DK1005492T3 - Oprensning af von Willebrand-faktor ved kationbytterchromatografi - Google Patents

Oprensning af von Willebrand-faktor ved kationbytterchromatografi

Info

Publication number
DK1005492T3
DK1005492T3 DK98901870T DK98901870T DK1005492T3 DK 1005492 T3 DK1005492 T3 DK 1005492T3 DK 98901870 T DK98901870 T DK 98901870T DK 98901870 T DK98901870 T DK 98901870T DK 1005492 T3 DK1005492 T3 DK 1005492T3
Authority
DK
Denmark
Prior art keywords
purification
cation exchange
exchange chromatography
von willebrand
willebrand factor
Prior art date
Application number
DK98901870T
Other languages
English (en)
Inventor
Bernhard Fischer
Oeyvind L Schoenberger
Artur Mitterer
Christian Fiedler
Friedrich Dorner
Johann Eibl
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Application granted granted Critical
Publication of DK1005492T3 publication Critical patent/DK1005492T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Detergent Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Confectionery (AREA)
DK98901870T 1997-02-27 1998-02-18 Oprensning af von Willebrand-faktor ved kationbytterchromatografi DK1005492T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0033797A AT405403B (de) 1997-02-27 1997-02-27 Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie
PCT/AT1998/000034 WO1998038219A1 (de) 1997-02-27 1998-02-18 Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie

Publications (1)

Publication Number Publication Date
DK1005492T3 true DK1005492T3 (da) 2007-08-13

Family

ID=3487918

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98901870T DK1005492T3 (da) 1997-02-27 1998-02-18 Oprensning af von Willebrand-faktor ved kationbytterchromatografi

Country Status (11)

