DK0988304T3 - Nukleosidanaloger såsom antivirale midler omfattende inhibitorer af retroviral revers transkriptase og DNA-polymerasen fra hepatitis B-virus (HBV) - Google Patents

Nukleosidanaloger såsom antivirale midler omfattende inhibitorer af retroviral revers transkriptase og DNA-polymerasen fra hepatitis B-virus (HBV)

Info

Publication number: DK0988304T3
Authority: DK; Denmark
Prior art keywords: antivirals; hbv; hepatitis; virus; inhibitors
Prior art date: 1997-08-15

Application number

DK98939041T

Other languages

Danish (da)

English (en)

Inventor

Xiao-Xiong Zhou

Nils-Gunnar Johansson

Horst Waehling

Original Assignee

Medivir Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-15

Filing date

1998-08-14

Publication date

2001-08-20

1997-08-15 Priority claimed from SE9702957A external-priority patent/SE9702957D0/xx

1997-11-12 Priority claimed from SE9704147A external-priority patent/SE9704147D0/xx

1998-02-13 Priority claimed from SE9800452A external-priority patent/SE9800452D0/xx

1998-08-14 Application filed by Medivir Ab filed Critical Medivir Ab

2001-08-20 Application granted granted Critical

2001-08-20 Publication of DK0988304T3 publication Critical patent/DK0988304T3/da

Links

229940127073 nucleoside analogue Drugs 0.000 title abstract 2
108010014303 DNA-directed DNA polymerase Proteins 0.000 title 1
102000016928 DNA-directed DNA polymerase Human genes 0.000 title 1
241000700721 Hepatitis B virus Species 0.000 title 1
102100034343 Integrase Human genes 0.000 title 1
108010092799 RNA-directed DNA polymerase Proteins 0.000 title 1
239000003443 antiviral agent Substances 0.000 title 1
229940121357 antivirals Drugs 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
230000001177 retroviral effect Effects 0.000 title 1
-1 hydroxy, amino Chemical group 0.000 abstract 3
125000005647 linker group Chemical group 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical class CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
150000001408 amides Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
150000004665 fatty acids Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Gastroenterology & Hepatology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)

DK98939041T 1997-08-15 1998-08-14 Nukleosidanaloger såsom antivirale midler omfattende inhibitorer af retroviral revers transkriptase og DNA-polymerasen fra hepatitis B-virus (HBV) DK0988304T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
SE9702957A SE9702957D0 (sv)	1997-08-15	1997-08-15	Antivirals
SE9704147A SE9704147D0 (sv)	1997-11-12	1997-11-12	Nucleosides
SE9800452A SE9800452D0 (sv)	1998-02-13	1998-02-13	Antivirals
PCT/SE1998/001467 WO1999009031A1 (en)	1997-08-15	1998-08-14	Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the dna polymerase of hepatitis b virus (hbv)

Publications (1)

Publication Number	Publication Date
DK0988304T3 true DK0988304T3 (da)	2001-08-20

Family

ID=27355886

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98939041T DK0988304T3 (da)	1997-08-15	1998-08-14	Nukleosidanaloger såsom antivirale midler omfattende inhibitorer af retroviral revers transkriptase og DNA-polymerasen fra hepatitis B-virus (HBV)

Country Status (23)

