ES2136011A1 - Procedimiento para la preparacion de un intermedio util en la sintesis de medios de contraste yodados. - Google Patents

Procedimiento para la preparacion de un intermedio util en la sintesis de medios de contraste yodados.

Info

Publication number
ES2136011A1
ES2136011A1 ES009700637A ES9700637A ES2136011A1 ES 2136011 A1 ES2136011 A1 ES 2136011A1 ES 009700637 A ES009700637 A ES 009700637A ES 9700637 A ES9700637 A ES 9700637A ES 2136011 A1 ES2136011 A1 ES 2136011A1
Authority
ES
Spain
Prior art keywords
synthesis
preparation
procedure
contrast media
useful intermediate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009700637A
Other languages
English (en)
Other versions
ES2136011B1 (es
Inventor
Marco Villa
Antonio Nardi
Maurizio Paiocchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Publication of ES2136011A1 publication Critical patent/ES2136011A1/es
Application granted granted Critical
Publication of ES2136011B1 publication Critical patent/ES2136011B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)

Abstract

Procedimiento para la preparación de un intermedio útil en la síntesis de medios de contraste yodados.Se describe un procedimiento para la preparación de (S) - n,n"'' - bis [2 - hidroxi - 1 - (hidroximetil) etil] - 5 - (2 - acetoxi - propionilamino) - 2, 4, 6 - triyodo - isoftalamida, un intermedio útil para la síntesis de iopamidol, mediante reacción entre dicloruro de L - 5 - (2 - acetoxi - propionilamino) - 2, 4, 6 - triyodo - isoftaloilo y 2 - amino - 1,3 - propandiol en N-metilpirrolidona y en presencia de unabase.
ES009700637A 1996-03-29 1997-03-25 Procedimiento para la preparacion de un intermedio util en la sintesis de medios de contraste yodados. Expired - Fee Related ES2136011B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI000621A IT1283319B1 (it) 1996-03-29 1996-03-29 Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati

Publications (2)

Publication Number Publication Date
ES2136011A1 true ES2136011A1 (es) 1999-11-01
ES2136011B1 ES2136011B1 (es) 2000-07-01

Family

ID=11373817

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009700637A Expired - Fee Related ES2136011B1 (es) 1996-03-29 1997-03-25 Procedimiento para la preparacion de un intermedio util en la sintesis de medios de contraste yodados.

Country Status (21)

Country Link
US (1) US5817861A (es)
JP (1) JP4035198B2 (es)
BE (1) BE1010961A3 (es)
CA (1) CA2201012C (es)
CH (1) CH692044A5 (es)
CZ (1) CZ96097A3 (es)
DE (1) DE19713456B4 (es)
DK (1) DK32297A (es)
ES (1) ES2136011B1 (es)
FI (1) FI971318L (es)
FR (1) FR2746796B1 (es)
GB (1) GB2311524B (es)
HU (1) HU225647B1 (es)
IE (1) IE970214A1 (es)
IL (1) IL120483A (es)
IT (1) IT1283319B1 (es)
NL (1) NL1005650C2 (es)
NO (1) NO322508B1 (es)
PT (1) PT101982B (es)
SE (1) SE9701145L (es)
ZA (1) ZA972627B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262303B1 (en) 1998-05-08 2001-07-17 Dibra S.P.A. Process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamide
IT1299202B1 (it) * 1998-05-08 2000-02-29 Dibra Spa Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
IT1302200B1 (it) 1998-09-11 2000-07-31 Dibra Spa PROCESSO PER LA PREPARAZIONE DELLA S-N,N'-BIS°2-IDROSSI-1-(IDROSSIMETIL)ETILé-5-°(2-IDROSSI-1-
KR20000075115A (ko) * 1999-05-28 2000-12-15 강재헌 불순물 ｃ가 제거된 이오파미돌의 신규 제조방법
JP5536087B2 (ja) * 2008-11-18 2014-07-02 ブラッコ・イメージング・ソシエタ・ペル・アチオニ ヨウ化造影剤の製造方法
CN105272899B (zh) * 2015-11-17 2017-09-22 浙江海洲制药有限公司 一种化合物及其用于合成碘帕醇杂质d、杂质f、杂质g和杂质j的方法
WO2019160037A1 (ja) * 2018-02-14 2019-08-22 国立大学法人 東京大学 酸ハロゲン化物による化合物の製造方法
GB202009917D0 (en) * 2020-06-29 2020-08-12 Ge Healthcare As Process for the preparation of iopamidol
CN116063195A (zh) * 2023-01-07 2023-05-05 安庆朗坤药业有限公司 一种碘帕醇中间体碘化物的制备方法
EP4727912A1 (en) 2023-06-13 2026-04-22 Bracco Imaging SPA Synthesis of non-ionic radiographic contrast agents by means of reactive extrusion

