DK1043327T3 - Phosphonocephem-derivater, fremgangsmåde til fremstilling af disse og anvendelse deraf - Google Patents

Phosphonocephem-derivater, fremgangsmåde til fremstilling af disse og anvendelse deraf

Info

Publication number: DK1043327T3
Authority: DK; Denmark
Prior art keywords: processes; preparation; phosphonocephem; derivatives; phosphonocephem derivatives
Prior art date: 1997-12-19

Application number

DK98961385T

Other languages

English (en)

Inventor

Tomoyasu Ishikawa

Shohei Hashiguchi

Yuji Iizawa

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-19

Filing date

1998-12-17

Publication date

2009-08-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18417716&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1043327(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-12-17 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2009-08-17 Application granted granted Critical

2009-08-17 Publication of DK1043327T3 publication Critical patent/DK1043327T3/da

Links

JKKCZQKHMGGMQT-LWOQYNTDSA-N P(=O)(O)(O)C1S[C@H]2N(C=C1)C(C2)=O Chemical class P(=O)(O)(O)C1S[C@H]2N(C=C1)C(C2)=O JKKCZQKHMGGMQT-LWOQYNTDSA-N 0.000 title 1
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)

DK98961385T 1997-12-19 1998-12-17 Phosphonocephem-derivater, fremgangsmåde til fremstilling af disse og anvendelse deraf DK1043327T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP35149997		1997-12-19
PCT/JP1998/005709 WO1999032497A1 (en)	1997-12-19	1998-12-17	Phosphonocephem derivatives, process for the preparation of the same, and use thereof

Publications (1)

Publication Number	Publication Date
DK1043327T3 true DK1043327T3 (da)	2009-08-17

Family

ID=18417716

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98961385T DK1043327T3 (da)	1997-12-19	1998-12-17	Phosphonocephem-derivater, fremgangsmåde til fremstilling af disse og anvendelse deraf

Country Status (19)

Country	Link
US (1)	US6417175B1 (da)
EP (2)	EP2080765A1 (da)
JP (3)	JP3467418B2 (da)
KR (1)	KR100384047B1 (da)
CN (2)	CN1194980C (da)
AT (1)	ATE430155T1 (da)
AU (1)	AU1683299A (da)
BE (1)	BE2013C004I2 (da)
CA (1)	CA2314564C (da)
CY (2)	CY1109276T1 (da)
DE (1)	DE69840796D1 (da)
DK (1)	DK1043327T3 (da)
ES (1)	ES2325139T3 (da)
FR (1)	FR13C0008I2 (da)
LU (1)	LU92134I2 (da)
NL (1)	NL300568I1 (da)
PT (1)	PT1043327E (da)
TW (1)	TW473479B (da)
WO (1)	WO1999032497A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1310502E (pt) *	2000-08-10	2009-07-31	Takeda Pharmaceutical	Composto de fosfonocefem
US20070249577A1 (en) *	2005-05-10	2007-10-25	Hopkins Scott J	Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
US20070238720A1 (en) *	2005-05-10	2007-10-11	Hopkins Scott J	Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
US20070238719A1 (en) *	2005-05-10	2007-10-11	Hopkins Scott J	Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
CN101357929B (zh) *	2007-06-22	2010-12-15	山东轩竹医药科技有限公司	含有巯基噻二唑的头孢菌素衍生物
BRPI0816412A2 (pt) *	2007-09-21	2017-05-16	Forest Laboratories Holdings Ltd	forma de dosagem, e, método para tratar uma infecção bacteriana
CN102292079B (zh) *	2008-08-28	2014-03-12	阿斯利康(瑞典)有限公司	包含头孢洛林的组合物和治疗方法
US8247400B2 (en) *	2009-02-23	2012-08-21	Dedhiya Mahendra G	Cephem compounds useful for the treatment of bacterial infections
WO2011035305A1 (en)	2009-09-21	2011-03-24	Forest Laboratories Holdings Limited	Compositions and methods for treating bacterial infections using ceftaroline
FR2951171A1 (fr) *	2009-10-09	2011-04-15	Novexel	Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
US8829191B2 (en)	2011-06-17	2014-09-09	Melanie Simone Ronsheim	Processes for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
WO2013084171A1 (en)	2011-12-07	2013-06-13	Ranbaxy Laboratories Limited	Process for preparing ceftaroline salts or hydrates thereof
ES2721623T3 (es) *	2012-10-19	2019-08-02	Sandoz Ag	Procedimiento novedoso para la preparación de ceftarolina fosamil
CN102977124B (zh) *	2012-12-13	2014-11-26	山东诚创医药技术开发有限公司	7β-[(苯乙酰)氨基]-3-[4-(1-甲基-4-吡啶鎓)-2-噻唑硫基]-3-头孢烯-4-羧酸二苯甲基酯的制备方法
JP2016501903A (ja) *	2012-12-20	2016-01-21	サンド・アクチエンゲゼルシヤフト	新規結晶形のセフタロリンフォサミル
CN105612166B (zh)	2014-02-21	2019-02-19	上海盟科药业有限公司	治疗用水溶性(o-羰基)氨基磷酸酯前药
CN106565784B (zh) *	2016-10-31	2019-02-26	瑞阳制药有限公司	头孢洛林酯二钠盐的纯化方法
CN110872322B (zh) *	2018-08-29	2022-08-02	上海博志研新药物技术有限公司	乙酸头孢罗膦一水合物及其中间体的制备方法
CN113072567B (zh) *	2021-03-26	2022-10-14	海南海灵化学制药有限公司	一种拉氧头孢钠合成工艺
CN113214323A (zh) *	2021-04-30	2021-08-06	瑞阳制药股份有限公司	分段式头孢罗膦高效稳定析晶方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5941999B2 (ja)	1975-07-24	1984-10-11	武田薬品工業株式会社	セフエムまたはベナム化合物の製造法
JPS5511600A (en) *	1978-07-10	1980-01-26	Fujisawa Pharmaceut Co Ltd	Cephem compound, its salt, their preparation and remedy and prophylactic for microbism containing mainly the same
US4268509A (en)	1978-07-10	1981-05-19	Fujisawa Pharmaceutical Co., Ltd.	New cephem compounds and processes for preparation thereof
FR2511372A1 (fr) *	1981-08-17	1983-02-18	Rhone Poulenc Sante	Nouveaux derives de la cephalosporine et leur preparation
US4563449A (en)	1982-07-19	1986-01-07	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds
JPS5931791A (ja) *	1982-07-19	1984-02-20	Fujisawa Pharmaceut Co Ltd	新規セフエム化合物およびその製造法、並びに細菌感染症予防・治療剤
JPS62238291A (ja) *	1986-04-10	1987-10-19	Fujisawa Pharmaceut Co Ltd	セフエム化合物および医薬として許容されるその塩
US4978663A (en) *	1989-08-16	1990-12-18	Hoechst-Roussel Pharmaceuticals Inc.	5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility
JP3514495B2 (ja)	1992-10-02	2004-03-31	エーザイ株式会社	ハロゲン化アミノチアジアゾリル酢酸誘導体の製造法
JP3927262B2 (ja)	1995-07-19	2007-06-06	武田薬品工業株式会社	セフェム化合物、その製造法および抗菌組成物
JPH10265488A (ja) *	1997-03-27	1998-10-06	Takeda Chem Ind Ltd	ホスフォノセフェム誘導体

