DK1075462T3 - Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid. - Google Patents

Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid.

Info

Publication number: DK1075462T3
Authority: DK; Denmark
Prior art keywords: hydroxy; triiodo; oxopropyl; amino; benzenedicarboxamide
Prior art date: 1998-05-08

Application number

DK99924824T

Other languages

Danish (da)

English (en)

Inventor

Nicola Desantis

Salvatore Incandela

Original Assignee

Bracco Imaging Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-08

Filing date

1999-04-26

Publication date

2003-10-13

1999-04-26 Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa

2003-10-13 Application granted granted Critical

2003-10-13 Publication of DK1075462T3 publication Critical patent/DK1075462T3/da

Links

MCZYFQHMXGCFDR-UHFFFAOYSA-N 3-n-(1,3-dihydroxypropan-2-yl)-5-(2-hydroxypropanoylamino)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound CC(O)C(=O)NC1=C(I)C(C(N)=O)=C(I)C(C(=O)NC(CO)CO)=C1I MCZYFQHMXGCFDR-UHFFFAOYSA-N 0.000 title 1
-1 monoalkyl ether glycols Chemical class 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 abstract 1
229940035437 1,3-propanediol Drugs 0.000 abstract 1
150000001298 alcohols Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229920000166 polytrimethylene carbonate Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Epoxy Compounds (AREA)

DK99924824T 1998-05-08 1999-04-26 Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid. DK1075462T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT98MI001005A IT1299202B1 (it)	1998-05-08	1998-05-08	Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
PCT/EP1999/002804 WO1999058494A2 (en)	1998-05-08	1999-04-26	Process for the preparation of s- n,n'- bis[2- hydroxy-1- (hydroxymethyl) ethyl]-5- [(2- hydroxy-1- oxopropyl)- amino]- 2,4,6- triiodo- 1,3- benzenedicarboxamide

Publications (1)

Publication Number	Publication Date
DK1075462T3 true DK1075462T3 (da)	2003-10-13

Family

ID=11379983

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99924824T DK1075462T3 (da)	1998-05-08	1999-04-26	Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid.

Country Status (15)

Country	Link
EP (1)	EP1075462B1 (cs)
JP (1)	JP4390389B2 (cs)
KR (1)	KR100612480B1 (cs)
CN (1)	CN100336800C (cs)
AT (1)	ATE243676T1 (cs)
AU (1)	AU749785B2 (cs)
CA (1)	CA2331660C (cs)
CZ (1)	CZ293801B6 (cs)
DE (1)	DE69909078T2 (cs)
DK (1)	DK1075462T3 (cs)
ES (1)	ES2201719T3 (cs)
IT (1)	IT1299202B1 (cs)
NO (1)	NO326203B1 (cs)
PT (1)	PT1075462E (cs)
WO (1)	WO1999058494A2 (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101098553B1 (ko) *	2008-04-30	2011-12-26	주식회사 엘지생명과학	이오프로마이드의 신규한 제조방법
EP2365963B1 (en) *	2008-11-18	2017-06-28	Bracco Imaging S.p.A	Process for the preparation of iodinated contrast agent
EP2230227A1 (en)	2009-03-20	2010-09-22	Bracco Imaging S.p.A	Process for the preparation of triiodinated carboxylic aromatic derivatives
HUE040143T2 (hu)	2012-12-11	2019-02-28	Bracco Imaging Spa	Folyamatos eljárás (S)-2-acetiloxipropionsav elõállítására
PT3369724T (pt)	2013-11-05	2021-02-10	Bracco Imaging Spa	Processo para a preparação de iopamidol
EP3154928B1 (en)	2014-06-10	2020-03-04	Bracco Imaging S.p.A	Method for the preparation of (s)-2-acetyloxypropionic acid and derivatives thereof
CN105272899B (zh) *	2015-11-17	2017-09-22	浙江海洲制药有限公司	一种化合物及其用于合成碘帕醇杂质d、杂质f、杂质g和杂质j的方法
WO2018104228A1 (en)	2016-12-05	2018-06-14	Bracco Imaging Spa	Mechanochemical synthesis of radiographic agents intermediates
CN110687226B (zh) *	2019-10-18	2022-10-25	上海明捷医药科技有限公司	一种测定碘帕醇中2-氯丙酸含量的方法
EP4452931A1 (en) *	2021-12-20	2024-10-30	Bracco Imaging SPA	Process for the preparation of 2,4,6-triiodoisophthalic bisamides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH608189A5 (cs) *	1974-12-13	1978-12-29	Savac Ag
DE2628517C2 (de) *	1976-06-23	1985-02-21	Schering AG, 1000 Berlin und 4709 Bergkamen	Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
DE2928417A1 (de) *	1979-07-12	1981-01-29	Schering Ag	Trijodierte basen
IT1256163B (it) *	1992-10-27	1995-11-29	Zambon Spa	Processo per la preparazione di un intermedio della sintesi organica
IT1283319B1 (it) *	1996-03-29	1998-04-16	Zambon Spa	Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1288114B1 (it) *	1996-06-13	1998-09-10	Fructamine Spa	Processo per la purificazione di un intermedio

