DK0978565T3 - Fremgangsmåde til fremstilling af peptid under anvendelse af et hjælperpeptid - Google Patents

Fremgangsmåde til fremstilling af peptid under anvendelse af et hjælperpeptid

Info

Publication number: DK0978565T3
Authority: DK; Denmark
Prior art keywords: peptide; target; protein; producing; solubility
Prior art date: 1998-01-30

Application number

DK99901926T

Other languages

Danish (da)

English (en)

Inventor

Kazuhiro Ohsuye

Masayuki Yabuta

Yuji Suzuki

Original Assignee

Asubio Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-30

Filing date

1999-01-29

Publication date

2008-02-04

1999-01-29 Application filed by Asubio Pharma Co Ltd filed Critical Asubio Pharma Co Ltd

2008-02-04 Application granted granted Critical

2008-02-04 Publication of DK0978565T3 publication Critical patent/DK0978565T3/da

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
238000000034 method Methods 0.000 title abstract 3
101800000324 Immunoglobulin A1 protease translocator Proteins 0.000 title 1
108090000623 proteins and genes Proteins 0.000 abstract 5
102000004169 proteins and genes Human genes 0.000 abstract 4
238000006911 enzymatic reaction Methods 0.000 abstract 2
238000000746 purification Methods 0.000 abstract 2
230000004520 agglutination Effects 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
230000003028 elevating effect Effects 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
238000004255 ion exchange chromatography Methods 0.000 abstract 1
230000006798 recombination Effects 0.000 abstract 1
238000005215 recombination Methods 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Diabetes (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK99901926T 1998-01-30 1999-01-29 Fremgangsmåde til fremstilling af peptid under anvendelse af et hjælperpeptid DK0978565T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP3227298		1998-01-30
PCT/JP1999/000406 WO1999038984A1 (fr)	1998-01-30	1999-01-29	Procede de production de peptide au moyen d'un peptide accessoire

Publications (1)

Publication Number	Publication Date
DK0978565T3 true DK0978565T3 (da)	2008-02-04

Family

ID=12354362

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99901926T DK0978565T3 (da)	1998-01-30	1999-01-29	Fremgangsmåde til fremstilling af peptid under anvendelse af et hjælperpeptid

Country Status (12)