1998
- 1998-12-02 TW TW087119933A patent/TW473479B/zh not_active IP Right Cessation
- 1998-12-17 KR KR10-2000-7006796A patent/KR100384047B1/ko not_active Expired - Lifetime
- 1998-12-17 AU AU16832/99A patent/AU1683299A/en not_active Abandoned
- 1998-12-17 EP EP09158866A patent/EP2080765A1/en not_active Withdrawn
- 1998-12-17 ES ES98961385T patent/ES2325139T3/es not_active Expired - Lifetime
- 1998-12-17 WO PCT/JP1998/005709 patent/WO1999032497A1/ja not_active Ceased
- 1998-12-17 CN CNB988122944A patent/CN1194980C/zh not_active Expired - Lifetime
- 1998-12-17 CN CN2005100079635A patent/CN1679595B/zh not_active Expired - Lifetime
- 1998-12-17 CA CA002314564A patent/CA2314564C/en not_active Expired - Lifetime
- 1998-12-17 US US09/555,949 patent/US6417175B1/en not_active Expired - Lifetime
- 1998-12-17 AT AT98961385T patent/ATE430155T1/de active
- 1998-12-17 DK DK98961385T patent/DK1043327T3/da active
- 1998-12-17 PT PT98961385T patent/PT1043327E/pt unknown
- 1998-12-17 EP EP98961385A patent/EP1043327B1/en not_active Expired - Lifetime
- 1998-12-17 JP JP35888798A patent/JP3467418B2/ja not_active Expired - Lifetime
- 1998-12-17 DE DE69840796T patent/DE69840796D1/de not_active Expired - Lifetime
2000
- 2000-07-04 JP JP2000206824A patent/JP2001048893A/ja active Pending
2009
- 2009-01-16 JP JP2009007750A patent/JP2009114202A/ja not_active Abandoned
- 2009-07-29 CY CY20091100809T patent/CY1109276T1/el unknown
2013
- 2013-01-07 CY CY2013003C patent/CY2013003I2/el unknown
- 2013-01-08 BE BE2013C004C patent/BE2013C004I2/fr unknown
- 2013-01-11 NL NL300568C patent/NL300568I1/nl unknown
- 2013-01-16 LU LU92134C patent/LU92134I2/fr unknown
- 2013-02-06 FR FR13C0008C patent/FR13C0008I2/fr active Active

