DK1027339T3 - Fremgangsmåde og reagenser til N-alkylering af ureider - Google Patents
Fremgangsmåde og reagenser til N-alkylering af ureiderInfo
- Publication number
- DK1027339T3 DK1027339T3 DK98949706T DK98949706T DK1027339T3 DK 1027339 T3 DK1027339 T3 DK 1027339T3 DK 98949706 T DK98949706 T DK 98949706T DK 98949706 T DK98949706 T DK 98949706T DK 1027339 T3 DK1027339 T3 DK 1027339T3
- Authority
- DK
- Denmark
- Prior art keywords
- ureas
- alkylation
- reagents
- methoxymethyl
- diphenylbarbituric
- Prior art date
Links
- 238000007126 N-alkylation reaction Methods 0.000 title 1
- 235000013877 carbamide Nutrition 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
- SQCVEQVZGPHNTJ-UHFFFAOYSA-N 1-(methoxymethyl)-5,5-diphenyl-1,3-diazinane-2,4,6-trione Chemical compound O=C1N(COC)C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 SQCVEQVZGPHNTJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000007945 N-acyl ureas Chemical class 0.000 abstract 1
- 229960002767 ethosuximide Drugs 0.000 abstract 1
- 229960002972 glutethimide Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
- C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/942,636 US6093820A (en) | 1997-10-02 | 1997-10-02 | Method and reagents for N-alkylating ureides |
| PCT/US1998/020665 WO1999018084A1 (fr) | 1997-10-02 | 1998-10-02 | Procede et reactifs de n-alkylation d'ureides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1027339T3 true DK1027339T3 (da) | 2004-05-03 |
Family
ID=25478386
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98949706T DK1027339T3 (da) | 1997-10-02 | 1998-10-02 | Fremgangsmåde og reagenser til N-alkylering af ureider |
| DK03011817T DK1342718T3 (da) | 1997-10-02 | 1998-10-02 | N-alkylerede ureider |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03011817T DK1342718T3 (da) | 1997-10-02 | 1998-10-02 | N-alkylerede ureider |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6093820A (fr) |
| EP (2) | EP1342718B1 (fr) |
| JP (2) | JP4061018B2 (fr) |
| CN (2) | CN1193019C (fr) |
| AT (2) | ATE299500T1 (fr) |
| AU (1) | AU758506B2 (fr) |
| CA (1) | CA2304970C (fr) |
| DE (2) | DE69830860T2 (fr) |
| DK (2) | DK1027339T3 (fr) |
| ES (2) | ES2243833T3 (fr) |
| IL (2) | IL135284A (fr) |
| PT (2) | PT1342718E (fr) |
| WO (1) | WO1999018084A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6093820A (en) | 1997-10-02 | 2000-07-25 | Taro Pharmaceutical Industries Ltd. | Method and reagents for N-alkylating ureides |
| US7683071B2 (en) * | 2000-07-26 | 2010-03-23 | Taro Pharmaceuticals Industries Ltd. | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid |
| US6939873B2 (en) * | 2000-07-26 | 2005-09-06 | Taro Pharmaceuticals Industries Limited | Non-sedating barbituric acid derivatives |
| US6756379B2 (en) | 2001-07-26 | 2004-06-29 | Taro Pharmaceutical Industries Ltd. | Non-sedating barbiturate compounds as neuroprotective agents |
| EP1485101A4 (fr) * | 2002-01-30 | 2006-04-12 | Taro Pharma Ind | Derives d'acide barbiturique non sedatifs |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| JP4739760B2 (ja) * | 2002-12-11 | 2011-08-03 | タロー・ファーマシューティカル・インダストリーズ・リミテッド | バルビツール酸誘導体を使用する運動障害の治療方法 |
