DK1044209T3 - Fremgangsmåde till fremstilling af 6-O-methylerythromycin A ved at anvende derivater af 9-hydroxyerythromycin - Google Patents

Fremgangsmåde till fremstilling af 6-O-methylerythromycin A ved at anvende derivater af 9-hydroxyerythromycin

Info

Publication number: DK1044209T3
Authority: DK; Denmark
Prior art keywords: erythromycin; hydroxyerythromycin; methylerythromycin; derivatives; preparation
Prior art date: 1997-12-16

Application number

DK98959481T

Other languages

English (en)

Inventor

David A Riley

Yi-Yin Ku

Elaine C Lee

Jien-Heh J Tien

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-16

Filing date

1998-11-17

Publication date

2004-11-22

1998-11-17 Application filed by Abbott Lab filed Critical Abbott Lab

2004-11-22 Application granted granted Critical

2004-11-22 Publication of DK1044209T3 publication Critical patent/DK1044209T3/da

Links

229960002626 clarithromycin Drugs 0.000 title abstract 3
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 title abstract 3
229930006677 Erythromycin A Natural products 0.000 abstract 3
229960003276 erythromycin Drugs 0.000 abstract 3
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000001035 methylating effect Effects 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK98959481T 1997-12-16 1998-11-17 Fremgangsmåde till fremstilling af 6-O-methylerythromycin A ved at anvende derivater af 9-hydroxyerythromycin DK1044209T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/991,648 US5892008A (en)	1997-12-16	1997-12-16	Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
PCT/US1998/024498 WO1999031114A1 (en)	1997-12-16	1998-11-17	Process for the preparation of 6-o-methyl erythromycin a using 9-hydroxy erythromycin derivatives
EP98959481A EP1044209B1 (en)	1997-12-16	1998-11-17	Process for the preparation of 6-o-methyl erythromycin a using 9-hydroxy erythromycin derivatives

Publications (1)

Publication Number	Publication Date
DK1044209T3 true DK1044209T3 (da)	2004-11-22

Family

ID=25537423

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98959481T DK1044209T3 (da)	1997-12-16	1998-11-17	Fremgangsmåde till fremstilling af 6-O-methylerythromycin A ved at anvende derivater af 9-hydroxyerythromycin

Country Status (13)

Country	Link
US (1)	US5892008A (da)
EP (1)	EP1044209B1 (da)
JP (1)	JP2002508385A (da)
KR (1)	KR20010033178A (da)
AT (1)	ATE273988T1 (da)
AU (1)	AU1526999A (da)
CA (2)	CA2315209C (da)
DE (1)	DE69825785T2 (da)
DK (1)	DK1044209T3 (da)
ES (1)	ES2229552T3 (da)
IL (1)	IL136237A0 (da)
PT (1)	PT1044209E (da)
WO (1)	WO1999031114A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3054699B2 (ja) *	1998-08-07	2000-06-19	工業技術院長	Ｏ−シリル化含水酸基環状エーテルの製造方法
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
KR100336447B1 (ko) *	1999-11-24	2002-05-15	민경윤	클라리스로마이신의 개선된 제조방법
PT1254146E (pt) *	1999-12-16	2005-10-31	Teva Pharma	Processos de preparacao de polimeros de claritromicina e novo polimorfo iv
PL356645A1 (en)	2000-01-11	2004-06-28	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin polymorphs
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en) *	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
AU2578701A (en)	2000-02-29	2001-09-12	Teva Pharma	Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
US6605707B1 (en)	2000-03-23	2003-08-12	Abbott Laboratories	Process for the preparation of 6-O-propargyl erythromycin derivatives
US6541014B2 (en) *	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20020068078A1 (en) *	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US20020197314A1 (en) *	2001-02-23	2002-12-26	Rudnic Edward M.	Anti-fungal composition
ITMI20021726A1 (it) *	2002-08-01	2004-02-02	Zambon Spa	Macrolidi ad attivita' antiinfiammatoria.
EP1648415A4 (en) *	2003-07-21	2011-11-16	Middlebrook Pharmaceuticals Inc	ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
EP1648418A4 (en) *	2003-07-21	2011-11-16	Middlebrook Pharmaceuticals Inc	ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
CA2533292C (en)	2003-07-21	2013-12-31	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
WO2005016311A1 (en) *	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Robust pellet
CA2535398C (en) *	2003-08-12	2013-11-12	Advancis Pharmaceuticals Corporation	Antibiotic product, use and formulation thereof
EP1658034A4 (en) *	2003-08-29	2011-06-22	Middlebrook Pharmaceuticals Inc	ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
WO2005027877A1 (en) *	2003-09-15	2005-03-31	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
US8715727B2 (en) *	2004-07-02	2014-05-06	Shionogi Inc.	Tablet for pulsed delivery
US8778924B2 (en) *	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) *	2007-08-09	2009-02-26	Vinod Kumar Kansal	Process for the preparation of clarithromycin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4331803A (en) *	1980-06-04	1982-05-25	Taisho Pharmaceutical Co., Ltd.	Novel erythromycin compounds
JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
US4670549A (en) *	1985-03-18	1987-06-02	Taisho Pharmaceutical Co., Ltd.	Method for selective methylation of erythromycin a derivatives
US4640910A (en) *	1985-11-12	1987-02-03	Abbott Laboratories	Erythromycin A silylated compounds and method of use
KR960000434B1 (ko) *	1986-12-17	1996-01-06	다이쇼 세이야꾸 가부시끼가이샤	에리스로마이신 a유도체 및 그의 제조 방법
US5872229A (en) *	1995-11-21	1999-02-16	Abbott Laboratories	Process for 6-O-alkylation of erythromycin derivatives