Also Published As

Publication number	Publication date
KR20010015885A (ko)	2001-02-26
JP3467418B2 (ja)	2003-11-17
JP2001048893A (ja)	2001-02-20
FR13C0008I2 (fr)	2013-08-16
CN1194980C (zh)	2005-03-30
JP2009114202A (ja)	2009-05-28
NL300568I2 (da)	2016-01-18
KR100384047B1 (ko)	2003-05-14
EP2080765A1 (en)	2009-07-22
JPH11255772A (ja)	1999-09-21
EP1043327A4 (en)	2001-12-12
CY2013003I2 (el)	2015-08-05
US6417175B1 (en)	2002-07-09
ES2325139T3 (es)	2009-08-26
FR13C0008I1 (da)	2013-03-22
CA2314564C (en)	2008-11-18
PT1043327E (pt)	2009-07-02
LU92134I2 (fr)	2013-03-18
WO1999032497A1 (en)	1999-07-01
CA2314564A1 (en)	1999-07-01
EP1043327A1 (en)	2000-10-11
ATE430155T1 (de)	2009-05-15
AU1683299A (en)	1999-07-12
TW473479B (en)	2002-01-21
NL300568I1 (da)	2016-01-18
CY2013003I1 (el)	2014-07-02
CN1679595B (zh)	2010-05-12
BE2013C004I2 (en)	2018-01-29
EP1043327B1 (en)	2009-04-29
CN1282335A (zh)	2001-01-31
DE69840796D1 (de)	2009-06-10
CY1109276T1 (el)	2014-07-02
CN1679595A (zh)	2005-10-12

Publication	Publication Date	Title
NL300568I2 (da)	2016-01-18
ATE215954T1 (de)	2002-04-15	Pyrazolo(4,3-d)pyrimidin-derivate und diese enthaltende pharmazeutische zubereitungen
ES2070660B1 (es)	1996-01-01	Un procedimiento para la preparacion de 2,5-damino-3-hidroxihexanos sustituidos, utiles como inhibidores de proteasas retrovirales.
NZ238403A (en)	1992-09-25	Heterocyclically-substituted phthalides and condensed analogues; herbicidal compositions thereof
FI920261L (fi)	1992-08-23	((2-(amino-3,4-dioxo-1-cyklobuten-1-yl)amino)-alkyl)syraderivat
NO302884B1 (no)	1998-05-04	Krystallinske 3,4,4-trisubstituert-piperidinyl-N-alkylkarboksylater og mellomprodukter, fremgangsmåte for fremstilling av de krystallinske karboksylatene, farmasöytiske preparater inneholdende disse og deres anvendelse
AU3973697A (en)	1998-03-06	Isoxazoline derivatives useful as antimicrobials
DK0513543T3 (da)	1996-02-26	Amidinophenylalaninderivater, fremgangsmåde til deres fremstilling, deres anvendelse og antikoagulationsmidler med indehold deraf
DE122006000065I1 (de)	2007-03-01	Cephalosporine und ihre homologen, zubereitungen und Pharmazeutische Pr{parate
FI981956A0 (fi)	1998-09-11	2-(4-hydroksipiperidino)-1-alkanolijohdannaisia verettömyyden vastaisia aineina
FI963885L (fi)	1996-11-26	Pyrimidiini- tai triatsiinikarboksyylihappojohdannaiset käytettäväksi lääkaineina
DK0435333T3 (da)	1996-06-24	Cephalosporinderivater, fremgangsmåde til fremstilling deraf og antimikrobielt præparat indeholdende derivaterne
DE69818261D1 (en)	2003-10-23	Hydroxycyclopentanone
ZA200305877B (en)	2004-04-28	Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof.
MX9207429A (es)	1993-06-01	Nuevo uso de derivados de aminoacido.
EP0416810A3 (en)	1992-04-01	Cephalosporin compounds, process for their preparation, pharmaceutical compositions and intermediates
HUT76480A (en)	1997-09-29	Alkyl-5-methyl-sulphonyl-benzoyl-guanidine derivatives, process for the preparation thereof and pharmaceutical compositions containing them
SE9101687D0 (sv)	1991-06-04	Dikloranilinfoerening
DK0418990T3 (da)	1994-03-14	13-brom- og 13,14-dibrom-ergoliner, deres fremstilling og anvendelse i lægemidler
NO871375D0 (no)	1987-04-02	Bis-tertiaerbutylamino-substituerte 1,3,5-triazinderivater, fremgangsmaate til deres fremstilling, legemidler inneholdende disse forbindelser og deres anvendelse.
DK0432898T3 (da)	1994-05-16	Glutarsyrederivater og fremstillingen deraf
EP0994111A4 (en)	2001-01-24	TETRAHYDROFURANNE DERIVATIVES
NO972942L (no)	1997-12-29	4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, fremgangsmåter for deres fremstilling, legemidler inneholdende disse forbindelsene og deres anvendelse
DK0390066T3 (da)	1997-02-17	Cephalosporinderivater og fremgangsmåde til deres fremstilling
FI921475A7 (fi)	1992-04-03	1,4-dihydro-4-okso-3-kinoliinijohdannaisia selektiivisesti toksisina n isäkkään antibakteerisina aineina