DK1019048T3 - Anvendelse af en angiotensin II-reseptorantagonist til fremstilling af lægemidler til forøgelse af overlevelsesfrekvensen af nyretransplanterede patienter - Google Patents

Anvendelse af en angiotensin II-reseptorantagonist til fremstilling af lægemidler til forøgelse af overlevelsesfrekvensen af nyretransplanterede patienter

Info

Publication number: DK1019048T3
Authority: DK; Denmark
Prior art keywords: transplant patients; preparation; increase; receptor antagonist; survival rate
Prior art date: 1997-09-30

Application number

DK98946713T

Other languages

English (en)

Inventor

Giuseppe Remuzzi

Original Assignee

Merck Sharp Dohme Italia S P A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-30

Filing date

1998-09-30

Publication date

2004-05-03

1998-09-30 Application filed by Merck Sharp Dohme Italia S P A filed Critical Merck Sharp Dohme Italia S P A

2004-05-03 Application granted granted Critical

2004-05-03 Publication of DK1019048T3 publication Critical patent/DK1019048T3/da

Links

229940079593 drug Drugs 0.000 title abstract 2
239000003814 drug Substances 0.000 title abstract 2
230000004083 survival effect Effects 0.000 title abstract 2
239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
229940126317 angiotensin II receptor antagonist Drugs 0.000 title 1
210000003734 kidney Anatomy 0.000 title 1
239000002083 C09CA01 - Losartan Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
229960000519 losartan potassium Drugs 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1
239000011591 potassium Substances 0.000 abstract 1
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

DK98946713T 1997-09-30 1998-09-30 Anvendelse af en angiotensin II-reseptorantagonist til fremstilling af lægemidler til forøgelse af overlevelsesfrekvensen af nyretransplanterede patienter DK1019048T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT97RM000586A IT1295405B1 (it)	1997-09-30	1997-09-30	Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
PCT/IT1998/000259 WO1999016437A1 (en)	1997-09-30	1998-09-30	Use of an angiotensin ii receptor antagonist for the preparation of drugs to increase the survival rate of renal transplant patients

Publications (1)

Publication Number	Publication Date
DK1019048T3 true DK1019048T3 (da)	2004-05-03

Family

ID=11405271

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98946713T DK1019048T3 (da)	1997-09-30	1998-09-30	Anvendelse af en angiotensin II-reseptorantagonist til fremstilling af lægemidler til forøgelse af overlevelsesfrekvensen af nyretransplanterede patienter

Country Status (12)

Country	Link
US (1)	US6576652B2 (da)
EP (1)	EP1019048B1 (da)
JP (1)	JP2001517698A (da)
AT (1)	ATE258051T1 (da)
AU (1)	AU754852B2 (da)
CA (1)	CA2303217C (da)
DE (1)	DE69821252T2 (da)
DK (1)	DK1019048T3 (da)
ES (1)	ES2213296T3 (da)
IT (1)	IT1295405B1 (da)
PT (1)	PT1019048E (da)
WO (1)	WO1999016437A1 (da)

Families Citing this family (10)

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Publication number	Priority date	Publication date	Assignee	Title
US6638937B2 (en)	1998-07-06	2003-10-28	Bristol-Myers Squibb Co.	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
BR0102252B1 (pt)	2001-04-10	2013-10-22		Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso
WO2003093262A2 (en)	2002-04-29	2003-11-13	Teva Pharmaceutical Industries Ltd.	Processes for preparing losartan and losartan potassium
WO2005097109A1 (en) *	2004-04-01	2005-10-20	Daniel Batlle	Methods for achieving a protective ace2 expression level
US20050282877A1 (en) *	2004-04-13	2005-12-22	Becker Bryan N	Method of decreasing inflammation in kidney transplantion using angiotensin receptor blockers
US7531560B2 (en) *	2004-11-10	2009-05-12	Boehringer Ingelheim Pharmaceuticals, Inc.	Anti-cytokine heterocyclic compounds
US8859600B2 (en) *	2009-04-28	2014-10-14	Daiichi Sankyo Company, Limited	Acetone solvate crystals of trityl olmesartan medoxomil
PE20150974A1 (es) *	2012-11-14	2015-07-04	Teijin Pharma Ltd	Derivados de piridina
WO2018002673A1 (en)	2016-07-01	2018-01-04	N4 Pharma Uk Limited	Novel formulations of angiotensin ii receptor antagonists
KR20200136974A (ko) *	2018-03-29	2020-12-08	브루노 라이케르트	심장, 신장, 폐 또는 간의 동소성 및 이소성 이종 이식 후 생존을 연장하기 위한 조성물