1998
- 1998-05-08 IT IT98MI001005A patent/IT1299202B1/it active IP Right Grant
1999
- 1999-04-26 EP EP19990924824 patent/EP1075462B1/en not_active Expired - Lifetime
- 1999-04-26 DK DK99924824T patent/DK1075462T3/da active
- 1999-04-26 JP JP2000548298A patent/JP4390389B2/ja not_active Expired - Lifetime
- 1999-04-26 PT PT99924824T patent/PT1075462E/pt unknown
- 1999-04-26 AU AU41356/99A patent/AU749785B2/en not_active Expired
- 1999-04-26 CZ CZ20004124A patent/CZ293801B6/cs not_active IP Right Cessation
- 1999-04-26 WO PCT/EP1999/002804 patent/WO1999058494A2/en not_active Ceased
- 1999-04-26 CN CNB998059226A patent/CN100336800C/zh not_active Expired - Lifetime
- 1999-04-26 ES ES99924824T patent/ES2201719T3/es not_active Expired - Lifetime
- 1999-04-26 AT AT99924824T patent/ATE243676T1/de active
- 1999-04-26 DE DE69909078T patent/DE69909078T2/de not_active Expired - Lifetime
- 1999-04-26 KR KR1020007012448A patent/KR100612480B1/ko not_active Expired - Lifetime
- 1999-04-26 CA CA002331660A patent/CA2331660C/en not_active Expired - Lifetime
2000
- 2000-11-07 NO NO20005616A patent/NO326203B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69909078T2 (de)	2003-12-18
ITMI981005A1 (it)	1999-11-08
PT1075462E (pt)	2003-10-31
DE69909078D1 (de)	2003-07-31
NO326203B1 (no)	2008-10-20
CZ20004124A3 (cs)	2002-03-13
JP4390389B2 (ja)	2009-12-24
EP1075462A2 (en)	2001-02-14
CA2331660C (en)	2008-07-08
NO20005616L (no)	2000-11-07
AU4135699A (en)	1999-11-29
CZ293801B6 (cs)	2004-08-18
WO1999058494A2 (en)	1999-11-18
IT1299202B1 (it)	2000-02-29
KR20010071221A (ko)	2001-07-28
CN1302288A (zh)	2001-07-04
ES2201719T3 (es)	2004-03-16
EP1075462B1 (en)	2003-06-25
CN100336800C (zh)	2007-09-12
NO20005616D0 (no)	2000-11-07
AU749785B2 (en)	2002-07-04
CA2331660A1 (en)	1999-11-18
ATE243676T1 (de)	2003-07-15
WO1999058494A3 (en)	2000-01-20
JP2002517381A (ja)	2002-06-18
KR100612480B1 (ko)	2006-08-16

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