DK1082109T3 - Oral formulering omfattende biguanid og en organisk syre - Google Patents

Oral formulering omfattende biguanid og en organisk syre

Info

Publication number
DK1082109T3
DK1082109T3 DK99917144T DK99917144T DK1082109T3 DK 1082109 T3 DK1082109 T3 DK 1082109T3 DK 99917144 T DK99917144 T DK 99917144T DK 99917144 T DK99917144 T DK 99917144T DK 1082109 T3 DK1082109 T3 DK 1082109T3
Authority
DK
Denmark
Prior art keywords
biguanide
organic acid
oral formulation
saltiness
bitterness
Prior art date
Application number
DK99917144T
Other languages
Danish (da)
English (en)
Inventor
Hiroyuki Nishii
Hirohisa Kobayashi
Kazuya Otoda
Original Assignee
Sumitomo Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharma filed Critical Sumitomo Pharma
Application granted granted Critical
Publication of DK1082109T3 publication Critical patent/DK1082109T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK99917144T 1998-04-29 1999-04-26 Oral formulering omfattende biguanid og en organisk syre DK1082109T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13612698 1998-04-29

Publications (1)

Publication Number Publication Date
DK1082109T3 true DK1082109T3 (da) 2004-08-09

Family

ID=15167924

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99917144T DK1082109T3 (da) 1998-04-29 1999-04-26 Oral formulering omfattende biguanid og en organisk syre

Country Status (11)

Country Link
US (1) US6517870B1 (de)
EP (1) EP1082109B1 (de)
JP (2) JP4606582B2 (de)
AT (1) ATE269069T1 (de)
AU (1) AU3536299A (de)
CA (1) CA2330485C (de)
DE (1) DE69918105T2 (de)
DK (1) DK1082109T3 (de)
ES (1) ES2224634T3 (de)
PT (1) PT1082109E (de)
WO (1) WO1999055320A1 (de)

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FR2818906B1 (fr) * 2000-12-29 2004-04-02 Dospharma Association medicamenteuse d'une biguanine et d'un transporteur, par exemple de metformine et d'arginine
FR2818908B1 (fr) * 2000-12-29 2004-04-02 Dospharma Utilisation en tant que medicament d'un compose restituant in vivo des principes actifs
CA2434693A1 (en) 2001-01-18 2002-10-17 Genzyme Corporation Ionene polymers and their use as antimicrobial agents
US7220312B2 (en) * 2002-03-13 2007-05-22 Micron Technology, Inc. Methods for treating semiconductor substrates
US7959946B2 (en) 2002-09-20 2011-06-14 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en) 2002-09-20 2010-08-31 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US9060941B2 (en) 2002-09-20 2015-06-23 Actavis, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8084058B2 (en) 2002-09-20 2011-12-27 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8992980B2 (en) 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
FR2858556B1 (fr) * 2003-08-06 2006-03-10 Galenix Innovations Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
EP1674088A4 (de) * 2003-10-17 2009-04-15 Medrx Co Ltd Gel-präparat mit bioguanid-medikament
JP2005139173A (ja) * 2003-10-17 2005-06-02 Medorekkusu:Kk ビグアナイド系薬剤を含有するゼリー製剤
KR20060126688A (ko) * 2003-12-09 2006-12-08 다이닛본 스미토모 세이야꾸 가부시끼가이샤 약물-함유 입자 및 그 입자를 함유하는 고형 제제
DE10360924A1 (de) * 2003-12-23 2005-07-28 IIP - Institut für industrielle Pharmazie, Forschungs- und Entwicklungsgesellschaft mbH Metformin-haltige pharmazeutische Zusammensetzung
JP4814636B2 (ja) * 2004-01-29 2011-11-16 大日本住友製薬株式会社 ビグアナイド系薬物の内服製剤
EP1568369A1 (de) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Verwendung von Meloxicam zur Behandlung von Atemwegserkrankungen bei Schweinen
DE102005006539A1 (de) * 2005-02-11 2006-08-24 Merck Patent Gmbh Biguanid enthaltende Zusammensetzungen
UY29445A1 (es) * 2005-03-30 2006-10-02 Generex Pharm Inc Composiciones para la transmisión transmucosa oral de la metformina
CN101198319B (zh) * 2005-04-26 2012-08-01 大日本住友制药株式会社 含有双胍化合物的颗粒制剂
EP1942877A4 (de) * 2005-11-02 2011-09-14 Teikoku Pharma Usa Inc Organoleptisch annehmbare orale dosierformen von ibuprofen, herstellungsverfahren und anwendung
US20080107787A1 (en) * 2006-11-02 2008-05-08 The Coca-Cola Company Anti-Diabetic Composition with High-Potency Sweetener
WO2008097861A2 (en) * 2007-02-02 2008-08-14 Braincells, Inc. MODULATION OF NEUROGENESIS WITH BIGUANIDES AND GSK3-ß AGENTS
BRPI0809430A2 (pt) * 2007-07-23 2014-09-09 Teikoku Pharma Usa Inc Formulações de dosagem oral, organolepticamente aceitáveis, de um agonista indol do receptor de cerotonina e métodos de utilização das mesmas
JP2009067790A (ja) * 2007-08-21 2009-04-02 Nihon Generic Co Ltd エカベトナトリウムの不快な味をマスキングしてなるゼリー状製剤
JP5292404B2 (ja) * 2007-09-21 2013-09-18 ハンオル バイオファーマ カンパニー，リミテッド Ｎ，ｎ−ジメチルイミドジカルボンイミド酸ジアミドのジカルボン酸塩、その製造方法、及びその薬剤学的組成物
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets
WO2011154975A2 (en) 2010-06-08 2011-12-15 Cadila Healthcare Limited Pharmaceutical compositions of metformin
US9339543B2 (en) 2011-10-12 2016-05-17 Merck Sharp & Dohme Corp. Pharmaceutical compositions that inhibit disproportionation
AR088372A1 (es) * 2011-10-19 2014-05-28 Otsuka Pharma Co Ltd Solucion para administracion oral
US9382187B2 (en) 2012-07-10 2016-07-05 Thetis Pharmaceuticals Llc Tri-salt form of metformin
US8765811B2 (en) 2012-07-10 2014-07-01 Thetis Pharmaceuticals Llc Tri-salt form of metformin
WO2015171516A1 (en) 2014-05-05 2015-11-12 Thetis Pharmaceuticals Llc Compositions and methods relating to ionic salts of peptides
US9242008B2 (en) 2014-06-18 2016-01-26 Thetis Pharmaceuticals Llc Mineral amino-acid complexes of fatty acids
CN107074884A (zh) 2014-06-18 2017-08-18 西蒂斯制药有限责任公司 活性剂的矿物质氨基酸复合物
KR102437682B1 (ko) 2016-06-03 2022-08-29 테티스 파마수티컬스 엘엘씨 특화된 사전 해소 매개체의 염에 관한 조성물 및 방법