Country	Link
EP (1)	EP0978565B1 (fr)
JP (1)	JP4331270B2 (fr)
KR (1)	KR100627590B1 (fr)
CN (1)	CN1198937C (fr)
AT (1)	ATE375393T1 (fr)
AU (1)	AU765206B2 (fr)
CA (1)	CA2284847A1 (fr)
DE (1)	DE69937272T2 (fr)
DK (1)	DK0978565T3 (fr)
IL (1)	IL132030A (fr)
NZ (1)	NZ338004A (fr)
WO (1)	WO1999038984A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000052193A1 (fr)	1999-03-04	2000-09-08	Suntory Limited	Procede de controle de clivage par la protease de l'ompt
WO2001027310A1 (fr) *	1999-10-15	2001-04-19	Shionogi & Co., Ltd.	Procede de production d'un precurseur d'adrenomeduline
KR100407792B1 (ko) *	2000-08-02	2003-12-01	한국생명공학연구원	인간 글루카곤 유사펩타이드를 융합파트너로 이용한재조합 단백질의 제조방법
GB0121591D0 (en)	2001-09-06	2001-10-24	Chiron Spa	Hybrid and tandem expression of neisserial proteins
ATE469915T1 (de)	2001-07-27	2010-06-15	Novartis Vaccines & Diagnostic	Antikörper gegen das meningokokken adhäsin app
US7176278B2 (en)	2001-08-30	2007-02-13	Biorexis Technology, Inc.	Modified transferrin fusion proteins
US8129504B2 (en)	2001-08-30	2012-03-06	Biorexis Technology, Inc.	Oral delivery of modified transferrin fusion proteins
CN100491395C (zh)	2002-04-11	2009-05-27	阿斯比奥制药株式会社	修饰肽的制造方法
CA2485701A1 (fr) *	2002-05-24	2003-12-04	Fred W. Wagner	Methode de production enzymatique de peptides amides glp-1 (7-36)
CA2485695A1 (fr)	2002-05-24	2003-12-04	Fred W. Wagner	Methode de production enzymatique universelle de peptides bioactifs
AU2003243316A1 (en)	2002-05-24	2003-12-12	Nps Allelix Corp.	Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
JPWO2004037859A1 (ja) *	2002-10-11	2006-02-23	株式会社三和化学研究所	Ｇｌｐ−１誘導体及びその経粘膜吸収型製剤
HUE031886T2 (en)	2002-10-11	2017-08-28	Glaxosmithkline Biologicals Sa	Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines
EP1626981A4 (fr) *	2003-03-04	2006-11-22	Biorexis Pharmaceutical Corp	Proteines protegees contre la dipeptidylpeptidase
HRP20120315T1 (hr)	2003-11-21	2012-05-31	Nps Pharmaceuticals	Proizvodnja peptida 2 nalik glukagonu i analoga
US20130172274A1 (en)	2005-12-20	2013-07-04	Duke University	Methods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en)	2005-12-20	2014-09-23	Duke University	Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
DK2038423T3 (da)	2006-06-21	2013-04-02	Biocon Ltd	Fremgangsmåde til fremstilling af biologisk aktive polypeptider med insulinotropisk aktivitet
CN101511868B (zh)	2006-07-24	2013-03-06	比奥雷克西斯制药公司	毒蜥外泌肽融合蛋白
CA2663047A1 (fr) *	2006-09-06	2008-03-13	Phase Bioscience, Inc.	Proteines de fusion de polypeptide de type elastine therapeutique
CN102131516B (zh)	2008-06-27	2016-03-16	杜克大学	包含弹性蛋白样肽的治疗剂
CN104936610A (zh) *	2012-11-13	2015-09-23	益普生制药股份有限公司	Glp-1类似物的纯化方法
CN104592381A (zh) *	2013-10-31	2015-05-06	江苏万邦生化医药股份有限公司	一种利拉鲁肽中间体多肽的制备方法
RU2544959C1 (ru) *	2014-04-04	2015-03-20	Александр Владимирович Бубнов	Способ получения пептидов
CN107532190B (zh)	2014-12-01	2021-07-09	菲尼克斯公司	用于肽生产的融合伴侣
CN105669856A (zh) *	2016-02-13	2016-06-15	王大勇	一种基因重组长效人促肾上腺皮质激素及其制备方法
KR102665710B1 (ko)	2017-08-24	2024-05-14	노보 노르디스크 에이/에스	Glp-1 조성물 및 그 용도
CN111378027B (zh) *	2018-12-29	2022-04-15	万新医药科技(苏州)有限公司	一种索玛鲁肽前体的制备方法
JP7761567B2 (ja)	2020-02-18	2025-10-28	ノヴォノルディスクアー／エス	医薬製剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3531947B2 (ja) *	1991-08-19	2004-05-31	第一サントリーファーマ株式会社	ペプチドの製造方法
JP3995279B2 (ja) *	1994-09-07	2007-10-24	アスビオファーマ株式会社	蛋白の製造方法
CA2198966C (fr) *	1996-03-04	2011-06-21	Yuji Suzuki	Methode de clivage d'une proteine chimere a l'aide d'une enzyme de traitement

1999
- 1999-01-29 EP EP99901926A patent/EP0978565B1/fr not_active Expired - Lifetime
- 1999-01-29 CN CNB998001139A patent/CN1198937C/zh not_active Expired - Fee Related
- 1999-01-29 KR KR1019997008935A patent/KR100627590B1/ko not_active Expired - Fee Related
- 1999-01-29 WO PCT/JP1999/000406 patent/WO1999038984A1/fr not_active Ceased
- 1999-01-29 IL IL132030A patent/IL132030A/en not_active IP Right Cessation
- 1999-01-29 DE DE69937272T patent/DE69937272T2/de not_active Expired - Lifetime
- 1999-01-29 JP JP53918299A patent/JP4331270B2/ja not_active Expired - Fee Related
- 1999-01-29 AT AT99901926T patent/ATE375393T1/de active
- 1999-01-29 DK DK99901926T patent/DK0978565T3/da active
- 1999-01-29 CA CA002284847A patent/CA2284847A1/fr not_active Abandoned
- 1999-01-29 NZ NZ338004A patent/NZ338004A/en not_active IP Right Cessation
- 1999-01-29 AU AU21857/99A patent/AU765206B2/en not_active Ceased

