DK0979089T3 - Fremgangsmåder til anvendelse af makrocykliske lacton-forbindelser som multilægemiddel-resistens-reverterende midler i tumor og andre celler - Google Patents

Fremgangsmåder til anvendelse af makrocykliske lacton-forbindelser som multilægemiddel-resistens-reverterende midler i tumor og andre celler

Info

Publication number: DK0979089T3
Authority: DK; Denmark
Prior art keywords: macrocyclic lactone; lactone compounds; tumor; cells; methods
Prior art date: 1997-04-30

Application number

DK98917538T

Other languages

Danish (da)

English (en)

Inventor

Roger K Prichard

Jean-Francois Pouliot

Elias Georges

Original Assignee

Univ Mcgill

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-30

Filing date

1998-04-29

Publication date

2005-12-12

1998-04-29 Application filed by Univ Mcgill filed Critical Univ Mcgill

2005-12-12 Application granted granted Critical

2005-12-12 Publication of DK0979089T3 publication Critical patent/DK0979089T3/da

Links

-1 Lactone Compounds Chemical class 0.000 title abstract 4
206010028980 Neoplasm Diseases 0.000 title 1
230000036457 multidrug resistance Effects 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 abstract 4
229940127089 cytotoxic agent Drugs 0.000 abstract 4
241000124008 Mammalia Species 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
239000000824 cytostatic agent Substances 0.000 abstract 2
230000001085 cytostatic effect Effects 0.000 abstract 2
230000002209 hydrophobic effect Effects 0.000 abstract 2
230000001988 toxicity Effects 0.000 abstract 2
231100000419 toxicity Toxicity 0.000 abstract 2
239000005660 Abamectin Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 abstract 1
ZLBGSRMUSVULIE-GSMJGMFJSA-N milbemycin A3 Chemical class O1[C@H](C)[C@@H](C)CC[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 ZLBGSRMUSVULIE-GSMJGMFJSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
YNFMRVVYUVPIAN-AQUURSMBSA-N nemadectin Chemical compound C1[C@H](O)[C@H](C)[C@@H](C(/C)=C/C(C)C)O[C@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 YNFMRVVYUVPIAN-AQUURSMBSA-N 0.000 abstract 1
YNFMRVVYUVPIAN-UHFFFAOYSA-N nemadectin alpha Natural products C1C(O)C(C)C(C(C)=CC(C)C)OC11OC(CC=C(C)CC(C)C=CC=C2C3(C(C(=O)O4)C=C(C)C(O)C3OC2)O)CC4C1 YNFMRVVYUVPIAN-UHFFFAOYSA-N 0.000 abstract 1
210000004881 tumor cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK98917538T 1997-04-30 1998-04-29 Fremgangsmåder til anvendelse af makrocykliske lacton-forbindelser som multilægemiddel-resistens-reverterende midler i tumor og andre celler DK0979089T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4516197P	1997-04-30	1997-04-30
US09/067,677 US6114376A (en)	1997-04-30	1998-04-28	Methods for using macrocyclic lactone compounds as multidrug resistance reversing agents in tumor and other cells

Publications (1)

Publication Number	Publication Date
DK0979089T3 true DK0979089T3 (da)	2005-12-12

Family

ID=26722446

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98917538T DK0979089T3 (da)	1997-04-30	1998-04-29	Fremgangsmåder til anvendelse af makrocykliske lacton-forbindelser som multilægemiddel-resistens-reverterende midler i tumor og andre celler

Country Status (10)

Country	Link
US (1)	US6114376A (de)
EP (1)	EP0979089B1 (de)
AT (1)	ATE309805T1 (de)
AU (1)	AU744406B2 (de)
CA (1)	CA2289086C (de)
DE (1)	DE69832375T2 (de)
DK (1)	DK0979089T3 (de)
ES (1)	ES2252832T3 (de)
NZ (1)	NZ500429A (de)
WO (1)	WO1998048813A1 (de)

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US7020893B2 (en) *	2001-06-15	2006-03-28	Intel Corporation	Method and apparatus for continuously and opportunistically driving an optimal broadcast schedule based on most recent client demand feedback from a distributed set of broadcast clients
US20020194585A1 (en) *	2001-06-15	2002-12-19	Connelly Jay H.	Methods and apparatus for providing ranking feedback for content in a broadcast system
US20020193066A1 (en) *	2001-06-15	2002-12-19	Connelly Jay H.	Methods and apparatus for providing rating feedback for content in a broadcast system
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US8943540B2 (en)	2001-09-28	2015-01-27	Intel Corporation	Method and apparatus to provide a personalized channel
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US9351988B2 (en)	2011-05-02	2016-05-31	Universite De Geneve	Macrocyclic lactones and use thereof
HUE032885T2 (en) *	2011-12-20	2017-12-28	Ectin Res Ab	Synergistic combination comprising avermectins and a nsaid for tumor inhibition
US20140271812A1 (en) *	2013-03-14	2014-09-18	Panacea Pharmaceuticals	Treatment for chemotherapy-induced cognitive impairment
CN112898224B (zh) *	2019-12-04	2023-02-17	中国科学院上海药物研究所	一种烯丙基醇支撑的大环内酯化合物及其用途
CN115227691B (zh) *	2022-06-15	2023-05-05	福建卫生职业技术学院	源于细曲霉的内酯类化合物在抗人乳腺癌药物中的应用

