DK1095656T3 - Farmaceutiske sammensætninger med cholinesterasehæmmeren galanthamin - Google Patents

Farmaceutiske sammensætninger med cholinesterasehæmmeren galanthamin

Info

Publication number: DK1095656T3
Authority: DK; Denmark
Prior art keywords: pharmaceutical compositions; cholinesterase inhibitor; galanthamine; inhibitor galanthamine; extraction
Prior art date: 1995-03-17

Application number

DK01100944T

Other languages

Danish (da)

English (en)

Inventor

Hans-Rainer Hoffmann

Rudolf Matusch

Thomas Hille

Mirko Kreh

Original Assignee

Lohmann Therapie Syst Lts

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-17

Filing date

1996-03-14

Publication date

2003-12-08

1996-03-14 Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts

2003-12-08 Application granted granted Critical

2003-12-08 Publication of DK1095656T3 publication Critical patent/DK1095656T3/da

Links

ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title abstract 4
HPOIPOPJGBKXIR-UHFFFAOYSA-N 3,6-dimethoxy-10-methyl-galantham-1-ene Natural products O1C(C(=CC=2)OC)=C3C=2CN(C)CCC23C1CC(OC)C=C2 HPOIPOPJGBKXIR-UHFFFAOYSA-N 0.000 title abstract 2
LPCKPBWOSNVCEL-UHFFFAOYSA-N Chlidanthine Natural products O1C(C(=CC=2)O)=C3C=2CN(C)CCC23C1CC(OC)C=C2 LPCKPBWOSNVCEL-UHFFFAOYSA-N 0.000 title abstract 2
229960003980 galantamine Drugs 0.000 title abstract 2
BGLNUNCBNALFOZ-WMLDXEAASA-N galanthamine Natural products COc1ccc2CCCC[C@@]34C=CCC[C@@H]3Oc1c24 BGLNUNCBNALFOZ-WMLDXEAASA-N 0.000 title abstract 2
ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 title abstract 2
IYVSXSLYJLAZAT-NOLJZWGESA-N lycoramine Natural products CN1CC[C@@]23CC[C@H](O)C[C@@H]2Oc4cccc(C1)c34 IYVSXSLYJLAZAT-NOLJZWGESA-N 0.000 title abstract 2
229940122041 Cholinesterase inhibitor Drugs 0.000 title 1
239000000544 cholinesterase inhibitor Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229930013930 alkaloid Natural products 0.000 abstract 1
150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
239000000356 contaminant Substances 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000000638 solvent extraction Methods 0.000 abstract 1
231100000331 toxic Toxicity 0.000 abstract 1
230000002588 toxic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Extraction Or Liquid Replacement (AREA)

DK01100944T 1995-03-17 1996-03-14 Farmaceutiske sammensætninger med cholinesterasehæmmeren galanthamin DK1095656T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19509663A DE19509663A1 (de)	1995-03-17	1995-03-17	Verfahren zur Isolierung von Galanthamin

Publications (1)

Publication Number	Publication Date
DK1095656T3 true DK1095656T3 (da)	2003-12-08

Family

ID=7756925

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK01100944T DK1095656T3 (da)	1995-03-17	1996-03-14	Farmaceutiske sammensætninger med cholinesterasehæmmeren galanthamin
DK96907470T DK0815112T3 (da)	1995-03-17	1996-03-14	Fremgangsmåde til isolering af galanthamin

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK96907470T DK0815112T3 (da)	1995-03-17	1996-03-14	Fremgangsmåde til isolering af galanthamin

Country Status (23)

