DK1030836T3 - Hydroxam- og carboxylsyrederivater der har MMP- og TNF-inhiberende aktivitet - Google Patents

Hydroxam- og carboxylsyrederivater der har MMP- og TNF-inhiberende aktivitet

Info

Publication number: DK1030836T3
Authority: DK; Denmark
Prior art keywords: mmp; inhibitory activity; hydroxamic; carboxylic acid; acid derivatives
Prior art date: 1997-11-12

Application number

DK98952927T

Other languages

English (en)

Inventor

Andrew Douglas Darwin D Baxter

David Alan Owen

John Gary Montana

Robert John Watson

Original Assignee

Darwin Discovery Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-12

Filing date

1998-11-12

Publication date

2003-05-26

1997-11-12 Priority claimed from GBGB9723906.5A external-priority patent/GB9723906D0/en

1998-02-06 Priority claimed from GBGB9802618.0A external-priority patent/GB9802618D0/en

1998-06-26 Priority claimed from GBGB9813933.0A external-priority patent/GB9813933D0/en

1998-11-12 Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd

2003-05-26 Application granted granted Critical

2003-05-26 Publication of DK1030836T3 publication Critical patent/DK1030836T3/da

Links

230000002401 inhibitory effect Effects 0.000 title abstract 2
NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
150000001732 carboxylic acid derivatives Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/04—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Diabetes (AREA)
Oncology (AREA)
Virology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Hospice & Palliative Care (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)

DK98952927T 1997-11-12 1998-11-12 Hydroxam- og carboxylsyrederivater der har MMP- og TNF-inhiberende aktivitet DK1030836T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9723906.5A GB9723906D0 (en)	1997-11-12	1997-11-12	Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activiy
GBGB9802618.0A GB9802618D0 (en)	1998-02-06	1998-02-06	Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
GBGB9813933.0A GB9813933D0 (en)	1998-06-26	1998-06-26	Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
PCT/GB1998/003395 WO1999024399A1 (en)	1997-11-12	1998-11-12	Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity

Publications (1)

Publication Number	Publication Date
DK1030836T3 true DK1030836T3 (da)	2003-05-26

Family

ID=27269088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98952927T DK1030836T3 (da)	1997-11-12	1998-11-12	Hydroxam- og carboxylsyrederivater der har MMP- og TNF-inhiberende aktivitet

Country Status (18)