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JPS5671074A (en)	1979-11-12	1981-06-13	Takeda Chem Ind Ltd	1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
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FI833794A0 (fi)	1983-10-18	1983-10-18	Farmos Oy	Substituerade 2-merkapto-imidazoler
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US5064825A (en) *	1989-06-01	1991-11-12	Merck & Co., Inc.	Angiotensin ii antagonists
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US5492904A (en) *	1991-05-15	1996-02-20	E. I. Du Pont De Nemours And Company	Composition of angiotensin-II receptor antagonists and calcium channel blockers
US5130439A (en)	1991-11-18	1992-07-14	Lo Young S	Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists
JPH08500323A (ja)	1991-11-18	1996-01-16	イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー	Ａ▲ｉｉ▼受容体アンタゴニストの合成のためのテトラゾリルフェニルボロン酸中間体
US5219856A (en) *	1992-04-06	1993-06-15	E. I. Du Pont De Nemours And Company	Angiotensin-II receptor blocking, heterocycle substituted imidazoles
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1997
- 1997-09-30 IT IT97RM000586A patent/IT1295405B1/it active IP Right Grant
1998
- 1998-09-30 EP EP98946713A patent/EP1019048B1/en not_active Expired - Lifetime
- 1998-09-30 WO PCT/IT1998/000259 patent/WO1999016437A1/en not_active Ceased
- 1998-09-30 CA CA002303217A patent/CA2303217C/en not_active Expired - Fee Related
- 1998-09-30 JP JP2000513573A patent/JP2001517698A/ja active Pending
- 1998-09-30 DK DK98946713T patent/DK1019048T3/da active
- 1998-09-30 DE DE1998621252 patent/DE69821252T2/de not_active Expired - Lifetime
- 1998-09-30 AT AT98946713T patent/ATE258051T1/de active
- 1998-09-30 ES ES98946713T patent/ES2213296T3/es not_active Expired - Lifetime
- 1998-09-30 AU AU93666/98A patent/AU754852B2/en not_active Ceased
- 1998-09-30 PT PT98946713T patent/PT1019048E/pt unknown
2002
- 2002-02-19 US US10/076,396 patent/US6576652B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2001517698A (ja)	2001-10-09
AU754852B2 (en)	2002-11-28
DE69821252T2 (de)	2004-11-18
IT1295405B1 (it)	1999-05-12
US6576652B2 (en)	2003-06-10
DE69821252D1 (de)	2004-02-26
EP1019048A1 (en)	2000-07-19
ES2213296T3 (es)	2004-08-16
CA2303217A1 (en)	1999-04-08
ITRM970586A1 (it)	1999-03-30
ATE258051T1 (de)	2004-02-15
EP1019048B1 (en)	2004-01-21
AU9366698A (en)	1999-04-23
WO1999016437A1 (en)	1999-04-08
US20020115702A1 (en)	2002-08-22
PT1019048E (pt)	2004-05-31
CA2303217C (en)	2005-08-09

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ATE146076T1 (de)	1996-12-15	Behandlung des chronischen nierenversagens mit imidazol-angiotensin-ii-rezeptorantagonisten
BR0215202A (pt)	2004-10-13	Compostos antagonistas seletivos a2b de pirimidina, sua sìntese e uso
KR910007918A (ko)	1991-05-30	치환된5-[(테트라졸릴)알케닐]이미다졸
EP1327631A3 (en)	2004-02-11	Fused heterocyclic compounds, their production and use as angiotensin II antagonists
MXPA06013534A (es)	2007-05-10	Compuesto de cinamida.
MXPA05008142A (es)	2005-09-30	Medicamento para la profilaxis y el tratamiento de arteriosclerosis e hipertension.
RU98118906A (ru)	2000-06-27	Амидные производные или их соли
IT1295405B1 (it)	1999-05-12	Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
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NO914236L (no)	1992-05-04	Fremstilling og anvendelse av tienoimidazolderivater
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