ATE173738T1 - Alkylthioalkylavermectine sind aktive antiparasitäre wirkstoffe - Google Patents

Alkylthioalkylavermectine sind aktive antiparasitäre wirkstoffe

Info

Publication number: ATE173738T1
Authority: AT; Austria
Prior art keywords: avermectin; compounds; alkylthioalkylavermectines; antiparasite; actives
Prior art date: 1992-03-24

Application number

AT93907512T

Other languages

English (en)

Inventor

Bruce O Linn

Helmut Mrozik

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-24

Filing date

1993-03-16

Publication date

1998-12-15

1993-03-16 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1998-12-15 Application granted granted Critical

1998-12-15 Publication of ATE173738T1 publication Critical patent/ATE173738T1/de

Links

230000002141 anti-parasite Effects 0.000 title 1
239000005660 Abamectin Substances 0.000 abstract 4
RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical class C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
239000003096 antiparasitic agent Substances 0.000 abstract 1
229940125687 antiparasitic agent Drugs 0.000 abstract 1
-1 avermectin monosaccharides Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Tropical Medicine & Parasitology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

AT93907512T 1992-03-24 1993-03-16 Alkylthioalkylavermectine sind aktive antiparasitäre wirkstoffe ATE173738T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/857,035 US5229415A (en)	1992-03-24	1992-03-24	Alkylthio alkyl avermectins are active antiparasitic agents

Publications (1)

Publication Number	Publication Date
ATE173738T1 true ATE173738T1 (de)	1998-12-15

Family

ID=25325031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93907512T ATE173738T1 (de)	1992-03-24	1993-03-16	Alkylthioalkylavermectine sind aktive antiparasitäre wirkstoffe

Country Status (9)

Country	Link
US (1)	US5229415A (de)
EP (1)	EP0632725B1 (de)
JP (1)	JP3135918B2 (de)
AT (1)	ATE173738T1 (de)
AU (1)	AU669358B2 (de)
CA (1)	CA2132429C (de)
DE (1)	DE69322265T2 (de)
WO (1)	WO1993018778A1 (de)
ZA (1)	ZA932048B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5691320A (en)	1987-10-28	1997-11-25	Pro-Neuron, Inc.	Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis
GB9205007D0 (en) *	1992-03-07	1992-04-22	Pfizer Ltd	Antiparasitic agents
US5229416A (en) *	1992-04-29	1993-07-20	Merck & Co., Inc.	Avermectin difluoro derivatives
SI9420059A (en) *	1993-10-05	1997-02-28	Pfizer	Process and antiparasitic intermediates for doramectin
GB9402916D0 (en)	1994-02-16	1994-04-06	Pfizer Ltd	Antiparasitic agents
SE521031C2 (sv)	1999-05-05	2003-09-23	Srinivas Uppugunduri	Nya specifika inhibitorer av akut och kronisk inflammation
WO2002012248A1 (en) *	2000-08-09	2002-02-14	The Kitasato Institute	Avermectin derivatives
JPWO2002012261A1 (ja) *	2000-08-09	2004-01-15	社団法人北里研究所	エバーメクチン誘導体
EG23124A (en) *	2001-02-27	2004-04-28	Syngenta Participations Ag	Avermectins substituted in the 4-position having pesticidal properties
CR6574A (es) *	2001-02-27	2004-10-28	Syngenta Participations Ag	Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
AR036486A1 (es) *	2001-08-28	2004-09-15	Syngenta Participations Ag	Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion
AR040073A1 (es) *	2002-05-07	2005-03-16	Syngenta Participations Ag	Derivados de 4''-desoxi-4''-(s)-amido avermectina y su uso como plaguicidas
GB0302308D0 (en) *	2003-01-31	2003-03-05	Syngenta Participations Ag	Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties
GB0302310D0 (en) *	2003-01-31	2003-03-05	Syngenta Participations Ag	Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties
GB0302309D0 (en) *	2003-01-31	2003-03-05	Syngenta Participations Ag	Avermectin monosaccharide derivatives substituted in the 4 -position having pesticidal properties
GB0302547D0 (en) *	2003-02-04	2003-03-12	Syngenta Participations Ag	Avermectins and avermectin monosaccharide substituted in the 4'- and 4" position having pesticidal properties
GB0320176D0 (en) *	2003-08-28	2003-10-01	Syngenta Participations Ag	Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties
DE102007007750A1 (de) *	2006-08-17	2008-02-21	Bayer Cropscience Ag	Avermectinderivate
EP2274617A4 (de)	2008-04-10	2011-11-09	Massachusetts Inst Technology	Verfahren zur erkennung und verwendung von auf krebsstammzellen abzielenden mitteln
US10106778B2 (en)	2012-11-08	2018-10-23	Whitehead Institute For Biomedical Research	Selective targeting of cancer stem cells
WO2015168255A1 (en)	2014-04-29	2015-11-05	Whitehead Institute For Biomedical Research	Methods and compositions for targeting cancer stem cells

