ES2070855T3 - Metodo para purificar una proteina. - Google Patents

Metodo para purificar una proteina.

Info

Publication number
ES2070855T3
ES2070855T3 ES88309824T ES88309824T ES2070855T3 ES 2070855 T3 ES2070855 T3 ES 2070855T3 ES 88309824 T ES88309824 T ES 88309824T ES 88309824 T ES88309824 T ES 88309824T ES 2070855 T3 ES2070855 T3 ES 2070855T3
Authority
ES
Spain
Prior art keywords
purify
protein
impurities
technique
rsina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88309824T
Other languages
English (en)
Other versions
ES2070855T5 (es
Inventor
David Naveh
John Chu-Tay Tang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22340970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2070855(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of ES2070855T3 publication Critical patent/ES2070855T3/es
Application granted granted Critical
Publication of ES2070855T5 publication Critical patent/ES2070855T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

TECNICA DE CROMATOGRAFIA DE INTERCAMBIO IONICO PARA PURIFICAR PROTEINAS CRUZADAS, QUE CONTIENEN INPUREZAS MUY SIMILARES, EN LA QUE SE DETERMINAN LOS PUNTOS ISOELECTRICOS DE LA PROTEINA DESEADA Y DE LAS INPUREZAS. TAMBIEN SE INCLUYE LA APLICACION DE LA TECNICA A LA PURIFICACION DE GM - CSF USANDO UNA RSINA CAMBIADORA DE CATIONES.
ES88309824T 1987-10-23 1988-10-19 Metodo para purificar una proteina. Expired - Lifetime ES2070855T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11188687A 1987-10-23 1987-10-23
US111886 1987-10-23

Publications (2)

Publication Number Publication Date
ES2070855T3 true ES2070855T3 (es) 1995-06-16
ES2070855T5 ES2070855T5 (es) 2004-03-01

Family

ID=22340970

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88309824T Expired - Lifetime ES2070855T5 (es) 1987-10-23 1988-10-19 Metodo para purificar una proteina.

Country Status (21)

Country Link
EP (2) EP0313343B2 (es)
JP (1) JPH0788395B2 (es)
KR (1) KR930008447B1 (es)
CN (1) CN1031943C (es)
AT (1) ATE121418T1 (es)
AU (1) AU626008B2 (es)
DE (1) DE3853610T3 (es)
DK (1) DK99690A (es)
ES (1) ES2070855T5 (es)
FI (1) FI103974B1 (es)
HU (1) HU204537B (es)
IE (1) IE72219B1 (es)
IL (1) IL88118A (es)
MY (1) MY108512A (es)
NO (1) NO303451B1 (es)
NZ (1) NZ226651A (es)
OA (1) OA09787A (es)
PT (1) PT88813B (es)
TN (1) TNSN88111A1 (es)
WO (1) WO1989003840A1 (es)
ZA (1) ZA887862B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0133561B1 (ko) * 1988-05-13 1998-04-21 스티븐 엠. 오드레 과립구 군체 자극인자의 정제방법
US7217689B1 (en) 1989-10-13 2007-05-15 Amgen Inc. Glycosylation analogs of erythropoietin
US5110913A (en) * 1990-05-25 1992-05-05 Miles Inc. Antibody purification method
US5463029A (en) * 1992-11-23 1995-10-31 Immunex Corporation Purification of fusion proteins comprising GM-CSF and IL-3
CA2171832C (en) * 1993-09-15 2001-01-02 Harutyun Eran Alpha1-acid glycoprotein purification process and product
US5808011A (en) * 1996-07-01 1998-09-15 Biopure Corporation Method for chromatographic removal of prions
US7304150B1 (en) 1998-10-23 2007-12-04 Amgen Inc. Methods and compositions for the prevention and treatment of anemia
AU763039B2 (en) 1999-04-08 2003-07-10 Genentech Inc. Composition based on oppositely-charged polypeptides
EP3225625A1 (en) * 2002-09-11 2017-10-04 Chugai Seiyaku Kabushiki Kaisha Protein purification method
DE10360841A1 (de) * 2003-12-20 2005-07-14 Henkel Kgaa Helle, stabile, staub- und geruchsarme Enzymgranulate
EP1869065B1 (en) * 2005-03-11 2020-05-06 Wyeth LLC A method of weak partitioning chromatography
SE529259C2 (sv) * 2005-08-31 2007-06-12 Ge Healthcare Bio Sciences Ab Tillverkning av kromarografimatriser, en kromarografimatris, en vätskekromatografikolonn, prcess för att isolera målföreningar och användning av en kromarografimatris för vätskekromatografi
CA2702645C (en) * 2006-11-10 2018-01-02 Agriculture Victoria Services Pty Ltd Process for the preparation of angiogenin
CN101556261B (zh) * 2009-05-25 2012-01-11 北京理工大学 微管内等电聚焦和剪断吹出培养测定微生物等电点的方法
CN101556260B (zh) * 2009-05-25 2012-01-11 北京理工大学 固定化pH梯度毛细管等电聚焦测定微生物等电点的方法
WO2013075740A1 (en) * 2011-11-23 2013-05-30 Sanofi Antibody purification method
RU2648999C2 (ru) * 2011-12-22 2018-03-29 Дженентек, Инк. Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии
EP3301115B1 (en) 2013-05-06 2021-11-10 Sanofi Continuous multistep process for purifying antibodies
EP3546475A1 (en) 2018-03-27 2019-10-02 Sanofi Full flow-through process for purifying recombinant proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4658018A (en) * 1984-03-13 1987-04-14 Immunex Corporation Process for producing homogeneous colony stimulating factor
IL76360A0 (en) * 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
ZA872781B (en) * 1986-05-19 1987-10-05 Immunology Ventures B-cell stimulating factor

Also Published As

Publication number Publication date
HU886264D0 (en) 1990-07-28
NO901769D0 (no) 1990-04-20
ATE121418T1 (de) 1995-05-15
EP0313343B1 (en) 1995-04-19
IL88118A0 (en) 1989-06-30
KR930008447B1 (ko) 1993-09-04
DE3853610T2 (de) 1995-08-31
IE72219B1 (en) 1997-04-09
MY108512A (en) 1996-10-31
DE3853610D1 (de) 1995-05-24
DK99690D0 (da) 1990-04-23
EP0391934A1 (en) 1990-10-17
HUT52783A (en) 1990-08-28
FI103974B (fi) 1999-10-29
FI103974B1 (fi) 1999-10-29
TNSN88111A1 (fr) 1990-07-10
HU204537B (en) 1992-01-28
FI902017A0 (fi) 1990-04-23
PT88813B (pt) 1993-01-29
AU2624788A (en) 1989-05-23
CN1032661A (zh) 1989-05-03
CN1031943C (zh) 1996-06-05
NZ226651A (en) 1990-09-26
ZA887862B (en) 1989-06-28
IE883168L (en) 1989-04-23
JPH03500649A (ja) 1991-02-14
KR890701618A (ko) 1989-12-22
JPH0788395B2 (ja) 1995-09-27
ES2070855T5 (es) 2004-03-01
AU626008B2 (en) 1992-07-23
EP0313343A1 (en) 1989-04-26
DE3853610T3 (de) 2004-05-13
IL88118A (en) 1993-06-10
EP0313343B2 (en) 2003-07-23
NO303451B1 (no) 1998-07-13
NO901769L (no) 1990-04-20
WO1989003840A1 (en) 1989-05-05
DK99690A (da) 1990-04-23
OA09787A (en) 1994-04-15

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