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1472050A (en) * 1974-12-13 1977-04-27 Savac Ag Non-ionic x-ray contrast agents
ES2017277A6 (es) * 1989-09-20 1991-01-16 Juste Sa Un procedimiento para la preparacion de nuevos agentes iodados no ionicos de contraste.
ES2067710T3 (es) * 1990-01-05 1995-04-01 Guerbet Sa Compuestos no ionicos yodados, su procedimiento de preparacion y productos de contraste que contienen los mismos.
ES2073370A1 (es) * 1992-10-27 1995-08-01 Zambon Spa Procedimiento para la preparacion del compuesto bis-(1,3-dihidroxi-propilamida) del acido l-5-(2-acetoxi-propionilamino)-2,4,6-triyodo-isoftalico.
FR2716881A1 (fr) * 1994-03-03 1995-09-08 Zambon Spa Procédé de préparation et de purification d'Iopamidol.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH616403A5 (en) * 1975-10-29 1980-03-31 Bracco Ind Chimica Spa Process for the preparation of 2,4,6-triodoisophthalamides which are readily soluble in water.
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
DE4320499A1 (de) * 1993-05-14 1994-11-17 Bayer Ag Verfahren zur Herstellung von 2-Oximinoessigsäurederivaten

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1472050A (en) * 1974-12-13 1977-04-27 Savac Ag Non-ionic x-ray contrast agents
ES2017277A6 (es) * 1989-09-20 1991-01-16 Juste Sa Un procedimiento para la preparacion de nuevos agentes iodados no ionicos de contraste.
ES2067710T3 (es) * 1990-01-05 1995-04-01 Guerbet Sa Compuestos no ionicos yodados, su procedimiento de preparacion y productos de contraste que contienen los mismos.
ES2073370A1 (es) * 1992-10-27 1995-08-01 Zambon Spa Procedimiento para la preparacion del compuesto bis-(1,3-dihidroxi-propilamida) del acido l-5-(2-acetoxi-propionilamino)-2,4,6-triyodo-isoftalico.
FR2716881A1 (fr) * 1994-03-03 1995-09-08 Zambon Spa Procédé de préparation et de purification d'Iopamidol.

Also Published As

Publication number Publication date
JP4035198B2 (ja) 2008-01-16
NO971426L (no) 1997-09-30
DE19713456B4 (de) 2007-01-11
US5817861A (en) 1998-10-06
IL120483A0 (en) 1997-07-13
DE19713456A1 (de) 1997-10-30
CA2201012A1 (en) 1997-09-29
HU225647B1 (en) 2007-05-29
ZA972627B (en) 1997-10-23
NO322508B1 (no) 2006-10-16
ITMI960621A1 (it) 1997-09-29
IT1283319B1 (it) 1998-04-16
IL120483A (en) 2000-07-16
PT101982A (pt) 1997-11-28
HUP9700667A2 (hu) 1999-06-28
CZ96097A3 (cs) 1998-04-15
ITMI960621A0 (es) 1996-03-29
PT101982B (pt) 1999-06-30
GB2311524B (en) 1999-04-07
CA2201012C (en) 2005-07-12
CH692044A5 (it) 2002-01-15
JPH107636A (ja) 1998-01-13
GB9706095D0 (en) 1997-05-14
ES2136011B1 (es) 2000-07-01
FI971318A0 (fi) 1997-03-27
HUP9700667A3 (en) 2001-12-28
GB2311524A (en) 1997-10-01
FI971318A7 (fi) 1997-09-30
NL1005650C2 (nl) 2000-05-31
NO971426D0 (no) 1997-03-25
HU9700667D0 (en) 1997-05-28
BE1010961A3 (fr) 1999-03-02
DK32297A (da) 1997-09-30
FR2746796B1 (fr) 1998-09-11
NL1005650A1 (nl) 1997-09-30
SE9701145D0 (sv) 1997-03-27
IE970214A1 (en) 1997-10-08
FI971318L (fi) 1997-09-30
FR2746796A1 (fr) 1997-10-03
SE9701145L (sv) 1997-09-30

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