Country	Link
EP (1)	EP1030836B1 (da)
JP (1)	JP2001522832A (da)
KR (1)	KR100609926B1 (da)
CN (1)	CN1283183A (da)
AT (1)	ATE231837T1 (da)
AU (1)	AU748843B2 (da)
BR (1)	BR9814147A (da)
CA (1)	CA2308359A1 (da)
DE (1)	DE69811111T2 (da)
DK (1)	DK1030836T3 (da)
ES (1)	ES2190115T3 (da)
HU (1)	HUP0100152A3 (da)
IL (1)	IL135921A (da)
NO (1)	NO20002440L (da)
NZ (1)	NZ504387A (da)
PL (1)	PL340551A1 (da)
RU (1)	RU2210567C2 (da)
WO (1)	WO1999024399A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0000852A2 (hu) *	1997-02-03	2001-05-28	Pfizer Products Inc.	Aril-szulfonil-amino-hidroxámsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények
GB9801690D0 (en)	1998-01-27	1998-03-25	Pfizer Ltd	Therapeutic agents
US6479502B1 (en)	1998-08-29	2002-11-12	British Biotech Pharmaceuticals	Hydroxamic acid derivatives as proteinase inhibitors
US6706719B1 (en)	1998-11-12	2004-03-16	Darwin Discovery, Ltd.	Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
US6800646B1 (en)	1999-02-08	2004-10-05	Pharmacia Corporation	Sulfamato hydroxamic acid metalloprotease inhibitor
AU775701B2 (en)	1999-02-08	2004-08-12	G.D. Searle & Co.	Sulfamato hydroxamic acid metalloprotease inhibitor
GB9929527D0 (en) *	1999-12-14	2000-02-09	Smithkline Beecham Plc	Novel compounds
JP2003533513A (ja) *	2000-05-15	2003-11-11	ダーウィン・ディスカバリー・リミテッド	Ｍｍｐおよびｔｎｆ阻害活性を有するヒドロキサム酸およびカルボン酸誘導体
EP1282614B1 (en) *	2000-05-15	2003-11-12	Darwin Discovery Limited	Hydroxamic acid derivatives
EP1286994A1 (en)	2000-05-15	2003-03-05	Darwin Discovery Limited	Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
CA2423868C (en)	2000-09-29	2011-06-07	Prolifix Limited	Carbamic acid compounds comprising an amide linkage as hdac inhibitors
EP2292593A3 (en)	2000-09-29	2011-05-25	TopoTarget UK Limited	Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors
MXPA03008180A (es) *	2001-03-15	2003-12-12	Astrazeneca Ab	Inhibidores de metaloproteinasa.
SE0100902D0 (sv) *	2001-03-15	2001-03-15	Astrazeneca Ab	Compounds
GB0119396D0 (en) *	2001-08-09	2001-10-03	Celltech R&D Ltd	Hydroxamic acid derivatives
SE0103710D0 (sv)	2001-11-07	2001-11-07	Astrazeneca Ab	Compounds
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
NZ536116A (en)	2002-04-03	2007-01-26	Topotarget Uk Ltd	Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors
CA2483314A1 (en)	2002-04-25	2003-11-06	Pharmacia Corporation	Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors
GB0216382D0 (en) *	2002-07-13	2002-08-21	Astrazeneca Ab	Compounds
GB0216383D0 (en) *	2002-07-13	2002-08-21	Astrazeneca Ab	Compounds
SE0202539D0 (sv)	2002-08-27	2002-08-27	Astrazeneca Ab	Compounds
JP4612621B2 (ja)	2003-01-17	2011-01-12	トポターゲットユーケーリミテッド	Ｈｄａｃ阻害剤としてのエステル又はケトン結合を含むカルバミン酸化合物
SE0401762D0 (sv)	2004-07-05	2004-07-05	Astrazeneca Ab	Novel compounds
US7648992B2 (en)	2004-07-05	2010-01-19	Astrazeneca Ab	Hydantoin derivatives for the treatment of obstructive airway diseases
RU2277418C1 (ru) *	2004-12-08	2006-06-10	Государственное научное учреждение (ГНУ) Всероссийский научно-исследовательский ветеринарный институт патологии, фармакологии и терапии (ВНИВИПФиТ)	Препарат для лечения бронхопневмонии у телят
SE0403085D0 (sv)	2004-12-17	2004-12-17	Astrazeneca Ab	Novel componds
SE0403086D0 (sv)	2004-12-17	2004-12-17	Astrazeneca Ab	Compounds
RU2286141C1 (ru) *	2005-03-03	2006-10-27	Общество с ограниченной ответственностью "Фарм-Лад"	Мазь для наружного применения
EP2040698A4 (en) *	2006-07-14	2011-08-10	Shionogi & Co	OXIM CONNECTIONS AND ITS USE
EP2164325B1 (en)	2007-05-31	2013-04-24	Shionogi&Co., Ltd.	Oxyimino compounds and the use thereof
WO2009151152A1 (en)	2008-06-11	2009-12-17	Shionogi & Co., Ltd.	Oxycarbamoyl compounds and the use thereof
KR20220164216A (ko) *	2021-06-04	2022-12-13	에스티팜 주식회사	신규한 에르고스텐올 유도체 및 이의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1067965A (en) *	1965-01-22	1967-05-10	Beecham Group Ltd	Penicillins, esters, amides and salts thereof
US5239079A (en) *	1988-05-12	1993-08-24	Eisai Co., Ltd.	Pyridinium salt and pharmacological composition containing the same
DK0780386T3 (da) *	1995-12-20	2003-02-03	Hoffmann La Roche	Matrixmetalloproteaseinhibitorer

