NO20084343L - Fremgangsmate for fremstilling av 6-(4-fenylbutoksy)heksylaminderivater - Google Patents
Fremgangsmate for fremstilling av 6-(4-fenylbutoksy)heksylaminderivaterInfo
- Publication number
- NO20084343L NO20084343L NO20084343A NO20084343A NO20084343L NO 20084343 L NO20084343 L NO 20084343L NO 20084343 A NO20084343 A NO 20084343A NO 20084343 A NO20084343 A NO 20084343A NO 20084343 L NO20084343 L NO 20084343L
- Authority
- NO
- Norway
- Prior art keywords
- phenylbutoxy
- preparation
- hexylamine
- derivatives
- benzyl
- Prior art date
Links
- GNSOSZKMHANCMP-UHFFFAOYSA-N 6-(4-phenylbutoxy)hexan-1-amine Chemical class NCCCCCCOCCCCC1=CC=CC=C1 GNSOSZKMHANCMP-UHFFFAOYSA-N 0.000 title abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000000093 1,3-dioxanes Chemical class 0.000 abstract 1
- 125000006091 1,3-dioxolane group Chemical class 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/40—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the same carbon atom of the carbon skeleton, e.g. amino-ketals, ortho esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Foreliggende oppfinnelse omhandler en fremgangsmåte for fremskaffelse av derivater av 6-(4-fenylbutoksy)heksylamin med den generelle formelen (I): (I) der: R, er CHO eller CHOR3OR4, der R3 og R4 uavhengig er metyl, etyl, benzyl, eller de danner enten 1,3-dioksolaner eller 1,3-dioksaner; og R2 er H, benzyl eller tert-butoksykarbonyl, benzyloksykarbonyl, etoksykarbonyl, acetyl, benzoyl eller trifluoracetyl.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009802014A ES2142771B1 (es) | 1998-09-28 | 1998-09-28 | Nuevos derivados de la 6-(4-fenil-butoxi) hexilamina y procedimiento para la obtencion de salmeterol. |
| PCT/ES1999/000294 WO2000018722A2 (es) | 1998-09-28 | 1999-09-20 | Nuevos derivados de la 6-(4-fenilbutoxi)hexilamina y procedimiento para la obtencion de salmeterol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20084343L true NO20084343L (no) | 2001-03-28 |
Family
ID=8305274
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20011197A NO327780B1 (no) | 1998-09-28 | 2001-03-08 | Nye 6-(4-fenylbutoksy)heksylamin derivater og fremgangsmate for fremstilling av salmeterol |
| NO20084343A NO20084343L (no) | 1998-09-28 | 2008-10-16 | Fremgangsmate for fremstilling av 6-(4-fenylbutoksy)heksylaminderivater |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20011197A NO327780B1 (no) | 1998-09-28 | 2001-03-08 | Nye 6-(4-fenylbutoksy)heksylamin derivater og fremgangsmate for fremstilling av salmeterol |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6388134B1 (no) |
| EP (1) | EP1132373B1 (no) |
| JP (1) | JP3786834B2 (no) |
| KR (1) | KR100479256B1 (no) |
| CN (1) | CN1189446C (no) |
| AT (1) | ATE254596T1 (no) |
| AU (1) | AU756042B2 (no) |
| BR (1) | BR9913989A (no) |
| CA (1) | CA2344647C (no) |
| CZ (2) | CZ296901B6 (no) |
| DE (1) | DE69912984D1 (no) |
| EA (1) | EA003397B1 (no) |
| ES (2) | ES2142771B1 (no) |
| HU (1) | HUP0103969A3 (no) |
| IL (1) | IL141991A (no) |
| IS (1) | IS2016B (no) |
| NO (2) | NO327780B1 (no) |
| NZ (1) | NZ511157A (no) |
| OA (1) | OA11660A (no) |
| PL (1) | PL196116B1 (no) |
| PT (1) | PT1132373E (no) |
| SK (1) | SK284366B6 (no) |
| TR (1) | TR200100862T2 (no) |
| WO (1) | WO2000018722A2 (no) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6835857B2 (en) | 2002-03-05 | 2004-12-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene |
