DK1042349T3 - Anvendelse af polyamid-nukleinsyre-oligomerer til frembringelse af et biologisk respons - Google Patents
Anvendelse af polyamid-nukleinsyre-oligomerer til frembringelse af et biologisk responsInfo
- Publication number
- DK1042349T3 DK1042349T3 DK98953610T DK98953610T DK1042349T3 DK 1042349 T3 DK1042349 T3 DK 1042349T3 DK 98953610 T DK98953610 T DK 98953610T DK 98953610 T DK98953610 T DK 98953610T DK 1042349 T3 DK1042349 T3 DK 1042349T3
- Authority
- DK
- Denmark
- Prior art keywords
- pna oligomers
- materials
- biological response
- oligomers
- provides methods
- Prior art date
Links
- 230000008512 biological response Effects 0.000 title abstract 5
- 239000004952 Polyamide Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 229920002647 polyamide Polymers 0.000 title 1
- 238000000034 method Methods 0.000 abstract 6
- 239000000463 material Substances 0.000 abstract 5
- 241001465754 Metazoa Species 0.000 abstract 2
- 230000004888 barrier function Effects 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 230000007306 turnover Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3181—Peptide nucleic acid, PNA
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/953,269 US6472209B1 (en) | 1997-10-17 | 1997-10-17 | Using polyamide nucleic acid oligomers to engender a biological response |
| US09/016,685 US6743627B1 (en) | 1997-10-17 | 1998-01-30 | Using polyamide nucleic acid oligomers to engender a biological response |
| US16851998A | 1998-10-08 | 1998-10-08 | |
| US09/168,714 US6989270B1 (en) | 1997-10-17 | 1998-10-08 | Using polyamide nucleic acid oligomers to engender a biological response |
| US09/168,791 US6723560B2 (en) | 1998-10-08 | 1998-10-08 | Using polyamide nucleic acid oligomers to engender a biological response |
| PCT/US1998/021888 WO1999020643A1 (en) | 1997-10-17 | 1998-10-16 | Using polyamide nucleic acid oligomers to engender a biological response |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1042349T3 true DK1042349T3 (da) | 2008-11-10 |
Family
ID=27533701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98953610T DK1042349T3 (da) | 1997-10-17 | 1998-10-16 | Anvendelse af polyamid-nukleinsyre-oligomerer til frembringelse af et biologisk respons |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6989270B1 (da) |
| EP (1) | EP1042349B1 (da) |
| JP (1) | JP2003523307A (da) |
| AT (1) | ATE405575T1 (da) |
| AU (1) | AU741246B2 (da) |
| BR (1) | BR9814866A (da) |
| CA (1) | CA2306731A1 (da) |
| DE (1) | DE69839921D1 (da) |
| DK (1) | DK1042349T3 (da) |
| ES (1) | ES2312192T3 (da) |
| IL (1) | IL135705A0 (da) |
| WO (1) | WO1999020643A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6472209B1 (en) | 1997-10-17 | 2002-10-29 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
| US6723560B2 (en) | 1998-10-08 | 2004-04-20 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
| US6989270B1 (en) | 1997-10-17 | 2006-01-24 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
| US6806363B1 (en) | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
| CA2427146A1 (en) | 2000-10-25 | 2002-07-18 | Mayo Foundation For Medical Education And Research | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5470974A (en) | 1985-03-15 | 1995-11-28 | Neu-Gene Development Group | Uncharged polynucleotide-binding polymers |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| WO1986005519A1 (en) | 1985-03-15 | 1986-09-25 | James Summerton | Polynucleotide assay reagent and method |