1998
- 1998-11-12 WO PCT/GB1998/003395 patent/WO1999024399A1/en not_active Ceased
- 1998-11-12 JP JP2000520413A patent/JP2001522832A/ja active Pending
- 1998-11-12 AU AU10469/99A patent/AU748843B2/en not_active Ceased
- 1998-11-12 BR BR9814147-3A patent/BR9814147A/pt not_active IP Right Cessation
- 1998-11-12 RU RU2000114881/04A patent/RU2210567C2/ru not_active IP Right Cessation
- 1998-11-12 DE DE69811111T patent/DE69811111T2/de not_active Expired - Fee Related
- 1998-11-12 DK DK98952927T patent/DK1030836T3/da active
- 1998-11-12 HU HU0100152A patent/HUP0100152A3/hu unknown
- 1998-11-12 NZ NZ504387A patent/NZ504387A/xx unknown
- 1998-11-12 ES ES98952927T patent/ES2190115T3/es not_active Expired - Lifetime
- 1998-11-12 PL PL98340551A patent/PL340551A1/xx not_active Application Discontinuation
- 1998-11-12 IL IL13592198A patent/IL135921A/xx not_active IP Right Cessation
- 1998-11-12 EP EP98952927A patent/EP1030836B1/en not_active Expired - Lifetime
- 1998-11-12 CN CN98812677A patent/CN1283183A/zh active Pending
- 1998-11-12 CA CA002308359A patent/CA2308359A1/en not_active Abandoned
- 1998-11-12 KR KR1020007005163A patent/KR100609926B1/ko not_active Expired - Fee Related
- 1998-11-12 AT AT98952927T patent/ATE231837T1/de not_active IP Right Cessation
2000
- 2000-05-11 NO NO20002440A patent/NO20002440L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20002440D0 (no)	2000-05-11
IL135921A0 (en)	2001-05-20
DE69811111D1 (de)	2003-03-06
WO1999024399A1 (en)	1999-05-20
EP1030836A1 (en)	2000-08-30
HUP0100152A3 (en)	2002-07-29
IL135921A (en)	2005-08-31
RU2210567C2 (ru)	2003-08-20
CN1283183A (zh)	2001-02-07
EP1030836B1 (en)	2003-01-29
ES2190115T3 (es)	2003-07-16
BR9814147A (pt)	2000-10-03
ATE231837T1 (de)	2003-02-15
HUP0100152A2 (hu)	2002-02-28
PL340551A1 (en)	2001-02-12
AU1046999A (en)	1999-05-31
NZ504387A (en)	2002-10-25
NO20002440L (no)	2000-05-11
JP2001522832A (ja)	2001-11-20
DE69811111T2 (de)	2003-07-24
CA2308359A1 (en)	1999-05-20
AU748843B2 (en)	2002-06-13
KR20010032042A (ko)	2001-04-16
KR100609926B1 (ko)	2006-08-04

Publication	Publication Date	Title
NO20002440D0 (no)	2000-05-11	Hydroksam- og karboksylsyrederivater med MMP- og TNF- inhiberende aktivitet
TR199800849T2 (xx)	1998-07-21	Siklikle heterosiklik N-ikame edilmi� alfa-iminohidroksamla karbon asitleri
NZ335981A (en)	2000-04-28	Ketobenzamides as calpain inhibitors
FI971412A0 (fi)	1997-04-04	Peptididyyliyhdisteet ja niiden terapeuttinen käyttö metalloproteaasien estäjinä
DE59709414D1 (de)	2003-04-03	Oxyiminopregnancarbolactone
BR9808214A (pt)	2000-05-16	Compostos de n-hidróxi 4-sulfonil butanamida
DE69926806D1 (de)	2005-09-22	N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
GB9801690D0 (en)	1998-03-25	Therapeutic agents
ATE224374T1 (de)	2002-10-15	1,2-substituierte imidazolylverbindungen zur behandlung von entzündungen
ID18143A (id)	1998-03-05	Penghambat metaloprotease amina siklik tersubstitusi
NO950297D0 (no)	1995-01-26	Prolinamidderivater
BR0109188A (pt)	2003-03-18	Diarilaminas 5-amida substituìdas como inibidores de mex
CA2318145A1 (en)	1999-08-26	Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
ATE359264T1 (de)	2007-05-15	Sulfonierte aminosäurederivate und metalloproteinase-inhibitoren, die diese enthalten
ATE302606T1 (de)	2005-09-15	N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
ATE283848T1 (de)	2004-12-15	Thiarylsulfonamid-hydroxamsäurederivate
ATE423557T1 (de)	2009-03-15	Carbocyclische kaliumkanalhemmer
IL138402A0 (en)	2001-10-31	Heterocyclically substituted amides used as calpain inhibitors
DE60143906D1 (de)	2011-03-03	Verwendung von derivaten der 2-oxothiazolidin-4-corbonsäure als prä-abschuppungsmittel
ATE290382T1 (de)	2005-03-15	Heterozyklische kalium-kanal inhibitoren
FI925787A0 (fi)	1992-12-18	Proteolytiska enzymers sackarinderivatinhibitorer
DE60120881D1 (de)	2006-08-03	Sulfonamide als matrix-metalloproteinase inhibitoren
EA200000204A1 (ru)	2000-10-30	Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов
DE60027434D1 (de)	2006-05-24	Petroselinsäure enthaltendes hautpflegemittel
ATE292109T1 (de)	2005-04-15	Substituierte benzamide als inhibitoren von rhinovirus 3c protease