| DE10209583B4 (de) * | 2002-03-05 | 2006-01-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von 4-(6-Bromhexyloxy)-butylbenzol |
| CA2838520C (en) | 2005-10-17 | 2017-02-21 | Vinayak G. Gore | Processes for the preparation of salmeterol and its salts |
| ES2288114B1 (es) * | 2006-04-26 | 2008-12-01 | Quimica Sintetica S.A. | Nuevo procedimiento de sintesis de (6-(4-fenilbutoxi)hexil)aminas n-sustituidas y su uso en la sintesis de salmeterol xinafoato. |
| EP2127641A1 (en) | 2008-05-26 | 2009-12-02 | Inke, S.A. | Micronisable form of salmeterol xinafoate |
| CN101712622B (zh) * | 2009-11-10 | 2012-10-03 | 浙江万里学院 | 抗哮喘药物沙美特罗的制备方法 |
| CN103435505A (zh) * | 2013-09-05 | 2013-12-11 | 南京工业大学 | 一种合成(r)-沙美特罗的方法 |
| US9447067B2 (en) | 2014-10-03 | 2016-09-20 | Amphastar Pahmaceuticals, Inc. | Method of preparing intermediate of salmeterol |
| KR20230001708U (ko) | 2022-02-17 | 2023-08-24 | 유기택 | 재접착식 슬림 평면형 액자 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZW6584A1 (en) * | 1983-04-18 | 1985-04-17 | Glaxo Group Ltd | Phenethanolamine derivatives |
| EP0162576B1 (en) * | 1984-04-17 | 1989-07-26 | Glaxo Group Limited | Ethanolamine compounds |
| ES2065269B1 (es) * | 1993-05-11 | 1995-10-01 | S A L V A T Lab Sa | 6-(4-(fenilbutoxi) hexilaminometil-4-hidroxi-a1,a3-bencenodimetanol. procedimiento para la obtencion del mismo y nuevos intermedios utilizados en su preparacion. |
-
1998
- 1998-09-28 ES ES009802014A patent/ES2142771B1/es not_active Expired - Fee Related
-
1999
- 1999-09-20 DE DE69912984T patent/DE69912984D1/de not_active Expired - Lifetime
- 1999-09-20 AU AU59839/99A patent/AU756042B2/en not_active Ceased
- 1999-09-20 IL IL14199199A patent/IL141991A/en not_active IP Right Cessation
- 1999-09-20 EA EA200100391A patent/EA003397B1/ru not_active IP Right Cessation
- 1999-09-20 CZ CZ20010958A patent/CZ296901B6/cs not_active IP Right Cessation
- 1999-09-20 SK SK386-2001A patent/SK284366B6/sk not_active IP Right Cessation
- 1999-09-20 TR TR2001/00862T patent/TR200100862T2/xx unknown
- 1999-09-20 JP JP2000572184A patent/JP3786834B2/ja not_active Expired - Fee Related
- 1999-09-20 CZ CZ20033118A patent/CZ296902B6/cs not_active IP Right Cessation
- 1999-09-20 AT AT99969711T patent/ATE254596T1/de not_active IP Right Cessation
- 1999-09-20 NZ NZ511157A patent/NZ511157A/xx not_active IP Right Cessation
- 1999-09-20 EP EP99969711A patent/EP1132373B1/en not_active Expired - Lifetime
- 1999-09-20 CN CNB998114324A patent/CN1189446C/zh not_active Expired - Fee Related
- 1999-09-20 PT PT99969711T patent/PT1132373E/pt unknown
- 1999-09-20 HU HU0103969A patent/HUP0103969A3/hu unknown
- 1999-09-20 OA OA1200100079A patent/OA11660A/en unknown
- 1999-09-20 KR KR10-2001-7003977A patent/KR100479256B1/ko not_active Expired - Fee Related
- 1999-09-20 BR BR9913989-8A patent/BR9913989A/pt not_active Application Discontinuation
- 1999-09-20 CA CA002344647A patent/CA2344647C/en not_active Expired - Fee Related
- 1999-09-20 WO PCT/ES1999/000294 patent/WO2000018722A2/es not_active Ceased
- 1999-09-20 PL PL348572A patent/PL196116B1/pl not_active IP Right Cessation
- 1999-09-20 ES ES99969711T patent/ES2212672T3/es not_active Expired - Lifetime
- 1999-09-20 US US09/806,538 patent/US6388134B1/en not_active Expired - Lifetime
-
2001
- 2001-03-08 IS IS5880A patent/IS2016B/is unknown
- 2001-03-08 NO NO20011197A patent/NO327780B1/no not_active IP Right Cessation
-
2008
- 2008-10-16 NO NO20084343A patent/NO20084343L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |