DK0983264T3 - Fremgangsmåde til fremstilling af sertindol - Google Patents
Fremgangsmåde til fremstilling af sertindolInfo
- Publication number
- DK0983264T3 DK0983264T3 DK98919090T DK98919090T DK0983264T3 DK 0983264 T3 DK0983264 T3 DK 0983264T3 DK 98919090 T DK98919090 T DK 98919090T DK 98919090 T DK98919090 T DK 98919090T DK 0983264 T3 DK0983264 T3 DK 0983264T3
- Authority
- DK
- Denmark
- Prior art keywords
- sertindole
- preparation
- fluorophenyl
- indole
- chloro
- Prior art date
Links
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N sertindole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C2CCN(CCN3C(NCC3)=O)CC2)=C1 GZKLJWGUPQBVJQ-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000652 sertindole Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- VRJHQPZVIGNGMX-UHFFFAOYSA-N 4-piperidinone Chemical compound O=C1CCNCC1 VRJHQPZVIGNGMX-UHFFFAOYSA-N 0.000 abstract 2
- YGSFFDHIYYOVHV-UHFFFAOYSA-N 1-(2-chloroethyl)imidazolidin-2-one Chemical compound ClCCN1CCNC1=O YGSFFDHIYYOVHV-UHFFFAOYSA-N 0.000 abstract 1
- WLQZFXJVVNNEJU-UHFFFAOYSA-N 5-chloro-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)indole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C=2CCNCC=2)=C1 WLQZFXJVVNNEJU-UHFFFAOYSA-N 0.000 abstract 1
- JYEKQDWSLSXYTJ-UHFFFAOYSA-N 5-chloro-1-(4-fluorophenyl)indole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C=C1 JYEKQDWSLSXYTJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4601197P | 1997-05-09 | 1997-05-09 | |
| DK53697 | 1997-05-09 | ||
| EP98919090A EP0983264B1 (en) | 1997-05-09 | 1998-05-07 | Method of manufacturing sertindole |
| PCT/DK1998/000183 WO1998051685A1 (en) | 1997-05-09 | 1998-05-07 | Method of manufacturing sertindole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0983264T3 true DK0983264T3 (da) | 2004-06-14 |
Family
ID=26064179
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98919090T DK0983264T3 (da) | 1997-05-09 | 1998-05-07 | Fremgangsmåde til fremstilling af sertindol |
| DK02018748T DK1260511T3 (da) | 1997-05-09 | 1998-05-07 | Fremgangsmåde til fremstilling af sertindol |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02018748T DK1260511T3 (da) | 1997-05-09 | 1998-05-07 | Fremgangsmåde til fremstilling af sertindol |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6335463B1 (da) |
| EP (2) | EP0983264B1 (da) |
| JP (1) | JP2002515904A (da) |
| KR (2) | KR100627616B1 (da) |
| CN (2) | CN1301963C (da) |
| AT (2) | ATE286047T1 (da) |
| AU (1) | AU731835B2 (da) |
| BG (1) | BG64007B1 (da) |
| BR (1) | BR9808740A (da) |
| CA (1) | CA2288334C (da) |
| CZ (2) | CZ298509B6 (da) |
| DE (2) | DE69828454T2 (da) |
| DK (2) | DK0983264T3 (da) |
| EA (1) | EA003248B1 (da) |
| ES (2) | ES2213897T3 (da) |
| HU (1) | HU226858B1 (da) |
| IL (1) | IL132461A (da) |
| IS (2) | IS2158B (da) |
| NO (2) | NO325918B1 (da) |
| NZ (1) | NZ500700A (da) |
| PL (1) | PL191174B1 (da) |
| PT (2) | PT1260511E (da) |
| SI (2) | SI1260511T1 (da) |
| SK (2) | SK285410B6 (da) |
| TR (2) | TR199902759T2 (da) |
| UA (1) | UA61105C2 (da) |
| WO (1) | WO1998051685A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6489341B1 (en) | 1999-06-02 | 2002-12-03 | Sepracor Inc. | Methods for the treatment of neuroleptic and related disorders using sertindole derivatives |
| AR039116A1 (es) * | 2002-03-27 | 2005-02-09 | Lundbeck & Co As H | Metodo para la manufactura de sertindol |
| AU2003256970A1 (en) * | 2002-08-02 | 2004-02-23 | Rhodia Pharma Solutions Inc. | Copper catalyzed arylation |
| KR20070026396A (ko) * | 2004-01-30 | 2007-03-08 | 베이징 투올린 메디슨 사이언스 앤드 테크놀로지 컴파니 리미티드 | 마라스미우스 안드로사세우스 Ｌ．ｅｓ Ｆｒ 추출물,피페리돈 유도체 및 항고혈압제로서의 그 용도 |
| KR100683274B1 (ko) * | 2004-02-12 | 2007-02-15 | 에스케이케미칼주식회사 | 치환된 벤조피란 화합물의 제조방법 |
| US20070212412A1 (en) * | 2005-09-08 | 2007-09-13 | H. Lundbeck A/S | Stable solid formulation of sertindole |
| TW200821296A (en) * | 2006-06-01 | 2008-05-16 | Lundbeck & Co As H | Use of sertindole for the preventive treatment of suicidal behaviour |
