DK1030838T3 - Fremgangsmåde til syntese af pyrrolamider - Google Patents

Fremgangsmåde til syntese af pyrrolamider

Info

Publication number: DK1030838T3
Authority: DK; Denmark
Prior art keywords: reaction; pyrrolamides; synthesis; followed; cycloakane
Prior art date: 1997-11-13

Application number

DK98946678T

Other languages

English (en)

Inventor

John Anthony Ragan

Teresa Woodall Makowski

Ende David Jon Am

Pamela Jane Clifford

Gregory Randall Young

Alyson Kay Conrad

Shane Allen Eisenbeis

George Joseph Quallich

Douglas John Meldrum Allen

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-13

Filing date

1998-10-21

Publication date

2003-02-24

1998-10-21 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2003-02-24 Application granted granted Critical

2003-02-24 Publication of DK1030838T3 publication Critical patent/DK1030838T3/da

Links

238000000034 method Methods 0.000 title abstract 2
RLOQBKJCOAXOLR-UHFFFAOYSA-N 1h-pyrrole-2-carboxamide Chemical class NC(=O)C1=CC=CN1 RLOQBKJCOAXOLR-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
NHNHWBFFDARHFO-UHFFFAOYSA-N 2-(1h-pyrrol-2-yl)acetamide Chemical class NC(=O)CC1=CC=CN1 NHNHWBFFDARHFO-UHFFFAOYSA-N 0.000 abstract 1
RGHQKFQZGLKBCF-UHFFFAOYSA-N 2-bromoethyl acetate Chemical compound CC(=O)OCCBr RGHQKFQZGLKBCF-UHFFFAOYSA-N 0.000 abstract 1
102000027484 GABAA receptors Human genes 0.000 abstract 1
108091008681 GABAA receptors Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000004982 aromatic amines Chemical class 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Tea And Coffee (AREA)
Fats And Perfumes (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)

DK98946678T 1997-11-13 1998-10-21 Fremgangsmåde til syntese af pyrrolamider DK1030838T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US6542297P	1997-11-13	1997-11-13
US7426698P	1998-02-10	1998-02-10
PCT/IB1998/001672 WO1999025684A1 (en)	1997-11-13	1998-10-21	Method of synthesis of pyrrole amides

Publications (1)

Publication Number	Publication Date
DK1030838T3 true DK1030838T3 (da)	2003-02-24

Family

ID=26745584

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98946678T DK1030838T3 (da)	1997-11-13	1998-10-21	Fremgangsmåde til syntese af pyrrolamider

Country Status (35)

Country	Link
US (1)	US6262272B1 (da)
EP (1)	EP1030838B1 (da)
JP (1)	JP3497469B2 (da)
KR (1)	KR100386722B1 (da)
CN (2)	CN1280566A (da)
AT (1)	ATE231492T1 (da)
AU (1)	AU745788B2 (da)
BG (1)	BG64530B1 (da)
BR (1)	BR9814161A (da)
CA (1)	CA2310095A1 (da)
CZ (1)	CZ20001769A3 (da)
DE (1)	DE69810959T2 (da)
DK (1)	DK1030838T3 (da)
DZ (1)	DZ2651A1 (da)
EA (1)	EA002243B1 (da)
ES (1)	ES2186232T3 (da)
HR (1)	HRP20000298A2 (da)
HU (1)	HUP0100235A3 (da)
ID (1)	ID24135A (da)
IL (1)	IL135710A0 (da)
IS (1)	IS5469A (da)
MA (1)	MA24697A1 (da)
NO (1)	NO20002214L (da)
NZ (1)	NZ503916A (da)
OA (1)	OA11378A (da)
PA (1)	PA8462901A1 (da)
PL (1)	PL340554A1 (da)
PT (1)	PT1030838E (da)
SK (1)	SK6872000A3 (da)
TN (1)	TNSN98204A1 (da)
TR (1)	TR200001343T2 (da)
TW (1)	TW509675B (da)
UY (1)	UY25249A1 (da)
WO (1)	WO1999025684A1 (da)
YU (1)	YU27300A (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
OA12015A (en) *	1999-08-31	2006-04-19	Neurogen Corp	Fused pyrrolecarboxamides: gaba brain receptor ligands.
BR0113697A (pt) *	2000-09-06	2003-07-22	Neurogen Corp	Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto ou sal, embalagem e métodos para, para alterar a atividade transdutora de sinal dos receptores de gabaa, para tratar ansiedade, depressão, um distúrbio do sono, ou demência de alzheimer, para demonstrar a presença dos receptores de gabaa em células ou amostras de tecido e para preparar um composto
EP1339681A1 (en) *	2000-12-04	2003-09-03	Pfizer Products Inc.	Synthesis of fused pyrrolecarboxamides
BR0307504A (pt)	2002-02-07	2004-12-07	Neurogen Corp	Composto ou sal farmaceuticamente aceitável, composição farmacêutica, métodos tratar doenças, para potencializar um efeito terapêutico de um agente para o snc, para melhorar a memória de curto prazo em um paciente, para determinar a presença ou ausência de receptores gabaa em uma amostra, e para alterar a atividade transdutora de sinal do receptor gabaa, embalagem, e, uso de um composto ou sal
US20080153629A1 (en) *	2004-05-07	2008-06-26	Sullivan Michael J	Thick Outer Cover Layer Golf Ball
CN102786458B (zh) *	2012-06-04	2014-02-12	天津渤海职业技术学院	吡咯甲酰胺衍生物、其制备方法和用途
EP3097095A1 (en) *	2014-01-24	2016-11-30	AbbVie Inc.	Furo-3-carboxamide derivatives and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5750702A (en)	1993-10-27	1998-05-12	Neurogen Corporation	Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US5484944A (en) *	1993-10-27	1996-01-16	Neurogen Corporation	Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
US5804686A (en) *	1996-01-19	1998-09-08	Neurogen Corporation	fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
WO1997034870A1 (en)	1996-03-22	1997-09-25	Neurogen Corporation	Certain fused pyrrolecarboxamides as gaba brain receptor ligands

