DK1054885T3 - Benzisoxasolderivater med D4-antagonistisk virkning - Google Patents

Benzisoxasolderivater med D4-antagonistisk virkning

Info

Publication number: DK1054885T3
Authority: DK; Denmark
Prior art keywords: amino; sulfonyl; group; dialkyl; alkoxy
Prior art date: 1998-02-09

Application number

DK99914450T

Other languages

English (en)

Inventor

Hartog Jacobus A J Den

Steen Bartholomeus J Van

Martinus T M Tulp

Eric Ronken

Cornelis G Kruse

Josephus H M Lange

Gerben M Visser

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-09

Filing date

1999-02-05

Publication date

2007-10-15

1999-02-05 Application filed by Duphar Int Res filed Critical Duphar Int Res

2007-10-15 Application granted granted Critical

2007-10-15 Publication of DK1054885T3 publication Critical patent/DK1054885T3/da

Links

150000008316 benzisoxazoles Chemical class 0.000 title abstract 2
230000003042 antagnostic effect Effects 0.000 title 1
-1 nitro, amino Chemical group 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 abstract 2
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000004174 2-benzimidazolyl group Chemical group [H]N1C(*)=NC2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
102000003962 Dopamine D4 receptors Human genes 0.000 abstract 1
108090000357 Dopamine D4 receptors Proteins 0.000 abstract 1
239000005977 Ethylene Substances 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK99914450T 1998-02-09 1999-02-05 Benzisoxasolderivater med D4-antagonistisk virkning DK1054885T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98200400		1998-02-09
PCT/EP1999/000852 WO1999040067A2 (en)	1998-02-09	1999-02-05	Benzisoxazole derivatives having d4-antagonistic activity

Publications (1)

Publication Number	Publication Date
DK1054885T3 true DK1054885T3 (da)	2007-10-15

Family

ID=8233376

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99914450T DK1054885T3 (da)	1998-02-09	1999-02-05	Benzisoxasolderivater med D4-antagonistisk virkning

Country Status (11)

Country	Link
US (1)	US6335326B1 (da)
EP (1)	EP1054885B1 (da)
JP (1)	JP4627882B2 (da)
AT (1)	ATE367389T1 (da)
AU (1)	AU3327399A (da)
CA (1)	CA2320120C (da)
DE (1)	DE69936572T2 (da)
DK (1)	DK1054885T3 (da)
ES (1)	ES2291023T3 (da)
PT (1)	PT1054885E (da)
WO (1)	WO1999040067A2 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4627882B2 (ja)	1998-02-09	2011-02-09	デユフアー・インターナシヨナル・リサーチ・ベー・ブイ	Ｄ４−アンタゴニスト活性を有するベンズイソキサゾール誘導体
PT1216249E (pt) *	1999-09-14	2004-04-30	Aventis Pharma Inc	Derivados de etilicos e propilicos insubstituidos de tienoisoxazol-fenoxi uteis como antagonistas d4
DK1216250T3 (da) *	1999-09-14	2004-02-23	Aventis Pharma Inc	Thienoisoxazolyl- og thienylpyrazolyl-phenoxy- substituerede propylderivater som D4-antagonister
US7091199B1 (en)	1999-09-14	2006-08-15	Aventis Pharmaceuticals Inc.	Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7253165B2 (en)	1999-09-14	2007-08-07	Aventis Pharmaceuticals Inc.	Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
ATE247110T1 (de) *	1999-09-14	2003-08-15	Aventis Pharma Inc	Benzisoxazolyl-, pyridoisoxazolyl- und benzthienyl-phenoxy derivate als d4 antagonisten
US7125903B1 (en)	1999-09-14	2006-10-24	Aventis Pharmaceuticals Inc.	Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
AU2002258506A1 (en)	2001-03-12	2002-09-24	The Mclean Hospital Corporation	Dopamine d4 receptor antagonists as treatment for attention deficit-hyperactivity disorder
US8816090B2 (en) *	2005-02-25	2014-08-26	Pfizer Inc.	Benzisoxazole derivatives
WO2009013212A2 (en) *	2007-07-26	2009-01-29	F. Hoffmann-La Roche Ag	Dual modulators of 5-ht2a and d3 receptors
US8877778B2 (en)	2010-12-15	2014-11-04	Hoffmann-La Roche Inc.	Benzofurane compounds
US8921397B2 (en)	2011-05-04	2014-12-30	Hoffmann-La Roche Inc.	Benzofurane-piperidine compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4352811A (en) *	1981-11-12	1982-10-05	Hoechst-Roussel Pharmaceuticals Inc.	3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
CA2116117A1 (en)	1991-08-22	1993-03-04	Hiroyuki Sueoka	Benzisoxazole compound and use thereof
JPH0641125A (ja) *	1992-03-26	1994-02-15	Yoshitomi Pharmaceut Ind Ltd	ベンゾイソオキサゾール化合物およびその用途
DK60593D0 (da) *	1993-05-26	1993-05-26	Novo Nordisk As	Kemiske forbindelser, deres fremstilling og anvendelse
FR2749304B1 (fr) *	1996-06-04	1998-06-26	Adir	Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
JP4627882B2 (ja) *	1998-02-09	2011-02-09	デユフアー・インターナシヨナル・リサーチ・ベー・ブイ	Ｄ４−アンタゴニスト活性を有するベンズイソキサゾール誘導体

