DK1004586T3 - Fremgangsm de til fremstilling af 2-methylspiro(1,3-Oxathiolan-5,3')quinuclidin - Google Patents

Fremgangsm de til fremstilling af 2-methylspiro(1,3-Oxathiolan-5,3')quinuclidin

Info

Publication number: DK1004586T3
Authority: DK; Denmark
Prior art keywords: methylspiro; oxathiolane; quinuclidine; preparation; msoq
Prior art date: 1994-05-19

Application number

DK99117275T

Other languages

English (en)

Inventor

Koji Hayashi

Sho Tokumoto

Hiroshi Yoshizawa

Tatsuo Isogai

Masaru Kimura

Masahiko Sawaki

Takayoshi Ando

Isamu Katsuyama

Hayato Ariyoshi

Tadashi Nakamura

Original Assignee

Ishihara Sangyo Kaisha

Daiichi Sankyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-19

Filing date

1995-05-19

Publication date

2009-09-07

1995-05-19 Application filed by Ishihara Sangyo Kaisha, Daiichi Sankyo Co Ltd filed Critical Ishihara Sangyo Kaisha

2009-09-07 Application granted granted Critical

2009-09-07 Publication of DK1004586T3 publication Critical patent/DK1004586T3/da

Links

SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 title abstract 2
150000003839 salts Chemical class 0.000 abstract 2
OBEOJOQKVZXCRH-UHFFFAOYSA-N 3-(sulfanylmethyl)-1-azabicyclo[2.2.2]octan-3-ol Chemical compound C1CC2C(O)(CS)CN1CC2 OBEOJOQKVZXCRH-UHFFFAOYSA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
-1 tin halides Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D497/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)

DK99117275T 1994-05-19 1995-05-19 Fremgangsm de til fremstilling af 2-methylspiro(1,3-Oxathiolan-5,3')quinuclidin DK1004586T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP13090794		1994-05-19
JP15287394		1994-06-10
JP25880294		1994-09-27
JP8746195		1995-03-20

Publications (1)

Publication Number	Publication Date
DK1004586T3 true DK1004586T3 (da)	2009-09-07

Family

ID=27467385

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK99117275T DK1004586T3 (da)	1994-05-19	1995-05-19	Fremgangsm de til fremstilling af 2-methylspiro(1,3-Oxathiolan-5,3')quinuclidin
DK95107738T DK0683168T3 (da)	1994-05-19	1995-05-19	Fremgangsmåde til fremstilling af 2-methylspiro(1,3-oxathiolan-5,3')quinuclidin

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK95107738T DK0683168T3 (da)	1994-05-19	1995-05-19	Fremgangsmåde til fremstilling af 2-methylspiro(1,3-oxathiolan-5,3')quinuclidin

Country Status (11)

Country	Link
US (1)	US5571918A (da)
EP (2)	EP0683168B1 (da)
JP (1)	JP2782330B2 (da)
KR (3)	KR100371892B1 (da)
AT (2)	ATE435228T1 (da)
DE (2)	DE69535977D1 (da)
DK (2)	DK1004586T3 (da)
ES (2)	ES2164119T3 (da)
PT (2)	PT683168E (da)
SI (1)	SI0683168T1 (da)
TW (1)	TW394772B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4447685B2 (ja) *	1999-01-14	2010-04-07	第一三共株式会社	皮膚乾燥症治療剤
US8080663B2 (en) *	2007-04-04	2011-12-20	Apotex Pharmachem Inc	Process for the preparation of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine
US8143400B2 (en)	2008-01-10	2012-03-27	Apotex Pharmachem Inc.	Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride
JP5452165B2 (ja) *	2009-10-23	2014-03-26	第一ファインケミカル株式会社	キヌクリジン類の製造法
US8450487B2 (en) *	2010-06-08	2013-05-28	Apicore, Llc	Process for the preparation of cis-2-methylspiro (1,3-oxathiolane 5-3′) quinuclidine
US20180250270A1 (en)	2015-09-11	2018-09-06	Chase Pharmaceuticals Corporation	Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
JP2019052093A (ja) *	2016-02-01	2019-04-04	宇部興産株式会社	２−メチルスピロ（１，３−オキサチオラン−５，３’）キヌクリジン硫酸塩の製造方法
WO2025181811A1 (en) *	2024-02-28	2025-09-04	Kalintis Healthcare Private Limited	Industrial improved process for preparation of cis cevimeline hydrochloride

