DK1066269T3 - Trisubstituerede 1,3,5-triazinderivater til behandling af HIV-infektioner - Google Patents

Trisubstituerede 1,3,5-triazinderivater til behandling af HIV-infektioner

Info

Publication number
DK1066269T3
DK1066269T3 DK99917863T DK99917863T DK1066269T3 DK 1066269 T3 DK1066269 T3 DK 1066269T3 DK 99917863 T DK99917863 T DK 99917863T DK 99917863 T DK99917863 T DK 99917863T DK 1066269 T3 DK1066269 T3 DK 1066269T3
Authority
DK
Denmark
Prior art keywords
trisubstituted
treatment
triazine derivatives
hiv infections
hiv
Prior art date
Application number
DK99917863T
Other languages
English (en)
Inventor
Frederik Frans Desire Daeyaert
Corte Bart De
Jonge Marc Rene De
Jan Heeres
Chih Yung Ho
Paul Adriaan Jan Janssen
Robert W Kavash
Michael Joseph Kukla
Donald William Ludovici
Lucien Maria Henricus Koymans
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK1066269T3 publication Critical patent/DK1066269T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/66—Derivatives of melamine in which a hetero atom is directly attached to a nitrogen atom of melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/70—Other substituted melamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK99917863T 1998-03-27 1999-03-24 Trisubstituerede 1,3,5-triazinderivater til behandling af HIV-infektioner DK1066269T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7963398P 1998-03-27 1998-03-27
EP98201589A EP0945447A1 (en) 1998-03-27 1998-05-14 Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections
PCT/EP1999/002044 WO1999050256A1 (en) 1998-03-27 1999-03-24 Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections
EP99917863A EP1066269B1 (en) 1998-03-27 1999-03-24 Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections

Publications (1)

Publication Number Publication Date
DK1066269T3 true DK1066269T3 (da) 2005-09-05

Family

ID=22151790

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99917863T DK1066269T3 (da) 1998-03-27 1999-03-24 Trisubstituerede 1,3,5-triazinderivater til behandling af HIV-infektioner

Country Status (32)

Country Link
US (3) US6150360A (da)
EP (2) EP0945447A1 (da)
JP (1) JP2002511390A (da)
KR (1) KR100593396B1 (da)
CN (1) CN1157386C (da)
AP (1) AP1475A (da)
AR (1) AR018169A1 (da)
AT (1) ATE295355T1 (da)
AU (1) AU758624C (da)
BG (1) BG64903B1 (da)
BR (1) BR9909197A (da)
CA (1) CA2324921C (da)
DE (1) DE69925256T2 (da)
DK (1) DK1066269T3 (da)
EA (1) EA004540B1 (da)
EE (1) EE200000535A (da)
ES (1) ES2243056T3 (da)
HR (1) HRP20000621A2 (da)
HU (1) HUP0101372A3 (da)
ID (1) ID26043A (da)
IL (1) IL138670A (da)
NO (1) NO317425B1 (da)
NZ (1) NZ506787A (da)
OA (1) OA11493A (da)
PL (1) PL194660B1 (da)
PT (1) PT1066269E (da)
SI (1) SI1066269T1 (da)
SK (1) SK14052000A3 (da)
TR (1) TR200002761T2 (da)
TW (1) TW570917B (da)
WO (1) WO1999050256A1 (da)
ZA (1) ZA200006042B (da)

