DK1082109T3 - Oral formulering omfattende biguanid og en organisk syre - Google Patents

Oral formulering omfattende biguanid og en organisk syre

Info

Publication number
DK1082109T3
DK1082109T3 DK99917144T DK99917144T DK1082109T3 DK 1082109 T3 DK1082109 T3 DK 1082109T3 DK 99917144 T DK99917144 T DK 99917144T DK 99917144 T DK99917144 T DK 99917144T DK 1082109 T3 DK1082109 T3 DK 1082109T3
Authority
DK
Denmark
Prior art keywords
biguanide
organic acid
oral formulation
saltiness
bitterness
Prior art date
Application number
DK99917144T
Other languages
Danish (da)
English (en)
Inventor
Hiroyuki Nishii
Hirohisa Kobayashi
Kazuya Otoda
Original Assignee
Sumitomo Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharma filed Critical Sumitomo Pharma
Application granted granted Critical
Publication of DK1082109T3 publication Critical patent/DK1082109T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK99917144T 1998-04-29 1999-04-26 Oral formulering omfattende biguanid og en organisk syre DK1082109T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13612698 1998-04-29

Publications (1)

Publication Number Publication Date
DK1082109T3 true DK1082109T3 (da) 2004-08-09

Family

ID=15167924

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99917144T DK1082109T3 (da) 1998-04-29 1999-04-26 Oral formulering omfattende biguanid og en organisk syre

Country Status (11)

Country Link
US (1) US6517870B1 (de)
EP (1) EP1082109B1 (de)
JP (2) JP4606582B2 (de)
AT (1) ATE269069T1 (de)
AU (1) AU3536299A (de)
CA (1) CA2330485C (de)
DE (1) DE69918105T2 (de)
DK (1) DK1082109T3 (de)
ES (1) ES2224634T3 (de)
PT (1) PT1082109E (de)
WO (1) WO1999055320A1 (de)

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BR0113102A (pt) 2000-08-07 2003-07-08 Ranbaxy Signature Llc Formulação lìquida de metformina
JP4706096B2 (ja) * 2000-10-23 2011-06-22 大正製薬株式会社 不快な味を呈する塩基性薬物配合製剤
FR2818906B1 (fr) 2000-12-29 2004-04-02 Dospharma Association medicamenteuse d'une biguanine et d'un transporteur, par exemple de metformine et d'arginine
FR2818908B1 (fr) * 2000-12-29 2004-04-02 Dospharma Utilisation en tant que medicament d'un compose restituant in vivo des principes actifs
NZ526821A (en) 2001-01-18 2005-02-25 Genzyme Corp Ionene polymers and their use as antimicrobial agents
US7220312B2 (en) * 2002-03-13 2007-05-22 Micron Technology, Inc. Methods for treating semiconductor substrates
US7785627B2 (en) 2002-09-20 2010-08-31 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US9060941B2 (en) 2002-09-20 2015-06-23 Actavis, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7959946B2 (en) 2002-09-20 2011-06-14 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8084058B2 (en) 2002-09-20 2011-12-27 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8992980B2 (en) 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
FR2858556B1 (fr) * 2003-08-06 2006-03-10 Galenix Innovations Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
WO2005037264A1 (ja) * 2003-10-17 2005-04-28 Medrx Co., Ltd. ビグアナイド系薬剤を含有するゼリー製剤
JP2005139173A (ja) * 2003-10-17 2005-06-02 Medorekkusu:Kk ビグアナイド系薬剤を含有するゼリー製剤
CN1913876B (zh) * 2003-12-09 2013-06-26 大日本住友制药株式会社 含药物的颗粒和包含这种颗粒的固体制剂
DE10360924A1 (de) * 2003-12-23 2005-07-28 IIP - Institut für industrielle Pharmazie, Forschungs- und Entwicklungsgesellschaft mbH Metformin-haltige pharmazeutische Zusammensetzung
JP4814636B2 (ja) * 2004-01-29 2011-11-16 大日本住友製薬株式会社 ビグアナイド系薬物の内服製剤
EP1568369A1 (de) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Verwendung von Meloxicam zur Behandlung von Atemwegserkrankungen bei Schweinen
DE102005006539A1 (de) * 2005-02-11 2006-08-24 Merck Patent Gmbh Biguanid enthaltende Zusammensetzungen
PE20061245A1 (es) * 2005-03-30 2007-01-06 Generex Pharm Inc Composiciones para la transmision transmucosa oral de la metformina
CA2607419C (en) 2005-04-26 2014-06-17 Dainippon Sumitomo Pharma Co., Ltd. Granular preparation containing biguanide compound
KR20080034166A (ko) * 2005-11-02 2008-04-18 테이코쿠 팔마 유에스에이, 인코포레이티드 감각기관 수용성 이부프로펜 경구 투약 제형 및 동일물의제조 및 사용 방법
US20080107787A1 (en) * 2006-11-02 2008-05-08 The Coca-Cola Company Anti-Diabetic Composition with High-Potency Sweetener
US20080188457A1 (en) * 2007-02-02 2008-08-07 Braincells, Inc. Modulation of Neurogenesis with Biguanides and GSK3-beta Agents
WO2009014960A1 (en) * 2007-07-23 2009-01-29 Teikoku Pharma Usa, Inc. Organoleptically acceptable indole serotonin receptor agonist oral dosage formulations and methods of using the same
JP2009067790A (ja) * 2007-08-21 2009-04-02 Nihon Generic Co Ltd エカベトナトリウムの不快な味をマスキングしてなるゼリー状製剤
EP2203418B1 (de) * 2007-09-21 2017-10-25 HanAll Biopharma Co., Ltd. N,n-dimethyl-imidodicarbonimid-diamid-dicarboxylat, verfahren zu seiner herstellung und pharmazeutische zusammensetzungen damit
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets
WO2011154975A2 (en) 2010-06-08 2011-12-15 Cadila Healthcare Limited Pharmaceutical compositions of metformin
US9339543B2 (en) 2011-10-12 2016-05-17 Merck Sharp & Dohme Corp. Pharmaceutical compositions that inhibit disproportionation
AR088372A1 (es) * 2011-10-19 2014-05-28 Otsuka Pharma Co Ltd Solucion para administracion oral
US8765811B2 (en) 2012-07-10 2014-07-01 Thetis Pharmaceuticals Llc Tri-salt form of metformin
US9382187B2 (en) 2012-07-10 2016-07-05 Thetis Pharmaceuticals Llc Tri-salt form of metformin
US9505709B2 (en) 2014-05-05 2016-11-29 Thetis Pharmaceuticals Llc Compositions and methods relating to ionic salts of peptides
KR20170023061A (ko) 2014-06-18 2017-03-02 테티스 파마수티컬스 엘엘씨 활성제의 미네랄 아미노산 복합체
US9242008B2 (en) 2014-06-18 2016-01-26 Thetis Pharmaceuticals Llc Mineral amino-acid complexes of fatty acids
CA3026264A1 (en) 2016-06-03 2017-12-07 Thetis Pharmaceuticals Llc Compositions and methods relating to salts of specialized pro-resolving mediators

