DK1036202T3 - Fremgangsmåde til identifikation af nucleinsyrer ved matriksassisteret laserdesorptions/ionisationsmassespektrometri - Google Patents

Fremgangsmåde til identifikation af nucleinsyrer ved matriksassisteret laserdesorptions/ionisationsmassespektrometri

Info

Publication number
DK1036202T3
DK1036202T3 DK98966608T DK98966608T DK1036202T3 DK 1036202 T3 DK1036202 T3 DK 1036202T3 DK 98966608 T DK98966608 T DK 98966608T DK 98966608 T DK98966608 T DK 98966608T DK 1036202 T3 DK1036202 T3 DK 1036202T3
Authority
DK
Denmark
Prior art keywords
nucleic acids
mass spectrometry
laser desorption
assisted laser
ionization mass
Prior art date
Application number
DK98966608T
Other languages
English (en)
Inventor
Kurt Berlin
Hans Lehrach
Ivo Glynne Gut
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of DK1036202T3 publication Critical patent/DK1036202T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6872Methods for sequencing involving mass spectrometry
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409Sample holders or containers
    • H01J49/0418Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK98966608T 1997-12-05 1998-12-04 Fremgangsmåde til identifikation af nucleinsyrer ved matriksassisteret laserdesorptions/ionisationsmassespektrometri DK1036202T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97121471 1997-12-05
PCT/EP1998/007911 WO1999029898A2 (de) 1997-12-05 1998-12-04 Verfahren zur identifikation von nucleinsäuren durch matrix-assistierte laser desorptions/ionisations massenspektrometrie

Publications (1)

Publication Number Publication Date
DK1036202T3 true DK1036202T3 (da) 2002-08-12

Family

ID=8227757

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98966608T DK1036202T3 (da) 1997-12-05 1998-12-04 Fremgangsmåde til identifikation af nucleinsyrer ved matriksassisteret laserdesorptions/ionisationsmassespektrometri

Country Status (8)

Country Link
EP (1) EP1036202B1 (da)
JP (1) JP2001526381A (da)
AT (1) ATE217028T1 (da)
CA (1) CA2312052A1 (da)
DE (1) DE59804008D1 (da)
DK (1) DK1036202T3 (da)
ES (1) ES2173670T3 (da)
WO (1) WO1999029898A2 (da)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19938138C2 (de) * 1999-08-16 2003-02-13 November Ag Molekulare Medizin Verfahren und Vorrichtung zur Identifikation einer Biopolymersequenz auf Festkörperoberflächen
DE19957827C2 (de) * 1999-11-25 2003-06-12 Epigenomics Ag Verwendung eines Oligomer-Arrays mit PNA- und/oder DNA-Oligomeren auf einer Oberfläche
EP1274865B1 (en) * 2000-04-06 2007-02-14 Epigenomics AG Diagnosis of diseases associated with apoptosis by means of assessing the methylation status of genes associated with apoptosis
DE10027120A1 (de) * 2000-05-23 2001-12-06 Epigenomics Ag Probenträger für Massenspektrometer
WO2002000926A2 (en) * 2000-06-30 2002-01-03 Epigenomics Ag Diagnosis of diseases associated with signal transduction
DE10054974A1 (de) * 2000-11-06 2002-06-06 Epigenomics Ag Diagnose von mit Cdk4 assoziierten Krankheiten
DE10061338A1 (de) * 2000-12-06 2002-06-20 Epigenomics Ag Diagnose von mit Angiogenese assoziierten Krankheiten
EP1215199A1 (en) * 2000-12-08 2002-06-19 Sony International (Europe) GmbH Linker molecules for selective metallisation of nucleic acids and their uses
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
JP2002372517A (ja) * 2001-05-31 2002-12-26 Inst Of Physical & Chemical Res 質量分析法によるタンパク質の構造解析方法
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
AU2003227544A1 (en) * 2002-03-25 2003-10-08 Epigenomics Ag Method for the analysis of methylation patterns within nucleic acids by means of mass spectrometry
EP1522853A4 (en) * 2002-06-24 2005-10-19 Canon Kk DNA MICROARRAY WITH STANDARD PROBE AND KIT CONTAINING THE MICROARRAY
JP2006516193A (ja) 2002-12-06 2006-06-29 アイシス・ファーマシューティカルス・インコーポレーテッド ヒトおよび動物における病原体の迅速な同定方法
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US7956175B2 (en) 2003-09-11 2011-06-07 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
EP2458619B1 (en) 2004-05-24 2017-08-02 Ibis Biosciences, Inc. Mass spectrometry with selective ion filtration by digital thresholding
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
WO2006135400A2 (en) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Methods for rapid identification of recombinant organisms
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
WO2006094238A2 (en) 2005-03-03 2006-09-08 Isis Pharmaceuticals, Inc. Compositions for use in identification of adventitious viruses
CA2616281C (en) 2005-07-21 2014-04-22 Isis Pharmaceuticals, Inc. Methods for rapid identification and quantitation of mitochondrial dna variants
EP1775348A1 (en) * 2005-10-17 2007-04-18 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method of analyzing nucleic acid with mass spectrometry
US8088582B2 (en) 2006-04-06 2012-01-03 Ibis Biosciences, Inc. Compositions for the use in identification of fungi
JP5420412B2 (ja) 2006-09-14 2014-02-19 アイビス バイオサイエンシズ インコーポレイティッド 病原体の同定のための標的全ゲノム増幅方法
JP4984900B2 (ja) * 2007-01-12 2012-07-25 株式会社島津製作所 ポリマー被覆微粒子を用いる質量分析法
JP5680304B2 (ja) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド 迅速な法医学的dna分析法
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
EP2344893B1 (en) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Microplate handling systems and methods
WO2010033599A2 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, systems, and methods
EP2396803A4 (en) 2009-02-12 2016-10-26 Ibis Biosciences Inc IONIZATION PROBE ASSEMBLIES
WO2010104798A1 (en) 2009-03-08 2010-09-16 Ibis Biosciences, Inc. Bioagent detection methods
WO2010114842A1 (en) 2009-03-30 2010-10-07 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
US9194877B2 (en) 2009-07-17 2015-11-24 Ibis Biosciences, Inc. Systems for bioagent indentification
WO2011014811A1 (en) 2009-07-31 2011-02-03 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
EP2462244B1 (en) 2009-08-06 2016-07-20 Ibis Biosciences, Inc. Non-mass determined base compositions for nucleic acid detection
ES2628739T3 (es) 2009-10-15 2017-08-03 Ibis Biosciences, Inc. Amplificación por desplazamiento múltiple
WO2011115840A2 (en) 2010-03-14 2011-09-22 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
KR20120090473A (ko) * 2011-02-08 2012-08-17 주식회사 아스타 말디 이미징용 매트릭스 용액 및 이를 이용한 생체 분자의 말디 이미징의 측정 방법
NL2022038B1 (en) * 2018-11-21 2020-06-05 Biosparq B V Method for analysing an analyte sample and matrix material therefore