Country	Link
EP (2)	EP0988304B1 (cs)
JP (1)	JP3844654B2 (cs)
KR (1)	KR100529272B1 (cs)
CN (2)	CN1130362C (cs)
AT (2)	ATE293112T1 (cs)
AU (1)	AU728892B2 (cs)
CA (1)	CA2298704C (cs)
CZ (1)	CZ300757B6 (cs)
DE (3)	DE69800753D1 (cs)
DK (1)	DK0988304T3 (cs)
ES (2)	ES2158689T3 (cs)
GR (1)	GR3036004T3 (cs)
HU (1)	HU228060B1 (cs)
IL (2)	IL134503A0 (cs)
MY (1)	MY116269A (cs)
NZ (1)	NZ502837A (cs)
PL (1)	PL338643A1 (cs)
PT (1)	PT988304E (cs)
SG (1)	SG96604A1 (cs)
SI (1)	SI0988304T1 (cs)
TR (2)	TR200002273T2 (cs)
TW (1)	TW580500B (cs)
WO (1)	WO1999009031A1 (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458772B1 (en) *	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
FR2794752A1 (fr) *	1999-06-11	2000-12-15	Laphal Sa Lab	Nouveaux composes derives de nucleosides, leurs procedes de preparation, et les compositions pharmaceutiques en renfermant
FR2796384A1 (fr) *	1999-07-12	2001-01-19	Laphal Sa Lab	Nouveaux esters derives de nucleosides, leurs procedes de preparation et les compositions pharmaceutiques en renfermant
MY141789A (en)	2001-01-19	2010-06-30	Lg Chem Investment Ltd	Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
AUPS037002A0 (en) *	2002-02-07	2002-02-28	Melbourne Health	Viral variants and uses therefor
EP1610797A1 (en) *	2003-03-27	2006-01-04	Boehringer Ingelheim International GmbH	Antiviral combination of nevirapine and a further antiretroviral compound
WO2004087139A1 (en) *	2003-03-27	2004-10-14	Boehringer Ingelheim International Gmbh	Antiviral combination of tipranavir and a further antiretroviral compound
EP1610782A1 (en) *	2003-03-27	2006-01-04	Boehringer Ingelheim International GmbH	Antiviral combination of a dipyridodiazepinone and a further antiretroviral compound
GB0400290D0 (en)	2004-01-08	2004-02-11	Medivir Ab	dUTPase inhibitors
GB0513835D0 (en)	2005-07-07	2005-08-10	Medivir Ab	HIV inhibitors
KR20140007443A (ko) *	2011-02-21	2014-01-17	메디비르 아베	Ｆｌｇ의 합성
CN113061089A (zh) *	2015-09-23	2021-07-02	凯瑞康宁生物工程（武汉）有限公司	γ-羟基丁酸的前药及其组合物和用途
EP4045504A1 (en) *	2019-10-17	2022-08-24	Ai-biopharma	Anti-viral and hepatic-targeted drugs
CN114686188B (zh) *	2020-12-31	2023-05-02	中石化石油工程技术服务有限公司	一种核苷磷脂钻井液润滑剂及其制备方法
CN117624115A (zh) *	2022-08-19	2024-03-01	张家港市国泰华荣化工新材料有限公司	一种新型硫酸酯及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8602981D0 (sv) *	1986-07-04	1986-07-04	Astra Laekemedel Ab	Novel medicinal use
GB8719367D0 (en) *	1987-08-15	1987-09-23	Wellcome Found	Therapeutic compounds
JP2894610B2 (ja) *	1987-10-28	1999-05-24	プロ−ニューロン，インコーポレーテッド	アシル化ウリジンおよびシチジンならびにその使用
DE68922903T2 (de) *	1988-12-19	1995-11-23	Wellcome Found	Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
IL100874A (en) *	1991-02-08	1996-01-19	Pro Neuron Inc	Oxypurine nucleosides and related compounds for use as medicaments their preparation and pharmaceutical compositions containing them
DE4311801A1 (de) *	1993-04-09	1994-10-13	Hoechst Ag	Neue Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung
PE32296A1 (es) *	1994-07-28	1996-08-07	Hoffmann La Roche	Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
AU1592897A (en) *	1996-01-26	1997-08-20	F. Hoffmann-La Roche Ag	Process for preparing purine derivatives
US5869493A (en) *	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
JP2001503767A (ja) *	1996-11-12	2001-03-21	メディヴィル・アクチボラグ	ヌクレオシド

