DK1054018T3 - Fab-fragmentbiblioteker og fremgangsmåde til anvendelse deraf - Google Patents

Fab-fragmentbiblioteker og fremgangsmåde til anvendelse deraf

Info

Publication number
DK1054018T3
DK1054018T3 DK99201558T DK99201558T DK1054018T3 DK 1054018 T3 DK1054018 T3 DK 1054018T3 DK 99201558 T DK99201558 T DK 99201558T DK 99201558 T DK99201558 T DK 99201558T DK 1054018 T3 DK1054018 T3 DK 1054018T3
Authority
DK
Denmark
Prior art keywords
fab fragment
fragment libraries
fab
libraries
fabs
Prior art date
Application number
DK99201558T
Other languages
Danish (da)
English (en)
Inventor
Hendricus Renerus Jacobus Mattheus Hoogenboom
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp filed Critical Dyax Corp
Application granted granted Critical
Publication of DK1054018T3 publication Critical patent/DK1054018T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK99201558T 1999-05-18 1999-05-18 Fab-fragmentbiblioteker og fremgangsmåde til anvendelse deraf DK1054018T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99201558A EP1054018B1 (fr) 1999-05-18 1999-05-18 Banques de fragments Fab et leurs procédes d'utilisation

Publications (1)

Publication Number Publication Date
DK1054018T3 true DK1054018T3 (da) 2009-05-18

Family

ID=8240210

Family Applications (2)

Application Number Title Priority Date Filing Date
DK99201558T DK1054018T3 (da) 1999-05-18 1999-05-18 Fab-fragmentbiblioteker og fremgangsmåde til anvendelse deraf
DK09151233.5T DK2067788T3 (da) 1999-05-18 1999-05-18 Fab-fragmentbiblioteker og fremgangsmåder til anvendelse deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK09151233.5T DK2067788T3 (da) 1999-05-18 1999-05-18 Fab-fragmentbiblioteker og fremgangsmåder til anvendelse deraf

Country Status (10)

Country Link
EP (2) EP1054018B1 (fr)
JP (3) JP4741086B2 (fr)
AT (1) ATE421976T1 (fr)
AU (1) AU780145B2 (fr)
CA (1) CA2372582C (fr)
DE (1) DE69940364D1 (fr)
DK (2) DK1054018T3 (fr)
ES (2) ES2321568T3 (fr)
PT (2) PT1054018E (fr)
WO (1) WO2000070023A1 (fr)