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DE2124256A1 (en) 1971-05-15 1972-11-30 Dr Christian Brunnengraber Chemi sehe Fabrik & Co mbH 2400 Lübeck Oral antidiabetics - contg dicarboxylic amino acids
JPS5840529B2 (ja) * 1975-09-29 1983-09-06 明治製菓株式会社 ケイコウヨウセイザイノセイホウ
US4089957A (en) 1976-06-11 1978-05-16 Ab Kabi Therapeutic compositions against recurrent thrombosis
US5324748A (en) 1981-07-14 1994-06-28 Efamol Limited Method for enhancement of 1-series PG production
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FR2611500B1 (fr) * 1987-03-06 1990-05-04 Lipha Emploi de derives du biguanide dans la preparation de medicaments
JP2643260B2 (ja) 1988-03-22 1997-08-20 藤沢薬品工業株式会社 シロップ剤
US4975465A (en) 1989-03-28 1990-12-04 American Home Products Corporation Orally administrable ibuprofen compositions
US5260275A (en) 1990-08-14 1993-11-09 Amylin Pharmaceuticals, Inc. Hypoglycemics
US5411755A (en) * 1993-02-16 1995-05-02 The Procter & Gamble Company Process and composition for sweet juice from cucurbitaceae fruit
JP2705787B2 (ja) 1994-09-30 1998-01-28 山之内製薬株式会社 苦味改善易服用性ｈ▲２▼ブロッカー固形製剤
JP3294033B2 (ja) * 1994-12-24 2002-06-17 俊博 森田 オブラート
JPH104939A (ja) * 1996-06-27 1998-01-13 Nippon Shinyaku Co Ltd 飲 料
JPH1036252A (ja) 1996-07-22 1998-02-10 Taisho Pharmaceut Co Ltd ベラドンナ（総）アルカロイド配合内服液剤
JP3658878B2 (ja) * 1996-08-05 2005-06-08 大正製薬株式会社 内服液剤
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CA2312990C (en) * 1997-12-08 2008-04-29 Bristol-Myers Squibb Company Novel salts of metformin and method

Also Published As

Publication number Publication date
DE69918105D1 (de) 2004-07-22
EP1082109A1 (de) 2001-03-14
CA2330485C (en) 2008-07-08
JP5255604B2 (ja) 2013-08-07
JP2010195839A (ja) 2010-09-09
EP1082109B1 (de) 2004-06-16
ATE269069T1 (de) 2004-07-15
JP2002512953A (ja) 2002-05-08
PT1082109E (pt) 2004-10-29
JP4606582B2 (ja) 2011-01-05
WO1999055320A1 (en) 1999-11-04
ES2224634T3 (es) 2005-03-01
DE69918105T2 (de) 2005-07-07
US6517870B1 (en) 2003-02-11
AU3536299A (en) 1999-11-16
CA2330485A1 (en) 1999-11-04

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