| ES2421139T3 (es) * | 2003-07-30 | 2013-08-29 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias |
| WO2006003651A2 (fr) | 2004-07-02 | 2006-01-12 | Taro Pharmaceutical Industries, Ltd | Procede de preparation d'acide 1-methoxymethyl-5,5-diphenylbarbiturique |
| EP1625848A1 (fr) * | 2004-08-10 | 2006-02-15 | Taro Pharmaceuticals North America, Inc. | Composition et procédé pour améliorer l'administration de l'acide 5,5-diphénylbarbiturique |
| US7449458B2 (en) | 2005-01-19 | 2008-11-11 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| US8853257B2 (en) | 2005-11-21 | 2014-10-07 | Mordechai Sharir | Succinimide derivatives as ocular hypotensive agents |
| US20090318515A1 (en) * | 2005-11-21 | 2009-12-24 | Mordechai Sharir | Succinimide derivatives as ocular hypotensive agents |
| EP2081576A4 (fr) * | 2006-11-14 | 2010-06-30 | Taro Pharmaceuticals North Ame | Procédé d'amélioration de la biodisponibilité pour les barbituriques non sédatifs |
| AU2011320608A1 (en) | 2010-10-27 | 2013-05-23 | The Gillette Company | Composition dispensing device comprising a non-foaming hydrating composition |
| US20120278179A1 (en) | 2011-04-28 | 2012-11-01 | Ray Campbell | Systems and methods for deducing user information from input device behavior |
| MX2014001892A (es) | 2011-08-16 | 2014-05-27 | Gillette Co | Dispositivo dispensador de composiciones que comprende una composicion hidratante. |
| SG10201803685TA (en) | 2013-11-01 | 2018-06-28 | Gillette Co Llc | Shave care composition for a liquid dispensing razor |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2673205A (en) | 1951-02-13 | 1954-03-23 | Ciba Pharm Prod Inc | 3-disubstituted dioxopiperidines and the manufacture thereof |
| AR204518A1 (es) * | 1973-02-28 | 1976-02-12 | Kendall & Co | Procedimiento para preparar n-mono(alcoximetil)fenobarbital |
| DE2622981A1 (de) * | 1976-05-21 | 1977-12-08 | Unisearch Ltd | Verfahren zur herstellung von halogenalkylierten verbindungen |
| IL69722A (en) * | 1983-09-14 | 1986-09-30 | Taro Pharma Ind | Oxopyrimidine derivatives and pharmaceutical compositions containing them |
| DE4028040A1 (de) * | 1990-09-05 | 1992-03-12 | Chemie Linz Deutschland | Verfahren zur n-alkylierung von harnstoffen |
| DE19504623A1 (de) | 1995-02-13 | 1996-08-14 | Bayer Ag | Verfahren zur Herstellung von N-substituierten cyclischen Imiden |
| US6184238B1 (en) | 1996-12-26 | 2001-02-06 | Nikken Chemicals Co., Ltd. | N-hydroxyurea derivative and pharmaceutical composition containing the same |
| US6093820A (en) * | 1997-10-02 | 2000-07-25 | Taro Pharmaceutical Industries Ltd. | Method and reagents for N-alkylating ureides |
| CA2331735A1 (fr) | 1998-05-08 | 1999-11-18 | Smithkline Beecham P.L.C. | Derives de phenyluree et de (phenylthio)uree |
| JP2002516315A (ja) | 1998-05-26 | 2002-06-04 | ナチュラル ドラッグ サイエンシズ，リミティド ライアビリティ カンパニー | ５−オキシミノバルビツール酸のｎ−置換誘導体 |
| CA2306170A1 (fr) | 2000-04-18 | 2001-10-18 | Kenneth Curry | Nouveaux derives amines et carboxyles de l'acide barbiturique |
| WO2002007729A1 (fr) | 2000-07-26 | 2002-01-31 | Taro Pharmaceutical Industries Ltd. | Composes de barbiturique non sedatifs en tant qu'agents neuroprotecteurs |
