DK0994119T3 - Stereoselektiv fremgangsmåde til fremstilling af 22R-epimeren af budesonid - Google Patents

Stereoselektiv fremgangsmåde til fremstilling af 22R-epimeren af budesonid

Info

Publication number: DK0994119T3
Authority: DK; Denmark
Prior art keywords: budesonide; alpha; epimer; iodo; bromo
Prior art date: 1998-10-13

Application number

DK99120330T

Other languages

Danish (da)

English (en)

Inventor

Loggia Filippo La

Pierfranco Dotti

Original Assignee

Farmabios Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-13

Filing date

1999-10-12

Publication date

2004-08-02

1999-10-12 Application filed by Farmabios Spa filed Critical Farmabios Spa

2004-08-02 Application granted granted Critical

2004-08-02 Publication of DK0994119T3 publication Critical patent/DK0994119T3/da

Links

229960004436 budesonide Drugs 0.000 title abstract 6
230000000707 stereoselective effect Effects 0.000 title abstract 3
VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 abstract 2
HEPIBRLGCSXTQU-JNQJZLCISA-N (1S,2S,4R,8S,9S,11S,12R,13S)-12-bromo-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(Br)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO HEPIBRLGCSXTQU-JNQJZLCISA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229960003662 desonide Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
HGBOYTHUEUWSSQ-UHFFFAOYSA-N valeric aldehyde Natural products CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK99120330T 1998-10-13 1999-10-12 Stereoselektiv fremgangsmåde til fremstilling af 22R-epimeren af budesonid DK0994119T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT1998MI002196A IT1302657B1 (it)	1998-10-13	1998-10-13	Processo stereoselettivo per la preparazione di budesonide nella formadi epimero 22-r.

Publications (1)

Publication Number	Publication Date
DK0994119T3 true DK0994119T3 (da)	2004-08-02

Family

ID=11380860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99120330T DK0994119T3 (da)	1998-10-13	1999-10-12	Stereoselektiv fremgangsmåde til fremstilling af 22R-epimeren af budesonid

Country Status (8)

Country	Link
EP (1)	EP0994119B1 (fr)
JP (1)	JP2000128897A (fr)
AT (1)	ATE263184T1 (fr)
DE (1)	DE69915965T2 (fr)
DK (1)	DK0994119T3 (fr)
ES (1)	ES2218929T3 (fr)
IT (1)	IT1302657B1 (fr)
PT (1)	PT994119E (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0012260D0 (en) *	2000-05-19	2000-07-12	Astrazeneca Ab	Novel composition
EP2262823B1 (fr) *	2008-03-13	2013-01-23	Farmabios S.p.A.	Procédé pour la préparation de dérivés de prégnane
CN111018932B (zh) *	2019-11-28	2021-07-02	奥锐特药业股份有限公司	一种甾体化合物9-位脱卤的方法
IT202000006442A1 (it) *	2020-03-27	2021-09-27	Genetic S P A	Budesonide 21-phosphate salts and pharmaceutical compositions containing the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1196142B (it) *	1984-06-11	1988-11-10	Sicor Spa	Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) *	1986-09-25	1986-09-25	Astra Pharma Prod	A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
FR2675146A1 (fr) *	1991-04-10	1992-10-16	Roussel Uclaf	Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires.
IT1291288B1 (it) *	1997-04-30	1999-01-07	Farmabios Srl	Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.

1998
- 1998-10-13 IT IT1998MI002196A patent/IT1302657B1/it active IP Right Grant
1999
- 1999-10-12 ES ES99120330T patent/ES2218929T3/es not_active Expired - Lifetime
- 1999-10-12 AT AT99120330T patent/ATE263184T1/de not_active IP Right Cessation
- 1999-10-12 DE DE69915965T patent/DE69915965T2/de not_active Expired - Fee Related
- 1999-10-12 DK DK99120330T patent/DK0994119T3/da active
- 1999-10-12 PT PT99120330T patent/PT994119E/pt unknown
- 1999-10-12 EP EP99120330A patent/EP0994119B1/fr not_active Expired - Lifetime
- 1999-10-13 JP JP11291384A patent/JP2000128897A/ja active Pending

Also Published As

Publication number	Publication date
DE69915965T2 (de)	2005-03-17
EP0994119A1 (fr)	2000-04-19
JP2000128897A (ja)	2000-05-09
EP0994119B1 (fr)	2004-03-31
ITMI982196A1 (it)	2000-04-13
IT1302657B1 (it)	2000-09-29
ES2218929T3 (es)	2004-11-16
PT994119E (pt)	2004-08-31
ATE263184T1 (de)	2004-04-15
DE69915965D1 (de)	2004-05-06

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