Also Published As

Publication number	Publication date
WO1999038984A1 (fr)	1999-08-05
CA2284847A1 (fr)	1999-08-05
AU2185799A (en)	1999-08-16
EP0978565A1 (fr)	2000-02-09
IL132030A0 (en)	2001-03-19
KR20010005859A (ko)	2001-01-15
ATE375393T1 (de)	2007-10-15
CN1255945A (zh)	2000-06-07
DE69937272D1 (de)	2007-11-22
IL132030A (en)	2009-06-15
NZ338004A (en)	2001-08-31
KR100627590B1 (ko)	2006-09-25
EP0978565B1 (fr)	2007-10-10
JP4331270B2 (ja)	2009-09-16
DE69937272T2 (de)	2008-07-10
EP0978565A4 (fr)	2003-05-02
CN1198937C (zh)	2005-04-27
AU765206B2 (en)	2003-09-11

Publication	Publication Date	Title
DK0978565T3 (da)	2008-02-04	Fremgangsmåde til fremstilling af peptid under anvendelse af et hjælperpeptid
DK1422237T3 (da)	2007-06-11	Fremgangsmåder til rekombinant frembringelse af antifusogene peptider
EP1350842A3 (fr)	2004-01-02	Préparation et utilisation d'une terminal déoxynucléotidyl transférase améliorée
EA200100387A1 (ru)	2001-10-22	Роль секретазы в болезни альцгеймера
PT670896E (pt)	2002-07-31	Clonagem e expressao de alfa-galactosidase biologicamente activa
AR023230A1 (es)	2002-09-04	Polipeptidos mutantes con actividad de alfa-amilasa alcalina y usos de dichos polipeptidos.
BR0012712B1 (pt)	2011-12-13	métodos de produção de l-aminoácidos aumentando-se o nadph celular.
RU2004102689A (ru)	2005-05-10	Способ модифицирования фермента и вариант оксидоредуктазы
TR200402085T4 (tr)	2004-09-21	Bazik bir amino asidi fermentasyon ortamından ayırmak için metod.
CY1106978T1 (el)	2012-09-26	Ενζυμα φωσφοδιεστερασης
PL353085A1 (en)	2002-10-07	Method of obtaining l-amino acids not forming any proteins
DE60323215D1 (de)	2008-10-09	Neue carbonylreduktase, diese codierendes gen und verfahren zur produktion optisch-aktiver alkohole damit
ATE461997T1 (de)	2010-04-15	Neuartige glukose-6-phosphat dehydrogenase
TR200000086T2 (tr)	2000-08-21	Heparin üretimi için işlem.
ID29693A (id)	2001-09-27	Rangkaian-rangkaian nukleotida yang mengkode gen dapc dan proses untuk memproduksi l-lisin
DK183489D0 (da)	1989-04-17	Proces til fremstilling af organiske kemikalier
ATE30246T1 (de)	1987-10-15	Verfahren zur herstellung reifer proteine aus schmelzproteinen hergestellt in pro- oder eukaryotischen zellen.
ES8707554A1 (es)	1987-08-01	Procedimiento para preparar interferon-a recombinante
ATE319850T1 (de)	2006-03-15	Verfahren zur herstellung von aminosäuren
DK383984A (da)	1985-02-11	Fremgangsmaade til fremstilling af sekretin
CA2327524A1 (fr)	2000-09-08	Procede de controle de clivage par la protease de l'ompt
RU2002104355A (ru)	2003-12-10	Способ получения L-аминокислот из их рацемических N-ацетил-D, L-производных посредством ферментативного расщепления рацемата посредством выделенных, рекомбинантных ферментов
ATE399152T1 (de)	2008-07-15	Verfahren zur herstellung von optisch aktiven azetidin-2-carbonsäuren
DK0860500T3 (da)	2004-12-27	Oprenset syrestabil alfa-amylase af svampeoprindelse
Miyazawa et al.	1998	Protease-catalyzed incorporation of non-protein amino acids into peptides via the kinetically controlled approach