-
1997
- 1997-10-02 US US08/942,636 patent/US6093820A/en not_active Ceased
-
1998
- 1998-10-02 EP EP03011817A patent/EP1342718B1/fr not_active Expired - Lifetime
- 1998-10-02 EP EP98949706A patent/EP1027339B1/fr not_active Expired - Lifetime
- 1998-10-02 IL IL13528498A patent/IL135284A/xx not_active IP Right Cessation
- 1998-10-02 DK DK98949706T patent/DK1027339T3/da active
- 1998-10-02 ES ES03011817T patent/ES2243833T3/es not_active Expired - Lifetime
- 1998-10-02 AT AT03011817T patent/ATE299500T1/de active
- 1998-10-02 AU AU95976/98A patent/AU758506B2/en not_active Ceased
- 1998-10-02 WO PCT/US1998/020665 patent/WO1999018084A1/fr not_active Ceased
- 1998-10-02 ES ES98949706T patent/ES2214736T3/es not_active Expired - Lifetime
- 1998-10-02 AT AT98949706T patent/ATE257153T1/de active
- 1998-10-02 DE DE69830860T patent/DE69830860T2/de not_active Expired - Lifetime
- 1998-10-02 CA CA2304970A patent/CA2304970C/fr not_active Expired - Fee Related
- 1998-10-02 DK DK03011817T patent/DK1342718T3/da active
- 1998-10-02 PT PT03011817T patent/PT1342718E/pt unknown
- 1998-10-02 JP JP2000514895A patent/JP4061018B2/ja not_active Expired - Fee Related
- 1998-10-02 CN CNB988098342A patent/CN1193019C/zh not_active Expired - Fee Related
- 1998-10-02 PT PT98949706T patent/PT1027339E/pt unknown
- 1998-10-02 CN CNA2005100026661A patent/CN1699349A/zh active Pending
- 1998-10-02 DE DE69820895T patent/DE69820895T2/de not_active Expired - Lifetime
-
2002
- 2002-02-12 US US10/073,051 patent/US6664262B2/en not_active Expired - Fee Related
-
2003
- 2003-02-27 US US10/375,340 patent/USRE38934E1/en not_active Expired - Lifetime
- 2003-10-17 US US10/687,712 patent/US6906079B2/en not_active Expired - Fee Related
-
2004
- 2004-11-07 IL IL16508004A patent/IL165080A0/xx unknown
-
2007
- 2007-10-23 JP JP2007275316A patent/JP2008101002A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69820895D1 (de) | 2004-02-05 |
| PT1027339E (pt) | 2004-05-31 |
| CN1273581A (zh) | 2000-11-15 |
| EP1027339A1 (fr) | 2000-08-16 |
| USRE38934E1 (en) | 2006-01-10 |
| AU758506B2 (en) | 2003-03-20 |
| US20040167358A1 (en) | 2004-08-26 |
| EP1027339B1 (fr) | 2004-01-02 |
| DE69830860T2 (de) | 2006-04-27 |
| IL165080A0 (en) | 2005-12-18 |
| DE69820895T2 (de) | 2004-10-28 |
| CA2304970A1 (fr) | 1999-04-15 |
| DE69830860D1 (de) | 2005-08-18 |
| WO1999018084A1 (fr) | 1999-04-15 |
| US6664262B2 (en) | 2003-12-16 |
| AU9597698A (en) | 1999-04-27 |
| EP1342718B1 (fr) | 2005-07-13 |
| ATE299500T1 (de) | 2005-07-15 |
| PT1342718E (pt) | 2005-11-30 |
| CN1699349A (zh) | 2005-11-23 |
| JP2001519334A (ja) | 2001-10-23 |
| JP2008101002A (ja) | 2008-05-01 |
| EP1342718A1 (fr) | 2003-09-10 |
| US6906079B2 (en) | 2005-06-14 |
| ES2243833T3 (es) | 2005-12-01 |
| CN1193019C (zh) | 2005-03-16 |
| IL135284A (en) | 2005-11-20 |
| ATE257153T1 (de) | 2004-01-15 |
| CA2304970C (fr) | 2010-07-13 |
| JP4061018B2 (ja) | 2008-03-12 |
| DK1342718T3 (da) | 2005-09-26 |
| US6093820A (en) | 2000-07-25 |
| US20030018080A1 (en) | 2003-01-23 |
| ES2214736T3 (es) | 2004-09-16 |
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