Country	Link
US (5)	US5877172A (fr)
EP (2)	EP0815112B1 (fr)
JP (1)	JP3863180B2 (fr)
KR (1)	KR100427093B1 (fr)
CN (1)	CN1088460C (fr)
AT (2)	ATE247473T1 (fr)
AU (1)	AU707203B2 (fr)
CA (1)	CA2215351C (fr)
CZ (1)	CZ294722B6 (fr)
DE (3)	DE19509663A1 (fr)
DK (2)	DK1095656T3 (fr)
ES (2)	ES2206356T3 (fr)
HU (1)	HU225267B1 (fr)
IL (1)	IL117371A (fr)
MY (1)	MY114698A (fr)
NO (1)	NO316380B1 (fr)
NZ (1)	NZ304008A (fr)
PL (1)	PL184238B1 (fr)
PT (2)	PT815112E (fr)
SI (1)	SI1095656T1 (fr)
SK (1)	SK283861B6 (fr)
WO (1)	WO1996029332A1 (fr)
ZA (1)	ZA962140B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
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DE19509663A1 (de) *	1995-03-17	1996-09-19	Lohmann Therapie Syst Lts	Verfahren zur Isolierung von Galanthamin
AT402691B (de) *	1996-01-26	1997-07-25	Sanochemia Ltd	Verwendung von galanthamin zum herstellen von arzneimitteln zur behandlung von trisomie 21 oder verwandter trisomie-syndrome
EP1150695B1 (fr) *	1999-01-11	2007-02-28	Atanas Russinov Djananov	Complement alimentaire vegetal servant a ameliorer la resistance musculaire et l'endurance d'athletes
US8603546B2 (en) *	1999-01-11	2013-12-10	Herbaceuticals Inc.	Herbal supplement for increased muscle strength and endurance for athletes
DE19906975B4 (de) *	1999-02-19	2004-04-15	Lts Lohmann Therapie-Systeme Ag	Arzneiform zur Behandlung von Alzheimer'scher Demenz
DE19906974C2 (de) *	1999-02-19	2003-10-09	Lohmann Therapie Syst Lts	Verwendung von Desoxypeganin zur Behandlung des Alkoholismus
GB9909469D0 (en) *	1999-04-23	1999-06-23	Wilkinson John A	Insectidal composition
US6426097B2 (en) *	2000-01-28	2002-07-30	Herbaceuticals Inc.	Herbal supplement for cognitive related impairment due to estrogen loss
CA2310926C (fr) *	2000-04-03	2002-10-15	Janssen Pharmaceutica N.V.	Utilisation de la galantamine pour le traitement du comportement neuropsychiatrique associe a la maladie d'alzheimer
DE10119862A1 (de)	2001-04-24	2002-11-07	Hf Arzneimittelforsch Gmbh	Verwendung von Galanthamin zur Behandlung von Krankheitserscheinungen des zentralen Nervensystems aufgrund von Intoxikationen mit psychotropen Substanzen
DE10129265A1 (de) *	2001-06-18	2003-01-02	Hf Arzneimittelforsch Gmbh	Wirkstoff-Kombination zur medikamentösen Sucht- oder Rauschmitteltherapie
DE10134038A1 (de) *	2001-07-12	2003-02-06	Hf Arzneimittelforsch Gmbh	Wirkstoff-Kombination zur medikamentösen Therapie der Nikotinabhängigkeit
AU2002366555A1 (en) *	2001-12-10	2003-06-23	Washington University	Diagnostic for early stage alzheimer's disease
US20040067934A1 (en) *	2002-10-03	2004-04-08	Parys Wim Louis Julien	Use of galantamine for the treatment of neuropsychiatric behaviour associated with alzheimer's disease
AU2004216360B2 (en) *	2003-02-27	2009-09-17	Eisai R & D Management Co., Ltd.	Pharmaceutical composition for treatment of drug dependence
US20050143350A1 (en) *	2003-11-19	2005-06-30	Seed John C.	Combination drug therapy to treat obesity
CA2551946A1 (fr) *	2003-12-31	2005-07-21	Actavis Group Hf	Formulations de galantamine
WO2005065662A1 (fr) *	2003-12-31	2005-07-21	Actavis Group Hf	Formulations solides d'administration de galantamine
WO2006013546A2 (fr) *	2004-07-28	2006-02-09	Ranbaxy Laboratories Limited	Procede de preparation de galantamine pure
FR2879599B1 (fr) *	2004-12-16	2007-03-23	Centre Nat Rech Scient Cnrse	Utilisation de la chromatographie de partage centrifuge pour la purification de la galanthamine
ITMI20042413A1 (it) *	2004-12-17	2005-03-17	Indena Spa	Processo per la preparazione di galantamina bromidrato
KR20070119641A (ko) *	2005-03-17	2007-12-20	아이박스 파마슈티컬스 에스.알.오.	생체 물질로부터 갈란타민을 단리하는 방법
WO2006124585A2 (fr) *	2005-05-13	2006-11-23	Alza Corporation	Systeme d'administration de galantamine a couches multiples equipe d'une protection contre l ecoulement un flux de matiere de reservoir
CN1307180C (zh) *	2005-05-24	2007-03-28	天津大学	从石蒜或雪花莲属原料中提取加兰他敏的方法
EP1937226A2 (fr) *	2005-09-23	2008-07-02	Alza Corporation	Systeme d'administration transdermique de galantamine
US7446352B2 (en) *	2006-03-09	2008-11-04	Tela Innovations, Inc.	Dynamic array architecture
EP2039302A3 (fr)	2007-09-18	2009-06-10	Ethicon Endo-Surgery, Inc.	Dispositifs pour prévenir un iléus post-opératoire
WO2010029554A1 (fr)	2008-09-11	2010-03-18	I.B.R. Israeli Biotechnology Research Ltd.	Extraits de bulbe de leucojum et utilisation de ceux-ci
US8247405B2 (en) *	2008-12-10	2012-08-21	Conopco, Inc.	Skin lightening compositions with acetylcholinesterase inhibitors
CN101602767B (zh) *	2009-05-26	2012-01-11	苏州派腾生物医药科技有限公司	一种加兰他敏的制备方法
DE102009040381A1 (de)	2009-09-07	2011-03-17	Kallimopoulos, Thomas, Dr.	Verfahren zur Isolierung von Alkaloiden aus Pflanzen
CN101787028B (zh) *	2010-01-12	2012-01-04	恩施清江生物工程有限公司	一种从忽地笑中提取加兰他敏的方法
CN102050826B (zh) *	2010-12-21	2012-11-14	浙江工业大学	一种分离加兰他敏的方法
BG67337B1 (bg)	2018-05-23	2021-06-15	Софарма Ад	Метод за получаване на пречистен галантамин хидробромид
CN117717558A (zh) *	2023-12-06	2024-03-19	艾威药业(珠海)有限公司	加兰他敏及其药学上可接受的盐在制备治疗眼部疾病的药物中的应用