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4705134A (en)	1985-04-30	1987-11-10	Fuji Jukogyo Kabushiki Kaisha	System for controlling a transfer clutch of a four-wheel drive vehicle
US4855290A (en)	1985-05-10	1989-08-08	State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research	Derivatives of quinuclidine
JP2529576B2 (ja)	1987-07-10	1996-08-28	石原産業株式会社	トランス型２−メチルスピロ（１，３−オキサチオラン−５，３▲’▼）キヌクリジンの異性化方法
JP2529577B2 (ja)	1987-08-13	1996-08-28	石原産業株式会社	トランス型２−メチルスピロ（１，３−オキサチオラン−５，３▲’▼）キヌクリジン又はこれらの酸付加塩の異性化方法
JPH0816111B2 (ja)	1987-07-21	1996-02-21	石原産業株式会社	トランス型２−メチルスピロ（１，３−オキサチオラン−５，３’）キヌクリジン又はこれらの酸付加塩の異性化方法
US4861886A (en) *	1987-07-10	1989-08-29	Ishahara Sangyo Kaisha Ltd	Method for isomerization of trans-form 2-methylspiro (1,3-oxathiolane-5,3')q
IL87234A (en) *	1987-08-13	1992-02-16	Israel Inst Biolog Res	Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them
JPH01290680A (ja) *	1988-05-18	1989-11-22	Ishihara Sangyo Kaisha Ltd	シス型キヌクリジン誘導体の分離方法

1995
- 1995-05-11 US US08/439,576 patent/US5571918A/en not_active Expired - Lifetime
- 1995-05-13 TW TW084104751A patent/TW394772B/zh not_active IP Right Cessation
- 1995-05-18 KR KR1019950012364A patent/KR100371892B1/ko not_active Expired - Lifetime
- 1995-05-19 JP JP7145696A patent/JP2782330B2/ja not_active Expired - Lifetime
- 1995-05-19 EP EP95107738A patent/EP0683168B1/en not_active Expired - Lifetime
- 1995-05-19 DE DE69535977T patent/DE69535977D1/de not_active Expired - Lifetime
- 1995-05-19 EP EP99117275A patent/EP1004586B1/en not_active Expired - Lifetime
- 1995-05-19 DK DK99117275T patent/DK1004586T3/da active
- 1995-05-19 DE DE69522603T patent/DE69522603T2/de not_active Expired - Lifetime
- 1995-05-19 AT AT99117275T patent/ATE435228T1/de active
- 1995-05-19 PT PT95107738T patent/PT683168E/pt unknown
- 1995-05-19 DK DK95107738T patent/DK0683168T3/da active
- 1995-05-19 PT PT99117275T patent/PT1004586E/pt unknown
- 1995-05-19 ES ES95107738T patent/ES2164119T3/es not_active Expired - Lifetime
- 1995-05-19 ES ES99117275T patent/ES2328754T3/es not_active Expired - Lifetime
- 1995-05-19 AT AT95107738T patent/ATE205495T1/de active
- 1995-05-19 SI SI9530467T patent/SI0683168T1/xx unknown
2002
- 2002-10-14 KR KR1020020062524A patent/KR100371894B1/ko not_active Expired - Lifetime
- 2002-10-14 KR KR1020020062520A patent/KR100371893B1/ko not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69522603T2 (de)	2002-04-18
KR950032189A (ko)	1995-12-20
PT1004586E (pt)	2009-07-13
PT683168E (pt)	2001-12-28
KR100371894B1 (ko)	2003-02-12
EP1004586A2 (en)	2000-05-31
SI0683168T1 (en)	2002-02-28
KR100371893B1 (ko)	2003-02-12
TW394772B (en)	2000-06-21
ES2164119T3 (es)	2002-02-16
EP1004586A3 (en)	2001-09-12
KR100371892B1 (ko)	2003-03-19
DE69522603D1 (de)	2001-10-18
DK0683168T3 (da)	2001-12-03
JPH08319287A (ja)	1996-12-03
EP1004586B1 (en)	2009-07-01
ES2328754T3 (es)	2009-11-17
ATE435228T1 (de)	2009-07-15
DE69535977D1 (de)	2009-08-13
EP0683168B1 (en)	2001-09-12
ATE205495T1 (de)	2001-09-15
US5571918A (en)	1996-11-05
EP0683168A1 (en)	1995-11-22
JP2782330B2 (ja)	1998-07-30