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU645915B2 (en) * 1991-07-23 1994-01-27 F. Hoffmann-La Roche Ag Improvements in the in situ PCR
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
GB9504598D0 (en) * 1995-03-03 1995-04-26 Imp Cancer Res Tech Method of nucleic acid analysis
ATE374836T1 (de) * 1997-01-15 2007-10-15 Xzillion Gmbh & Co Kg Massenmarkierte hybridisierungssonden

Also Published As

Publication number Publication date
ES2173670T3 (es) 2002-10-16
WO1999029898A2 (de) 1999-06-17
ATE217028T1 (de) 2002-05-15
EP1036202B1 (de) 2002-05-02
DE59804008D1 (de) 2002-06-06
WO1999029898A3 (de) 1999-10-28
JP2001526381A (ja) 2001-12-18
CA2312052A1 (en) 1999-06-17
EP1036202A2 (de) 2000-09-20

Similar Documents

Publication Publication Date Title
DK1036202T3 (da) Fremgangsmåde til identifikation af nucleinsyrer ved matriksassisteret laserdesorptions/ionisationsmassespektrometri
DK1159453T3 (da) Fremgangsmåde til direkte nukleinsyresekventering
Wind et al. Spotting and quantification of phosphoproteins purified by gel electrophoresis and laser ablation‐element mass spectrometry with phosphorus‐31 detection
DE69607830D1 (de) Verfahren zur isothermer amplifikation von nukleinsäure molekülen
Smirnov et al. Application of DNA‐binding polymers for preparation of DNA for analysis by matrix‐assisted laser desorption/ionization mass spectrometry
BR9707056B1 (pt) processos e composições para determinar a seqüência de moléculas de ácido nucleico.
ATE66695T1 (de) Verfahren zur erhoehung der empfindlichkeit von nukleinsaeure-hybridisierungstesten.
NZ336769A (en) Method of determining hybridization of a probe to a target nucleic acid
WO2004072228A3 (en) Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
DK1157264T3 (da) Biokemiske oprensningsindretninger med immobiliserede opfangningsprober og anvendelser deraf
ATE485390T1 (de) Multiplex sequenzvariationsanalyse von dna-proben mittels massenspektrometrie
WO2003062462A3 (en) Method for isolating nucleic acids and protein from a single sample
DE69939896D1 (de) Methoden zur detektion von nukleinsäuren unter verwendung von zymogenen und dazugehörige kits
DE602004021185D1 (de) Auf bio-barcodes beruhender nachweis von zielanalyten
DE69937447D1 (de) Verfahren zur erkennung von nukleinsäuren
WO2005123959A3 (en) Multiplexing assays for analyte detection
Huge et al. Capillary electrophoresis coupled with automated fraction collection
ATE280838T1 (de) Verfahren zur identifikation von nucleinsäuren durch elektrospray massenspektrometrie
Harsch et al. Interfacing of CE in a PVP matrix to ion trap mass spectrometry: analysis of isomeric and structurally related (N-acetylamino) fluorene-modified oligonucleotides
Xu et al. Discovered triethylamine as impurity in synthetic DNAs for and by electrochemiluminescence techniques
Wunschel et al. Electrospray ionization Fourier transform ion
JP2000125900A5 (da)
Palm et al. On-column electroextraction and separation of antisense oligonucleotides in human plasma by capillary gel electrophoresis
US7871507B2 (en) Medium for enhanced staining of single strand nucleic acids in electrophoresis
CN101581696A (zh) 毛细管电泳中的连续样品注射