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DE1193061B (de) *	1961-12-20	1965-05-20	Vni Chimiko Pharmazewtitschesk	Verfahren zur Gewinnung von Galanthamin-hydrobromid aus Pflanzen der Familie der Amaryllidaceen
US4663318A (en) *	1986-01-15	1987-05-05	Bonnie Davis	Method of treating Alzheimer's disease
DE4010079A1 (de) *	1990-03-29	1991-10-02	Lohmann Therapie Syst Lts	Pharmazeutische formulierung zur behandlung des alkoholismus
US5519017A (en) *	1990-03-29	1996-05-21	Lts Lohmann Therapie-Systeme Gmbh + Co. Kg	Pharmaceutic formulation for the treatment of alcoholism
US5336675A (en) *	1991-05-14	1994-08-09	Ernir Snorrason	Method of treating mania in humans
EP0584185B1 (fr) *	1991-05-14	1999-08-11	Ernir Snorrason	Traitement des etats de fatigue a l'aide d'inhibiteurs de cholinesterase
DE4301782C1 (de) *	1993-01-23	1994-08-25	Lohmann Therapie Syst Lts	Verwendung von Galanthamin zur Behandlung der Nicotinabhängigkeit
DE4301783C1 (de)	1993-01-23	1994-02-03	Lohmann Therapie Syst Lts	Transdermales therapeutisches System mit Galanthamin als wirksamem Bestandteil
US5428159A (en) *	1994-04-08	1995-06-27	Ciba-Geigy Corporation	Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
DE19509663A1 (de) *	1995-03-17	1996-09-19	Lohmann Therapie Syst Lts	Verfahren zur Isolierung von Galanthamin