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1998
- 1998-04-28 US US09/067,677 patent/US6114376A/en not_active Expired - Fee Related
- 1998-04-29 WO PCT/IB1998/000750 patent/WO1998048813A1/en not_active Ceased
- 1998-04-29 CA CA002289086A patent/CA2289086C/en not_active Expired - Fee Related
- 1998-04-29 NZ NZ500429A patent/NZ500429A/en unknown
- 1998-04-29 AU AU70736/98A patent/AU744406B2/en not_active Ceased
- 1998-04-29 DE DE69832375T patent/DE69832375T2/de not_active Expired - Lifetime
- 1998-04-29 ES ES98917538T patent/ES2252832T3/es not_active Expired - Lifetime
- 1998-04-29 AT AT98917538T patent/ATE309805T1/de not_active IP Right Cessation
- 1998-04-29 EP EP98917538A patent/EP0979089B1/de not_active Expired - Lifetime
- 1998-04-29 DK DK98917538T patent/DK0979089T3/da active

Also Published As

Publication number	Publication date
DE69832375D1 (de)	2005-12-22
CA2289086C (en)	2008-07-15
EP0979089B1 (de)	2005-11-16
US6114376A (en)	2000-09-05
AU7073698A (en)	1998-11-24
CA2289086A1 (en)	1998-11-05
ES2252832T3 (es)	2006-05-16
AU744406B2 (en)	2002-02-21
ATE309805T1 (de)	2005-12-15
DE69832375T2 (de)	2006-06-01
EP0979089A1 (de)	2000-02-16
WO1998048813A1 (en)	1998-11-05
NZ500429A (en)	2001-05-25

Publication	Publication Date	Title
DK0979089T3 (da)	2005-12-12	Fremgangsmåder til anvendelse af makrocykliske lacton-forbindelser som multilægemiddel-resistens-reverterende midler i tumor og andre celler
NZ336344A (en)	2001-03-30	Endoparasiticidal and ectoparasiticidal compositions comprising an avermectin, ivermectin or milemycin with antagonists or agonists of nicotinergic acetylcholine receptors
ES2154720T3 (es)	2001-04-16	Esteres heterociclicos de la rapamicina y composiciones farmaceuticas que los contienen.
ES2166300A1 (es)	2002-04-01	Nueva asociacion parasiticida.
NO20020759L (no)	1999-02-19	N<o>6</o> heterocykliske substituerte adenosinderivater
DK1067933T3 (da)	2007-12-27	Semisyntetiske ecteinascidiner
ES2176698T3 (es)	2002-12-01	Nuevos derivados de la eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.
ATE173738T1 (de)	1998-12-15	Alkylthioalkylavermectine sind aktive antiparasitäre wirkstoffe
CA2074348A1 (en)	1993-01-24	Stable compositions for parenteral administration and their use
BR0013642A (pt)	2002-05-07	Análogos de nucleosìdeo de pirrolo[2,3-d]pirimidina
ES2194279T3 (es)	2003-11-16	Composiciones de ciclodextrina que contienen un derivado de avermectina o de milbemicina.
MX9301255A (es)	1993-09-01	Derivados de avermectina y milbemicina como agentes antiparasitarios.
AU737680C (en)	2002-05-02	Novel compounds having antiviral activity
EP1834670A3 (de)	2010-11-24	Avermectinen oder Milbemycine und bis-Aryl-Derivate enthaltende Anthelminthische Zusammensetzungen.
PT1213972E (pt)	2003-09-30	Composicao compreendendo um inibidor da alfa-amilase e pelo menos um composto fisiologicamente aceitavel capaz de reduzir a absorcao intestinal dos "acucares rapidos"
FI844225A0 (fi)	1984-10-26	Griseolinsyraderivat och deras anvaendning.
GT199700104AA (es)	1999-03-28	Procedimientos e intermedios para preparar derivados de cromanol sustituidos
FR2775288B1 (fr)	2000-03-31	Derives de streptogramines, leur preparation et les compositons qui les contiennent
YU47802A (sh)	2006-03-03	Postupci i kompozicije za levovirin
ES2164660T3 (es)	2002-03-01	Derivados difluoro de avermectina.
ATE285771T1 (de)	2005-01-15	Diaminotrifluoromethylpyrimidinderivate enthaltende antikrebs-zusammensetzung
CA2358361A1 (en)	2002-04-10	Stable compositions for parenteral administration and their use
GT200000185A (es)	2002-04-18	Derivados de higromicina.
GT199900074A (es)	2000-12-19	3-ceto derivados tricìclicos de 6-0metileritromicina.-
EP0950714A4 (de)	2000-01-05	Neue antitumorverbindungen und deren verwendung