DK1031552T3 - Mellemprodukter til syntese af Vitamin D - Google Patents

Mellemprodukter til syntese af Vitamin D

Info

Publication number: DK1031552T3
Authority: DK; Denmark
Prior art keywords: indene; methyl; bromooctahydro; reductate; dione
Prior art date: 1999-02-23

Application number

DK00102948T

Other languages

English (en)

Inventor

Andrzej Robert Daniewski

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-23

Filing date

2000-02-14

Publication date

2003-08-04

2000-02-14 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-08-04 Application granted granted Critical

2003-08-04 Publication of DK1031552T3 publication Critical patent/DK1031552T3/da

Links

229930003316 Vitamin D Natural products 0.000 title 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
235000019166 vitamin D Nutrition 0.000 title 1
239000011710 vitamin D Substances 0.000 title 1
150000003710 vitamin D derivatives Chemical class 0.000 title 1
229940046008 vitamin d Drugs 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
LYXZMWUBUGPEMB-JUWDTYFHSA-N (3ar,4s,7as)-4-bromo-7a-methyl-2,3,3a,4,6,7-hexahydroindene-1,5-dione Chemical compound C1CC(=O)[C@@H](Br)[C@@H]2CCC(=O)[C@]21C LYXZMWUBUGPEMB-JUWDTYFHSA-N 0.000 abstract 1
FNYAZSZTENLTRT-JTQLQIEISA-N (7as)-7a-methyl-2,3,6,7-tetrahydroindene-1,5-dione Chemical compound C1CC(=O)C=C2CCC(=O)[C@]21C FNYAZSZTENLTRT-JTQLQIEISA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
SIPUZPBQZHNSDW-UHFFFAOYSA-N bis(2-methylpropyl)aluminum Chemical compound CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
239000012039 electrophile Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Steroid Compounds (AREA)
Catalysts (AREA)

DK00102948T 1999-02-23 2000-02-14 Mellemprodukter til syntese af Vitamin D DK1031552T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US12120999P	1999-02-23	1999-02-23

Publications (1)

Publication Number	Publication Date
DK1031552T3 true DK1031552T3 (da)	2003-08-04

Family

ID=22395260

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00102948T DK1031552T3 (da)	1999-02-23	2000-02-14	Mellemprodukter til syntese af Vitamin D

Country Status (11)

Country	Link
US (1)	US6284928B1 (da)
EP (1)	EP1031552B1 (da)
JP (1)	JP3532488B2 (da)
KR (1)	KR100367440B1 (da)
CN (1)	CN1137076C (da)
AT (1)	ATE238262T1 (da)
CA (1)	CA2298944C (da)
DE (1)	DE60002242T2 (da)
DK (1)	DK1031552T3 (da)
ES (1)	ES2194635T3 (da)
MX (1)	MXPA00001800A (da)

2000
- 2000-02-10 US US09/501,359 patent/US6284928B1/en not_active Expired - Fee Related
- 2000-02-14 ES ES00102948T patent/ES2194635T3/es not_active Expired - Lifetime
- 2000-02-14 DE DE60002242T patent/DE60002242T2/de not_active Expired - Lifetime
- 2000-02-14 DK DK00102948T patent/DK1031552T3/da active
- 2000-02-14 AT AT00102948T patent/ATE238262T1/de not_active IP Right Cessation
- 2000-02-14 EP EP00102948A patent/EP1031552B1/en not_active Expired - Lifetime
- 2000-02-18 CA CA002298944A patent/CA2298944C/en not_active Expired - Fee Related
- 2000-02-21 MX MXPA00001800 patent/MXPA00001800A/es unknown
- 2000-02-21 KR KR10-2000-0008229A patent/KR100367440B1/ko not_active Expired - Fee Related
- 2000-02-22 JP JP2000044130A patent/JP3532488B2/ja not_active Expired - Fee Related
- 2000-02-22 CN CNB001027867A patent/CN1137076C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP3532488B2 (ja)	2004-05-31
KR20010006669A (ko)	2001-01-26
US6284928B1 (en)	2001-09-04
MXPA00001800A (es)	2001-01-01
ES2194635T3 (es)	2003-12-01
DE60002242T2 (de)	2004-03-04
JP2000247922A (ja)	2000-09-12
KR100367440B1 (ko)	2003-01-14
EP1031552A1 (en)	2000-08-30
EP1031552B1 (en)	2003-04-23
DE60002242D1 (de)	2003-05-28
CN1137076C (zh)	2004-02-04
CN1267659A (zh)	2000-09-27
CA2298944A1 (en)	2000-08-23
MX210327B (da)	2002-09-13
CA2298944C (en)	2009-01-13
ATE238262T1 (de)	2003-05-15

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