| CN101362748B (zh) * | 2008-09-23 | 2012-09-05 | 上海医药工业研究院 | 一种制备舍吲哚的方法 |
| CN101362704B (zh) * | 2008-09-23 | 2012-04-18 | 上海医药工业研究院 | N-(4-氟苯基)-n-(2-羧基-4-氯苯基)甘氨酸的制备方法 |
| CN101591330B (zh) * | 2009-06-29 | 2013-03-06 | 上海医药工业研究院 | 舍吲哚晶型及其制备方法 |
| CN101899036B (zh) * | 2010-07-22 | 2012-12-19 | 郑州大学 | 以烷基咪唑型离子液体为溶剂制备舍吲哚的方法 |
| CN103214463A (zh) * | 2013-03-30 | 2013-07-24 | 北京德众万全药物技术开发有限公司 | 一种新的舍吲哚制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3131527A1 (de) * | 1981-08-08 | 1983-02-24 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| IT1271352B (it) * | 1993-04-08 | 1997-05-27 | Boehringer Ingelheim Italia | Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale |
| DE19532054A1 (de) * | 1995-08-31 | 1997-03-06 | Hoechst Ag | Verfahren zur Herstellung von N-Carboxymethylen-4-chlor-anthranilsäure, sowie deren Dialkylestern |
-
1998
- 1998-05-07 SK SK54-2006A patent/SK285410B6/sk not_active IP Right Cessation
- 1998-05-07 NZ NZ500700A patent/NZ500700A/xx not_active IP Right Cessation
- 1998-05-07 TR TR1999/02759T patent/TR199902759T2/xx unknown
- 1998-05-07 TR TR2000/03421T patent/TR200003421T2/xx unknown
- 1998-05-07 CN CNB2003101046201A patent/CN1301963C/zh not_active Expired - Fee Related
- 1998-05-07 CZ CZ0396099A patent/CZ298509B6/cs not_active IP Right Cessation
- 1998-05-07 DK DK98919090T patent/DK0983264T3/da active
- 1998-05-07 CZ CZ20050518A patent/CZ299015B6/cs not_active IP Right Cessation
- 1998-05-07 ES ES98919090T patent/ES2213897T3/es not_active Expired - Lifetime
- 1998-05-07 JP JP54871198A patent/JP2002515904A/ja not_active Ceased
- 1998-05-07 EP EP98919090A patent/EP0983264B1/en not_active Expired - Lifetime
- 1998-05-07 CA CA002288334A patent/CA2288334C/en not_active Expired - Fee Related
- 1998-05-07 AT AT02018748T patent/ATE286047T1/de active
- 1998-05-07 DE DE69828454T patent/DE69828454T2/de not_active Expired - Lifetime
- 1998-05-07 DK DK02018748T patent/DK1260511T3/da active
- 1998-05-07 WO PCT/DK1998/000183 patent/WO1998051685A1/en not_active Ceased
- 1998-05-07 SK SK1527-99A patent/SK285221B6/sk not_active IP Right Cessation
- 1998-05-07 SI SI9830747T patent/SI1260511T1/xx unknown
- 1998-05-07 AT AT98919090T patent/ATE258929T1/de active
- 1998-05-07 EP EP02018748A patent/EP1260511B1/en not_active Expired - Lifetime
- 1998-05-07 DE DE69821477T patent/DE69821477T2/de not_active Expired - Lifetime
- 1998-05-07 PT PT02018748T patent/PT1260511E/pt unknown
- 1998-05-07 SI SI9830608T patent/SI0983264T1/xx unknown
- 1998-05-07 CN CNB988048353A patent/CN1243001C/zh not_active Expired - Fee Related
- 1998-05-07 AU AU72062/98A patent/AU731835B2/en not_active Ceased
- 1998-05-07 KR KR1020057015729A patent/KR100627616B1/ko not_active Expired - Fee Related
- 1998-05-07 HU HU0003365A patent/HU226858B1/hu not_active IP Right Cessation
- 1998-05-07 KR KR1019997010319A patent/KR100546477B1/ko not_active Expired - Fee Related
- 1998-05-07 ES ES02018748T patent/ES2234961T3/es not_active Expired - Lifetime
- 1998-05-07 BR BR9808740-1A patent/BR9808740A/pt not_active Application Discontinuation
- 1998-05-07 PT PT98919090T patent/PT983264E/pt unknown
- 1998-05-07 US US09/423,096 patent/US6335463B1/en not_active Expired - Fee Related
- 1998-05-07 PL PL336578A patent/PL191174B1/pl not_active IP Right Cessation
- 1998-05-07 IL IL13246198A patent/IL132461A/xx not_active IP Right Cessation
- 1998-05-07 EA EA199901021A patent/EA003248B1/ru not_active IP Right Cessation
- 1998-07-05 UA UA99116293A patent/UA61105C2/uk unknown
-
1999
- 1999-10-19 IS IS5222A patent/IS2158B/is unknown
- 1999-11-04 BG BG103857A patent/BG64007B1/bg unknown
- 1999-11-08 NO NO19995457A patent/NO325918B1/no not_active IP Right Cessation
-
2006
- 2006-05-15 IS IS8468A patent/IS2324B/is unknown
-
2007
- 2007-12-03 NO NO20076208A patent/NO331924B1/no not_active IP Right Cessation
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