LU90829I2 - Tepoxalin-zubrin et ses d-riv-s pharmaceutiquement acceptables - Google Patents

Tepoxalin-zubrin et ses d-riv-s pharmaceutiquement acceptables

Info

Publication number
LU90829I2
LU90829I2 LU90829C LU90829C LU90829I2 LU 90829 I2 LU90829 I2 LU 90829I2 LU 90829 C LU90829 C LU 90829C LU 90829 C LU90829 C LU 90829C LU 90829 I2 LU90829 I2 LU 90829I2
Authority
LU
Luxembourg
Prior art keywords
zubrin
tepoxalin
pharmaceutically acceptable
acceptable derivatives
derivatives
Prior art date
Application number
LU90829C
Other languages
English (en)
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of LU90829I2 publication Critical patent/LU90829I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LU90829C 1986-05-29 2001-09-10 Tepoxalin-zubrin et ses d-riv-s pharmaceutiquement acceptables LU90829I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86799686A 1986-05-29 1986-05-29
US07/042,661 US4826868A (en) 1986-05-29 1987-04-29 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use

Publications (1)

Publication Number Publication Date
LU90829I2 true LU90829I2 (fr) 2001-11-12

Family

ID=26719497

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90829C LU90829I2 (fr) 1986-05-29 2001-09-10 Tepoxalin-zubrin et ses d-riv-s pharmaceutiquement acceptables

Country Status (21)

Country Link
US (1) US4826868A (fr)
EP (1) EP0248594B1 (fr)
JP (1) JP2512751B2 (fr)
KR (1) KR960007163B1 (fr)
CN (1) CN1028227C (fr)
AU (1) AU596844B2 (fr)
CA (1) CA1337122C (fr)
DE (2) DE10199049I2 (fr)
DK (1) DK170202B1 (fr)
ES (1) ES2059377T3 (fr)
FI (1) FI94340C (fr)
HK (1) HK14094A (fr)
HU (1) HU221300B1 (fr)
IE (1) IE63856B1 (fr)
IL (1) IL82671A0 (fr)
LU (1) LU90829I2 (fr)
NL (1) NL300057I2 (fr)
NO (2) NO172236C (fr)
NZ (1) NZ220353A (fr)
PH (1) PH25126A (fr)
PT (1) PT84964B (fr)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
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AU611437B2 (en) * 1987-05-29 1991-06-13 Ortho Pharmaceutical Corporation Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-n-hydroxypropanamides and method for synthesizing the same
EP0293221A3 (fr) * 1987-05-29 1990-07-04 Ortho Pharmaceutical Corporation Synthèse régioselective des pyrazoles 1,5-disubstituées
US4898952A (en) * 1987-05-29 1990-02-06 Ortho Pharmaceutical Corporation Regioselective synthesis of a 1,5-disubstituted pyrazole
CA1334975C (fr) * 1987-11-13 1995-03-28 James H. Holms Composes inhibiteurs de type lipoxygenase contenant des groupes furane et pyrrole
US5096919A (en) * 1989-01-05 1992-03-17 Ciba-Geigy Corporation Pyrrolylphenyl-substituted hydroxamic acid derivatives
US4960787A (en) * 1989-02-06 1990-10-02 Ciba-Geigy Corporation Certain pyrrolyl-substituted hydroxamic acid derivatives
US4994482A (en) * 1989-07-31 1991-02-19 Bristol-Myers Squibb Company Arylpyrazol derivatives as anti-platelet agents, compositions and use
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
EP0442448A3 (en) 1990-02-13 1992-08-12 Bristol-Myers Squibb Company Heterocyclic carboxylic acids and esters
US4956379A (en) * 1990-02-13 1990-09-11 Bristol-Myers Squibb Company Pyrazole carboxylic acids and esters and inhibition of blood platelet aggregation therewith
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
CA2052950A1 (fr) * 1990-10-10 1992-04-11 David P. Evitts Microemulsions aqueuses de tepoxalin a usage ophtalmique
US5366987A (en) * 1991-08-22 1994-11-22 Warner-Lambert Company Isoxazolyl-substituted alkyl amide ACAT inhibitors
US5260458A (en) * 1991-09-26 1993-11-09 Ortho Pharmaceutical Corporation 2-oxo tetrahydrofuran compounds
US5117054A (en) * 1991-09-26 1992-05-26 Ortho Pharmaceutical Corporation N-hydroxy, N-methyl propanamides
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5550147A (en) * 1992-02-05 1996-08-27 Fujisawa Pharmaceutical Co., Ltd. Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5387602A (en) * 1993-08-30 1995-02-07 Ortho Pharmaceutical Corporation 1.5-diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles
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DE69422306T4 (de) * 1993-11-30 2000-09-07 G.D. Searle & Co., Chicago Substituierte pyrazolyl-benzolsulfonamide zur behandlung von entzündungen
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US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
WO1996014302A1 (fr) * 1994-11-08 1996-05-17 Eisai Co., Ltd. Derives pyrazole presentant des effets anti-inflammatoires et analgesiques
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DE69531506T2 (de) * 1994-12-13 2004-06-24 Euroceltique S.A. Arylthioxanthine
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
CA2223154A1 (fr) 1995-06-02 1996-12-05 G.D. Searle & Co. Derives heterocyclo-substitues d'acide hydroxamique utilises comme inhibiteurs de la cyclo-oxygenase-2 et de la 5-lipoxygenase
ES2247604T3 (es) * 1995-06-12 2006-03-01 G.D. SEARLE & CO. Composiciones que comprenden un inhibidor de ciclooxigenasa-2 y un inhibidor de 5-lipoxigenasa.
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5783597A (en) * 1997-03-04 1998-07-21 Ortho Pharmaceutical Corporation 2,5-disubstituted thiophenes: inhibitors of 5-lipoxygenase and inducible cyclooxygenase (COX-2) enzymes, composition and use
DE19816880A1 (de) * 1998-04-17 1999-10-21 Boehringer Ingelheim Pharma Neue Diphenyl-substituierte 5-Ring-Heterocyclen, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
US6191147B1 (en) 1998-12-24 2001-02-20 Ppd Discovery, Inc. Pyrazole compounds and uses thereof
PT1144382E (pt) * 1999-08-03 2005-02-28 Ortho Mcneil Pharm Inc Processo para a preparacao de 1,5-diaril-3-(substituido)pirazoles
EP2316468A1 (fr) 2002-02-22 2011-05-04 Shire LLC Système de distribution et méthodes de protection et d'administration de dextroamphetamine
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WO2004016741A2 (fr) * 2002-08-14 2004-02-26 Ppd Discovery, Inc. Inhibiteurs de la prenylation contenant du dimethylcyclobutane, leurs methodes de synthese et leur utilisation
AU2003265395A1 (en) * 2002-08-14 2004-03-03 Ppd Discovery, Inc. Prenylation inhibitors and methods of their synthesis and use
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EP2388005A1 (fr) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Ligands sigma pour la prévention et/ou le traitement du vomissement induit par la chimiothérapie ou la radiothérapie
EP2395003A1 (fr) * 2010-05-27 2011-12-14 Laboratorios Del. Dr. Esteve, S.A. Composés pyrazoliques en tant qu'inhibiteurs du récepteur sigma
WO2011161615A1 (fr) * 2010-06-24 2011-12-29 Ranbaxy Laboratories Limited Inhibiteurs de la 5-lipoxygénase
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CA2803880C (fr) * 2010-06-28 2018-09-25 President And Fellows Of Harvard College Composes pour inhiber la proliferation cellulaire
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TN2016000228A1 (en) 2013-12-17 2017-10-06 Esteve Labor Dr SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS.

