DK1066399T3 - Fremgangsmåde til mikrobiel omdannelse af phytosteroler til androstendion og androstadiendion - Google Patents

Fremgangsmåde til mikrobiel omdannelse af phytosteroler til androstendion og androstadiendion

Info

Publication number: DK1066399T3
Authority: DK; Denmark
Prior art keywords: androstendione; dione; phytosterols; microbial conversion; nutrient medium
Prior art date: 1998-03-26

Application number

DK99911540T

Other languages

English (en)

Inventor

Radka K Milanova

James P Kutney

Christo Dimitrov Vassilev

Svetoslav Stefanov Stefanov

Natalya Velikova Nedelcheva

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-26

Filing date

1999-03-26

Publication date

2006-03-13

1999-03-26 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

2006-03-13 Application granted granted Critical

2006-03-13 Publication of DK1066399T3 publication Critical patent/DK1066399T3/da

Links

AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
238000006243 chemical reaction Methods 0.000 title 1
230000000813 microbial effect Effects 0.000 title 1
229940068065 phytosterols Drugs 0.000 title 1
241000186359 Mycobacterium Species 0.000 abstract 2
LUJVUUWNAPIQQI-QAGGRKNESA-N androsta-1,4-diene-3,17-dione Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 LUJVUUWNAPIQQI-QAGGRKNESA-N 0.000 abstract 2
AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
235000015097 nutrients Nutrition 0.000 abstract 2
LUJVUUWNAPIQQI-UHFFFAOYSA-N (+)-androsta-1,4-diene-3,17-dione Natural products O=C1C=CC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 LUJVUUWNAPIQQI-UHFFFAOYSA-N 0.000 abstract 1
BTTWKVFKBPAFDK-UHFFFAOYSA-N (9beta,10alpha)-Androst-4-ene-3,17-dione Natural products OC1CCC2(C)C3CCC(C)(C(CC4)O)C4C3CCC2=C1 BTTWKVFKBPAFDK-UHFFFAOYSA-N 0.000 abstract 1
229960005471 androstenedione Drugs 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
235000013379 molasses Nutrition 0.000 abstract 1
229920001451 polypropylene glycol Polymers 0.000 abstract 1
229920001296 polysiloxane Polymers 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000003381 solubilizing effect Effects 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/005—Degradation of the lateral chains at position 17
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Cosmetics (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

DK99911540T 1998-03-26 1999-03-26 Fremgangsmåde til mikrobiel omdannelse af phytosteroler til androstendion og androstadiendion DK1066399T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/048,432 US6071714A (en)	1998-03-26	1998-03-26	Process for the microbial conversion of phytosterols to androstenedione and androstadienedione

Publications (1)

Publication Number	Publication Date
DK1066399T3 true DK1066399T3 (da)	2006-03-13

Family

ID=21954545

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99911540T DK1066399T3 (da)	1998-03-26	1999-03-26	Fremgangsmåde til mikrobiel omdannelse af phytosteroler til androstendion og androstadiendion

Country Status (13)