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DE2124256A1 (en) 1971-05-15 1972-11-30 Dr Christian Brunnengraber Chemi sehe Fabrik & Co mbH 2400 Lübeck Oral antidiabetics - contg dicarboxylic amino acids
JPS5840529B2 (ja) * 1975-09-29 1983-09-06 明治製菓株式会社 ケイコウヨウセイザイノセイホウ
US4089957A (en) 1976-06-11 1978-05-16 Ab Kabi Therapeutic compositions against recurrent thrombosis
US5324748A (en) 1981-07-14 1994-06-28 Efamol Limited Method for enhancement of 1-series PG production
JPS60246325A (ja) 1984-05-18 1985-12-06 Takeda Chem Ind Ltd 苦味が軽減された苦味成分含有水性溶液
FR2611500B1 (fr) * 1987-03-06 1990-05-04 Lipha Emploi de derives du biguanide dans la preparation de medicaments
JP2643260B2 (ja) 1988-03-22 1997-08-20 藤沢薬品工業株式会社 シロップ剤
US4975465A (en) 1989-03-28 1990-12-04 American Home Products Corporation Orally administrable ibuprofen compositions
US5260275A (en) 1990-08-14 1993-11-09 Amylin Pharmaceuticals, Inc. Hypoglycemics
US5411755A (en) * 1993-02-16 1995-05-02 The Procter & Gamble Company Process and composition for sweet juice from cucurbitaceae fruit
JP2705787B2 (ja) 1994-09-30 1998-01-28 山之内製薬株式会社 苦味改善易服用性ｈ▲２▼ブロッカー固形製剤
JP3294033B2 (ja) * 1994-12-24 2002-06-17 俊博 森田 オブラート
JPH104939A (ja) * 1996-06-27 1998-01-13 Nippon Shinyaku Co Ltd 飲 料
JPH1036252A (ja) 1996-07-22 1998-02-10 Taisho Pharmaceut Co Ltd ベラドンナ（総）アルカロイド配合内服液剤
JP3658878B2 (ja) * 1996-08-05 2005-06-08 大正製薬株式会社 内服液剤
US6399658B1 (en) 1996-12-24 2002-06-04 Sumitomo Pharmaceuticals Co., Ltd. Composition containing ascorbic acid
ATE261935T1 (de) * 1997-12-08 2004-04-15 Bristol Myers Squibb Co Neue metformin salze und verfahren

Also Published As

Publication number Publication date
DE69918105D1 (de) 2004-07-22
AU3536299A (en) 1999-11-16
ATE269069T1 (de) 2004-07-15
EP1082109B1 (de) 2004-06-16
US6517870B1 (en) 2003-02-11
JP5255604B2 (ja) 2013-08-07
JP4606582B2 (ja) 2011-01-05
CA2330485C (en) 2008-07-08
JP2002512953A (ja) 2002-05-08
EP1082109A1 (de) 2001-03-14
CA2330485A1 (en) 1999-11-04
DE69918105T2 (de) 2005-07-07
WO1999055320A1 (en) 1999-11-04
ES2224634T3 (es) 2005-03-01
PT1082109E (pt) 2004-10-29
JP2010195839A (ja) 2010-09-09

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