1999
- 1999-02-05 JP JP2000530498A patent/JP4627882B2/ja not_active Expired - Fee Related
- 1999-02-05 EP EP99914450A patent/EP1054885B1/en not_active Expired - Lifetime
- 1999-02-05 US US09/601,795 patent/US6335326B1/en not_active Expired - Lifetime
- 1999-02-05 WO PCT/EP1999/000852 patent/WO1999040067A2/en not_active Ceased
- 1999-02-05 AT AT99914450T patent/ATE367389T1/de active
- 1999-02-05 AU AU33273/99A patent/AU3327399A/en not_active Abandoned
- 1999-02-05 DE DE69936572T patent/DE69936572T2/de not_active Expired - Lifetime
- 1999-02-05 DK DK99914450T patent/DK1054885T3/da active
- 1999-02-05 PT PT99914450T patent/PT1054885E/pt unknown
- 1999-02-05 ES ES99914450T patent/ES2291023T3/es not_active Expired - Lifetime
- 1999-02-05 CA CA002320120A patent/CA2320120C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1054885B1 (en)	2007-07-18
US6335326B1 (en)	2002-01-01
EP1054885A2 (en)	2000-11-29
AU3327399A (en)	1999-08-23
CA2320120A1 (en)	1999-08-12
DE69936572T2 (de)	2008-06-19
ES2291023T3 (es)	2008-02-16
WO1999040067A3 (en)	1999-11-25
CA2320120C (en)	2009-08-11
DE69936572D1 (de)	2007-08-30
ATE367389T1 (de)	2007-08-15
JP4627882B2 (ja)	2011-02-09
PT1054885E (pt)	2007-10-03
JP2002502842A (ja)	2002-01-29
WO1999040067A2 (en)	1999-08-12

Publication	Publication Date	Title
DK0858461T3 (da)	2003-01-27	Kondenserede tropanderivater som neurotransmittergenoptagelsesinhibitorer
DK1054885T3 (da)	2007-10-15	Benzisoxasolderivater med D4-antagonistisk virkning
UA72917C2 (en)	2005-05-16	Cyclic carbamates derivatives, pharmaceutical composition containing said derivatives of cyclic carbamates and active ingredients as modulators of the progesterone receptor
MEP61208A (en)	2011-05-10	Novel compounds having inhibitory activity against sodium-dependant transporter
MX9709951A (es)	1998-03-29	Derivados de benzamida y su uso como antagonistas de vasopresina.
MY114679A (en)	2002-12-31	Aroyl-piperidine derivatives
NO20033385L (no)	2003-09-30	Fuserte heterocykliske forbindelser
TR199902724T2 (xx)	2000-04-21	Dopamine D3 resept�rleri mod�lat�rleri olarak tetrahidroisokuinolin t�revleri.
ATE175661T1 (de)	1999-01-15	Benzamid-derivate als vasopressin-antagonisten
ZA939068B (en)	1994-08-09	Amine derivatives
EA199901062A1 (ru)	2000-08-28	Производные хинолин-4-карбоксамида как антагонисты рецепторов нк-2 и нк-3
NO964698D0 (no)	1996-11-06	Bicykliske aminderivater som inhibitorer av nitrogenoksid-syntetase
NO305287B1 (no)	1999-05-03	AMPA antagonister
PE20060770A1 (es)	2006-10-03	Derivados de n-[(4,5-difenil-3-alquil-2-tienil)metil]amina como antagonistas de los receptores cannabinoides cb1
HUP9700955A2 (hu)	1998-03-02	Szubsztituált 2-naftoil-guanidin-származékok, előállításuk, valamint az e vegyületeket tartalmazó gyógyszerkészítmények
PE20001384A1 (es)	2000-12-30	Derivados de acetamida no peptidicos como antagonistas de receptor de nk1
CY1108837T1 (el)	2014-07-02	ΝΕΑ ΠΑΡΑΓΩΓΑ ΑΜΙΝΟΠΥΡΙΔΙΝΗΣ ΩΣ ΑΝΤΑΓΩΝΙΣΤΕΣ mGluR5
DE69907636D1 (de)	2003-06-12	2-aminochinolinderivate mit d4-agonistischer wirkung
DK0712406T3 (da)	1999-07-05	Kondenserende indolderivater som 5-HT4-receptorantagonister
NO954769L (no)	1996-01-25	3-(indol-3-yl)propensyrederivater som NMDA-antagonister
ES2132748T3 (es)	1999-08-16	Herbicidas de carbamato.
AR014847A1 (es)	2001-03-28	4-amino-(etilamino)-oxindoles agonistas del autoreceptor de dopamina y una composicion farmaceutica que los comprende
ES2161892T3 (es)	2001-12-16	Derivados de indol como profarmacos de agonistas de los receptores afines a 5-ht1.