NO20005616L - Fremgangsmåte fro fremstilling av S-N,N'-bis[2-hydroksy-1- - Google Patents

Fremgangsmåte fro fremstilling av S-N,N'-bis[2-hydroksy-1-

Info

Publication number
NO20005616L
NO20005616L NO20005616A NO20005616A NO20005616L NO 20005616 L NO20005616 L NO 20005616L NO 20005616 A NO20005616 A NO 20005616A NO 20005616 A NO20005616 A NO 20005616A NO 20005616 L NO20005616 L NO 20005616L
Authority
NO
Norway
Prior art keywords
hydroxy
bis
triiodo
oxopropyl
amino
Prior art date
Application number
NO20005616A
Other languages
English (en)
Other versions
NO20005616D0 (no
NO326203B1 (no
Inventor
Nicola Desantis
Salvatore Incandela
Original Assignee
Dibra Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dibra Spa filed Critical Dibra Spa
Publication of NO20005616D0 publication Critical patent/NO20005616D0/no
Publication of NO20005616L publication Critical patent/NO20005616L/no
Publication of NO326203B1 publication Critical patent/NO326203B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
NO20005616A 1998-05-08 2000-11-07 Fremgangsmate for fremstilling av S-N,N'-bis[2-hydroksy-1-(hydroksymetyl)etyl]-[5-[(2-hydroksy-1-oksopropyl)-amino]-2,4,6-trijod-1,3-benzendikarboksamid NO326203B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT98MI001005A IT1299202B1 (it) 1998-05-08 1998-05-08 Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
PCT/EP1999/002804 WO1999058494A2 (en) 1998-05-08 1999-04-26 Process for the preparation of s- n,n'- bis[2- hydroxy-1- (hydroxymethyl) ethyl]-5- [(2- hydroxy-1- oxopropyl)- amino]- 2,4,6- triiodo- 1,3- benzenedicarboxamide

Publications (3)

Publication Number Publication Date
NO20005616D0 NO20005616D0 (no) 2000-11-07
NO20005616L true NO20005616L (no) 2000-11-07
NO326203B1 NO326203B1 (no) 2008-10-20

Family

ID=11379983

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005616A NO326203B1 (no) 1998-05-08 2000-11-07 Fremgangsmate for fremstilling av S-N,N'-bis[2-hydroksy-1-(hydroksymetyl)etyl]-[5-[(2-hydroksy-1-oksopropyl)-amino]-2,4,6-trijod-1,3-benzendikarboksamid

Country Status (15)

Country Link
EP (1) EP1075462B1 (no)
JP (1) JP4390389B2 (no)
KR (1) KR100612480B1 (no)
CN (1) CN100336800C (no)
AT (1) ATE243676T1 (no)
AU (1) AU749785B2 (no)
CA (1) CA2331660C (no)
CZ (1) CZ293801B6 (no)
DE (1) DE69909078T2 (no)
DK (1) DK1075462T3 (no)
ES (1) ES2201719T3 (no)
IT (1) IT1299202B1 (no)
NO (1) NO326203B1 (no)
PT (1) PT1075462E (no)
WO (1) WO1999058494A2 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101098553B1 (ko) * 2008-04-30 2011-12-26 주식회사 엘지생명과학 이오프로마이드의 신규한 제조방법
HUE034436T2 (en) * 2008-11-18 2018-02-28 Bracco Imaging Spa A method for producing iodinated contrast media
EP2230227A1 (en) 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
KR102044772B1 (ko) 2012-12-11 2019-11-14 브라코 이미징 에스.피.에이. (s)-2-아세틸옥시프로피온산 클로라이드의 제조를 위한 연속식 공정
CN105705483B (zh) 2013-11-05 2018-09-04 伯拉考成像股份公司 碘帕醇的制备方法
LT3154928T (lt) 2014-06-10 2020-05-11 Bracco Imaging S.P.A. (s)-2-acetiloksipropioninės rūgšties ir jos darinių gavimo būdas
CN105272899B (zh) * 2015-11-17 2017-09-22 浙江海洲制药有限公司 一种化合物及其用于合成碘帕醇杂质d、杂质f、杂质g和杂质j的方法
CN110023279B (zh) * 2016-12-05 2022-03-11 伯拉考成像股份公司 放射照相剂中间体的机械化学合成
CN110687226B (zh) * 2019-10-18 2022-10-25 上海明捷医药科技有限公司 一种测定碘帕醇中2-氯丙酸含量的方法
EP4452931A1 (en) * 2021-12-20 2024-10-30 Bracco Imaging SPA Process for the preparation of 2,4,6-triiodoisophthalic bisamides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (no) * 1974-12-13 1978-12-29 Savac Ag
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
DE2928417A1 (de) * 1979-07-12 1981-01-29 Schering Ag Trijodierte basen
IT1256163B (it) * 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1288114B1 (it) * 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio

Also Published As

Publication number Publication date
CA2331660C (en) 2008-07-08
NO20005616D0 (no) 2000-11-07
KR100612480B1 (ko) 2006-08-16
DE69909078D1 (de) 2003-07-31
ATE243676T1 (de) 2003-07-15
WO1999058494A3 (en) 2000-01-20
CN1302288A (zh) 2001-07-04
JP2002517381A (ja) 2002-06-18
DE69909078T2 (de) 2003-12-18
WO1999058494A2 (en) 1999-11-18
DK1075462T3 (da) 2003-10-13
AU749785B2 (en) 2002-07-04
CN100336800C (zh) 2007-09-12
JP4390389B2 (ja) 2009-12-24
CA2331660A1 (en) 1999-11-18
EP1075462A2 (en) 2001-02-14
CZ20004124A3 (cs) 2002-03-13
KR20010071221A (ko) 2001-07-28
ITMI981005A1 (it) 1999-11-08
ES2201719T3 (es) 2004-03-16
AU4135699A (en) 1999-11-29
NO326203B1 (no) 2008-10-20
CZ293801B6 (cs) 2004-08-18
PT1075462E (pt) 2003-10-31
EP1075462B1 (en) 2003-06-25
IT1299202B1 (it) 2000-02-29

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