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DE60237704D1 (de) 2001-10-16 2010-10-28 Government Of The Us Secretary Neutralisierende antikörper gegen hiv mit breiter kreuzreaktion, die mit hilfe von env-cd4-co-rezeptorkomplexen selektiert werden
CA2484930A1 (fr) * 2002-05-06 2003-11-13 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Identification d'anticorps monoclonaux humains largement neutralisants a reaction croisee au moyen d'un procede d'adherence sequentielle sur plaque d'antigenes de banques de presentation du phage
WO2003095492A1 (fr) 2002-05-06 2003-11-20 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Identification de nouveaux anticorps monoclonaux humains de neutralisation a activite sensiblement croisee contre le virus vih-1
DK2314629T4 (da) 2002-07-18 2023-02-06 Merus Nv Rekombinant produktion af blandinger af antistoffer
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
US20040072262A1 (en) * 2002-10-11 2004-04-15 Montero-Julian Felix A. Methods and systems for detecting MHC class I binding peptides
JP5438886B2 (ja) 2003-03-07 2014-03-12 タフツ メディカル センター インコーポレイテッド ＩｇＡ１沈着症の治療
US7157562B1 (en) * 2003-04-14 2007-01-02 The United States Of America As Represented By The Secretary Of The Army Bioprocess for the production of recombinant anti-botulinum toxin antibody
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
WO2004106375A1 (fr) 2003-05-30 2004-12-09 Merus Biopharmaceuticals B.V. I.O. Banque de fab pour la preparation de fab anti-vegf et antirabique
WO2005059176A1 (fr) * 2003-12-15 2005-06-30 Institut Pasteur Determination du repertoire d'une population de lymphocytes b
EP1737971B1 (fr) 2004-01-20 2017-08-16 Merus N.V. Mélanges de proteines de liason
EP1761561B1 (fr) 2004-01-20 2015-08-26 KaloBios Pharmaceuticals, Inc. Transfert de specificite d'anticorps au moyen de determinants de liaison essentielle minimale
CA2560305C (fr) 2004-03-19 2016-07-05 Imclone Systems Incorporated Anticorps du recepteur du facteur de croissance anti-epidermique humain
MY146381A (en) * 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
EP1707628B1 (fr) * 2005-03-30 2009-11-11 Sekisui Chemical Co., Ltd. Procédé de production d'immunoglobulines polyclonales recombinantes
EP2069558B1 (fr) 2006-10-02 2013-05-01 Sea Lane Biotechnologies,llc. Conception et construction de diverses banques de peptides et de polypeptides synthétiques
CN101126760B (zh) * 2007-01-17 2011-11-16 江苏省人民医院 全人源抗卵泡刺激素β单链抗体筛选方法及其用途
EP2894220B1 (fr) 2010-02-19 2017-11-22 Japan Science and Technology Agency Abzyme humain
JP6038121B2 (ja) 2011-04-21 2016-12-07 ガーバン インスティテュート オブ メディカル リサーチ 修飾された可変ドメイン分子及びその製造及び使用の方法ｂ
KR102096534B1 (ko) 2011-09-28 2020-04-03 에라 바이오테크, 에스.에이. 분할된 인테인 및 그의 이용
US9248181B2 (en) 2012-04-20 2016-02-02 Merus B.V. Methods and means for the production of Ig-like molecules
EP2968391A1 (fr) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Molécules polynucléotidiques à longue durée de vie
EP2883883A1 (fr) 2013-12-16 2015-06-17 Cardio3 Biosciences S.A. Cibles thérapeutiques et agents utiles dans le traitement des lésions ischémiques de reperfusion
RS61907B1 (sr) 2015-04-06 2021-06-30 Subdomain Llc Polipeptidi koji sadrže de novo vezujući domen i njihova primena
KR102165777B1 (ko) * 2016-04-06 2020-10-14 주무토르 바이오로직스 인코포레이티드 단백질의 클로닝 및 발현을 위한 벡터, 그 방법 및 적용
US20200182884A1 (en) 2016-06-27 2020-06-11 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
EP3475706B1 (fr) 2016-06-27 2021-08-11 Juno Therapeutics, Inc. Épitopes restreints au cmh-e, molécules de liaison, et procédés et utilisations associés
US20200033347A1 (en) 2017-04-18 2020-01-30 Universite Libre De Bruxelles Biomarkers And Targets For Proliferative Diseases
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
RS67119B1 (sr) 2017-11-14 2025-09-30 Arcellx Inc Polipeptidi koji obuhvataju d domen i njihove upotrebe
IL277307B2 (en) 2018-03-23 2025-03-01 Univ Bruxelles Wnt signaling agonist molecules
EP3833685A4 (fr) 2018-07-08 2022-08-17 Specifica Inc. Banques d'anticorps ayant des caractéristiques maximisées d'aptitude au développement d'anticorps
WO2026068859A1 (fr) 2024-09-30 2026-04-02 Université Libre de Bruxelles Molécules agonistes de signalisation wnt utilisées dans le traitement d'une maladie ou d'un trouble lié à l'os

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Also Published As

Publication number Publication date
WO2000070023A9 (fr) 2002-01-17
PT1054018E (pt) 2009-02-16
AU780145B2 (en) 2005-03-03
ATE421976T1 (de) 2009-02-15
PT2067788E (pt) 2015-10-29
JP2002543830A (ja) 2002-12-24
AU5142200A (en) 2000-12-05
ES2321568T3 (es) 2009-06-08
WO2000070023A1 (fr) 2000-11-23
EP2067788A3 (fr) 2010-04-21
DK2067788T3 (da) 2015-10-19
JP2013078315A (ja) 2013-05-02
CA2372582A1 (fr) 2000-11-23
HK1134303A1 (en) 2010-04-23
EP1054018A1 (fr) 2000-11-22
JP5159841B2 (ja) 2013-03-13
JP4741086B2 (ja) 2011-08-03
EP2067788B1 (fr) 2015-07-22
ES2549440T3 (es) 2015-10-28
EP2067788A2 (fr) 2009-06-10
CA2372582C (fr) 2013-08-13
DE69940364D1 (de) 2009-03-19
EP1054018B1 (fr) 2009-01-28
JP2010273689A (ja) 2010-12-09

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