1998
- 1998-08-14 EP EP98939041A patent/EP0988304B1/en not_active Expired - Lifetime
- 1998-08-14 JP JP2000509711A patent/JP3844654B2/ja not_active Expired - Fee Related
- 1998-08-14 MY MYPI98003706A patent/MY116269A/en unknown
- 1998-08-14 PT PT98939041T patent/PT988304E/pt unknown
- 1998-08-14 SG SG200101048A patent/SG96604A1/en unknown
- 1998-08-14 TR TR2000/02273T patent/TR200002273T2/xx unknown
- 1998-08-14 CN CN98810219A patent/CN1130362C/zh not_active Expired - Fee Related
- 1998-08-14 AT AT01103370T patent/ATE293112T1/de not_active IP Right Cessation
- 1998-08-14 ES ES98939041T patent/ES2158689T3/es not_active Expired - Lifetime
- 1998-08-14 ES ES01103370T patent/ES2239637T3/es not_active Expired - Lifetime
- 1998-08-14 KR KR10-2000-7001476A patent/KR100529272B1/ko not_active Expired - Fee Related
- 1998-08-14 AU AU87548/98A patent/AU728892B2/en not_active Ceased
- 1998-08-14 DE DE69800753A patent/DE69800753D1/de not_active Expired - Lifetime
- 1998-08-14 CZ CZ20000449A patent/CZ300757B6/cs not_active IP Right Cessation
- 1998-08-14 HU HU0100087A patent/HU228060B1/hu not_active IP Right Cessation
- 1998-08-14 IL IL13450398A patent/IL134503A0/xx unknown
- 1998-08-14 AT AT98939041T patent/ATE200900T1/de active
- 1998-08-14 CN CNB031579884A patent/CN1286845C/zh not_active Expired - Fee Related
- 1998-08-14 DE DE69829784T patent/DE69829784T2/de not_active Expired - Lifetime
- 1998-08-14 EP EP01103370A patent/EP1123935B1/en not_active Expired - Lifetime
- 1998-08-14 SI SI9830031T patent/SI0988304T1/xx unknown
- 1998-08-14 WO PCT/SE1998/001467 patent/WO1999009031A1/en not_active Ceased
- 1998-08-14 DK DK98939041T patent/DK0988304T3/da active
- 1998-08-14 TR TR2000/00398T patent/TR200000398T2/xx unknown
- 1998-08-14 TW TW087113427A patent/TW580500B/zh not_active IP Right Cessation
- 1998-08-14 NZ NZ502837A patent/NZ502837A/xx not_active IP Right Cessation
- 1998-08-14 CA CA002298704A patent/CA2298704C/en not_active Expired - Lifetime
- 1998-08-14 PL PL98338643A patent/PL338643A1/xx unknown
- 1998-08-14 DE DE69800753T patent/DE69800753T4/de not_active Expired - Lifetime
2000
- 2000-02-10 IL IL134503A patent/IL134503A/en not_active IP Right Cessation
2001
- 2001-06-06 GR GR20010400857T patent/GR3036004T3/el unknown

Also Published As

Publication number	Publication date
ES2158689T3 (es)	2001-09-01
DE69829784D1 (de)	2005-05-19
SG96604A1 (en)	2003-06-16
ES2239637T3 (es)	2005-10-01
DE69829784T2 (de)	2006-02-16
PL338643A1 (en)	2000-11-06
NZ502837A (en)	2001-01-26
TR200000398T2 (tr)	2000-07-21
AU8754898A (en)	1999-03-08
CZ2000449A3 (cs)	2000-08-16
EP1123935B1 (en)	2005-04-13
ATE293112T1 (de)	2005-04-15
HUP0100087A3 (en)	2003-01-28
CA2298704A1 (en)	1999-02-25
CA2298704C (en)	2006-07-11
HK1032968A1 (en)	2001-08-10
EP1123935A3 (en)	2001-09-05
WO1999009031A1 (en)	1999-02-25
EP0988304B1 (en)	2001-05-02
KR100529272B1 (ko)	2005-11-17
PT988304E (pt)	2001-10-31
TW580500B (en)	2004-03-21
DE69800753T2 (de)	2001-10-25
DE69800753D1 (de)	2001-06-07
IL134503A0 (en)	2001-04-30
KR20010022873A (ko)	2001-03-26
CN1275983A (zh)	2000-12-06
JP3844654B2 (ja)	2006-11-15
GR3036004T3 (en)	2001-09-28
CN1130362C (zh)	2003-12-10
TR200002273T2 (tr)	2002-06-21
EP0988304A1 (en)	2000-03-29
DE69800753T4 (de)	2002-02-21
MY116269A (en)	2003-12-31
ATE200900T1 (de)	2001-05-15
HU228060B1 (en)	2012-09-28
HUP0100087A1 (hu)	2002-01-28
AU728892B2 (en)	2001-01-18
HK1097550A1 (zh)	2007-06-29
CN1500800A (zh)	2004-06-02
JP2001515079A (ja)	2001-09-18
SI0988304T1 (en)	2001-08-31
CZ300757B6 (cs)	2009-08-05
IL134503A (en)	2010-06-30
EP1123935A2 (en)	2001-08-16
CN1286845C (zh)	2006-11-29

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