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE434277B (sv) *	1976-04-19	1984-07-16	Merck & Co Inc	Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4201861A (en) *	1977-10-03	1980-05-06	Merck & Co., Inc.	Acyl derivatives of C-076 compounds
US4199569A (en) *	1977-10-03	1980-04-22	Merck & Co., Inc.	Selective hydrogenation products of C-076 compounds and derivatives thereof
US4200581A (en) *	1978-08-04	1980-04-29	Merck & Co., Inc.	Alkyl derivatives of C-076 compounds
US4289760A (en) *	1980-05-02	1981-09-15	Merck & Co., Inc.	23-Keto derivatives of C-076 compounds
US4427663A (en) *	1982-03-16	1984-01-24	Merck & Co., Inc.	4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
PL152148B1 (en) *	1984-09-14	1990-11-30	Glaxo Group Ltd	Antibiotic compounds and their preparation
US4587247A (en) *	1985-02-25	1986-05-06	Merck & Co., Inc.	Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use
ATE75745T1 (de) *	1986-07-02	1992-05-15	Ciba Geigy Ag	Pestizide.
US4897416A (en) *	1987-02-18	1990-01-30	Ciba-Geigy Corporation	Insecticides and parasiticides
GB8714413D0 (en) *	1987-06-19	1987-07-22	Erba Farmitalia	6-substituted penem esters
US4895837A (en) *	1988-01-29	1990-01-23	Merck & Co., Inc.	Avermectin derivatives
US4906619A (en) *	1988-07-22	1990-03-06	Merck & Co., Inc.	Alkyl avermectin derivatives
US5208222A (en) *	1991-03-28	1993-05-04	Merck & Co., Inc.	4"-and 4'-alkylthio avermectin derivatives
US5262400A (en) *	1991-06-20	1993-11-16	Merck & Co., Inc.	4α-substituted avermectin derivatives
EP0530901A1 (de) *	1991-09-04	1993-03-10	Merck & Co. Inc.	13-Beta-O-Methoxymethyl-22,23-Dihydro Avermectin B1A/B1B Aglykone

1992
- 1992-03-24 US US07/857,035 patent/US5229415A/en not_active Expired - Lifetime
1993
- 1993-03-16 WO PCT/US1993/002362 patent/WO1993018778A1/en not_active Ceased
- 1993-03-16 CA CA002132429A patent/CA2132429C/en not_active Expired - Lifetime
- 1993-03-16 EP EP93907512A patent/EP0632725B1/de not_active Expired - Lifetime
- 1993-03-16 JP JP05516659A patent/JP3135918B2/ja not_active Expired - Lifetime
- 1993-03-16 AU AU38092/93A patent/AU669358B2/en not_active Expired
- 1993-03-16 DE DE69322265T patent/DE69322265T2/de not_active Expired - Lifetime
- 1993-03-16 AT AT93907512T patent/ATE173738T1/de not_active IP Right Cessation
- 1993-03-23 ZA ZA932048A patent/ZA932048B/xx unknown

Also Published As

Publication number	Publication date
DE69322265T2 (de)	1999-06-24
JPH07505363A (ja)	1995-06-15
WO1993018778A1 (en)	1993-09-30
CA2132429A1 (en)	1993-09-30
JP3135918B2 (ja)	2001-02-19
EP0632725A4 (de)	1997-03-19
US5229415A (en)	1993-07-20
CA2132429C (en)	2003-05-20
ZA932048B (en)	1993-10-19
EP0632725B1 (de)	1998-11-25
EP0632725A1 (de)	1995-01-11
AU669358B2 (en)	1996-06-06
DE69322265D1 (en)	1999-01-07
AU3809293A (en)	1993-10-21

Legal Events

Date	Code	Title	Description
1999-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE173738T1 (de)	1998-12-15	Alkylthioalkylavermectine sind aktive antiparasitäre wirkstoffe
DE69008399D1 (de)	1994-06-01	Avermectin-Ketal-Derivate, die als Antiparasitenmittel geeignet sind.
SE8802985D0 (sv)	1988-08-25	Kemiska foreningar och forfarande for deras framstellning
BG103673A (en)	2000-02-29	3'-n-oxide, 3'-n-dimethylamine, 9-oxime derivatives of erythromycin a
AU650143B2 (en)	1994-06-09	4a-substituted avermectin derivatives
NZ335825A (en)	2001-01-26	Use of azithromycin for treating atherosclerosis
ES2164660T3 (es)	2002-03-01	Derivados difluoro de avermectina.
ES2157221T3 (es)	2001-08-16	Composiciones metaloporfirinicas.
ES2152947T3 (es)	2001-02-16	Una cepa de streptomyces avermitilis y compuestos de avermectina glicosilados.
ES500197A0 (es)	1982-01-16	Procedimiento para la preparacion de derivados de oligorri- bosido de acido homocitrico
EP0335369A3 (de)	1990-03-28	Anthracyclin-Derivate und Verfahren zu deren Herstellung
SE8503877L (sv)	1986-02-25	Antracyklinglykosider
GB2158436B (en)	1987-08-05	Pyrano derivatives
EA200000025A1 (ru)	2000-08-28	13-дигидро-3'-азиридиноантрациклины
CA2053346A1 (en)	1992-04-16	Microcapsule compositions for torical treatment
IL125652A0 (en)	1999-04-11	Process for the glycosylation of 4,5-epoxymorphinanes using thioglycosides as glycoside donors