Country Link
US (1) US6465624B1 (da)
EP (1) EP1005492B1 (da)
JP (1) JP4250770B2 (da)
AT (2) AT405403B (da)
AU (1) AU737986B2 (da)
CA (1) CA2282843C (da)
DE (1) DE59813967D1 (da)
DK (1) DK1005492T3 (da)
ES (1) ES2285754T3 (da)
NO (1) NO324659B1 (da)
WO (1) WO1998038219A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT406373B (de) * 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
US6531577B1 (en) * 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
AT408443B (de) * 1998-02-27 2001-11-26 Immuno Ag Verfahren zur gewinnung von gereinigtem faktor viii:c/vwf-komplex
US6605222B1 (en) * 1998-05-20 2003-08-12 Baxter Aktiengesellschaft Method for producing a factor VIII/von Willebrand factor complex
FR2874216B1 (fr) * 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
EP1789096A4 (en) 2004-09-07 2009-07-08 Archemix Corp APTAMERS FOR THE VON WILLEBRAND FACTOR AND ITS USE AS THERAPEUTICS FOR THROMBOTIC DISEASES
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
KR20070101226A (ko) * 2004-09-07 2007-10-16 아케믹스 코포레이션 앱타머의 약화학
DE102004044429B4 (de) * 2004-09-14 2009-04-30 Biotest Ag Verfahren zur Herstellung einer Zusammensetzung enthaltend von Willebrand Faktor
DE102004044419B4 (de) 2004-09-14 2010-04-15 Biotest Ag Verfahren zur Aufreinigung eines von Willebrand Faktors mittels Hydroxylapatit-Durchlaufchromatographie
CN101163506B (zh) 2004-12-27 2012-09-26 巴克斯特国际公司 聚合物-von Willebrand因子偶联物
AU2007245190B2 (en) 2006-03-31 2011-07-21 Takeda Pharmaceutical Company Limited Pegylated factor VIII
WO2008150495A2 (en) * 2007-06-01 2008-12-11 Archemix Corp. Vwf aptamer formulations and methods for use
SG187410A1 (en) 2007-12-28 2013-02-28 Baxter Int Recombinant vwf formulations
US11197916B2 (en) 2007-12-28 2021-12-14 Takeda Pharmaceutical Company Limited Lyophilized recombinant VWF formulations
EP2349314B1 (en) 2008-10-21 2013-02-27 Baxter International Inc. Lyophilized recombinant vwf formulations
DK2467399T3 (da) * 2009-08-20 2017-01-23 Baxalta Inc Oprensning af vWF til øget fjernelse af non-lipid-kappeklædte vira
SG191186A1 (en) 2010-12-15 2013-07-31 Baxter Int Eluate collection using conductivity gradient
DK3412305T3 (da) * 2011-06-10 2021-03-01 Baxalta GmbH Behandling af koagulationssygdom ved administration af rekombinant vwf
CN106414719B (zh) 2014-06-13 2020-02-14 杰特有限公司 生物反应器中重组von Willebrand因子的改进生产
EP4424366A3 (en) 2017-07-07 2024-12-04 Takeda Pharmaceutical Company Limited Treatment of gastrointestinal bleeding in patients with severe von willebrand disease by administration of recombinant vwf
IL277464B1 (en) 2018-03-21 2026-04-01 Baxalta Inc Separation of VWF and VWF propeptide using chromatographic methods
EA202192140A1 (ru) 2019-02-01 2021-12-15 Такеда Фармасьютикал Компани Лимитед СПОСОБЫ ПРОФИЛАКТИЧЕСКОГО ЛЕЧЕНИЯ РЕКОМБИНАНТНЫМ ФВ (рФВ)
US20230022328A1 (en) 2019-12-10 2023-01-26 Biotest Ag Method for Manufacturing a Fibrinogen Preparation
CN116284337A (zh) * 2023-03-30 2023-06-23 同路生物制药有限公司 以冷沉淀peg沉淀及色谱层析法制备血友病因子的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361509A (en) 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US5006642A (en) 1987-06-29 1991-04-09 Rhone-Poulenc Rorer Pharmaceuticals Inc. Purification of von Willebrand Factor by affinity chromatography
FR2632309B1 (fr) 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
DE3904354A1 (de) 1989-02-14 1990-08-16 Behringwerke Ag Pasteurisiertes, gereinigtes von willebrand-faktor-konzentrat und verfahren zu seiner herstellung
FR2665449B1 (fr) * 1990-08-02 1995-04-14 Aquitaine Developp Transf Sang Procede de fabrication de facteur von willebrand ayant une tres haute purete, depourvu en majeure partie de facteur antihemophilique (fviiic), et facteur von willebrand ainsi obtenu, ainsi qu'une composition pharmaceutique le contenant.
NZ237244A (en) 1990-03-02 1992-10-28 Bio Technology General Corp Cloning and production of human von willebrand factor analogues and compositions thereof
FR2673632A1 (fr) 1991-03-08 1992-09-11 Lille Transfusion Sanguine Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique.
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
IT1256622B (it) * 1992-12-04 1995-12-12 Sclavo Spa Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale.
CA2159044A1 (en) 1994-09-26 1996-03-27 Falko-Guenter Falkner Method of quantitating nucleic acids
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
DE4435392B4 (de) 1994-10-04 2008-02-07 Immuno Ag Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
US5887152A (en) 1995-04-12 1999-03-23 Advanced Micro Devices, Inc. Load/store unit with multiple oldest outstanding instruction pointers for completing store and load/store miss instructions

Also Published As

Publication number Publication date
EP1005492B1 (de) 2007-04-11
US6465624B1 (en) 2002-10-15
CA2282843A1 (en) 1998-09-03
ATA33797A (de) 1998-12-15
AU5847098A (en) 1998-09-18
WO1998038219A1 (de) 1998-09-03
NO994138D0 (no) 1999-08-26
DE59813967D1 (de) 2007-05-24
NO324659B1 (no) 2007-11-26
CA2282843C (en) 2008-12-02
AT405403B (de) 1999-08-25
AU737986B2 (en) 2001-09-06
JP2001513088A (ja) 2001-08-28
ATE359301T1 (de) 2007-05-15
JP4250770B2 (ja) 2009-04-08
EP1005492A1 (de) 2000-06-07
NO994138L (no) 1999-08-26
ES2285754T3 (es) 2007-11-16

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