Country	Link
US (1)	US6071714A (da)
EP (1)	EP1066399B1 (da)
JP (1)	JP4038643B2 (da)
AT (1)	ATE314486T1 (da)
AU (1)	AU3020699A (da)
BR (1)	BRPI9909107B8 (da)
CA (1)	CA2326121A1 (da)
DE (1)	DE69929180T2 (da)
DK (1)	DK1066399T3 (da)
ES (1)	ES2257040T3 (da)
MX (1)	MXPA00009422A (da)
RU (1)	RU2252259C2 (da)
WO (1)	WO1999049075A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2231553C2 (ru) *	2001-12-11	2004-06-27	Андрюшина Валентина Александровна	Штамм бактерий mycobacterium neoaurum и способ его использования для получения андрост-4-ен-3,17-диона из стеринов растительного и животного происхождения
RU2004126437A (ru) *	2002-02-01	2006-01-27	Акцо Нобель Н.В. (NL)	Способ ферментации фитостеролов до адростадиендиона
CN102477404B (zh) *	2010-11-24	2014-04-02	北大方正集团有限公司	一种植物甾醇经微生物转化为add的方法及所用培养基
CN105175471A (zh) *	2014-06-06	2015-12-23	山东方明药业集团股份有限公司	一种从双液相系统中提取雄烯二酮粗品的方法
CN106282288B (zh) *	2015-05-15	2020-10-30	上海医药工业研究院	一种雄甾-1,4-二烯-3,17-二酮的制备方法
CN109355345A (zh) *	2018-11-22	2019-02-19	安徽建筑大学	一种利用分枝杆菌降解植物甾醇合成雄甾-4-烯-3,7-二酮的方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3684657A (en) *	1970-05-11	1972-08-15	Searle & Co	Selective microbiological degradation of steroidal 17-alkyls
GB1539233A (en) *	1975-06-06	1979-01-31	Noda Inst For Scientific Res	Microbiological 17-side chain degradation of steroids
DE2558088C2 (de) *	1975-12-19	1985-05-30	Schering AG, 1000 Berlin und 4709 Bergkamen	Verfahren zur Herstellung von 4-Androsten-3,17-dion-Derivaten
US4345030A (en)	1976-10-22	1982-08-17	The Upjohn Company	Microorganism mutant conversion of sterols to androsta-4-ene-3,17-dione
US4124607A (en) *	1977-04-15	1978-11-07	The Upjohn Company	Preparation of sterol substrates for bioconversion
IE47369B1 (en) *	1977-10-14	1984-03-07	Mitsubishi Chem Ind	A process for producing steroidal alcohols
US4444884A (en)	1982-05-25	1984-04-24	Wisconsin Alumni Research Foundation	Process for preparing steroids
DE3241829A1 (de) *	1982-11-09	1984-05-10	Schering AG, 1000 Berlin und 4709 Bergkamen	Biokatalysator
DD230641A3 (de) *	1983-11-09	1985-12-04	Zellstoff Und Zellwollewerke V	Pruefverfahren zur kontrolle des herstellungsprozesses eines zur fermentation geeigneten beta sitostorolkristallisates
US4923403A (en) *	1984-08-16	1990-05-08	South African Inventions Development Corp.	Microbiological process for degradation of steroids
DD248143B1 (de) *	1984-08-20	1991-01-03	Adw Ddr	Verfahren zur herstellung von produktionsgemischen mit 1,4-androstadien-3,17-dion sowie 4-androsten-3,17-dion
DD248144B1 (de) *	1984-08-20	1991-01-03	Akad Wissenschaften Ddr	Verfahren zur herstellung von 1,4-androstadien-3,17-dion durch fermentativen sterolabbau
DE3521111A1 (de) *	1985-06-10	1986-12-11	Schering AG, 1000 Berlin und 4709 Bergkamen	Verfahren zur herstellung von 4-androsten-3,17-dion und 1,4-androstadien-3,17-dion
DE3544662A1 (de) *	1985-12-13	1987-06-19	Schering Ag	Verfahren zur herstellung von 4-androsten-3,17-dion und 1,4-androstadien-3,17-dion
DD291341A5 (de) *	1989-12-29	1991-06-27	Veb Jenapharm,De	Verfahren zur herstellung von androst-4-en-3,17-dion, androsta-1,4-dien3,17-dion und 9alpha-hydroxy-androst-4-en-3,17-dion
RU2039824C1 (ru) *	1993-06-22	1995-07-20	Институт биохимии и физиологии микроорганизмов РАН	Способ получения андроста-1,4-диен-3,17-диона
RU2079258C1 (ru) *	1994-05-20	1997-05-10	Институт биохимии и физиологии микроорганизмов РАН	Способ получения андрост-4-ен-3,17-диона

1998
- 1998-03-26 US US09/048,432 patent/US6071714A/en not_active Expired - Lifetime
1999
- 1999-03-26 DK DK99911540T patent/DK1066399T3/da active
- 1999-03-26 CA CA002326121A patent/CA2326121A1/en not_active Abandoned
- 1999-03-26 JP JP2000538034A patent/JP4038643B2/ja not_active Expired - Fee Related
- 1999-03-26 AU AU30206/99A patent/AU3020699A/en not_active Abandoned
- 1999-03-26 WO PCT/CA1999/000267 patent/WO1999049075A1/en not_active Ceased
- 1999-03-26 ES ES99911540T patent/ES2257040T3/es not_active Expired - Lifetime
- 1999-03-26 BR BRPI9909107A patent/BRPI9909107B8/pt not_active IP Right Cessation
- 1999-03-26 DE DE69929180T patent/DE69929180T2/de not_active Expired - Lifetime
- 1999-03-26 EP EP99911540A patent/EP1066399B1/en not_active Expired - Lifetime
- 1999-03-26 RU RU2000126842/13A patent/RU2252259C2/ru not_active IP Right Cessation
- 1999-03-26 AT AT99911540T patent/ATE314486T1/de not_active IP Right Cessation
- 1999-03-26 MX MXPA00009422A patent/MXPA00009422A/es active IP Right Grant

Also Published As

Publication number	Publication date
DE69929180D1 (de)	2006-02-02
US6071714A (en)	2000-06-06
JP4038643B2 (ja)	2008-01-30
WO1999049075A1 (en)	1999-09-30
RU2252259C2 (ru)	2005-05-20
BR9909107A (pt)	2001-10-16
JP2002507432A (ja)	2002-03-12
CA2326121A1 (en)	1999-09-30
EP1066399A1 (en)	2001-01-10
MXPA00009422A (es)	2002-08-20
ATE314486T1 (de)	2006-01-15
ES2257040T3 (es)	2006-07-16
EP1066399B1 (en)	2005-12-28
BRPI9909107B8 (pt)	2021-05-25
BRPI9909107B1 (pt)	2015-09-01
AU3020699A (en)	1999-10-18
DE69929180T2 (de)	2006-07-13

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