1998
- 1998-10-21 IL IL13571098A patent/IL135710A0/xx unknown
- 1998-10-21 DK DK98946678T patent/DK1030838T3/da active
- 1998-10-21 WO PCT/IB1998/001672 patent/WO1999025684A1/en not_active Ceased
- 1998-10-21 CN CN98811119A patent/CN1280566A/zh active Pending
- 1998-10-21 YU YU27300A patent/YU27300A/sh unknown
- 1998-10-21 EP EP98946678A patent/EP1030838B1/en not_active Expired - Lifetime
- 1998-10-21 BR BR9814161-9A patent/BR9814161A/pt not_active Application Discontinuation
- 1998-10-21 PT PT98946678T patent/PT1030838E/pt unknown
- 1998-10-21 AT AT98946678T patent/ATE231492T1/de not_active IP Right Cessation
- 1998-10-21 US US09/403,985 patent/US6262272B1/en not_active Expired - Fee Related
- 1998-10-21 KR KR10-2000-7005185A patent/KR100386722B1/ko not_active Expired - Fee Related
- 1998-10-21 DE DE69810959T patent/DE69810959T2/de not_active Expired - Fee Related
- 1998-10-21 EA EA200000413A patent/EA002243B1/ru not_active IP Right Cessation
- 1998-10-21 HU HU0100235A patent/HUP0100235A3/hu unknown
- 1998-10-21 ES ES98946678T patent/ES2186232T3/es not_active Expired - Lifetime
- 1998-10-21 PL PL98340554A patent/PL340554A1/xx not_active Application Discontinuation
- 1998-10-21 JP JP2000521068A patent/JP3497469B2/ja not_active Expired - Fee Related
- 1998-10-21 CZ CZ20001769A patent/CZ20001769A3/cs unknown
- 1998-10-21 CN CNA031594727A patent/CN1508129A/zh active Pending
- 1998-10-21 TR TR2000/01343T patent/TR200001343T2/xx unknown
- 1998-10-21 ID IDW20000893A patent/ID24135A/id unknown
- 1998-10-21 AU AU93639/98A patent/AU745788B2/en not_active Ceased
- 1998-10-21 HR HR20000298A patent/HRP20000298A2/hr not_active Application Discontinuation
- 1998-10-21 NZ NZ503916A patent/NZ503916A/xx unknown
- 1998-10-21 SK SK687-2000A patent/SK6872000A3/sk unknown
- 1998-10-21 CA CA002310095A patent/CA2310095A1/en not_active Abandoned
- 1998-11-10 PA PA19988462901A patent/PA8462901A1/es unknown
- 1998-11-10 TW TW087118708A patent/TW509675B/zh not_active IP Right Cessation
- 1998-11-11 TN TNTNSN98204A patent/TNSN98204A1/fr unknown
- 1998-11-11 DZ DZ980261A patent/DZ2651A1/xx active
- 1998-11-11 MA MA25342A patent/MA24697A1/fr unknown
- 1998-11-13 UY UY25249A patent/UY25249A1/es not_active IP Right Cessation
2000
- 2000-04-26 IS IS5469A patent/IS5469A/is unknown
- 2000-04-28 NO NO20002214A patent/NO20002214L/no unknown
- 2000-05-09 BG BG104413A patent/BG64530B1/bg unknown
- 2000-05-12 OA OA1200000136A patent/OA11378A/en unknown

Also Published As

Publication number	Publication date
CA2310095A1 (en)	1999-05-27
ES2186232T3 (es)	2003-05-01
IS5469A (is)	2000-04-26
DE69810959D1 (de)	2003-02-27
CZ20001769A3 (cs)	2001-09-12
EP1030838B1 (en)	2003-01-22
HUP0100235A3 (en)	2002-04-29
UY25249A1 (es)	1999-07-19
SK6872000A3 (en)	2002-02-05
AU745788B2 (en)	2002-03-28
NO20002214L (no)	2000-05-12
WO1999025684A1 (en)	1999-05-27
PA8462901A1 (es)	2000-05-24
IL135710A0 (en)	2001-05-20
YU27300A (sh)	2002-10-18
NZ503916A (en)	2002-08-28
KR20010032063A (ko)	2001-04-16
OA11378A (en)	2004-01-27
DE69810959T2 (de)	2003-06-05
BG64530B1 (bg)	2005-06-30
ATE231492T1 (de)	2003-02-15
ID24135A (id)	2000-07-06
BR9814161A (pt)	2000-09-26
TW509675B (en)	2002-11-11
EA002243B1 (ru)	2002-02-28
KR100386722B1 (ko)	2003-06-09
DZ2651A1 (fr)	2003-03-15
MA24697A1 (fr)	1999-07-01
PL340554A1 (en)	2001-02-12
CN1508129A (zh)	2004-06-30
JP3497469B2 (ja)	2004-02-16
AU9363998A (en)	1999-06-07
HUP0100235A2 (hu)	2001-12-28
NO20002214D0 (no)	2000-04-28
EA200000413A1 (ru)	2000-12-25
US6262272B1 (en)	2001-07-17
TR200001343T2 (tr)	2001-02-21
CN1280566A (zh)	2001-01-17
EP1030838A1 (en)	2000-08-30
PT1030838E (pt)	2003-03-31
BG104413A (en)	2001-02-28
TNSN98204A1 (fr)	2005-03-15
JP2001523660A (ja)	2001-11-27
HRP20000298A2 (en)	2001-02-28

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