Publication	Publication Date	Title
DE68904986D1 (de)	1993-04-01	Verfahren zur herstellung von 1,1,1-trifluor-2,2-dichlorethan.
EP0638599A3 (de)	1995-10-18	Verfahren zur Herstellung von Polyacetalen.
FR2652346B1 (fr)	1991-11-29	Procede de preparation de disilane.
DK146489A (da)	1989-09-25	Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider
KR900700420A (ko)	1990-08-13	2,3-디플루오로벤젠의 제조방법
NO981937L (no)	1998-04-29	FremgangsmÕte for Õ fremstille 1,3-propandiol
DK1004586T3 (da)	2009-09-07	Fremgangsm de til fremstilling af 2-methylspiro(1,3-Oxathiolan-5,3')quinuclidin
NO960510L (no)	1996-08-12	Fremgangsmåte for å fremstille små, diskrete, sfæriske addukter
FI945322L (fi)	1995-05-16	Menetelmä 2',3'-didehydro-2',3'-dideoksinukleosidien laajamittaista valmistusta varten
FI960429L (fi)	1996-01-30	Menetelmä 1,4-butaanidiolin valmistamiseksi
DE3765956D1 (de)	1990-12-13	Verfahren zur herstellung von 1-methyl-3,5,7-triaza-1-azoniatricyclodecan-halogeniden.
DE69023328D1 (de)	1995-12-07	Verfahren zur herstellung von glycin.
DE58903458D1 (de)	1993-03-18	Verfahren zur herstellung von 1,5-dihydroxy- und 1,5 diaminonaphthalin.
DE68906500D1 (de)	1993-06-17	Verfahren zur herstellung von 2,6-dimethylnaphthalin.
DE68902658D1 (de)	1992-10-08	Verfahren zur herstellung von fluoroaromatischen verbindungen.
EP0453948A3 (en)	1992-12-02	Method for producing 1,4-butanediol
FI965228L (fi)	1997-02-26	Menetelmä 1,4-butaanidiolin valmistamiseksi
DE58904175D1 (de)	1993-06-03	Verfahren zur herstellung von 4,4'-dihalogeno-biphenylen.
FR2663941B1 (fr)	1994-09-02	Procede de production d'organosiloxanes.
DE68907180D1 (de)	1993-07-22	Verfahren zur herstellung von 2,3,5-trimethylbenzochinon.
DE58902813D1 (de)	1993-01-07	Verfahren zur herstellung von 4,4-dimethyl-l-(p-chlorphenyl)-pentan-3-on.
DE3789107D1 (de)	1994-03-24	Verfahren mit numerischer steuerung.
DE68907631D1 (de)	1993-08-26	Verfahren zum herstellen von monosilan.
DE3776860D1 (de)	1992-04-02	Verfahren zur herstellung von kleinsten, amorphen metallphosphat-partikeln.
FI911282L (fi)	1991-09-17	Menetelmä uusien terapeuttisesti käyttökelpoisten 3,4-dihydroksi-2,5-dihydrofuranonien valmistamiseksi