (en) *	1995-07-05	1995-09-06	Univ Bristol	Therapeutic agents

1998
- 1998-04-22 US US09/064,682 patent/US7097845B2/en not_active Expired - Fee Related
- 1998-04-23 EP EP98918742A patent/EP0977586B1/de not_active Expired - Lifetime
- 1998-04-23 JP JP54637498A patent/JP2001523249A/ja active Pending
- 1998-04-23 AT AT98918742T patent/ATE299711T1/de active
- 1998-04-23 AU AU71610/98A patent/AU7161098A/en not_active Abandoned
- 1998-04-23 WO PCT/US1998/008361 patent/WO1998047529A1/en not_active Ceased
- 1998-04-23 DE DE69830900T patent/DE69830900T2/de not_active Expired - Lifetime
- 1998-04-23 DK DK98918742T patent/DK0977586T3/da active

Also Published As

Publication number	Publication date
DE69830900D1 (de)	2005-08-25
JP2001523249A (ja)	2001-11-20
ATE299711T1 (de)	2005-08-15
US20020119159A1 (en)	2002-08-29
DE69830900T2 (de)	2006-05-24
WO1998047529A1 (en)	1998-10-29
AU7161098A (en)	1998-11-13
EP0977586A1 (de)	2000-02-09
EP0977586B1 (de)	2005-07-20
US7097845B2 (en)	2006-08-29

Publication	Publication Date	Title
DE69830900D1 (de)	2005-08-25	Immunologische toleranz induzierende zusammensetzungen enthaltend antigen und mukosale bindende verbindungen
BG99261A (en)	1995-06-30	Steroid glycosides for the treatment of hyperchlesterolemia
DE69837324D1 (de)	2007-04-26	Behandlung der multiplen sklerose durch einnahme von copolymer-1
NO934284D0 (no)	1993-11-26	Farmas!ytisk preparat inneholdende et definert lipidsystem
FI972945A7 (fi)	1997-07-11	Antigeenien antamiseen soveltuvia koostumuksia
IS5362A (is)	2000-01-25	Kvalastillandi lyfjablöndur gerðar af efnasamböndum sem vinna gegn flogaveiki og aðferðir til að nota þær
ATE463505T1 (de)	2010-04-15	Toll-ähnlichen-rezeptor-5-liganden und verwendungsverfahren
DK1093819T3 (da)	2006-09-11	Forbindelse og præparat til tilförsel af aktive midler
DK0865297T3 (da)	2003-03-03	Vaccinesammensætninger til intranasal administration omfattende chitosan og anvendelsen deraf
DE69840603D1 (de)	2009-04-09	Alpha-ketoamidhaltige multikatalytische protease inhibitoren
IL111134A (en)	2000-06-01	Immunological tolerance-inducing composition comprising a mucosa-binding molecule linked to a specific self-antigen/tolerogen
NO995718L (no)	2000-01-18	Urte-ekstraktsammensetning og metode med innum-"boosting"- evne
ATE231839T1 (de)	2003-02-15	Polyaromatische antivirale zusammensetzungen
DK0588578T3 (da)	2000-03-27	Immunogener
DK0789590T3 (da)	2002-11-04	Chitosaninduceret immunforstærkning
WO1998046270A3 (en)	1999-01-07	Polymeric conjugates polyvalently presenting an agent for therapy
RU95113454A (ru)	1997-06-10	Катехольные диэфиры как селективные ингибиторы фдэiv, фармацевтическая композиция, способы лечения
DK1053017T3 (da)	2004-11-22	Vacciner omfattende interleukin-12 og herpes simplex virusantigen
DK0712311T3 (da)	1999-06-21	Antiglucocorticoidsteroider til behandling af angstlidelser
NO996274D0 (no)	1999-12-17	CD154-blokkering for terapeutisk protein-inhibitorsyndrom
ID18542A (id)	1998-04-16	Rangkaian-rangkaian asam nukleat dan asam amino yang berhubungan dengan helicobacter pilory dan komposisi-komposisi vaksin dari padanya
DK1183037T3 (da)	2004-02-02	Sammensætninger til modulering af immunrespons og til behandling af inflammatoriske sygdomme
IL139832A0 (en)	2002-02-10	Therapeutic compositions that produce an immune response by altering the antigen
NO982463L (no)	1998-05-29	Anvendelse av en kombinasjon av pentoksyfyllin og type I-interferoner til behandling av multippel sklerose
DK0831881T3 (da)	2003-07-07	CETP til forøgelse af HDL-cholesterolniveau