1997
- 1997-12-16 US US08/991,648 patent/US5892008A/en not_active Expired - Lifetime
1998
- 1998-11-17 KR KR1020007006561A patent/KR20010033178A/ko not_active Withdrawn
- 1998-11-17 EP EP98959481A patent/EP1044209B1/en not_active Expired - Lifetime
- 1998-11-17 PT PT98959481T patent/PT1044209E/pt unknown
- 1998-11-17 ES ES98959481T patent/ES2229552T3/es not_active Expired - Lifetime
- 1998-11-17 CA CA002315209A patent/CA2315209C/en not_active Expired - Fee Related
- 1998-11-17 JP JP2000539037A patent/JP2002508385A/ja active Pending
- 1998-11-17 WO PCT/US1998/024498 patent/WO1999031114A1/en not_active Ceased
- 1998-11-17 AT AT98959481T patent/ATE273988T1/de not_active IP Right Cessation
- 1998-11-17 DK DK98959481T patent/DK1044209T3/da active
- 1998-11-17 CA CA002615701A patent/CA2615701A1/en not_active Abandoned
- 1998-11-17 AU AU15269/99A patent/AU1526999A/en not_active Abandoned
- 1998-11-17 DE DE69825785T patent/DE69825785T2/de not_active Expired - Fee Related
- 1998-11-17 IL IL13623798A patent/IL136237A0/xx unknown

Also Published As

Publication number	Publication date
ES2229552T3 (es)	2005-04-16
CA2315209A1 (en)	1999-06-24
PT1044209E (pt)	2004-11-30
JP2002508385A (ja)	2002-03-19
EP1044209B1 (en)	2004-08-18
AU1526999A (en)	1999-07-05
DE69825785T2 (de)	2005-08-18
CA2615701A1 (en)	1999-06-24
US5892008A (en)	1999-04-06
KR20010033178A (ko)	2001-04-25
IL136237A0 (en)	2001-05-20
EP1044209A1 (en)	2000-10-18
DE69825785D1 (de)	2004-09-23
WO1999031114A1 (en)	1999-06-24
CA2315209C (en)	2008-04-08
ATE273988T1 (de)	2004-09-15

Publication	Publication Date	Title
PT1044209E (pt)	2004-11-30	Processo para a preparacao de 6-0-metileritromicina a utilizando derivados 9-hidroxieritromicina
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DK1032581T3 (da)	2004-08-02	Kemisk syntese af 6-O-alkyl-erythromycin A
AR240833A1 (es)	1991-02-28	Metodo para preparar derivados de 6-o-metil-eritromicina a por metilacion selectiva de derivados 6-hidroxi de eritromicina a.
NO993876L (no)	1999-08-11	3'-N-oksid, 3'-N-dimetylamin, 9-oksim erytromycin A derivater
ES2191982T3 (es)	2003-09-16	Derivados de 6-o-alquilo de eritronolida b.
HU9400687D0 (en)	1994-06-28	Imidazolidyl macrolides
ATE196912T1 (de)	2000-10-15	Propargylethoxyamino nucleotide
WO2000061594A3 (de)	2002-04-04	Nucleosid-derivate mit photolabilen schutzgruppen
IE821260L (en)	1982-11-28	Anthracycline derivatives
HUP0104600A3 (en)	2003-12-29	Novel intermediates, process for preparing macrolide antibiotic agent therefrom
DE60031154D1 (de)	2006-11-16	Verfahren zur herstellung von clarithromycin
ATE294772T1 (de)	2005-05-15	Oxyalkylen-substituierte aminophenol-derivate
ES2079436T3 (es)	1996-01-16	Clonacion de genes de streptomyces avermitilis para biosintesis de avermectinas y procedimientos para su uso.
DE3770359D1 (de)	1991-07-04	6-amino-anthracycline, verfahren zu ihrer herstellung und ihre verwendung.
IL110968A0 (en)	1994-11-28	Nucleosides, nucleotides and oligonucleotides comprising tris-4,4',4"-tert-butylphenylmethyl, as protected group and their preparation
IL159004A0 (en)	2004-05-12	An arylation method for the functionalization of o-allyl erythromycin derivatives
NO175882C (no)	1994-12-28	Fremgangsmåte ved fremstilling av parenterale, antiparasittiske formuleringer av forbindelsen 25-cykloheksyl-avermectin B1
DK0637244T3 (da)	2001-01-29	En stamme af Streptomyces avermilitis glycosylerer avermectinforbindelser
BG106123A (en)	2002-05-31	Diphosphate salt of a 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin derivative and its pharmaceutical composition
PT88952A (pt)	1988-12-01	Processo para a preparacao de avermectinas etiladas
ES2195727A1 (es)	2003-12-01	Un procedimiento para la obtencion de claritromicina.
EP0311694A4 (en)	1991-05-08	Nucleoside derivatives and process for their preparation
ES2177448A1 (es)	2002-12-01	"oxima de eritromicina a."
BG103726A (en)	2000-12-29	New hydroxyderivatives of tylosin and method for their preparation