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US6645964B1 (en) * 1999-11-29 2003-11-11 Aventis Pharma S.A. Chemical derivatives and their application as antitelomerase agent
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US20020065270A1 (en) * 1999-12-28 2002-05-30 Moriarty Kevin Joseph N-heterocyclic inhibitors of TNF-alpha expression
US7034019B2 (en) 2000-05-08 2006-04-25 Janssen Pharmaceutica N.V. Prodrugs of HIV replication inhibiting pyrimidines
US7276510B2 (en) 2000-05-08 2007-10-02 Janssen Pharmaceutica, Inc. HIV replication inhibitors
US6858608B2 (en) * 2001-01-09 2005-02-22 Aventis Pharma S.A. Chemical derivatives and their application as antitelomerase agents
US6887873B2 (en) * 2001-03-23 2005-05-03 Aventis Pharma S.A. Triazine derivatives and their application as antitelomerase agents
US6958211B2 (en) 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
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US7132423B2 (en) * 2001-09-21 2006-11-07 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
US7112587B2 (en) * 2001-09-21 2006-09-26 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
US7169785B2 (en) * 2001-09-21 2007-01-30 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
US7163943B2 (en) * 2001-09-21 2007-01-16 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
EP1441683A4 (en) * 2001-10-12 2005-10-26 Univ New York TRISUBSTITUTED TRIAZIN COMPOUNDS AND METHOD FOR THE PREPARATION AND USE OF THE COMPOUNDS WITH ANTITUBULIN EFFECT
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US7335770B2 (en) * 2004-03-24 2008-02-26 Reddy U5 Therapeutics, Inc. Triazine compounds and their analogs, compositions, and methods
RU2401833C2 (ru) 2004-08-10 2010-10-20 Янссен Фармацевтика Н.В. Производные 1, 2, 4-триазин-6-она, ингибирующие вич
RU2410379C2 (ru) 2004-09-30 2011-01-27 Тиботек Фармасьютикалз Лтд. 5-замещенные пиримидины, ингибирующие вич
CA2577467C (en) 2004-09-30 2013-05-28 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 5-heterocyclyl pyrimidines
US7531548B2 (en) 2004-09-30 2009-05-12 Tibotec Pharmaceuticals Ltd HIV inhibiting 5-carbo- or heterocyclic substituted pyrimidines
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US7592451B2 (en) * 2005-06-23 2009-09-22 New York University Treatment for diabetes and obesity as well as method of screening compounds useful for such treatments
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Also Published As

Publication number Publication date
ID26043A (id) 2000-11-16
AU758624B2 (en) 2003-03-27
NO20004809L (no) 2000-11-24
US6774235B2 (en) 2004-08-10
KR100593396B1 (ko) 2006-06-28
NO317425B1 (no) 2004-10-25
EP1066269B1 (en) 2005-05-11
ES2243056T3 (es) 2005-11-16
EA004540B1 (ru) 2004-06-24
TR200002761T2 (tr) 2001-01-22
US20020115668A1 (en) 2002-08-22
US6372729B1 (en) 2002-04-16
PL343195A1 (en) 2001-07-30
CA2324921C (en) 2009-05-12
TW570917B (en) 2004-01-11
BG64903B1 (bg) 2006-08-31
AP1475A (en) 2005-10-03
AU758624C (en) 2004-03-11
EE200000535A (et) 2002-04-15
PL194660B1 (pl) 2007-06-29
AR018169A1 (es) 2001-10-31
WO1999050256A1 (en) 1999-10-07
US6150360A (en) 2000-11-21
DE69925256T2 (de) 2006-02-23
SI1066269T1 (en) 2005-10-31
NZ506787A (en) 2003-02-28
CN1295566A (zh) 2001-05-16
HK1032394A1 (en) 2001-07-20
CN1157386C (zh) 2004-07-14
DE69925256D1 (de) 2005-06-16
EA200000993A1 (ru) 2001-04-23
ATE295355T1 (de) 2005-05-15
OA11493A (en) 2004-05-07
SK14052000A3 (sk) 2001-06-11
NO20004809D0 (no) 2000-09-26
HUP0101372A3 (en) 2003-02-28
AU3599799A (en) 1999-10-18
IL138670A (en) 2005-12-18
HRP20000621A2 (en) 2001-04-30
BR9909197A (pt) 2000-12-05
BG104716A (en) 2001-04-30
JP2002511390A (ja) 2002-04-16
ZA200006042B (en) 2001-10-26
PT1066269E (pt) 2005-09-30
KR20010034270A (ko) 2001-04-25
HUP0101372A2 (hu) 2001-10-28
EP0945447A1 (en) 1999-09-29
EP1066269A1 (en) 2001-01-10
AP2000001913A0 (en) 2000-09-30
CA2324921A1 (en) 1999-10-07

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