1995
- 1995-03-17 DE DE19509663A patent/DE19509663A1/de active Pending
1996
- 1996-03-05 IL IL11737196A patent/IL117371A/xx not_active IP Right Cessation
- 1996-03-14 CZ CZ19972835A patent/CZ294722B6/cs not_active IP Right Cessation
- 1996-03-14 DE DE59610680T patent/DE59610680D1/de not_active Expired - Lifetime
- 1996-03-14 HU HU9802234A patent/HU225267B1/hu unknown
- 1996-03-14 PT PT96907470T patent/PT815112E/pt unknown
- 1996-03-14 KR KR1019970706476A patent/KR100427093B1/ko not_active Expired - Lifetime
- 1996-03-14 US US08/913,461 patent/US5877172A/en not_active Expired - Lifetime
- 1996-03-14 JP JP52805596A patent/JP3863180B2/ja not_active Expired - Lifetime
- 1996-03-14 NZ NZ304008A patent/NZ304008A/en not_active IP Right Cessation
- 1996-03-14 AU AU51088/96A patent/AU707203B2/en not_active Expired
- 1996-03-14 DK DK01100944T patent/DK1095656T3/da active
- 1996-03-14 EP EP96907470A patent/EP0815112B1/fr not_active Expired - Lifetime
- 1996-03-14 SI SI9630641T patent/SI1095656T1/xx unknown
- 1996-03-14 AT AT01100944T patent/ATE247473T1/de active
- 1996-03-14 CN CN96192578A patent/CN1088460C/zh not_active Expired - Lifetime
- 1996-03-14 WO PCT/EP1996/001094 patent/WO1996029332A1/fr not_active Ceased
- 1996-03-14 PT PT01100944T patent/PT1095656E/pt unknown
- 1996-03-14 ES ES01100944T patent/ES2206356T3/es not_active Expired - Lifetime
- 1996-03-14 PL PL96322463A patent/PL184238B1/pl unknown
- 1996-03-14 ES ES96907470T patent/ES2162035T3/es not_active Expired - Lifetime
- 1996-03-14 DE DE59607450T patent/DE59607450D1/de not_active Expired - Lifetime
- 1996-03-14 EP EP01100944A patent/EP1095656B1/fr not_active Expired - Lifetime
- 1996-03-14 SK SK1235-97A patent/SK283861B6/sk not_active IP Right Cessation
- 1996-03-14 DK DK96907470T patent/DK0815112T3/da active
- 1996-03-14 AT AT96907470T patent/ATE203993T1/de active
- 1996-03-14 CA CA002215351A patent/CA2215351C/fr not_active Expired - Lifetime
- 1996-03-15 ZA ZA962140A patent/ZA962140B/xx unknown
- 1996-03-15 MY MYPI96000954A patent/MY114698A/en unknown
1997
- 1997-09-08 NO NO19974119A patent/NO316380B1/no not_active IP Right Cessation
1998
- 1998-08-07 US US09/130,883 patent/US6194404B1/en not_active Expired - Lifetime
2000
- 2000-12-21 US US09/741,436 patent/US6335328B2/en not_active Expired - Lifetime
2001
- 2001-11-09 US US09/986,792 patent/US6573376B2/en not_active Expired - Lifetime
2002
- 2002-09-12 US US10/241,585 patent/US6617452B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20020028802A1 (en)	2002-03-07
JP3863180B2 (ja)	2006-12-27
PL184238B1 (pl)	2002-09-30
PT1095656E (pt)	2004-01-30
EP1095656A2 (fr)	2001-05-02
DE59607450D1 (de)	2001-09-13
US6194404B1 (en)	2001-02-27
HU225267B1 (en)	2006-08-28
NO974119L (no)	1997-09-08
IL117371A0 (en)	1996-07-23
AU5108896A (en)	1996-10-08
SK123597A3 (en)	1998-02-04
ES2162035T3 (es)	2001-12-16
MY114698A (en)	2002-12-31
CA2215351A1 (fr)	1996-09-26
CN1178533A (zh)	1998-04-08
KR19980703067A (ko)	1998-09-05
US20010001100A1 (en)	2001-05-10
EP1095656B1 (fr)	2003-08-20
US6617452B2 (en)	2003-09-09
JPH11505519A (ja)	1999-05-21
HUP9802234A2 (hu)	1999-02-01
SI1095656T1 (en)	2004-02-29
EP0815112A1 (fr)	1998-01-07
DK0815112T3 (da)	2001-11-12
EP0815112B1 (fr)	2001-08-08
AU707203B2 (en)	1999-07-08
ZA962140B (en)	1996-09-16
US5877172A (en)	1999-03-02
EP1095656A3 (fr)	2001-05-16
PT815112E (pt)	2002-01-30
ATE247473T1 (de)	2003-09-15
ES2206356T3 (es)	2004-05-16
DE19509663A1 (de)	1996-09-19
WO1996029332A1 (fr)	1996-09-26
CA2215351C (fr)	2005-01-11
MX9707015A (es)	1997-11-29
IL117371A (en)	2000-01-31
ATE203993T1 (de)	2001-08-15
NO974119D0 (no)	1997-09-08
CZ283597A3 (en)	1997-12-17
NO316380B1 (no)	2004-01-19
US20030012831A1 (en)	2003-01-16
US6573376B2 (en)	2003-06-03
HUP9802234A3 (en)	2000-03-28
NZ304008A (en)	1998-09-24
KR100427093B1 (ko)	2004-07-31
US6335328B2 (en)	2002-01-01
CZ294722B6 (cs)	2005-03-16
PL322463A1 (en)	1998-02-02
SK283861B6 (sk)	2004-03-02
CN1088460C (zh)	2002-07-31
DE59610680D1 (de)	2003-09-25

Publication	Publication Date	Title
DK1095656T3 (da)	2003-12-08	Farmaceutiske sammensætninger med cholinesterasehæmmeren galanthamin
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