DK1057826T3 - Substituerede dimere carboxamidforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse - Google Patents

Substituerede dimere carboxamidforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse

Info

Publication number
DK1057826T3
DK1057826T3 DK00610050T DK00610050T DK1057826T3 DK 1057826 T3 DK1057826 T3 DK 1057826T3 DK 00610050 T DK00610050 T DK 00610050T DK 00610050 T DK00610050 T DK 00610050T DK 1057826 T3 DK1057826 T3 DK 1057826T3
Authority
DK
Denmark
Prior art keywords
nr1c
nr2r3
processes
preparation
pharmaceutical compositions
Prior art date
Application number
DK00610050T
Other languages
English (en)
Inventor
Patrick Depreux
Said Yous
Gwenael Cheve
Gerald Guillaumet
Marie-Claude Viaud
Carlos Larraya
Caroline Bennejean
Philippe Delagrange
Pierre Regard
Carole Descamps-Francois
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK1057826T3 publication Critical patent/DK1057826T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK00610050T 1999-05-19 2000-05-22 Substituerede dimere carboxamidforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse DK1057826T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9906331A FR2793793B1 (fr) 1999-05-19 1999-05-19 Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
DK1057826T3 true DK1057826T3 (da) 2003-07-21

Family

ID=9545746

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00610050T DK1057826T3 (da) 1999-05-19 2000-05-22 Substituerede dimere carboxamidforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse

Country Status (20)

Country Link
US (1) US6310074B1 (da)
EP (1) EP1057826B1 (da)
JP (1) JP3688552B2 (da)
KR (1) KR100472520B1 (da)
CN (1) CN1128142C (da)
AT (1) ATE237610T1 (da)
AU (1) AU766322B2 (da)
BR (1) BR0003313A (da)
DE (1) DE60002126T2 (da)
DK (1) DK1057826T3 (da)
EA (1) EA003391B1 (da)
ES (1) ES2197062T3 (da)
FR (1) FR2793793B1 (da)
HU (1) HUP0001961A3 (da)
NO (1) NO20002548L (da)
NZ (1) NZ504613A (da)
PL (1) PL340165A1 (da)
PT (1) PT1057826E (da)
SI (1) SI1057826T1 (da)
ZA (1) ZA200002490B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1569638B1 (en) * 2002-12-03 2007-09-05 F. Hoffmann-La Roche Ag Aminoalkoxyindoles as 5-ht6-receptor ligands for the treatment of cns-disorders
JP5138938B2 (ja) 2003-12-19 2013-02-06 プレキシコン インコーポレーテッド Ｒｅｔ調節剤の開発のための化合物および方法
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
AU2006272951A1 (en) * 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
MY153898A (en) * 2005-06-22 2015-04-15 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
RU2009122670A (ru) 2006-12-21 2011-01-27 Плекссикон, Инк. (Us) Соединения и способы для модуляции киназ и показания к их применению
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
BRPI0916395A2 (pt) * 2008-07-30 2016-02-16 Ferrer Int compostos de 1,6-di-hidro-2h-3-oxa-6-aza-as-indaceno
CA2738573C (en) 2009-04-03 2013-02-19 F. Hoffmann-La Roche Ag Compositions of propane-1 sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and uses thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
JP2013510166A (ja) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド キナーゼ調節のための化合物、方法およびその適用
PE20141360A1 (es) 2011-02-07 2014-10-13 Plexxikon Inc Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
WO2025194599A1 (en) * 2024-03-18 2025-09-25 Galixir Technologies (Beijing) Limited Heterocycle ulk1/2 inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1639427A3 (ru) * 1987-07-03 1991-03-30 Глэксо Груп Лимитед (Фирма) Способ получени производных индола или их фармацевтически приемлемых солей
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ES2087463T3 (es) * 1991-11-18 1996-07-16 Lilly Industries Ltd Benzo(b)tiofen-2-carboxamidas para el tratamiento de trastornos del sistema nervioso central.
FR2689124A1 (fr) * 1992-03-27 1993-10-01 Adir Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2696453B1 (fr) * 1992-10-02 1994-12-23 Adir Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
AU5715494A (en) * 1992-12-21 1994-07-19 Taisho Pharmaceutical Co., Ltd. N-substituted indole derivative
MX9700080A (es) * 1994-06-29 1997-04-30 Pfizer Derivados de aril y heteroaril alcoxinaftaleno.
FR2731223A1 (fr) * 1995-03-02 1996-09-06 Pf Medicament Nouveaux derives bi-tryptaminiques, leur procede de preparation et leur utilisation a titre de medicaments

Also Published As

Publication number Publication date
KR20010029729A (ko) 2001-04-16
JP2001011035A (ja) 2001-01-16
PT1057826E (pt) 2003-08-29
PL340165A1 (en) 2000-11-20
US6310074B1 (en) 2001-10-30
FR2793793B1 (fr) 2004-02-27
DE60002126D1 (de) 2003-05-22
NZ504613A (en) 2001-06-29
EA003391B1 (ru) 2003-04-24
SI1057826T1 (en) 2003-08-31
EA200000431A2 (ru) 2000-12-25
ZA200002490B (en) 2000-11-20
HUP0001961A3 (en) 2002-10-28
EP1057826A1 (fr) 2000-12-06
AU766322B2 (en) 2003-10-16
CN1128142C (zh) 2003-11-19
FR2793793A1 (fr) 2000-11-24
HUP0001961A2 (hu) 2001-08-28
NO20002548D0 (no) 2000-05-18
CN1277962A (zh) 2000-12-27
AU3542000A (en) 2000-11-23
DE60002126T2 (de) 2004-03-18
ATE237610T1 (de) 2003-05-15
HK1030937A1 (en) 2001-05-25
ES2197062T3 (es) 2004-01-01
BR0003313A (pt) 2001-03-13
JP3688552B2 (ja) 2005-08-31
EP1057826B1 (fr) 2003-04-16
NO20002548L (no) 2000-11-20
EA200000431A3 (ru) 2001-02-26
HU0001961D0 (en) 2000-07-28
KR100472520B1 (ko) 2005-03-07

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