DK1068210T3 - Fremgangsmåde til fremstilling af purinderivater - Google Patents

Fremgangsmåde til fremstilling af purinderivater

Info

Publication number: DK1068210T3
Authority: DK; Denmark
Prior art keywords: 12alkyl; formula; compound; preparation; hydrogen
Prior art date: 1998-04-02

Application number

DK99917959T

Other languages

English (en)

Inventor

Graham Richard Geen

Andrew Colin Share

Original Assignee

Novartis Int Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-02

Filing date

1999-03-30

Publication date

2004-09-20

1999-03-30 Application filed by Novartis Int Pharm Ltd filed Critical Novartis Int Pharm Ltd

2004-09-20 Application granted granted Critical

2004-09-20 Publication of DK1068210T3 publication Critical patent/DK1068210T3/da

Links

238000000034 method Methods 0.000 title abstract 4
229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
-1 aryl carbonate Chemical compound 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 1
JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 abstract 1
150000001335 aliphatic alkanes Chemical class 0.000 abstract 1
125000005116 aryl carbamoyl group Chemical group 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000005104 aryl silyl group Chemical group 0.000 abstract 1
125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
125000005110 aryl thio group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
229960004396 famciclovir Drugs 0.000 abstract 1
GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
229960001179 penciclovir Drugs 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000006462 rearrangement reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK99917959T 1998-04-02 1999-03-30 Fremgangsmåde til fremstilling af purinderivater DK1068210T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9807116.0A GB9807116D0 (en)	1998-04-02	1998-04-02	Novel process

Publications (1)

Publication Number	Publication Date
DK1068210T3 true DK1068210T3 (da)	2004-09-20

Family

ID=10829765

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99917959T DK1068210T3 (da)	1998-04-02	1999-03-30	Fremgangsmåde til fremstilling af purinderivater

Country Status (16)

Country	Link
US (1)	US6437125B1 (da)
EP (1)	EP1068210B1 (da)
JP (1)	JP4459439B2 (da)
KR (1)	KR100613812B1 (da)
CN (1)	CN1125068C (da)
AT (1)	ATE268332T1 (da)
AU (1)	AU3605199A (da)
BR (1)	BR9908959A (da)
CA (1)	CA2323965A1 (da)
DE (1)	DE69917765T2 (da)
DK (1)	DK1068210T3 (da)
ES (1)	ES2222702T3 (da)
GB (1)	GB9807116D0 (da)
IL (1)	IL138289A0 (da)
PT (1)	PT1068210E (da)
WO (1)	WO1999051604A2 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60202245T2 (de)	2001-08-30	2005-09-01	Ajinomoto Co., Inc.	Herstellungsmethode von Famciclovir und Herstellungs- bzw. Kristallisationsmethode eines entsprechenden Intermediates
US20040097528A1 (en) *	2002-08-26	2004-05-20	Ben-Zion Dolitzky	Crystalline solid famciclovir forms I, II, III and preparation thereof
TW200613304A (en) *	2004-05-18	2006-05-01	Teva Pharma	Drying process for preparing crystalline solid famciclovir
GB2426247A (en) *	2005-05-20	2006-11-22	Arrow Int Ltd	Methods of preparing purine derivatives such as famciclovir
CN110386935A (zh) *	2018-04-20	2019-10-29	重庆常捷医药有限公司	一种泛昔洛韦中间体的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5684153A (en) *	1984-08-16	1997-11-04	Beecham Group Plc	Process for the preparation of purine derivatives
EP0141927B1 (en)	1983-08-18	1991-10-30	Beecham Group Plc	Antiviral guanine derivatives
EP0182024B1 (en) *	1984-09-20	1991-04-03	Beecham Group Plc	Purine derivatives and their pharmaceutical use
GB8817607D0 (en)	1988-07-23	1988-09-01	Beecham Group Plc	Novel process
US5688948A (en) *	1991-09-18	1997-11-18	Ajinomoto Co., Inc.	Process for isomerizing acyclic nucleosides and process for separating purine nucleosides
GB9407698D0 (en) *	1994-04-19	1994-06-15	Smithkline Beecham Plc	Pharmaceuticals
EP0827960A1 (en) *	1996-09-10	1998-03-11	Ajinomoto Co., Inc.	Process for producing purine derivatives

1998
- 1998-04-02 GB GBGB9807116.0A patent/GB9807116D0/en not_active Ceased
1999
- 1999-03-30 JP JP2000542325A patent/JP4459439B2/ja not_active Expired - Fee Related
- 1999-03-30 BR BR9908959-9A patent/BR9908959A/pt not_active Application Discontinuation
- 1999-03-30 EP EP19990917959 patent/EP1068210B1/en not_active Expired - Lifetime
- 1999-03-30 PT PT99917959T patent/PT1068210E/pt unknown
- 1999-03-30 CN CN99804402A patent/CN1125068C/zh not_active Expired - Fee Related
- 1999-03-30 AU AU36051/99A patent/AU3605199A/en not_active Abandoned
- 1999-03-30 AT AT99917959T patent/ATE268332T1/de not_active IP Right Cessation
- 1999-03-30 DK DK99917959T patent/DK1068210T3/da active
- 1999-03-30 DE DE69917765T patent/DE69917765T2/de not_active Expired - Fee Related
- 1999-03-30 IL IL13828999A patent/IL138289A0/xx not_active IP Right Cessation
- 1999-03-30 KR KR1020007010706A patent/KR100613812B1/ko not_active Expired - Fee Related
- 1999-03-30 ES ES99917959T patent/ES2222702T3/es not_active Expired - Lifetime
- 1999-03-30 US US09/623,700 patent/US6437125B1/en not_active Expired - Lifetime
- 1999-03-30 WO PCT/EP1999/002309 patent/WO1999051604A2/en not_active Ceased
- 1999-03-30 CA CA002323965A patent/CA2323965A1/en not_active Abandoned

Also Published As

Publication number	Publication date
IL138289A0 (en)	2001-10-31
JP2002510692A (ja)	2002-04-09
ATE268332T1 (de)	2004-06-15
EP1068210B1 (en)	2004-06-02
DE69917765T2 (de)	2005-07-14
CA2323965A1 (en)	1999-10-14
PT1068210E (pt)	2004-10-29
GB9807116D0 (en)	1998-06-03
DE69917765D1 (de)	2004-07-08
BR9908959A (pt)	2000-12-05
US6437125B1 (en)	2002-08-20
KR20010034701A (ko)	2001-04-25
ES2222702T3 (es)	2005-02-01
EP1068210A2 (en)	2001-01-17
CN1294591A (zh)	2001-05-09
WO1999051604A3 (en)	2000-02-17
WO1999051604A2 (en)	1999-10-14
AU3605199A (en)	1999-10-25
HK1035896A1 (en)	2001-12-14
KR100613812B1 (ko)	2006-08-18
CN1125068C (zh)	2003-10-22
JP4459439B2 (ja)	2010-04-28

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