| US5783682A (en) | 1990-07-27 | 1998-07-21 | Isis Pharmaceuticals, Inc. | Oligonucleotide mimics having nitrogen-containing linkages |
| US5641625A (en) | 1992-05-22 | 1997-06-24 | Isis Pharmaceuticals, Inc. | Cleaving double-stranded DNA with peptide nucleic acids |
| US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| AU7559894A (en) | 1993-08-05 | 1995-02-28 | Isis Pharmaceuticals, Inc. | Oligomers for modulating metabolic function |
| AU7523794A (en) | 1993-08-09 | 1995-02-28 | Isis Pharmaceuticals, Inc. | Oligomers for modulating viral processes |
| US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| GB2284209A (en) | 1993-11-25 | 1995-05-31 | Ole Buchardt | Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template |
| US5703067A (en) * | 1995-05-08 | 1997-12-30 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU5856596A (en) | 1995-05-10 | 1996-11-29 | Isis Pharmaceuticals, Inc. | Inhibition of transcription factor-mediated transcriptional activation by oligomer strand invasion |
| US6015710A (en) | 1996-04-09 | 2000-01-18 | The University Of Texas System | Modulation of mammalian telomerase by peptide nucleic acids |
| GB9608803D0 (en) | 1996-04-27 | 1996-07-03 | Univ Newcastle | Mitochondrial dna defects |
| CA2291839A1 (en) | 1997-05-28 | 1998-12-03 | Peter E. Nielsen | Conjugated peptide nucleic acids having enhanced cellular uptake |
| AU741546B2 (en) | 1997-07-24 | 2001-12-06 | Perseptive Biosystems, Inc. | Conjugates of transporter peptides and nucleic acid analogs, and their use |
| US6300318B1 (en) | 1997-09-16 | 2001-10-09 | Peter E. Nielsen | Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor |
| AU9570898A (en) | 1997-09-18 | 1999-04-05 | Gene Therapy Systems, Inc. | Chemical modification of dna using peptide nucleic acid conjugates |
| US6472209B1 (en) * | 1997-10-17 | 2002-10-29 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
| US6989270B1 (en) | 1997-10-17 | 2006-01-24 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
-
1998
- 1998-10-08 US US09/168,714 patent/US6989270B1/en not_active Expired - Fee Related
- 1998-10-16 IL IL13570598A patent/IL135705A0/xx unknown
- 1998-10-16 BR BR9814866-4A patent/BR9814866A/pt not_active IP Right Cessation
- 1998-10-16 DK DK98953610T patent/DK1042349T3/da active
- 1998-10-16 JP JP2000516984A patent/JP2003523307A/ja active Pending
- 1998-10-16 CA CA002306731A patent/CA2306731A1/en not_active Abandoned
- 1998-10-16 EP EP98953610A patent/EP1042349B1/en not_active Expired - Lifetime
- 1998-10-16 DE DE69839921T patent/DE69839921D1/de not_active Expired - Fee Related
- 1998-10-16 AT AT98953610T patent/ATE405575T1/de not_active IP Right Cessation
- 1998-10-16 AU AU10940/99A patent/AU741246B2/en not_active Ceased
- 1998-10-16 ES ES98953610T patent/ES2312192T3/es not_active Expired - Lifetime
- 1998-10-16 WO PCT/US1998/021888 patent/WO1999020643A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU1094099A (en) | 1999-05-10 |
| EP1042349A1 (en) | 2000-10-11 |
| EP1042349B1 (en) | 2008-08-20 |
| US6989270B1 (en) | 2006-01-24 |
| IL135705A0 (en) | 2001-05-20 |
| CA2306731A1 (en) | 1999-04-29 |
| EP1042349A4 (en) | 2004-07-28 |
| WO1999020643A9 (en) | 1999-08-05 |
| DE69839921D1 (de) | 2008-10-02 |
| WO1999020643A1 (en) | 1999-04-29 |
| AU741246B2 (en) | 2001-11-29 |
| ES2312192T3 (es) | 2009-02-16 |
| JP2003523307A (ja) | 2003-08-05 |
| BR9814866A (pt) | 2001-11-20 |
| ATE405575T1 (de) | 2008-09-15 |
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