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BE755924A (fr) * 1969-09-12 1971-02-15 Byk Gulden Lomberg Chem Fab Derives d'acide pyrazole-4-acetique, leur procede de preparation et medicaments en contenant
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DE3205187A1 (de) * 1982-02-13 1983-08-25 Hoechst Ag, 6230 Frankfurt Substituierte phenylpyrazolderivate, verfahren zu ihrer herstellung, arzneimittel auf basis dieser verbindungen, sowie deren verwendung

Also Published As

Publication number Publication date
ES2059377T3 (es) 1994-11-16
DE10199049I2 (de) 2003-01-09
PT84964B (pt) 1990-02-08
PT84964A (en) 1987-06-01
JP2512751B2 (ja) 1996-07-03
DK273587A (da) 1987-11-30
NO172236B (no) 1993-03-15
EP0248594A2 (fr) 1987-12-09
IE63856B1 (en) 1995-06-14
DK273587D0 (da) 1987-05-27
NL300057I1 (nl) 2001-12-01
DK170202B1 (da) 1995-06-12
NO872228L (no) 1987-11-30
AU7360887A (en) 1987-12-10
NO2001016I1 (no) 2001-10-01
IL82671A0 (en) 1987-11-30
HU221300B1 (en) 2002-09-28
HUT68247A (en) 1995-06-28
DE3788244D1 (de) 1994-01-05
DE3788244T2 (de) 1994-04-14
NO172236C (no) 1993-06-23
CA1337122C (fr) 1995-09-26
CN1028227C (zh) 1995-04-19
CN87103953A (zh) 1987-12-09
EP0248594A3 (en) 1988-11-17
NO872228D0 (no) 1987-05-27
FI872379A7 (fi) 1987-11-30
FI872379A0 (fi) 1987-05-28
AU596844B2 (en) 1990-05-17
KR960007163B1 (ko) 1996-05-29
PH25126A (en) 1991-02-19
US4826868A (en) 1989-05-02
EP0248594B1 (fr) 1993-11-24
IE871403L (en) 1987-11-29
NL300057I2 (nl) 2002-01-02
JPS6322080A (ja) 1988-01-29
NZ220353A (en) 1989-05-29
HK14094A (en) 1994-03-04
FI94340C (fi) 1995-08-25
DE10199049I1 (de) 2002-01-10
FI94340B (fi) 1995-05-15
KR870011100A (ko) 1987-12-21

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